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At least 55 records · Page 3Linked to original sources
PubMed1953

Chronic sodium chloride toxicity in the albino rat. II. Occurrence of hypertension and of a syndrome of edema and renal failure.

Sustained arterial hypertension developed in male, albino rats chronically fed diets rich in sodium chloride with demineralized drinking water available ad libitum. After 12 months of the experimental regimen a positive, linear correlation (r = 0.91) was found between the systolic blood pressure and the concentration of sodium chloride in the diet. A syndrome of edema and renal failure was observed in 18 per cent of the group fed at the level of 7.0 to 9.8 per cent of sodium chloride. Significant histologic changes occurred in the kidneys and certain other organs in rats consuming rations containing these levels of NaCl. The relative volume of the radiosodium space was increased in the rat by high dietary sodium chloride.

Animals↗
PubMed1958

Inhibition by various substances of oedema formation in the bind-paw of the rat induced by 5-hydroxytryptamine, histamine, dextran, egg-white and compound 48/80.

Of the substances studied for their inhibitory action of the oedema formation in the hind-paw of the rat, the most active was a new derivative of phenothiazine, related to chlorpromazine. It is methotrimeprazine {10-(3-dimethylamino-2-methylpropyl)-2-methoxyphenothiazine; 7044 RP}. This substance possesses potent antihistamine and anti-5-hydroxytryptamine properties, and doses of 0.25 mg./kg. inhibited the blueing and swelling of the foot after injections of histamine, 5-hydroxytryptamine, eggwhite, dextran or compound 48/80 into the feet of rats with sulphan blue (Evan's blue) dye in their circulation. The results indicate that both histamine and 5-hydroxytryptamine play rôles in increasing capillary permeability in the rat.

Animals↗
PubMed1959

Antiphlogistic activity of iproniazid.

Iproniazid was found to inhibit formalin-induced oedema of the foot, dextran-induced oedema and cotton-pellet-induced granulomatous tissue in the rat. The presence of the adrenals was essential for the antiphlogistic activity. The antiphlogistic action was not accompanied by any antipyretic effect. Inhibition of formalin-induced oedema was also observed with phenylbutazone and with salicylamide.

Animals↗