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[A case report of thrombosed St. Jude Medical valve in a patient with macroglobulinemia].

A 66-year-old man who had undergone MVR using a ST. Jude Medical valve entered the hospital with acute heart failure and cardiogenic shock 3 months after surgery. He had had a symptom of petechiae due to macrogloburinemia after initial MVR and had been in the poor control of anticoagulation therapy because of presence of petechiae. He was diagnosed as prosthetic valve thrombosis using echocardiography and underwent emergency re-MVR using a Central Open Bioprosthesis (COB) which was developed by our department. He was doing well 8 month after re-MVR. Selection of prosthetic valve should be performed carefully in the patient with hemorrhagic disease, and careful observation and proper anticoagulant therapy should be carried out after valve replacement.

Aged

[Asymptomatic aortic dissection associated with a mitral prosthetic leak: a clinical case report].

A case of aortic dissection ("DeBakey type III") in an asymptomatic 78-year-old woman is described. The patient underwent a mitral valve replacement (bioprosthesis Sorin) in June 1990 for severe mitral stenosis; in October 1990 she was admitted to our hospital for severe dyspnea and cardiac failure with good response to medical treatment. The routine echo color Doppler examination showed only a hint of paraprosthetic leak, which required further investigation by transesophageal echocardiography. This approach revealed the presence of a regurgitant jet extending from the prosthetic mitral valve toward the atrial septum. The examination of the thoracic aorta revealed the presence of a dissection flap; the color Doppler technique showed a bidirectional flow through the site of communication between the two lumina. The extension of the dissection from the aortic arch to the origin of the renal branches was confirmed by computerized axial tomography. We emphasize the importance of the transesophageal approach in elderly patients with aortic dissection, often asymptomatic.

Aged

Five-year results after valve replacement with the Björk-Shiley 70 degrees convexo-concave prosthesis.

In the 18 months up to July 1983, 120 Björk-Shiley convexo-concave prostheses with 70 degrees opening angle were implanted in 47 women and 61 men aged 19-78 (mean 58.6) years. The prosthetic valves were aortic in 65 cases, mitral in 23 and both aortic and mitral in 20 cases. Emergency operation was required in ten cases, and concomitant surgery was performed in 43 (39.8%). The early mortality was 5.5%. A follow-up study, comprising 498 patient years, revealed 73.1% 5-year survival. There were three mechanical failures of prosthesis, in one of which re-replacement was successful. Elective prosthesis replacement was performed in four other cases judged to be at high risk of strut fracture.

Adult

Failure of a Björk-Shiley mitral valve prosthesis to open: clinical recognition.

Failure of a Björk-Shiley mitral valve prosthesis to open was recognized early in the postoperative period and required immediate replacement. The clinical finding was sudden, intermittent, severe hypotension associated with absent poppet sounds and simultaneous elevation in left atrial pressure. This unique and unusual hemodynamic picture was duplicated in four animal experiments. Routine monitoring of left atrial pressure is a useful postoperative adjunct that can provide early documentation of obstruction to left atrial outflow. Early recognition of the problem and immediate operative correction are mandatory.

Animals

Late failure of the Manchester prosthesis. Its relationship to the disease process.

The results of thirty-one Manchester knee arthroplasties performed on twenty-eight patients are reviewed. There were sixteen patients with rheumatoid arthritis all of whom were satisfactory at the time of follow-up. Of the fifteen patients with osteoarthritis over half the arthroplasties failed after between twelve and thirty-six months. We suggest that resurfacing arthroplasty of the knee using the Manchester prosthesis should be used only for rheumatoid patients.

Adult

Risk factors for failure of immediate breast reconstruction with prosthesis after total mastectomy for breast cancer.

