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PubMed2004

Factors influencing the outcome of strabismus surgery in patients with exotropia.

PURPOSE: To determine the factors associated with favorable and less favorable outcomes in strabismus surgery for treatment of exotropia and to show the factors influencing the efficacy of the surgical procedure. METHODS: Case files of 225 patients with a diagnosis of primary exotropia were evaluated. Information about patient age at onset of deviation, patient age at surgery, interval between onset and surgery, preoperative deviation, refractive errors, degree of anisometropia, visual acuity, presence of amblyopia, presence of an A- or a V-pattern, amount of surgery performed, type of exotropia (intermittent or constant), and existence of binocular single vision before surgery were obtained and evaluated using multiple regression analysis. RESULTS: Preoperative deviation and refractive errors were proved to be significant factors influencing a favorable outcome in patients with surgically treated exotropia (r(2) = 0.12, P <.001, and r(2) = 0.07, P <.001 respectively). Preoperative deviation, amount of surgery performed, and refractive errors shifting toward myopia significantly influenced the efficacy of the surgery performed (r(2) = 0.31, 0.06, and 0.025, respectively). CONCLUSION: Special care should be paid to refractive errors in patients with exotropia before determining the amount of surgical intervention.

Child, Preschool↗

PubMed2005

Intermittent exotropia, overcorrecting minus lenses, and the Newcastle scoring system.

PURPOSE: We sought to determine whether the Newcastle Control Score (NCS) could be used to indicate a successful outcome in patients with intermittent exotropia that were treated with minus lenses. METHODS: We studied patients with an intermittent exotropia who were prescribed minus lens therapy in an effort to manage their strabismus conservatively. The NCS, which quantitatively estimates the control of an intermittent exotropia, was applied before treatment and 4 months after treatment. The results of minus lens therapy with a pretreatment NCS of > or =5 (group 1) were compared with those with a NCS of < or =4 (group 2). RESULTS: There were 24 patients (13 girls, 11 boys) treated with minus lenses. The mean age of the patients was 6.8 +/- 3.8 years (range, 2-17 years; median, 5). The mean pretreatment distance angle was 28.5 +/- 10 prism diopters (range, 6-45; median, 30) and the mean post-treatment distance angle was 18.3 +/- 8.9 prism diopters (range, 0-35; median, 18) P = 0.001. Using the NCS minus lenses significantly (P = 0.041) improved control of exotropia. In group 2 (n = 16) 75% had improved scores post-treatment compared with 62.5% in group 1 (n = 8), P = 0.68. CONCLUSIONS: These data suggest that the NCS is a useful method to indicate the success in the control of intermittent exotropia with conservative treatment with minus lens therapy.

Accommodation, Ocular↗

PubMed1997

Botulinum toxin management of childhood intermittent exotropia.

OBJECTIVE: Intermittent exotropia is a common form of childhood strabismus that has a late onset and presents a difficult and frustrating management dilemma. Surgical treatments have a high recurrence rate, and multiple surgeries often are required to achieve a desirable motor outcome. This study presents long-term observations on the use of botulinum toxin for the treatment of intermittent exotropia in children. DESIGN: This study is a nonrandomized, case-controlled study of consecutive pediatric patients who had intermittent exotropia. PARTICIPANTS: Thirty-two neurologically normal children ranging from 3 to 144 months in age were diagnosed with intermittent exotropia with a minimum distance deviation of 15 prism diopters (PD). INTERVENTION: Simultaneous bilateral injections of 2.5 units botulinum toxin type A were made into the lateral rectus muscles with the patient receiving nitrous oxide-ethrane inhalation anesthesia. Patients were observed for 12 to 44 months after the initial injection. MAIN OUTCOME MEASURES: A satisfactory outcome was considered to be stable binocular alignment of the eyes to an orthophoric range of +/-10 PD. RESULTS: Bilateral lateral rectus muscle injections of botulinum toxin were effective in reducing the mean preinjection deviation of -29 PD to an average exotropic angle of -6 PD. Stable orthophoria (+/-10 PD) was achieved in 22 patients (69%). Overall, male patients required significantly fewer injections than did female patients. All patients between 24 and 56 months of age, irrespective of gender, required only a single bilateral injection to achieve a favorable motor outcome. CONCLUSIONS: Botulinum toxin is at least as effective as surgical outcomes reported previously for the treatment of intermittent exotropia in children. This treatment method is particularly effective in children between 2 and 4.5 years of age irrespective of the initial strabismic angle and is not associated with any secondary abnormalities.

