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Child maltreatment: testing the social isolation hypothesis.

Several barriers limit our attempts to untangle the social context of child maltreatment. One major barrier is our inability to agree on or effectively communicate what social isolation is. In an attempt to clarify this construct, the introductory section traces the evolution of the social isolation construct over the last three decades and concludes it is not one etiologic factor for child maltreatment, but rather, a large set of variables linked to the parent's perception of support, and their informal and formal networks. The empirical section examines each component of the social isolation construct by comparing 300 maltreating and nonmaltreating low-income mothers. Considerable variation is found between the networks of different types of maltreating mothers and nonmaltreating mothers on structural network properties, perception of support, and the types of resources they do and do not receive. For example, neglectful mothers had fewer network members, fewer contacts, fewer members living within 1 hour, and received fewer emotional and instrumental resources. Despite these findings, the label "social isolation" may not accurately describe the networks of mothers who maltreat their children, since all three types of maltreaters had at least eight important network members and more than 100 contacts with these members in the month before completing the questionnaire.

Adult↗

Effect of social isolation on the reinforcing properties of morphine in the conditioned place preference test.

It is widely accepted that early environmental influences may affect the behaviour of the adult animal and the responsivity to psychotropic drugs. Isolation rearing is an important variable in this regard. The present experiments compared the effects of isolation and social rearing of rats on the reinforcing properties of morphine. Male Lister hooded rats were raised from weaning either alone (isolation reared rats) or in groups of four rats per cage (socially reared rats). Four weeks later, the rats were tested for their sensitivity to morphine using a conditioned place preference test. Comparisons were made between socially and isolation-reared rats with respect to preconditioning and postconditioning following either saline or morphine (1 and 5 mg/kg SC) pretreatment. The results from the preconditioning phase demonstrated that rats reared either socially or in isolation had least preference for one quadrant that was then selected as the treatment quadrant. After saline conditioning, the socially reared rats still showed a significant (p < 0.05) less preference for the treatment quadrant relative to the opposite quadrant. Following morphine (1 and 5 mg/kg) conditioning, socially reared rats spent significantly more time (p < 0.05) in the treatment quadrant relative to the opposite quadrant, whereas isolation-reared rats failed to display morphine-induced place preference. These results demonstrate that social isolation decreases the reinforcing properties of morphine.

Animals↗

The effects of early social isolation on the motivation for social play in juvenile rats.

Fifteen-day-old rats were subjected to one of three housing conditions: mother-and-peer (family), peer, and isolation conditions. At 24 days of age, all subjects were rehoused individually. In Experiment 1, play behaviors were monitored in like-raised pairs. Despite their gross lack of social experience, isolation-reared subjects did not exhibit a deficit in frequencies of rough-and-tumble play. It is concluded that the fundamental motivation for rough-and-tumble play is relatively independent of prior learning in rats. Indeed, their elevated dorsal contacts suggested that isolation-raised subjects may have higher appetitive motivation for play. In Experiment 2, the levels of social motivation were compared between family- and isolation-raised animals, using a T-maze. The isolation-raised animals made reliably more choices for social interaction reward over food reward than family-raised animals. Although inconclusive, the results from the two experiments suggest that prolonged social isolation increases the appetitive motivation for social play.

Animals↗

Malodorous fungating wounds: uncertain concepts underlying the management of social isolation.

Malodorous fungating wounds can exacerbate the social isolation of patients with palliative care needs through changes in patients' body image. There is a lack of consensus regarding the most effective management approaches for patients with malodorous fungating wounds. This appears to relate to the existence of different theoretical frameworks for understanding altered body image. This article explores the theories used to create frameworks that have been used for interventions with patients experiencing social isolation arising from altered body image. It argues that there is a need for health care professionals to appreciate the lack of consensus within the literature and to understand this in the context of the relationship between theory and research. The author offers research and clinical recommendations.

Adaptation, Psychological↗

Poor peer interactions and social isolation: a case report of successful in vivo social skills training on a child psychiatric inpatient unit.

