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At least 55 records · Page 3Linked to original sources
PubMed1977

[Genome structure in higher plants. Reassociation kinetics of DNA from Vicia faba and Vicia sativa].

The work been concerned with a study of the kinetics of reassociation of total DNA and that of the fraction of unique sequences in plants from the Vicia family, i. e. Vicia faba and Vicia sativa. The size of the genome was determined by the kinetics of reassociation of the DNA of the fraction of unique sequences and the amount of DNA per nucleus was determined cytophotometrically. It has been shown that the size of the genome expressed in C(0)t units and the size expressed in gramms are not the same which testifies to the absence of true unique genes in the genome of the species studied. The analysis of the possible methodical errors was carried out. On the basis of the data obtained a suggestion was made of a model of chromosomes organization including 12 units of polynemization for Vicia faba and 4 units for Vicia sativa.

Base Sequence↗
PubMed1978

[Localization of (3H)hydrocortisone in rat liver nuclei].

The content of hydrocortisone in rat liver nuclei reaches its maximum in 1 hour after its intravenous injection and remains stable for another hour. In three hours after introduction it falls to the initial level (15 min after the injection of [3H]hydrocortisone). The accumulation of the hormone in nuclei completely coincides with kinetics of reversible DNA supermethylation and correlates with the induction of transcription. No free [3H]hydrocortisone was found in nuclei, in isolated nuclei it is found in the fraction of nuclear membranes, nucleoplasma, nucleolus and chromatin. Specific radioactivity of [3H]hydrocortisone (d. p. m. per 1 mg of DNA) in active chromatin is 10--50-fold as high as in condensed chromatin and is 10--15-fold as high as in nucleolus. It is suggested that there are at least two types of binding hormonereceptor complexes with chromatin. The initial binding of these complexes with condensed chromatin may result in its structural rearrangement (euchromatization), in the appearance of more specific secondary sites for binding hormone-receptor complexes with chromatin DNA, and also in the appearance of methylation and transcription initiation sites in DNA.

Animals↗
PubMed1977

[Clinical heterogeneity of consciousness disorders in the mussitational variant of delirium tremens].

A clinical study of 183 patients detected the absence of a syndromological uniformity in the mussitative variant of delirium tremens. The dynamical clinical picture of psychosis may include during one of the stages of its development a delirious-amentive syndrome, short-time amentive states and oniric experiences. The seen variants of disordered consciousness have a tendency to a transition to clouded forms which subsequentive lead to a significant drop of socio-labour capacity making such disorders prognostically extremely significant. An analysis of "lucid periods" in this contingent demonstrated their affinity to one of the mild forms of disordered consciousness.

Alcohol Withdrawal Delirium↗
PubMed1977

[DNA from chromatin-nuclear membrane complex: reassociation kinetics at different stages of the cell cycle].

Base composition and reassociation kinetics of DNA from chromatin-nuclear membrane complex of rat liver cells at different stages of the cell cycle. The complex isolated in low ionic strength solutions contains about 9% of total nuclear DNA, and its density in sucrose solution is 1.27 g/cm2. DNA, isolated from the complex, is homogenous in its molecular weight (approximately 2-10(6) daltons) and is similar in its base composition to total nuclear DNA. However, DNAs from complexes, isolated at interphase and different S-phases of the cell cycle, differ from total nuclear DNA in reassociation kinetics: DNAs from complexes are enriched by approximately 10% with unique nucleotide sequences. It is concluded from the similarity of reassociation kinetics, that molecular population of nuclear membrane-bound DNA does not change considerably throughout the cell cycle.

Animals↗
PubMed1977

[Replication of DNA associated with nuclear envelope of regenerating rat liver].

DNA associated with nuclear envelopes was isolated from rat liver nuclear lysate using centrifugation in sucrose gradient. The specific radioactivity of DNA obtained in nuclear envelope was compared with that of overall nuclear DNA at different stages of the S-period after partial hepatectomy and 1-15 min following intravenous injection of 3H-thymidine. It was found that at various steps of the cell cycle (19, 24 and 27 hrs following partial hepatectomy) the specific radioactivities of nuclear membrane-linked and overall nuclear DNAs do not show any significant differences. No noticeable selective synthesis or initiation of DNA replication on the nuelear envelope were observed either.

Animals↗