PubMed HealthSearch

SEARCH · PubMed Health

Results for “Research And Development”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 55 records · Page 3Linked to original sources

Developing an effective nursing research committee.

If you want to challenge your critical care nurses to participate in nursing research, develop a nursing research committee. Participation on a research committee fosters nurses' research interests and provides an opportunity for them to learn about the research process from a practical perspective.

Budgets

The use and value of qualitative methods in health research in developing countries.

Qualitative and quantitative research methods for public health were integrated in the past. Work at the Polela Health Center and the Institute of Family and Community Health (South Africa) in the 1940's epitomized how true integration was possible. Since the 1950's the growth of disciplines and boundaries between them; the growing emphasis by funding agencies on quantitative research that yields results rapidly at low cost and the dominance of the medical profession in public health together resulted in a separation of approaches. Recently, recognition of the need for integrated approaches has reemerged but the capacity to conduct appropriate research in developing countries is weak and they have relied on importing both researchers and their methods. Examples are given (mainly using focus group methods) of how innovative integrated approaches in developing countries have been used to implement community diagnoses, understand factors affecting health service utilization and identify factors amenable to intervention. It is concluded that while qualitative methods are needed (and used) in developing countries, their use will only increase if appropriate training initiatives in developing countries are undertaken.

Cross-Cultural Comparison

Research and development contracting at the National Institute of Dental Research.

Government contracting for biomedical research and development is a cooperative venture of high public visibility. It must be soundly conceived, openly instituted, and skillfully managed. Because of the cooperative nature of contract activities, it is important for the scientific community to understand the contract mechanism and the concepts upon which its use is based. Therefore, these concepts are described and how this mechanism serves as an aid in accomplishing the mission of the National Institute of Dental Research is discussed.

Dentistry

Pharmaceutical research and development.

Some aspects of pharmaceutical research and development (R&D) are reviewed. The viability of major pharmaceutical manufacturers depends on their research and thus they commit substantial resources to R&D programs. Major pharmaceutical manufacturers in the United States employ about 40,000 R&D personnel, and worldwide pharmaceutical R&D expenditures reached $24 billion in 1990. The pharmaceutical industry is one of the most profitable; however, increasing prices of their products are often associated with increasing R&D costs, ignoring the many positive attributes of R&D. The Council on Competitiveness has recently proposed reforms in the approval process for new drugs, including accelerated approval, external review, and international cooperation. These reforms would help to preserve an R&D capability and a relatively unregulated pharmaceutical industry. Pharmaceutical R&D has made many important contributions, including increased life expectancy, the internationally competitive position of the US industry, and a positive balance of trade. However, a misunderstanding of the role of R&D could encourage development of policies and legislation detrimental to pharmaceutical R&D.

Drug Approval

Reproductive epidemiologic research in developing countries.

This paper discusses the scientific rationale for carrying out reproductive epidemiologic research in developing countries, and the generalizability of results of research done in developed countries to developing countries. Practical problems encountered in doing research in developing countries include limited resources, overcommitted researchers, cost, and study monitoring. Cultural differences that affect the design and conduct of research activities in developing countries are also discussed.

Anemia, Sickle Cell

Medical education and medical education research and development activities in modern China.

The development of medical education in China occurred quite differently to medical education in the rest of the world. A review of the literature has been presented regarding the historical development and the evolution of medical education research and development (MERAD) units in modern China. The history of medical education in modern China has been divided into three periods: (1) the 17 years before the 'Cultural Revolution' (1949-1966); (2) the period of the 'Cultural Revolution' (1966-1976); (3) the post 'Cultural Revolution' period (1976 onwards). Although a number of MERAD activities had existed on China's medical campuses since 1949, there was no formal organizational structure for MERAD before 1978. The change of the political situation in 1978 led China to seek modernization, with education as its basis. In the process of health care system modernization, medical education was given priority, and the Western model of establishing MERAD units as a means of improving the training of health professionals was introduced. The evolution of medical education research and development in modern China appears to be following the Western pattern due to the multitude of Western consultants and fellowships in Western countries provided to Chinese medical education leaders. A group of people from medicine is gathering in the MERAD field and MERAD units are beginning to take shape in modern China.

China

Narrowing the zone of uncertainty between research and development in biological warfare defense.