Anesthesia, Inhalation↗

PubMed2005

Survival analysis of 365 patients with exotropia after surgery.

PURPOSE: Few reports have included large numbers of exotropia patients. Thus, we undertook this study to perform a survival analysis of over 350 patients with exotropia and to determine which factors might affect the outcome of exotropia surgery. METHODS: The clinical records of 365 patients who underwent exotropia surgery by one surgeon were retrospectively reviewed. Preoperative patient characteristics, surgical procedures performed, and early postoperative ocular alignment were evaluated as potential risk factors of surgical outcome using survival analysis. RESULTS: The estimated median time from surgery to recurrence was 48.3 months. None of the characteristics or procedures were found to be significantly associated with surgical outcome. The likelihood of a good postoperative surgical outcome was highest with an initial postoperative alignment of more than 10 prism diopters of esotropia (P<0.001). CONCLUSIONS: Early postoperative overcorrection was the only predictor of a successful long-term outcome after exotropia surgery.

Adolescent↗

PubMed2001

[Results of combined divergence operation in intermittent exotropia in 120 children].

BACKGROUND: Intermittent exotropia is the most frequent indication for surgical correction of exodeviations in childhood. Overcorrection with prolongated or persistent consecutive esotropia can impair binocular vision particularly in early childhood. We wanted to investigate this potential risk and the dose/effect relation of recess-resect surgery on children. PATIENTS AND METHODS: 120 children up to ten years of age underwent recess-resect surgery for intermittent exotropia in our clinic from 1991 to 1999 (< 2% of the surgical cases). The cycloplegic refraction was spectacle corrected with a reduction of 0.5 dpt. Preoperatively, a diagnostic occlusion was performed for three days. The amount of surgery was calculated using our dosage schedules based on effects one week postoperatively. The squint angles as measured by the alternate prism and cover test at 5 m and 0.3 m pre- and 3 months postoperatively and the binocular functions as measured by the Bagolini striated glasses, Titmus, Randot, TNO, or Lang tests were evaluated. RESULTS: (Medians) Squint angles in primary position were: preoperative: distance (5 m)--15 degrees, near (0.3 m)--16 degrees; postoperative (n = 104); distance--4 degrees, near--3 degrees. Effectivity of surgery: distance: 1.3 degrees/mm, near 1.4 degrees/mm. Consecutive esotropia requiring surgical correction occurred in 1 child. Second surgery for intermittent exotropia in the years 1991 to 1999 was necessary in 5 children. Binocular functions (n = 95): Preoperative = postoperative: 61%, postoperative > preoperative 21%, postoperative < preoperative 18%. The diagnostic occlusion was helpful to differentiate "pseudo-divergence excess type" from "divergence excess type" exotropia. The average deviation did not increase under the diagnostic occlusion. The effectivity of surgery (degree/mm) in the children group was lower than in a compared group of older patients (> 10 years) with intermittent exotropia. CONCLUSION: Using our own dosage schedules and surgical technique, residual exodeviations are common after recess-resect surgery in childhood. The risk of consecutive esotropia or persistent impairment of binocular vision is low.

Child↗

PubMed2000

Bilateral lateral rectus recession for consecutive exotropia.

INTRODUCTION: Treatment of consecutive exotropia after bilateral medial rectus recessions has been rarely studied. Though several series have reported results of medial rectus advancement, none has described results of lateral rectus recessions. METHODS: We reviewed our results in 31 patients who underwent bilateral lateral rectus recessions for consecutive exotropia after bilateral medial rectus recessions. Mean follow-up was 30 months (range, 1-140 months) after the exotropia repair. RESULTS: At last follow-up, 20 of 31 patients (65%) had deviations of less than or equal to 10 PD. Limitation of adduction was not apparent. DISCUSSION: Cooper's dictum states that lateral rectus recession should be performed instead of medial rectus advancement. Our results suggest that this approach is generally successful. The outcome after exotropia repair in consecutive deviations is comparable to that after repair of primary exotropia.

