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At least 55 records · Page 3Linked to original sources
PubMed1979

Pituitary function testing in amenorrhea-galactorrhea-hyperprolactinemia.

Fifteen patients, age 16 to 55, presented with amenorrhea-galactorrhea-hyperprolactinemia. Pituitary function was evaluated by bolus injections of insulin, luteinizing hormone-releasing hormone (LHRH), and thyrotropin-releasing hormone (TRH) in 13 and by LHRH and TRH in 2. Responses to growth hormone (GH), thyroid-stimulating hormone (TSH), cortisol (F), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin were measured. GH, TSH, and F responses were normal in most cases. LH responses were decreased (P less than 0.025) in patients with abnormal sellar tomography, whereas FSH responses tended to decrease with elevated prolactin levels. Prolactin responses were absent in five of the seven cases which could be evaluated. The clinical value of such testing appears to be limited to an individualized basis, although some prognosis of ovulatory response to bromocriptine therapy may be obtained from the gonadotropin response.

Adolescent↗
PubMedDate not supplied

Hypothalamic pituitary function testing on children receiving carbamazepine or sodium valproate.

An investigation of hypothalamic pituitary axis (HPA) function was performed on children and adolescents receiving long-term monotherapy with either carbamazepine (CBZ) or sodium valproate (NaV). There was a significant reduction in total T4 in the CBZ group. Free T4, T3, and thyroid-stimulating hormone response to thyrotropin-releasing hormone were similar in both groups. All patients produced an adequate growth hormone response to either arginine or L-Dopa. Basal cortisol levels were similar in both groups. An appropriately increased response in luteinising hormone, prolactin, testosterone, and oestradiol occurred in those after puberty. The results suggest that HPA function in children is not compromised by long-term monotherapy with CBZ or NaV.

Adolescent↗