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Benign cartilaginous lesions of the upper extremity.

Common and rare benign cartilaginous neoplasms and diseases of multiple cartilaginous lesions are discussed. Particular attention is paid to patient demographics, physical and radiographic findings, pathology, and treatment.

Arm↗

Fibro-osseous, osseous, and cartilaginous lesions of the orbit and paraorbital region. Correlative clinicopathologic and radiographic features, including the diagnostic role of CT and MR imaging.

Fibro-osseous and cartilaginous lesions of the orbit and facial region share overlapping clinical, radiologic, and pathologic features that may lead to diagnostic confusion and possible misdiagnosis. The value of imaging studies in the histopathologic diagnosis of these lesions cannot be overemphasized. The histopathologic diagnosis of such lesions should not be rendered in the absence of radiographic correlation.

Cartilage Diseases↗

Occurrence, transplantation, and histologic characteristics of nephroblastoma in the Nb hooded rat.

Ten kidney tumors conforming to nephroblastoma were encountered during a 10-year period in a closed colony of Nb hooded rats. Histologic examination of the primary neoplasms, and of a limited number of transplanted derivatives, indicates that spontaneous nephroblastoma in the rat is exclusively an epithelial neoplasm, consisting of dense aggregates of undifferentiated, basophilic blast cells set in a connective tissue stroma of benign character. This uniform entity should be clearly distinguished from renal mesenchymal tumor, a connective tissue neoplasm of heterogeneous form which is induced frequently in rats by certain chemical carcinogens.

Age Factors↗

Linear nevi, hemihypertrophy, connective tissue hamartomas, and unusual neoplasms in children.

The association of cutaneous nevi, hemihypertrophy, and connective tissue overgrowth has been described in many patients. We report long-term follow-up in two boys with such association who in addition developed testicular neoplasms. One patient also had progressive spinal cord compression as a result of stenosis of the spinal canal, and required amputation of a severely deformed limb. The importance of careful, long-term management in such patients is emphasized.

Adenocarcinoma↗

A case-control study of prosthetic implants and selected chronic diseases.

We examined the association between prosthetic nonbreast implants and selected malignant neoplasms, connective tissue disorders, and neurologic diseases. We conducted a case-control study from an insurance claims database. We selected controls who had diseases for which no association with implants have been claimed or reported. Data were analyzed using both tabular and polytomous regression analysis methods, including methods to account for the large number of comparisons. All analyses exhibited positive associations between implants (both silicone and metal) and neurologic conditions, especially idiopathic progressive neuropathy and Meniere syndrome, as well as the expected associations with arthritic conditions. There also was an unexpected negative association between metal implants and brain tumors. In conclusion, further studies of prosthetic implants and neurologic diseases appear warranted. These studies should obtain medical histories to control for possible confounding effects of drug treatments associated with implant surgery.

Adult↗