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At least 55 records · Page 3Linked to original sources
PubMed1984

Cytotoxic effects of Eleutherococcus senticosus aqueous extracts in combination with N6-(delta 2-isopentenyl)-adenosine and 1-beta-D-arabinofuranosylcytosine against L1210 leukemia cells.

The use of the aqueous extracts of Eleutherococcus senticosus in combination with either cytarabine or N6-(delta 2-isopentenyl)-adenosine gave additive antiproliferative effects against L1210 murine leukemia. The ED50 for E. senticosus root extracts against L1210 cells was approximately 75 micrograms/mL. E. senticosus appears to be potentially useful for reducing the concentration of conventional antimetabolites used for their antiproliferative effects on tumor cells.

Adenine↗
PubMed1984

Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo and in vitro.

Eleutherococcus senticosus (Siberian Ginseng) is widely exported from China as a health food. Pharmacologically it has been classified as an adaptogen and enzyme induction has been proposed as its mechanism of action. To evaluate this hypothesis E. senticosus was administered to mice on an acute (40-320 mg/kg i.p., X 1 day) or chronic (80-320 mg/kg i.p., X 4-5 days) basis. Sleep latency and duration, in response to hexobarbital sodium (100 mg/kg i.p.), were determined either 1 h (acute and chronic) or 24 h (chronic) following the last E. senticosus injection. E. senticosus produced a sedative effect which decreased the sleep latency (47%) and increased sleep duration (45-228%) following acute administration. A similar effect was seen following chronic administration (125-202% increase in sleep duration). E. senticosus was also shown to produce an inhibition (66%) of hexobarbital metabolism, in vitro, as compared to controls. These data support enzyme inhibition rather than enzyme induction as a mechanism for the actions of Siberian Ginseng.

Animals↗
PubMed2001

Triiodobenzoic acid, an auxin polar transport inhibitor, suppresses somatic embryo formation and postembryonic shoot/root development in Eleutherococcus senticosus.

The effect of auxin polar transport inhibitor on somatic embryo development and postembryonic growth in Siberian ginseng (Eleutherococcus senticosus) was examined. In the presence of 2,3,5-triiodobenzoic acid (TIBA), an auxin polar transport inhibitor, embryo formation from embryogenic cells was suppressed, while cell division was not affected. When globular embryos at different stages were transferred onto medium containing TIBA, development of axial and bilateral polarity was suppressed in a stagespecific manner. In abnormal embryos induced by TIBA, further development of shoot and root apical meristems and vascular differentiation was also suppressed. Thus, abnormal development of embryos induced by inhibition of auxin polar transport resulted in plantlets without shoots and roots.

Journal Article↗
PubMedDate not supplied

Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots.

Intraperitoneal injection of an aqueous extract of the crude drug "shigoka" (Siberian ginseng), Eleutherococcus senticosus roots, remarkably diminished plasma-sugar level in mice. Fractionation of the extract by monitoring the activity yielded seven glycans, eleutherans A, B, C, D, E, F, and G, which exerted marked hypoglycemic effects in normal and alloxan-induced hyperglycemic mice.

Animals↗
PubMed1996

Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance.

We investigated the effect of Eleutherococcus senticosus Maxim L (ESML) on performance during submaximal and maximal aerobic exercise. Twenty highly trained distance runners randomly assigned in matched pairs to either an experimental (ESML) or placebo (PL) group, participated in an 8-wk double-blind study during which they completed five trails of a 10-min treadmill run at their 10 km (10K) race pace and a maximal treadmill test (T(max)). Following a baseline trail, ESML and PL consumed, respectively, 3.4 ml of ESML extract or placebo daily for 6 wk. Subjects were tested every 2 wk during supplementation and 2 wk following withdrawal. Heart rate (HR), oxygen consumption (VO2), expired minute volume (VE), ventilatory equivalent for oxygen (VE/VO2), respiratory exchange ratio (RER), and rating of perceived exertion (RPE) were measured during the 10K and T(max) tests. Resting, post-10K and post-T(max) blood samples were analyzed for serum lactate. No significant differences were observed between ESML and PL for: HR, VO2, VE, VE/VO2, RER, or RPE; T(max) time to exhaustion; or serum lactate. The data do not support an ergogenic effect of ESML supplementation on selected metabolic, performance, or psychologic parameters associated with submaximal and maximal aerobic exercise tasks.

