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Results for “Inosine Diphosphate”

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At least 55 records · Page 3Linked to original sources
PubMed1989

[Application of a method of material-energy balance for controlling the process of microbiological synthesis of riboxin].

Possible control of riboxin biosynthesis on the basis of the information provided with the method of material-energy balance was studied. Correspondence of the cultivation conditions to the directed biosynthesis was established by comparing the experimental values of the respiration coefficient delta CO2/delta O2, the coefficient of constructive and energy metabolism conjugate Cc/e and the ratio of the consumed amounts of glucose and ammonium nitrogen delta S/delta NH4+ with the theoretical values of these parameters. The control principle included changing of the process operation parameters for providing cultivation conditions approximating the experimental values of Cc/e, delta CO2/delta O2 and delta S/delta NH4+ to their theoretical values. It was shown possible to control directed aerobic growth of the culture by changing the aeration conditions. A decrease in the initial aeration rate promoted more rapid transition of the microbial population to the exponential growth phase and provided for a certain period cultivation conditions corresponding to the conditions of conjugate metabolism. It was found that the respiration coefficient could be used not only as a parameter reflecting one of the forms of the cell physiological activity manifestation but also as an optimization criterion in development of a controlled cultivation process.

Bacillus subtilis↗
PubMed1989

[The results of the use of riboxin in the combined treatment of patients with pulmonary tuberculosis].

Studies with infected animals showed that riboxine (inosine) having anabolic, antifibrotic, immunostimulating, antihypoxic and hepatoprotective activities, by the level of its therapeutic effect was not inferior to levamisole or sodium oxybutyrate and exceeded methyluracil. The evidence of the riboxine therapeutic effect mostly correlated with the antihypoxic activity. The use of riboxine at the early stages in the treatment of new cases with infiltrative destructive tuberculosis of the lungs of lobar and polysegmental extent promoted normalization of gaseous metabolism, significant improvement of capillary blood flow in the destructive zone, earlier and more frequent arresting of intoxication signs, sputum abacillation and elimination of the destructive cavities.

Adult↗
PubMed1987

[Assessment by the material and energy balance method of the directed biosynthesis of riboxin by altering the external culture conditions].

The effect of various agitation conditions on growth of the cell population of Bacillus subtilis and production of riboxin was studied. The physiological state of the culture was estimated by the relations for the respiration coefficient CO2/O2, the yield of the constructive metabolism products (X + P) by oxygen Yx + p/O2, the ratio of consumed glucose to ammonium nitrogen S/NH4+, the coefficient of the cell biosynthetic activity Yp/x and the parameter of the energetic efficiency of the substrate usage (eta). It was shown that the maximum biosynthetic activity was mainly defined by the culture state in the trophophase. The growth of the cell population in this case should proceed under conditions of conjugated aerobic metabolism. It was found that directed biosynthesis of riboxin could be provided by changing the cultivation conditions and estimation of the culture physiological state by the parameters of the material and energy balance.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Influence of kordaron, anaprilin, dimedrol and riboxin on the hemodynamic effects of strophanthin in experimental heart failure].

In experiments on 183 rats it was shown that cordarone, anapriline, dimedrol and riboxine increasing in experimental cardiac insufficiency tolerance to the cardiotoxic effect of strophanthin differ significantly by their influence on the hemodynamic effects of this cardiac glycoside. Cordarone increased intensity of the hemodynamic effects of strophanthin and accelerated their development. Under the action of anapriline and dimedrol the stimulating effect of strophanthin on hemodynamics decreased to a much lesser degree than its cardiotoxicity. Riboxine virtually abolished the hemodynamic effects of strophanthin.

Amiodarone↗
PubMedDate not supplied

[Phosphoenolpyruvate carboxykinase in Calicophoron erschowi (Trematoda: Paramphistomidae)].

The trematode Calicophoron erschowi possesses high active phosphoenolpyruvate carboxykinase. Enzyme activity is concentrated in the cytoplasm. The enzyme has the optimum pH 6.0 and is active in the presence of ions Mn++ and inosine diphosphate. Alanine does not affect its activity. Sulphide oxinide in concentration 1.4-10(-6) M inhibits the activity up to 93%. Some kinetic characteristics are presented.

Animals↗
PubMed1981

Activity of inosine triphosphate pyrophosphohydrolase in fresh and stored human erythrocytes.

The accumulation of inosine triphosphate (ITP) in human erythrocytes incubated with inosine depends on the activity of inosine triphosphate pyrophosphohydrolase (ITPH). High activity of this enzyme is accompanied by a low concentration of ITP and conversely. We showed that ITPH activity decreases with the prolongation of blood preservation time. As a consequence there is a lower accumulation of ITP in fresh erythrocytes incubated in a medium containing high concentrations of inosine, pyruvate and phosphate (IPP) than in red blood cells preserved at 4 degrees C. Synthesis of ITP in erythrocytes incubated in IPP medium being so intensive, it seems possible that during incubation an intermediate accumulates which decreases ITPH activity.

Blood Preservation↗
PubMedDate not supplied

[Effect of glucose and ammonium nitrogen concentrations on riboxine biosynthesis].

The effect of glucose and ammonium nitrogen concentrations on the riboxine biosynthesis by the culture Bacillus subtilis GEN 265 was investigated. The purpose of the investigation was to optimize the process with respect to these parameters. The investigation was carried out in a 1 m3 fermenter. Glucose and ammonium nitrate were added for various fermentation times. It was shown that riboxine biosynthesis did not require glucose dosing in the course of the process, with the optimal concentration being 13-15%. Optimal concentrations of ammonium nitrogen were determined. It was found that the dose of 0.35 mg/ml provided a 24% increase in the yield.

Bacillus subtilis↗