BACKGROUND: Immediate breast reconstruction (IBR) after mastectomy represents a clear improvement in the quality of life of patients with breast cancer, but prosthesis removal is relatively frequent. Therefore, it is important to identify risk factors related to this removal. METHODS: A series of 142 patients treated with mastectomy and IBR at the Institut Gustave-Roussy between January 1976 and December 1988 were studied. Forty-seven had an in situ carcinoma, 93 an infiltrating carcinoma, and 2 a fibrosarcoma. IBR failures were defined as removal of the prosthesis, and early failures as removal during the first 7 weeks after IBR. RESULTS: The early failure rate was significantly higher in patients with invasive carcinomas or fibrosarcomas than patients with in situ carcinomas (12% versus 0%, P = 0.04). The risk of late IBR failure was significantly higher in patients who had received postoperative radiation therapy than patients who did not (P = 0.0002). However, this increased risk applied only to women in whom the chest wall was exposed to radiation because of a high risk of recurrence. CONCLUSION: It might be preferable to postpone breast reconstruction for patients with infiltrating breast carcinoma because early complications are not infrequent and could delay adjuvant chemotherapy. Late complications associated with chest wall irradiation could be avoided with the use of alternative techniques such as the transverse rectus abdominis myocutaneous (TRAM) flap procedure.

Breast

Theoretical analysis of the fatigue life of fixture screws in osseointegrated dental implants.

Metal fatigue failure of the gold screw used to retain a fixed prosthesis to Brånemark osseointegrated fixtures/abutments has been analyzed theoretically. Mechanical engineering principles show the importance of appropriate preload being applied through the gold screw to the gold cylinder and abutment. The significance of the screw design and necessity of applying the correct torque to achieve a long fatigue life for the screw are also described. The consequence of misalignment of a gold cylinder to an abutment is discussed.

Dental Abutments

Osteonecrosis secondary to internal fixation.

Allergies to metals as a cause of failure of joint prostheses has historically been a controversial issue. Loosening of a prosthesis may be due to trauma, infection of the surrounding area, or a faulty implantation of the device. However, cases of loosening of the device do occur without any history of the above criteria. This leads one to consider other explanations for this phenomenon, such as sensitivity of the tissues to one of the metals in the implant. The following presentation demonstrates that metal allergies are a surgical concern when considering joint prostheses, or internal fixation.

Adolescent

Long-term results and survivorship analysis of 89 total condylar knee prostheses.

The results of 89 total condylar I prostheses were assessed using both the Hospital for Special Surgery rating system and survivorship analysis. At an average follow-up period of 9.5 years (range, 5-15) 61 patients (72 knees) were available for clinical and radiographic evaluation. Thirty (41.5%) knees were rated as excellent, 29 (40.5%) good, 4 (5.5%) fair, and 6 (8.5%) poor. Three (4%) cases were considered failures because they needed a second operation. Loss of the postoperative alignment often associated with lateral instability was observed in 23 knees. Loosening of the tibial plateau occurred in two knees; in one of these a successful revision was performed. Survivorship analysis, using deep infection and aseptic loosening as end-point criteria, gave a 15-year probability of survival of 95%. These results confirm the validity of the total condylar prosthesis and the reliability of cementation in knee arthroplasty.

Actuarial Analysis

Reoperations on cardiac valves.

As the number of patients undergoing cardiac valve replacement has grown, valve reoperations have become increasingly frequent. The newer generations of mechanical valves are far more efficient and freer from structural failure than the older ones. However, other valve and non-valve related complications still constitute a major cause of morbidity and mortality. On the other hand, bioprostheses, implanted in large numbers in the 1970's and early 1980's, have now gone into the second decade of life since implantation, when biodegradation becomes more frequent. Reoperations are technically more demanding than the original valve procedures because of the mediastinal and pericardial adhesions and the condition of the anulus after removal of the previous prosthesis. Greater awareness of the most dangerous steps and refinements to surgical technique have contributed to the decreased mortality observed in recent years. The risk is higher in certain conditions, such as the presence of prosthetic valve endocarditis and the patient being operated on an emergency basis in NYHA functional class IV. It may also be increased in females and the elderly. Multiple reoperations also carry a higher risk in most surgeon's experience. However, elective reoperations for defective mechanical valves and for replacement of a previously repaired mitral valve carry similar mortality rates to primary valve replacement procedures. The global mortality rates have not been significantly higher in the hands of experienced surgeons working in centers where reoperations are performed frequently. In smaller series high mortality rates are a constant, which underscores the importance of the learning curve. The indications for reoperation must therefore consider all risk factors and, when possible, the procedure must be performed by those who have the most experience. Under these circumstances, elective re-replacement of degenerating bioprostheses and of defective mechanical valves in asymptomatic patients may be advisable.