Adolescent↗

PubMedDate not supplied

The use of part-time occlusion for early onset unilateral exotropia.

Eleven patients (9 months to 5 years of age) with intermittent or constant exotropia of predominantly one eye on distant gaze were studied to investigate the effect of part-time occlusion. No patient had constant exotropia on near fixation. Visual acuity was found to be equal in both eyes. All patients were treated by part-time patching of the non-deviating eye from four to six hours a day and tapered as appropriate. If exotropia recurred after conversion to a heterophoria, part-time occlusion was reinstated. With occlusion, all patients converted to hetero- or orthophoria, at least temporarily. Mean follow-up (to last visit or surgical intervention) was 22 months (range 3 to 37 months). Three patients (27%) later developed constant exotropia (mean 28.3 months after beginning occlusion) and underwent surgery. Three patients (27%) became and remain orthophoric without further patching. Part-time occlusion for preschool patients with exodeviations that are predominantly unilateral can postpone surgical intervention and convert exotropia to orthophoria or exophoria.

Child, Preschool↗

PubMedDate not supplied

Secondary exotropia: a retrospective analysis of matched cases.

Secondary exotropia, that is exotropia following surgery for esotropia, remains frustratingly common, even among experienced strabismologists. In this study, we have compared a group of secondary exotropia cases with a matched group of cases of residual esotropia. Of the factors analyzed, only the presence of an A- or V-pattern preoperatively (P = .0077), the presence of limited postoperative adduction (P < .001), and postoperative binocular function (P = .0073) identified the secondary exotropes. The presence of reduced adduction postoperatively in subjects with secondary exotropia was a poor prognostic sign with 11 of the 13 cases requiring further surgery for poor cosmesis. The authors suggest two subclassifications of secondary exotropia.

Child↗

PubMedDate not supplied

Bilateral lateral rectus recession for exotropia: a survival analysis.

Exotropia may progress during the childhood years, and the ideal time for surgical intervention remains uncertain. We reviewed our results following bilateral lateral rectus recession in 57 consecutive patients. In order to identify possible predictive covariates, we performed survival analysis using survival time as the time from surgery to failure. The patients' age at the time of surgery ranged from 11 months to 50 years (mean, 68 months). Follow up after surgery ranged from 1 to 105 months (mean, 47 months). Outcomes were considered failures if there was (1) a distance exodeviation greater than 10 prism diopters at any time after surgery, (2) a distance esodeviation greater than 10 delta more than 6 months postoperatively, or (3) further surgery for exotropia or esotropia. By these criteria, surgery was successful in 58% of cases. Results of the survival analysis indicated an estimated mean time to failure of 68 months. Patients with intermittent exotropia were more likely to remain aligned postoperatively than were those with constant deviations. The age at onset of exotropia, age at surgery, angle of deviation at different fixation distances, early postoperative alignment, and presence of symptoms, amblyopia, anisometropia, or incomitance before surgery were not predictive of success. We conclude that exotropia surgery may be performed with the same likelihood of success at any age, but patients with intermittent deviations do better.

Adolescent↗

PubMedDate not supplied

Delayed consecutive exotropia following 7-millimeter bilateral medial rectus recession for congenital esotropia.

The rate of delayed consecutive exotropia after bilateral 7-millimeter medial rectus recession for large angle congenital esotropia in 88 patients was 27% (24/88), larger than previously reported. The rate was 38% (8/21) in infants having surgery prior to 7 months of age, 20% (10/49) in infants undergoing surgery at 7 to 12 months of age, and 33% (6/18) in patients undergoing surgery at 13 months of age or later. The onset of consecutive exotropia averaged 26.8 months postoperatively, allowing a long period of good alignment for binocular vision to develop before exotropia surgery was required. Physicians and parents should be aware that delayed consecutive exotropia may develop several years postoperatively. Since delayed consecutive exotropia may be characteristic of the 7-millimeter recession procedure or characteristic of all patients who have had surgery for congenital esotropia, a prospective long-term study to compare the 7-millimeter procedure with the three- and four-muscle procedure would be helpful.

