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At least 55 records · Page 3Linked to original sources
PubMed1985

Serial monitoring and achievement of steady state nortriptyline plasma levels in depressed children and adolescents: preliminary data.

Children and adolescents 6 to 16 years old (N = 25), who were diagnosed as having major depressive disorder, received a fixed daily dose of nortriptyline during an 8-week period. Nortriptyline plasma levels were drawn and assayed weekly. Data were analyzed for the total sample (N = 25) and separately for the subgroup of 6 to 9 year olds (N = 9) and for the subsample of 10 to 16 year olds (N = 16). There were no significant differences between the day 7 (week 1) plasma levels and the means of weeks 2 to 8 or between the means of weeks 1 to 4 and 5 to 8 within the total sample or within either subgroup. These findings suggest that nortriptyline steady state plasma levels within the pediatric age range are achieved by day 7 (week 1) and that nortriptyline (during the pediatric years) does not induce its own metabolism during an 8-week period. The achievement of steady state by day 7 is similar to that found in adults. The mean coefficients of variation were calculated for the total sample and for each subsample and were 13.7 +/- 4.0% (range, 8 to 20%) for the 6 to 9 year olds; 13.8 +/- 3.2% (range, 10 to 21%) for the 10 to 16 year olds; and 13.8 +/- 3.4% (range, 8 to 21%) for the total sample. These coefficients of variation are similar to the 10 to 20% range reported in adult subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed2004

Hazard identification and predictability of children's health risk from animal data.

Children differ from adults both physiologically and behaviorally. These differences can affect how and when exposures to xenobiotics occur and the resulting responses. Testing using animal models may be used to predict whether children display novel toxicities not observed in adults or whether children are more or less sensitive to known toxicities. Historically, evaluation of developmental toxicity has focused on gestational exposures and morphological changes resulting from this exposure. Functional consequences of gestational exposure and postnatal exposure have not been as well studied. Difficulties with postnatal toxicity evaluations include divergent differentiation of structure, function and physiology across species, lack of understanding of species differences in functional ontogeny, and lack of common end points and milestones across species.

Animals↗
PubMed1993

Recommendations for the assessment and design of young children's bicycles on the basis of anthropometric data.

Children's bicycles are the product most often involved in leisure accidents to children. One of the possible reasons for this might be a lack of fit between the dimensions of the bicycle and the dimensions of the child. In a project entitled KIMA-1, some 33 dimensions of 279 children (aged 2.5-5.5 years) were measured at seven infant welfare centres in the province of Zuid, Holland. These data were used to compare dimensions of children with dimensions of bicycles. Furthermore, the requirements regarding bicycle dimensions laid down in product safety acts of different countries were compared with both the results of KIMA-1 and some bicycles available in shops. It is concluded that maximum product safety and comfort of the bicycle are achieved when the bicycle is fitted to the dimensions of the child. Enhancement of this fitting process can be achieved by relating the dimensions of the bicycle to the stature rather than to the age of the child. The comparison of the KIMA-1 data to the dimensions laid down in product safety acts led to the conclusion that Dutch children are larger than the population on which the safety dimensions are based. Furthermore, secular changes in body dimensions call for a revision of the relevant safety dimensions in 10-15 years.

Journal Article↗
PubMed1996

Becoming circadian--A one-year study of the development of the sleep-wake cycle in children.

Data on three children's sleep-wake behavior during the first year of life submitted to spectral analysis reveal the presence of several frequencies in the circadian and ultradian ranges. The changes in the resulting spectra as age progresses show both an increase in overall rhythmicity, i.e., more data are explained by regular oscillations, and irregular changes in the circadian component. This circadian component shows an increase in power which appears at different ages among the individuals studied.

Circadian Rhythm↗
PubMed1994

Environmental influences on methods used to collect dietary data from children.

When collecting dietary data on children, confidence about responses is required. Children exist in multienvironments in their everyday lives, eg, the personal, school, home, peer, medical care, media, food industry, and fast-food facility environments. These macroenvironments influence the format and type of data-collection methods used to interview today's youth. Researchers should identify the influence of each environment on the child's eating pattern and nutrient intake, explore the pros and cons of various data-collection methods amid these environments, and determine unresolved methodological issues to stimulate future research. Standardized protocols for interviewing children, exclusion criteria for surrogate responses, and currency of nutrient data for new food products available to children are needed. Redefining our methods by understanding the macroenvironments of youth can create a dietary methodology for the 21st century--an evolutionary method that builds on past research and incorporates current technology and societal changes.

Aging↗
PubMed1985

Fractures of facial bones in children.

Data covering 205 children hospitalized for fractures of facial bones in 1971-1982 are presented. In individual types of fractures affecting the lower and middle third of the face, the mechanism of injury is followed up, and the period of time elapsed from the moment of injury to admission to the clinic is registered; results of particular treatment are recorded. New methods of treatment which proved to have a positive effect in practice are described. The necessity of a complex approach to the treatment of children with injuries of the orofacial region is stressed.

Adolescent↗
PubMed1993

Prevalence of xerophthalmia and efficacy of vitamin A prophylaxis in preventing xerophthalmia co-existing with malnutrition in rural Indian children.

Data of 4302 children, 0-6 years old were analysed to study the prevalence of vitamin A deficiency and the efficacy of vitamin A prophylaxis in preventing xerophthalmia co-existing with malnutrition. Manifestation of ocular signs of vitamin A deficiency were seen in 10 per cent children. The prevalence of xerophthalmia was higher in the normal and mild to moderately malnourished children, and lowest in the severely malnourished ones. The ability of vitamin A prophylaxis to curb xerophthalmia was greatest at the extreme ends of the nutritional grade spectrum. These findings have important implications for the existing national Vitamin A Prophylaxis Programme, and suggest that: (a) normal and mild to moderately malnourished children less than 6 years old, should be preferably considered for vitamin A mega dosing; (b) in the management of protein energy malnutrition, vitamin A status of the children should be monitored; and (c) the coverage should be improved as most children are in the mild and moderate degrees of malnutrition.

Age Factors↗