The effects of social skills training comprising didactic instructions, coaching, modeling, feedback and reinforcement were examined in a child diagnosed Conduct Disorder and Attention Deficit Disorder in whom social isolation and poor peer interactions were prominent features. Treatment was implemented in the specific settings in which deficient social performance was noted using a multiple baseline design. Application of social skills training led to increased rates of appropriate interactions with peers and decreased rates of playing alone. In addition, pre- and posttreatment scores on the Child Behavior Checklist and School Behavior Checklist showed significantly decreased dysfunctional behaviors after training. Follow-up contact 1 and 12 months following discharge indicated that the child continued to socialize more with peers and to show improved adjustment.

Adaptation, Psychological↗

Characteristics of socially isolated patients with coronary artery disease who are at elevated risk for mortality.

OBJECTIVES: Social isolation has been linked to poor survival in patients with coronary artery disease (CAD). Few studies have closely examined the psychosocial characteristics of CAD patients who lack social contact. METHODS: Social isolation was examined as a predictor of mortality in 430 patients with significant CAD. More isolated patients were compared with their less isolated counterparts on factors that might help explain the association between isolation and survival. RESULTS: The mortality rate was higher among isolated individuals. Those with three or fewer people in their social support network had a relative risk of 2.43 (p = .001) for cardiac mortality and 2.11 (p = .001) for all-cause mortality, controlling for age and disease severity. Adjustments for income, hostility, and smoking status did not alter the risk due to social isolation. With the exception of lower income, higher hostility ratings, and higher smoking rates, isolated patients did not differ from nonisolated patients on demographic indicators, disease severity, physical functioning, or psychological distress. Isolated patients reported less social support and were less pleased with the way they got along with network members, but they did not report less satisfaction with the amount of social contact received. CONCLUSIONS: Patients with small social networks had an elevated risk of mortality, but this greater risk was not attributable to confounding with disease severity, demographics, or psychological distress. These findings have implications for mechanisms linking social isolation to mortality and for the application of psychosocial interventions.

Aged↗

Increased 5-HT2C receptor responsiveness occurs on rearing rats in social isolation.

To investigate whether isolation rearing alters 5-hydroxytryptamine2C (5-HT2C) receptors, the effect of the serotonin agonist m-chlorophenylpiperazine (mCPP) was examined on elevated plus-maze behaviour, plasma corticosterone and brain 5-HT2C receptor protein levels in rats. There was no distinction between behaviour or corticosterone levels in drug-free isolates or socially housed rats exposed to the elevated plus-maze. The anxiogenic response to mCPP (decrease in open arm entry and time and an increase in stretch attend postures) on the elevated plus-maze was greater in isolation than in socially reared controls without any concomitant difference in the hypolocomotor effect of mCPP in the two groups. mCPP produced a greater elevation in plasma corticosterone in isolates than in group-housed controls. Hippocampal 5-HT2C receptor protein-like immunoreactive levels were significantly lower following mCPP than saline only in rats reared in isolation. These results indicate that increased 5-HT2C receptor responsiveness accompanies isolation-rearing and may contribute to the enhanced response to stress and the increased neophobia seen in this animal model of trait anxiety/depression. In isolation reared rats, rapid down-regulation of supersensitive 5-HT2C receptors may occur in the hippocampus following 5-HT agonist challenge.

Animals↗

Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation.

In cortex and hippocampus, protracted (>4 weeks) social isolation of adult male mice alters the subunit expression of GABA type A receptors (GABA(A)-Rs) as follows: (i) the mRNAs encoding GABA(A)-R alpha1, alpha2, and gamma2 subunits are decreased by approximately 50%, whereas those encoding alpha4 and alpha5 subunits are increased by approximately 100%; (ii) similarly, the synaptic membrane expression of the alpha1 subunit protein is down-regulated, and that of the alpha5 subunit protein is up-regulated; and (iii) the binding of [(3)H]flumazenil to hippocampal synaptic membranes is decreased. Behaviorally, socially isolated (SI) mice are resistant to the sedative effects of the positive allosteric GABA(A)-R modulators diazepam (DZP) and zolpidem. This resistance seems to be attributable to the decrease of alpha1-containing GABA(A)-Rs. Paradoxically, DZP, which, unlike zolpidem, acts at alpha5-containing GABA(A)-Rs, increases the locomotor activity of SI mice. Imidazenil, which fails to modulate alpha1-, alpha4-, and alpha6-containing GABA(A)-Rs but is a selective positive allosteric modulator of alpha5-containing GABA(A)-Rs, also increases locomotor activity in SI mice. Importantly, SI mice responded to muscimol, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one, and allopregnanolone similar to group-housed mice. These data suggest that a switch (a decrease in alpha1/alpha2 and gamma2 and an increase in alpha4 and alpha5 subunits) in the composition of the heteropentameric GABA(A)-R subunit assembly without a change in total GABA(A)-R number occurs during social isolation. Thus, the repertoire of DZP and imidazenil actions in SI mice appears to be elicited by the allosteric modulation of GABA(A)-Rs overexpressing alpha5 subunits. Benzodiazepine response mediated by alpha1-containing GABA(A)-Rs is expected to be silent or reduced.