Although "research" is not prohibited by the Biological Weapons Convention, States Parties to the Convention have maintained the spirit of the Convention in actions relating to research. The confidence-building measures agreed to at RC2 refer to research facilities, publication of research results, and promotion of contacts between scientists engaged in research related to the Convention. However, assessment of basic research on biological agents is not a productive way to distinguish an offensive from a defensive program. Additionally, if a country were to initiate a biological weapons program, basic research on biological agents may not be necessary. For example, the extensive published research on Bacillus anthracis, both as a cause of anthrax in cattle and other species and as a biological-warfare agent, would enable any motivated group or nation to initiate a biological weapons program that could immediately advance to the development and scale-up stages. Research on biological agents for offensive purposes would be characterized by activities such as selection for growth, virulence, and toxin production; improving stability under varying environmental conditions; and selection of strains that might overcome existing means of prophylaxis and treatment. A biological program with an offensive intent would in most cases be characterized by evidence of development efforts in mass production and dissemination, which are often agent-specific. Thus, an assessment of development may distinguish offensive from defensive programs. If a country were to initiate a biological weapons research program, and were willing to risk worldwide condemnation should existence of such a program become known, it is likely that such a program would include development and production capabilities. If a country were not committed to production capability, there would be no rationale for an offensive biological research that would bring worldwide condemnation. Critics of the U.S. Biological Defense Research Program have suggested that the program could easily and quickly be turned into an offensive effort. To accomplish this, however, we have to assume that all military personnel, including the civilians employed by the Department of the Army, are unethical and willing to break the law and run the risk of placing the U.S. in a noncompliance status. The Army is under constant scrutiny by governmental agencies, by visiting scientists, by audiences at scientific meetings, by scientists who review manuscripts for publications, by news media, and by private citizens.(ABSTRACT TRUNCATED AT 400 WORDS)

Biological Warfare

Nutrition and aging: potentials and problems for research in developing countries.

The demographic explosion of persons over 60 years of age is a reality in developed and developing countries alike. There is evidence that research on aging and nutrition in Third World countries is growing and developing. Specific research programs, and the linking of these programs in timely multicenter efforts, promise both valuable descriptive research for the benefit of national populations and comparative insights that will help us to learn more, collectively, about the intrinsic nature of the aging process itself.

Aged

Reforming the Department of Health's research and development policy: from the devil to the deep blue sea?

Research into health and social services in Britain is largely funded by the Department of Health. Regional NHS research and development has recently been reformed and a new report now proposes replacement of the 13 research units funded by the department with three or four large multidisciplinary centres. Evidence to support such a step is lacking, and many criticisms of the existing units arise from poor departmental planning rather than deficiencies of the units themselves. Large units may make research less responsive to the department's needs, and it is essential that the proposed new structure is thoroughly evaluated before it is introduced.

Academies and Institutes

Fertility regulation in the male.

The current state of research into new methods of male contraception is reviewed, with special emphasis on the efforts of the WHO Special Programme of Research, Development and Research Training in Human Reproduction. The article concentrates mainly on the development of orally administered or injectable substances capable of either (a) interfering with the hormonal control of testicular function, (b) disrupting spermatogenesis by direct influence on testis function, or (c) interfering with the fertilizing ability of the sperm and their transport. It is concluded that, despite the numerous areas of research currently being pursued, the availability of a new male contraceptive remains several years away.

Contraceptive Agents, Male

Health for all through research on primary care.

This paper first explores what Health for All (HFA) means as a policy goal. It calls for major changes in health care. In the European Region of WHO, 38 targets show how approaches to health problems, lifestyles, environment, health care and support measures (e.g., planning, management and training) should be changed to reach the goal. These changes must be based on sound scientific knowledge. HFA therefore also calls for a health research policy. The second part looks at the research implications of HFA. WHO analyzed the 38 targets to see what kind of research would help to achieve them. This analysis resulted in two health research policy documents jointly called Research for health for all (RHFA). The first one explains why a country needs a health research policy. The second volume identifies the research necessary to reach the targets. The third part describes the research priorities identified in RHFA and shows their relevance for the primary health care research community. It ends with the prerequisites needed to make research for HFA possible. They include changes in the incentives for and financing of research, personnel development, research organization and communication between the researchers and decision-makers.

Europe

The research and development agenda for cancer prevention and education in Australia.

In Australia the most important preventable causes of cancer, in order of importance, are tobacco smoking, diet, obesity, sunlight exposure, alcohol consumption and occupational exposure to carcinogens. We review and discuss these causes and their potential preventability and discuss three broad strategies in cancer prevention: public health policy and legislation, screening, and education and behavior change. In each of these broad areas, current research evidence and relevant approaches to research and development are considered. Six areas of research and development priority for cancer prevention and education are suggested: cigarette smoking (particularly among children and adolescents); protection of the skin from exposure to strong sunlight; screening; dietary choices; occupational exposures; and the social and environmental context of cancer prevention. All of these strategies and concerns will not apply to every country in the Asia-Pacific region but may be useful as guidelines and as a stimulus for determining particular local priorities.

Australia