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At least 55 records · Page 3Linked to original sources
PubMed1975

The effects of cosmic particle radiation on pocket mice aboard Apollo XVIII: VII: results of scalp examination.

The scalps of the four pocket mice that were recovered alive from the Apollo XVII flight contained acute focal lesions in the epidermis and an inflammatory reaction in the subjacent dermis and subcutaneous tissue. Hair follicles were focally damaged in three of the four mice. There were 13 scalp lesions singled out in the four flight mice because of histological features that distinguished them from changes observed in the scalps of the control mice. There was only one possible coincidence between a lesion and the trajectory of a cosmic ray particle registered in a subscalp dosimeter. There is, however, a possibility that at least some lesions were produced by unregistered particles.

Animals↗
PubMedDate not supplied

[Effectiveness of hypoxic hypoxia as a means of protecting the body from ionizing radiation exposure with the use of sodium oxybutyrate and mexamine].

While exerting a pronounced antihypoxic action on the body of white mice under nypoxic hypoxia, a combination of sodium hydroxybutyrate and mexamine given in comparatively low doses (100 and 2.5 mg/kg, respectively) did not remove the radioprotective effect of hypoxic hypoxia. In hemic and histotoxic hypoxia the drugs did not exhibit any antihy-oxic action.

5-Methoxytryptamine↗
PubMed1977

[Interaction and migration of T- and B-lymphocytes in immune responses during carcinogenesis induced by methylcholanthrene].

The (CBA X C57BL) F1 mice were injected intramuscularly with methylcholantrene (MCA) in a dose of 0.3 mg, and their T- and B-cells ability to cooperate in the immune response against sheep red blood cells, and also migration of these cells from the thymus and the bone marrow to the spleen were studied. The MCA immunosuppressive action proved to be associated with the inhibition of migration and cooperation of T- and B-lymphocytes in the immune response. A conclusion was drawn that the immunosuppressive effect developing during the carcinogenesis was complex and it was realized at various stages of immunogenesis.

Animals↗
PubMed1977

Patterns of exogenous and endogenous hematopoietic repopulation following radiation injury.

Patterns of hematopoietic recovery in mice given an LD50/30 radiation exposure were different from those in animals given an LD100/30 exposure and a marrow transplant sufficient to effect 50 per cent 30-day survival. Death occurred later, and recovery of some peripheral blood elements was delayed in the LD50/30 mice. Over the period of study, splenic hematopoiesis and stem cell renewal were insignificant in the LD50/30 mice yet were active in the marrow-transplanted animals. The slow recovery of erythropoiesis in the LD30/30 mice is explained in part by the lack of early splenic hematopoiesis. This effect appeared to be attributable to the splenic microenvironment which, although being suitable for growth of unirradiated hematopoietic cells, was not conducive to repair of radiated splenic hematopoietic cells.

Animals↗