Child, Preschool↗

PubMedDate not supplied

[Exotropia in black Cameroonians].

We carried out this study to increase our knowledge and understanding of exotropia (divergent strabismus) in general, but particularly in black people, in whom it occurs more frequently. We carried out a prospective study in the department of ophthalmology of Douala General Hospital from November 1991 to June 1998. All patients underwent oculomotor examination and skiascopye. In a series of 225 consecutive strabismus cases, we identified 147 cases of exotropia (59.51%) in 67 male patients (45.58%) and 80 female patients (54.42%). In 59.86% of these cases, exotropia was evident before the age of one year and 59.19% had amblyopia. The mean age at first examination was 17.04 years (+/- 12.12 years). Hyperopia was the most common form of ametropia (59.86%) and 39 patients (26.53%) had parents, children or siblings who also had exotropia. We found that exotropia was the most common form of strabismus in black people in Cameroon and that it spontaneously progressed to amblyopia in a significant number of cases. We therefore recommend early, active treatment.

Adolescent↗

PubMed2000

The use of binocular visual acuity in the assessment of intermittent exotropia.

BACKGROUND: It has been suggested that a decrease in distance stereoacuity in patients with intermittent exotropia is a good indicator of diminishing control. However, there has been no adequate explanation for this reported reduction in distance stereoacuity in these patients. We postulate that the decrease in stereoacuity is related to blurred visual acuity created by an increasing demand on accommodation, which these patients use in an attempt to control the exodeviation. This can best be assessed by measuring binocular visual acuity (BVA). Analysis of BVA could provide a useful clinical tool to evaluate control measures used by patients with intermittent exotropia. METHODS: A prospective study of patients with intermittent exotropia, ranging in age from 6 to 60 years, was performed. Only those patients with the presence of either basic or divergence excess (simulated or true) type exodeviation were included in the study. The data analysis included the age of these patients, age at onset of the deviation, monocular and binocular visual acuity, oculomotor and fusional status, and near and distance stereoacuity. RESULTS: Data from 36 patients show that the measurements of BVA correlated well with a corresponding loss of distance stereoacuity but not with the size of the deviation. CONCLUSION: The decrease of stereoacuity reported in patients with exotropia can be explained by increased accommodation and decreased distance BVA. This measurement can be a simple method of quantifying the fusional control of patients with intermittent exotropia.

Accommodation, Ocular↗

PubMed2002

[A comparison of master eye operation with slave eye operation on patients with large-angle exotropia].

OBJECTIVE: To search for an excellent therapy for patients with large-angle exotropia. METHODS: Strabotomy was performed on the master eyes in the 41 cases (master eye group) and slave eyes in the other 41 cases (slave eye group) with large-angle exotropia (>/= 60(Delta)). The post-operative visual acuity, ocular position, visual function and fixation, the average surgical amount and the frequency of strabotomy were statistically compared between the two groups. RESULTS: Post-operatively, orthophoria occurred in 39 cases and mild exotropia remained in 2 cases in each group. The statistic analyses showed that the surgical results were better in the master eye group in the visual acuity (P < 0.05), visual function (P < 0.05), average surgical amount and frequency (P < 0.01). CONCLUSIONS: The surgical results of strabotomy performed on the master eye in cases with large-angle exotropia are better than that on the slave eye, and the surgical damage in the master eye is less. Thus, the master eye strabotomy is especially suitable for children with large-angle exotropia under general anesthesia.

Adolescent↗

PubMed2004

Clinical features and surgical treatment of A-pattern exotropia.