Animals↗

Hyperphagia and polydipsia in socially isolated rhesus monkeys.

Three rhesus monkeys which had been isolated from social contact during their first year of life persistently overate and overdrank during adulthood. These monkeys ingested approximately twice as much fluid and food as the control animals reared normally.

Animals↗

[Isolation, social support, life events and health status].

Research on the influence of social networks and social support on health status, conducted in English-speaking countries over the past decade, is not yet widespread in France. A review of the literature reveals that this social support has undeniable effects on mental health, and less obvious effects on physical health; it also stresses the major conceptual and methodological problems encountered in socio-epidemiological approaches. It would appear necessary to construct an overall model integrating life events, coping abilities and individual psychological factors; Social support is considered as a function of social networks, fulfilling roles of emotional support, material help, information provider, egostrengthener and social normalizer. Its mechanisms for dealing with stress, especially the buffer-role hypothesis, are also discussed.

Health↗

d24-hour changes in circulating prolactin, follicle-stimulating hormone, luteinizing hormone and testosterone in male rats subjected to social isolation.

BACKGROUND: This work analyzes the effect of social isolation (a mild stressor) on the 24-h variation of pituitary-testicular function in young Wistar rats, assessed by measuring circulating levels of prolactin, FSH, LH and testosterone. METHODS: Animals were either individually caged or kept in groups (4-5 animals per cage) under a 12:12 h light-dark cycle (lights on at 0800 h) for 30 days starting on day 35 of life. Rats were killed at 4-h intervals during a 24-h cycle, beginning at 0900 h. RESULTS: Isolation brought about a decrease in prolactin, LH and testosterone secretion and an increase of FSH secretion. In isolated rats the 24-h secretory pattern of prolactin and testosterone became modified, i.e., the maximum in prolactin seen in control animals at the beginning of the activity span was no longer detected, whereas the maximum in circulating testosterone taking place at 1700 h in controls was phase-delayed to 2100 h in isolated rats. CONCLUSION: Social isolation affects the 24-h variation of pituitary-testicular function in young rats. Secretion of prolactin, LH and testosterone decreases, and secretion of FSH increases, in isolated rats. The maximum in prolactin seen in group-caged rats at the beginning of the activity span is not observed in isolated rats. The maximum in circulating testosterone taking place at the second part of the rest span in controls is phase-delayed to the light-dark transition in isolated rats.

Journal Article↗

Social isolation increases the response of peripheral benzodiazepine receptors in the rat.

Social isolation of rats for 30 days immediately after weaning reduces the cerebrocortical and plasma concentrations of progesterone, 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-TH PROG), and 3alpha,5alpha-tetrahydrodeoxycorticosterone (3alpha,5alpha-TH DOC). The percentage increases in the brain and plasma concentrations of these neuroactive steroids apparent 30 min after intraperitoneal injection of the peripheral benzodiazepine receptor (PBR) ligand CB 34 (25 mg/kg) have now been shown to be markedly greater in isolated rats than in group-housed controls. The CB 34-induced increase in the abundance of 3alpha,5alpha-TH PROG was more pronounced in the brain than in the plasma of isolated rats. Analysis of [3H]PK 11195 binding to membranes prepared from the cerebral cortex, adrenals, or testis revealed no significant difference in either the maximal number of binding sites for this PBR ligand or its dissociation constant between isolated and group-housed animals. Social isolation also induced a small but significant decrease in the plasma concentration of adrenocorticotropic hormone. Moreover, CB 34 increased the plasma concentration of this hormone to a greater extent in isolated rats than in group-housed animals. The persistent decrease in the concentrations of neuroactive steroids induced by social isolation might thus be due to an adaptive decrease in the activity either of the hypothalamic-pituitary-adrenal axis or of PBRs during the prolonged stress, reflecting a defense mechanism to limit glucocorticoid production. The larger increase in neuroactive steroid concentrations induced by CB 34 and the enhanced pituitary response to this compound in isolated rats indicate that this mild stressor increases the response of PBRs.