Bioprosthesis

Treatment of an early implant failure according to the principles of guided tissue regeneration (GTR).

The present case report demonstrates the application of guided tissue regeneration (GTR) in combination with antimicrobial therapy for the treatment of an early implant failure. This treatment approach both prevented further loss of bone as well as led to the regeneration of lost bone. By means of color-converted digital subtraction images, remodelling of the tissues adjacent to the defect was documented as early as one month postsurgically. The images demonstrated "bone-fill" in the apical portion of the defect and resorptive changes at the bone crest. This case report demonstrates that combined regenerative and antimicrobial therapy may be a successful treatment approach restoring osseointegration of dental implants following loss of bone due to infection. Continuously increasing bone-fill inside the defect was documented when comparing the radiograph obtained immediately before the GTR procedure and at months 1, 2, 4, 5 and 6 of the healing period, respectively. Clinical measurement obtained at the time of the surgery and at the time of the membrane removal confirmed the radiographic evidence of bone-fill by demonstrating new tissue resistant to probing in close contact to the implant surface at the site of the previous defect. Antimicrobial therapy included an antibiotic regimen during the 1st month of healing as well as topical rinses with an antiseptic (chlorhexidine) over the entire healing period of 6 months. As a result of this treatment approach, the implant was saved and could be used as an abutment for a bridge reconstruction.

Alveolar Bone Loss

Biomechanics of cemented and cementless prostheses.

The success of the cemented arthroplasty is due primarily due to excellent initial stability, intimate contact with the prepared bone and the isoelastic properties provided by the cement. In an experimental in vitro study, the initial stability of both the cemented and uncemented femoral components was measured and it was found that they were both very stable in simulated single limb stance (maximum motion of less than fifty microns). However, in simulated stair climbing, the uncemented components were more unstable than the cemented components (maximum micromotion of 76 microns for cemented and 280 microns for uncemented), and this relative instability of the uncemented femoral components could compromise the bone ingrowth. Studies on femurs retrieved at autopsy from patients who underwent cemented total hip arthroplasty two week sup to seventeen years earlier and were functioning well, have shown that the failure of cemented femoral components is initiated primarily by mechanical factors, consisting of debonding at the cement-prosthesis interface and fractures of the cement rather than lack of bone ingrowth or fibrous tissue formation at the interface. Thus the problems with using cemented femoral components involve the poor strength of the cement-prosthesis interface and the cement, while the problems with cementless components involve the difficulties in precisely machining the femoral canal, and providing rigid stability as well as accurate fit.

Adult

A six-year prosthodontic study of 509 consecutively inserted implants for the treatment of partial edentulism.

A total of 509 consecutive Brånemark TM implants (Nobelpharma AB, Gothenburg, Sweden) were inserted in 146 patients between December 1982 and May 1989, on which 217 fixed partial dentures were planned. The cumulative failure rates after abutment connection were 3.9% and 4.1% for the maxillae and mandible, respectively. The lack of continuous prosthesis stability was limited to 4.1% for the maxillae and 5.4% for the mandible. The average annual marginal bone loss was 0.77 mm (SD = 1.0) and 0.96 mm (SD = 0.9) for the maxillae and mandible, respectively, during the first year and averaged 0.1 mm for the following years. The mode of connection between teeth and implants or the use of porcelain instead of composite resin as occlusal material did not influence the marginal bone height around the implants. Technical complications were most often related to the materials used. The results of a medium-term follow-up encourage the use of the Brånemark osseointegration system in the treatment of partial edentulism.

Adult