PURPOSE: To investigate the clinical characteristics and determine the effective surgical managements of A-pattern exotropia. METHODS: Thirty-two patients with A-pattern exotropia underwent superior oblique muscle weakening procedures, medial rectus resection or (and) lateral rectus recession. Pre- and post-operative eye position, deviation angle, superior oblique function and binocular vision were examined and analyzed in the cases. RESULTS: Overaction of the superior oblique muscles (31/32) and underaction of the medial rectus muscle (20/32) were presented in the cases. Postoperatively, a satisfactory ocular alignment was obtained in 28 cases (87.5%), and the A-pattern was corrected in 31 cases (96.9%). Four cases got binocular vision after surgery. CONCLUSIONS: As one of the most common forms of A and V patterns, A-pattern exotropia showed clinical characteristics of superior oblique muscle overaction and medial rectus muscle underacion, which should be the primary factors in the etiology of A-pattern exotropia, and superior oblique weakening procedures combined with horizontal surgery should be an effective approach to A-pattern exotropia treatment.

Adolescent↗

PubMed1990

[Disproportionately large communicating fourth ventricle with bilateral exotropia: report of two cases].

Two cases of disproportionately large communicating fourth ventricle (DLCFV) accompanied by consciousness disturbance and bilateral exotropia are reported. Case #1 was a 21-year-old male who suffered from consciousness disturbance and bilateral exotropia due to malfunction of the ventriculoperitoneal shunt (VPS) which had previously been operated on twice for a left parietal arteriovenous malformation, which had caused ventricular hemorrhage several times. The last hemorrhage was massive and made ventricular casting, including the fourth ventricle. Both bilateral exotropia and the fourth ventricular dilatation were well controlled by the reconstruction of the VPS. Case #2 was a 66-year-old female, semicomatous because of massive subarachnoid hemorrhage with ventricular casting hematoma due to rupture of the right middle cerebral aneurysm. Though an improvement of the consciousness disturbance was obtained by continuous ventricular drainage (CVD), bilateral exotropia and consciousness deterioration appeared after lumboperitoneal shunt followed by the removal of the CVD. Another CVD was then carried out and some improvement was obtained again. However, the same symptoms appeared again after the VPS, followed by the removal of the CVD. The patient finally died despite a third CVD. Autopsy revealed a markedly dilated fourth ventricle and massive subarachnoid clots particularly around the foramen of Magendie and Luschka. The pathogenesis of DLCFV and bilateral exotropia are also discussed.

Adult↗

PubMed2003

Interventions for intermittent distance exotropia.

BACKGROUND: The clinical management of intermittent distance exotropia has been discussed frequently in the literature but there is a lack of clarity regarding the indications for intervention, the most effective type and the optimum age at which it should be carried out. OBJECTIVES: The objective of this review is to assess intervention criteria, the effects of various surgical and non-surgical treatments in people with intermittent distance exotropia and to determine the significance of factors such as age with respect to outcome. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials - CENTRAL (which contains the Cochrane Eyes and Vision Group trials register) on the Cochrane Library (Issue 4 2002), MEDLINE (1966 to November 2002), EMBASE (1980 to November 2002) and LILACS (Latin American and Caribbean Literature on Health Sciences) (1966 to 2002). We manually searched the British Orthoptic Journal, proceedings of the European Strabismological Association (ESA), International Strabismological Association (ISA) and American Academy of Paediatric Ophthalmology and Strabismus meeting (AAPOS). We contacted researchers who are active in the field for information about further published or unpublished studies. There were no language restrictions in the manual or electronic searches. SELECTION CRITERIA: We planned to include randomised controlled trials of any surgical or non-surgical treatment for intermittent distance exotropia. DATA COLLECTION AND ANALYSIS: Each reviewer independently assessed study abstracts identified from database and manual searches. Reviewer analysis was then compared and full papers for appropriate studies were obtained. MAIN RESULTS: No studies were found that met our selection criteria and therefore none were included for analysis. REVIEWER'S CONCLUSIONS: The available literature consists mainly of retrospective case reviews. These are difficult to compare and analyse due to a large variation in the definition of intermittent distance exotropia, intervention criteria and outcome measures. However there seems to be general agreement that non-surgical treatment is most appropriate in small angle deviations or as a supplement to surgery. Studies were found supporting both early and late surgical intervention so the optimal timing of surgical intervention cannot be concluded. Recent work indicates that bilateral surgery may be the most effective surgical procedure in these cases. There is clearly a need for carefully planned clinical trials to be undertaken to improve the evidence base for the management of this condition.

