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Results for “Glycerylphosphorylcholine”

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PubMed1992

alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects.

Growth hormone (GH) secretion is decreased during aging in humans and in rodents. This decrease may be due to increased hypothalamic somatostatin release, which is inhibited by cholinergic agonists, or to decreased secretion of GHRH. Alpha-glyceryl-phosphorylcholine (alpha-GFC) is a putative acetylcholine precursor used in the treatment of cognitive disorders in the elderly. In order to learn what effect alpha-GFC had on GH secretion, GH-release hormone (GHRH) was given to young and old human volunteers, with or without the addition of alpha-GFC. GH secretion was greater in the younger subjects than in the old individuals, and both groups had a greater GH response to the GHRH+alpha-GFC than to GHRH alone. The potentiating effect of alpha-GFC on GH secretion was more pronounced in the elderly subjects. These findings confirm the observation that aged individuals respond less well to GHRH than younger subjects, and provides further evidence that increased cholinergic tone enhances GH release.

Adult↗
PubMedDate not supplied

Glycerylphosphorylcholine in selected forms of male infertility.

GPC was studied in the seminal plasma of 35 normozoospermic men, 34 cases of azoospermia due to bilateral deferent obstruction, 34 cases of azoospermia due to bilateral ejaculatory duct obstruction, 10 vasectomized patients, 6 vasectomized patients after vasovasostomy and 118 cases of spermatogenetic arrest without obstruction of the seminal ducts. Values of GPC in azoospermia due to deferent or ejaculatory ducts obstruction and to vasectomy are significantly lower than in normozoospermic subjects (p less than 0.001). Levels of GPC increased (p less than 0.05) following vasovasostomy. Although GPC values in secretory azoospermia were higher than those in cases of duct obstruction, they were still lower than in normozoospermic (p less than 0.001). The most likely source of GPC is the epididymis. These results support the assumption that GPC originates mainly in the epididymis. The absence of germinal cells in the epididymis could explain the decreased levels of GPC in azoospermia due to arrest of spermatogenesis.

Citrates↗
PubMed1999

L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study.

The effects of L-alpha-glyceryl-phosphorylcholine (LGPC), a putative acetylcholine precursor, were studied on the pattern electroretinogram (PERG) in two rhesus monkeys. In the time interval 10-30 min after LGPC administration (85 mg/kg i.m.), the amplitude of the PERG increased significantly. In both monkeys the amplitude enhancement was more pronounced for low spatial frequency stimuli (1 cycle/degree) than for medium spatial frequency gratings (5 cycles/degree). This result suggests that besides the general facilitatory properties, LGPC may have specific spatial frequency tuning effects at the level of retinal information processing.

Analysis of Variance↗