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PubMedDate not supplied

Experimental research about the influence of pentazocine and reserpine on morphine addiction.

By means of a conveyer belt two types of conditioned reflexes were developed in rats, at two functional levels. When these had become stable, we observed the animals' behaviour during a morphine treatment, until they developed tolerance. Thereafter the treatment with morphine was suddenly discontinued, or morphine was replaced by pentazocine or reserpine. We found that morphine impaired both types of conditioned reflexes and that ni about two weeks drug tolerance appeared. When treatment was discontinued a syndrome of abstinence developed, which exclusively impaired the conditioned reflex of the second order. Pentazocine and reserpine prevent such manifestation of the abstinence syndrome. Moreover, reserpine suppresses the tolerance to morphine. Concerning these results we suppose that opioid receptors type mu are involved in behavioural trouble produced by morphine, while opioid receptors type k are involved in the abstinence syndrome. Certain adrenergic mechanisms operate both in the development of tolerance and in behavioural modifications caused by the syndrome of abstinence.

Animals↗
PubMed2004

Managing acute withdrawal syndrome on patients with heroin and morphine addiction by acupuncture therapy.

Though there are articles and case reports about using acupuncture to detoxify and to break the narcotic addiction, few articles describe in the West about using acupuncture therapy to treat the emergence of acute withdrawal symptom due to heroin, opium, or morphine. Most often the method of treatment are using the methadone or benzodiazepine and phenoziazine drugs this article describes many years of clinical experience with non-drug approach to treat the acute withdrawal symptoms with acupuncture therapy. Unlike the drug approach, which usually has side effects, there is no adverse effect with acupuncture therapy.

Acupuncture Therapy↗