Exotropia↗

PubMed2006

Conversion of intermittent exotropia types subsequent to part-time occlusion therapy and its sustainability.

PURPOSE: To evaluate the effects of part-time occlusion therapy on types of intermittent exotropia and sustainability of converted types. METHODS: Forty-four and 26 children with basic-type and convergence-insufficiency-type intermittent exotropia, respectively, were evaluated in this study. Upon initial examination, we obtained both distant and near deviating angles using prism cover tests, after correcting for refractive errors. We conducted occlusion of the nondeviating eye for 3 months at 3 h/day and assessed the changes in types of intermittent exotropia. We also observed the changes of deviating angles and sustainability of types after 3 months of cessation of part-time occlusion in patients who did not undergo surgery. RESULTS: Preocclusion deviating angles (mean +/- SD) were determined to be 27.1+/-7.46 prism diopters (PD) on distant measurements and 30.6+/-7.92 PD on near measurements. After 3 months of occlusion, the deviating angles were 25.9+/-9.10 PD on distant measurements and 21.4+/-11.00 PD on near measurements, corresponding to a significant reduction (p=0.005 and p<0.001, respectively). Fourteen patients (32%) suffering from basic type of intermittent exotropia converted to the pseudodivergence excess type. In patients suffering from the basic type who exhibited no changes in type, 9 patients (20%) exhibited reductions on both near and distant angle measurements. Among the convergence insufficiency type of patients, 18 (69%) converted to basic type and 2 patients (7%) converted to the pseudodivergence excess type. In the 15 patients who did not undergo surgery, the converted types were maintained in 6 patients, though the other 9 patients showed regression to the prepatching types after cessation of patching for 3 months. CONCLUSION: Part-time occlusion therapy resulted in the conversion of the basic and convergence insufficiency types to pseudodivergence excess and basic types in more than half of the intermittent exotropes. Future studies on correlation between type conversion and surgical outcome would be necessary.

Child↗

PubMed2006

Unilateral lateral rectus muscle recession and medial rectus muscle resection with or without advancement for postoperative consecutive exotropia.

PURPOSE: To evaluate the effectiveness of unilateral lateral rectus muscle recession and medial rectus muscle resection with or without advancement in treating postoperative consecutive exotropia. METHODS: We performed a retrospective review on 31 patients with consecutive exotropia who were treated with unilateral lateral rectus muscle recession and medial rectus muscle resection (17 patients) or unilateral lateral rectus muscle recession and medial rectus muscle partial resection combined with advancement (14 patients). All patients had exotropia with a less than 10 prism diopters (PD) distance near-disparity. The characteristics studied before surgery included type of esotropia surgery, detection of amblyopia, presence of an "A" or "V" pattern, dissociated vertical deviation, limitation of adduction, deviation angle measurement, and forced duction testing. Ocular alignment and status of adduction postoperatively at the last follow-up were recorded. RESULTS: Nineteen patients (61.3%) had amblyopia, 17 patients (54.8%) had limitation of adduction, 8 patients (25.8%) had dissociated vertical deviation, and 5 patients (16.1%) had an "A" or "V" pattern. The mean preoperative exodeviation was 47.3 PD. Overall 21 (67.7%) of 31 patients achieved a successful postoperative result (alignment within 10 PD of orthophoria). There was no significant difference in successful alignment in patients treated with unilateral medial rectus muscle resection compared with those treated with unilateral medial rectus muscle partial resection combined with advancement. There was no influence of amblyopia on the result. Twelve (70.6%) of the 17 patients with limited adduction preoperatively showed normalization of adduction postoperatively. CONCLUSIONS: Unilateral lateral rectus muscle recession and medial rectus muscle resection with or without advancement is an effective alternative for treating postoperative consecutive exotropia.

Adolescent↗