Adult↗
PubMed2000

The effect of siberian ginseng (Eleutherococcus senticosus) on substrate utilization and performance.

It has been suggested that Eleutherococcus senticosus (ES), also known as Siberian ginseng or ciwuija, increases fat utilization in humans. The purpose of this study was to examine the physiological responses to supplementation with ES in endurance cyclists. Using a randomized, double-blind crossover design, 9 highly-trained men (28 +/- 2 years, VáO2max 57.3 +/- 2.0 ml á kg-1 á min-1) cycled for 120 min at '60% VáO2max followed by a simulated 10-km time trial. Diet was controlled, and ES (1,200 mg á day-1) or a placebo (P) were administered for 7 days prior to each of the two trials. Oxygen consumption, respiratory exchange ratio, and heart rate were recorded every 30 min, and rating of perceived exertion, plasma [lactate], and plasma [glucose] were recorded every 20 min during the 120 min of steady state cycling. There were no significant differences (p >.05) between the ES and P groups at any steady-state time interval or during the cycling time trial (ES = 18.10 +/- 0.42, P = 17.83 +/- 0.47 min). In contrast with previous reports, the results of this study suggest that ES supplementation does not alter steady-state substrate utilization or 10-km cycling performance time.

Adult↗
PubMedDate not supplied

[Immunotropic effect of a tincture of the tissue culture biomass of ginseng cells and of an Eleutherococcus extract in mice].

The tincture from biomass of ginseng tissue culture was shown to exert the immunomodulatory effect on humoral immunity and to increase the thymus and spleen weight. It is of interest to note that the biomass preparation did not change the immunity of intact animals but exerted a strong immunomodulatory action on mice previously treated with cyclophosphane. Similar results have been obtained also for another adaptogen--Eleutherococcus.

Adjuvants, Immunologic↗
PubMed2005

Production of eleutherosides in in vitro regenerated embryos and plantlets of Eleutherococcus chiisanensis.

High frequency somatic embryogenesis of Eleutheorcoccus chiisanensis was achieved through suspension culture of embryogenic cells in hormone-free Murashige and Skoog liquid medium supplemented with 30 g sucrose l-1. Cotyledonary somatic embryos were germinated and converted into plantlets using 20 microM: gibberellic acid which were then grown in a 10 l airlift bioreactor. HPLC analysis revealed the accumulation of eleutheroside B, E and E1 in the embryos and plantlets. Thus mass production of embryos and plantlets of E. chiisanensis can be achieved in liquid cultures and the biomass produced may become an alternative source of eleutherosides.

Bioreactors↗
PubMed2005

Treatment of atopic dermatitis with herbal combination of Eleutherococcus, Achillea millefolium, and Lamium album has no advantage over placebo: a double blind, placebo-controlled, randomized trial.

OBJECTIVE: To test the efficacy of tri-herbal combination on atopic dermatitis in a randomized, placebo-controlled trial. METHODS: Forty-nine patients were included for 2 weeks of treatment. Patients were followed until week 8. RESULTS: The response to the real medication was significant in objective and subjective parameters. Patients maintained partial remission until the end of follow-up. The placebo-treated group had a similar response without a significant difference. CONCLUSIONS: Treatment with tri-herbal combination for atopic dermatitis does not differ from treatment with placebo.

Achillea↗
PubMedDate not supplied

[Effect of ionol and eleutherococcus on changes of the hypophyseo-adrenal system in rats under extreme conditions].

Total adaptational syndrome, developed in response to a number of stress situations, is of importance in formation of accommodation reactions. Long-term and severe effects of the syndrome caused morphological and functional alterations in various tissues and body systems: adrenal gland hypertrophy, involution of thymus and spleen, ulcerous impairment of gastric mucosal membrane. At the same time, lipid peroxidation was increased while accumulation of the peroxidation products was observed, which are responsible for various body impairments.

Animals↗
PubMed2000

S. Szolmicki, L. Samochowiec, J. Wojcicki and M. Drozdzik, 'The influence of active components of eleutherococcus senticosus on cellular defence and physical fitness in man'. Phytotherapy research 14(1) 2000, 30-35

The original article to which this Erratum refers was published in Phytotherapy Research 14(1) 2000,30-35. Following the publication of this paper, it came to our attention that the lead author's name was published incorrectly. The correct name of the first author of the above paper is Jaroslaw Szolomicki.

Journal Article↗