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Appropriate prevention and detection of gastrointestinal neoplasms in the elderly.

The incidence of colorectal carcinoma and gastric cancer is related to environmental factors and lifestyle. Long-term exposure to multiple mutagens is believed to initiate the carcinogenesis of colorectal and gastric cancer. Even though patients older than 65 years of age have developed particular modes of cooking and dietary preferences, these habits can be changed with instruction, patient-doctor rapport, and suggestions of alternative foodstuffs that are palatable to them. Elderly patients can be persuaded to avoid fatty foods; smoked, pickled, and salted fish; and red meat. They should be encouraged to eat chicken, fish, fresh fruit, and vegetables (especially cruciferous vegetables), to ingest vitamin C, and to avoid overcooking, frying, and excessive broiling of meat and fish. Surveillance examinations must be practiced in the elderly to avoid malignant conversion of adenomatous polyps. All patients who have undergone gastric resections for peptic ulcer disease need to be watched carefully, with identification of high-risk individuals who must undergo periodic endoscopy.

Age Factors↗

Radioimmunodetection of gastrointestinal neoplasms with antibodies to carcinoembryonic antigen.

Primary and secondary gastrointestinal tumors have been identified using sheep immunoglobulin G antibody to carcinoembryonic antigen radiolabeled with 131I. 99mTc-pertechnetate and 99mTc-human serum albumin were used to identify tissue spaces and blood pool and to facilitate external substraction imaging. In 13 patients with tumors, 4 of 5 primary sites and 8 of 11 secondary sites were successfully demonstrated. Two patients with benign disease had negative scans. Comparison with conventional methods of scanning showed good correlation.

Antibodies, Neoplasm↗

Sodium-glucose cotransporter-2 inhibitors and gastrointestinal neoplasm risk in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

The potential carcinogenic effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus (T2DM) remain controversial, particularly regarding site-specific gastrointestinal (GI) neoplasms. This systematic review and meta-analysis aimed to determine the relationship between SGLT2 inhibitors and the risk of GI neoplasms in patients with T2DM. We searched PubMed, EMBASE, Cochrane CENTRAL, Scopus, and Web of Science through March 17, 2025, for RCTs in T2DM comparing SGLT2 inhibitors with placebo or active comparators. Two reviewers independently screened studies, extracted data, and assessed the risk of bias. The primary outcome was GI neoplasms reported in publications, supplementary materials, or trial registries, usually as adverse events rather than centrally adjudicated cancer endpoints. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in Stata 17.0. In 48 RCTs (n = 48,765), SGLT2 inhibitor therapy was not associated with overall GI neoplasm risk (OR = 1.10, 95% CI: 0.84-1.44; p = 0.46; I² = 0%). Site-specific analyses showed no statistically significant association for esophageal (OR = 1.12, 95% CI 0.37-3.45), gastric (1.20, 0.65-2.23), hepatic (0.62, 0.31-1.22), pancreatic (0.91, 0.51-1.64), colonic (1.28, 0.78-2.08), colorectal (0.76, 0.27-2.17), and rectal neoplasms (0.98, 0.49-1.97), with all p-values > 0.05. Subgroup analyses by agents (e.g., canagliflozin, dapagliflozin, empagliflozin), baseline age, body mass index (BMI), HbA1c, treatment duration, and dose were also non-significant (all p > 0.05). Approximately half of the trials had follow-up of one year or less, limiting our ability to evaluate long-term risk. Available RCT evidence does not show a clear increase in GI neoplasm risk with SGLT2 inhibitors in T2DM. However, limited follow-up, low event counts, and non-cancer-specific outcome ascertainment, the findings should be interpreted as reassuring but not definitive evidence of long-term oncologic safety.Systematic review registration: PROSPERO No. CRD42024619019.

Humans↗

Interventional radiology in gastrointestinal neoplasms.

Interventional radiology plays a significant role in different fields of gastrointestinal oncology. Percutaneous techniques can be used to diagnose and stage bile duct and pancreatic cancer. Palliation of esophageal tumors and malignant biliary obstruction may be achieved with interventional techniques, whereas curative attempts are directed mainly towards primary and secondary liver tumors. The therapeutic potential of interventional radiology is still expanding, as are all other forms of minimally invasive therapy. This article reviews the relevant contributions on this subject that have appeared in the past year. The introduction of new techniques is described, and the results of clinical studies are discussed.

Bile Duct Neoplasms↗

Radiologic staging of gastrointestinal neoplasms.

In this article, the ability of computed tomography as well as other imaging methods to detect local and distant metastases in patients with either newly diagnosed or suspected recurrent gastrointestinal tumors is discussed. The role of the radiologic examination in the diagnosis of complications resulting from different types of treatment is also addressed.

Esophageal Neoplasms↗

[Carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen in gastrointestinal neoplasms. Comparison of markers].

CA 19-9, a new antigenic tumor marker for gastrointestinal tumors, has been assayed with Carcinoembriogenic antigen, in 90 healthy patients and 47 patients with gastric cancer (20) and colorectal cancer (27). A good specificity has been found for this antigen (97.7%). Its sensibility seems to be slightly superior to that of CEA. However the sensibility for tumors at Mo stage (38%) is indeed scarcely, on the contrary it clearly elevated for tumors at advanced stage (M1)(76%).

Adult↗

Streptococcus bovis bacteremia and underlying gastrointestinal neoplasms.

Two patients are described in whom Streptococcus bovis bacteremia was the only clue to the presence of a colonic neoplasm. A third patient had the rare association of gastric carcinoma and Streptococcus bovis bacteremia that followed an operation for the carcinoma. The need for both complete gastrointestinal survey in patients with Streptococcus bovis bacteremia and administration of appropriate antibiotic prophylaxis during surgical manipulation is emphasized.

Aged↗

[Artificial gastrointestinal tract in gastrointestinal neoplasms].

From 1970 to 1977 an artificial gut was used in 1350 patients suffering from gastrointestinal cancer. This type of prolonged intestinal assistance was recognized to be an important adjuvant in anticancer therapy with indications prior to, during and following the traditional course of treatment. Prolonged intestinal assistance makes it possible to reestablish or maintain a biological and clinical status in patients who must undergo aggressive anticancer therapy. The indications for its use are multiplying. In 54% of the cases parenteral nutrition is associated with therapy of the curative type and this percentage is continuously increasing.

Ambulatory Care↗

[Immunological aspects of gastrointestinal neoplasms].

The mammalian immune system appears to play an essential role in preventing the development, and/or in controlling growth and spread, of malignant tumor cells. Antigenic properties of neoplastic cells and defense mechanism of the tumor host are briefly reviewed. The relative importance of immune reactions and other "non-specific" means of host defense with regard to tumor development and growth are discussed in the light of available experimental and clinical evidence. An attempt is made to incorporate these considerations into a hypothesis relating to the development of intestinal neoplasms.

Antigens, Neoplasm↗