Adrenocorticotropic Hormone↗

Quantitative changes in reduced nicotinamide adenine dinucleotide phosphate-diaphorase-reactive neurons in the brain of Octodon degus after periodic maternal separation and early social isolation.

The influence of preweaning maternal separation and postweaning social isolation on the development of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase-reactive neurons in prefrontal cortical areas, in subdivisions of the nucleus accumbens and in the corpus callosum was quantitatively investigated in the precocious rodent Octodon degus. Forty-five-day-old degus from three animal groups were compared: (i) degus that were reared under normal undisturbed social conditions; (ii) degus that were repeatedly separated from their mothers during the first three postnatal weeks and thereafter reared with their family; and (iii) degus that remained undisturbed with the family until weaning (postnatal day 21) and thereafter were reared in social isolation. Preweaning maternal separation led to a significant decrease in NADPH-diaphorase-containing neurons in the corpus callosum in both genders (down to 33%) compared with the social control group. No significant changes were found in the subregions of the medial prefrontal cortex and nucleus accumbens. Postweaning social isolation led to a reduced density of NADPH-diaphorase-containing neurons in the corpus callosum in both genders (down to 52%) compared with the social control group. Furthermore, in the precentral medial cortex of female pups, a significant reduction in NADPH-diaphorase-reactive neurons (down to 72%) was detectable. All other regions of the medial prefrontal cortex and the nucleus accumbens remained unchanged. The observed deprivation-induced changes may reflect either an excessive reduction in NADPH-diaphorase-positive neurons or a down-regulation of the enzyme in neurons that normally express it.Our results indicate a link between early adverse socio-emotional experience and the maturation of NADPH-reactive neurons. Further studies are required to analyse the functional implications of this experience-induced brain pathology.

Animals↗

Social isolation effects on the "behavioral despair" forced swimming test: effect of age and duration of testing.

Social loss is considered to be one of the major precipitants of depression. Prior work with the Porsolt forced swimming test (FST) has failed to demonstrate increases in despair-like immobility as a result of prior social isolation in adult animals. In the present work, increased immobility was observed in young Swiss Webster mice that had been socially isolated for 24 h prior to a 15-minute FST. The effect was not apparent until after the first five minutes of testing. The increase in immobility as a result of social isolation was apparent in 17-21-day-old animals but not in 26-30-day-old ones. Control experiments indicated that the increase in immobility was not due to the slightly higher weight loss of the socially isolated animals. Administration of reserpine (0.25 mg/kg) induced a marginal increase in immobility in the youngest animals but decreased immobility at later ages. These data suggest that the mouse only exhibits a short period of time during early development where social isolation can promote despair-like immobility in the FST and suggest that analyses of depressive processes which result from social variables may be best studied during a limited age range in this species.

Aging↗

Effects of postnatal social isolation on hormonal and immune responses of pigs to an acute endotoxin challenge.

Social stress during early postnatal life often results in long-term effects on neuroendocrine and immune adaptation mechanisms. Therefore, the aim of the present study was to determine the influence of a 2-h daily social isolation from Day 3 to Day 11 on the acute and long-term proinflammatory and neuroendocrine responses of piglets challenged with the bacterial endotoxin lipopolysaccharide (LPS; 100 microg/kg body weight). Peripheral LPS administration significantly increased plasma concentrations of tumor necrosis factor-alpha (TNF-alpha), ACTH and cortisol in isolated and control pigs. However, the activity of the hypothalamic-pituitary-adrenal (HPA) axis after LPS stimulation was not significantly affected by isolation treatment, whereas the prior social isolation diminished the plasma TNF-alpha response to LPS 1 day as well as 45 days after the isolation period. The hippocampal TNF-alpha concentration in response to LPS was also reduced in priorly isolated pigs compared to control animals. Furthermore, the significant increase of TNF-alpha in the spleen caused by LPS was associated with a dramatic decrease in glucocorticoid receptor (GR) binding. The GR binding in hippocampus was increased in isolated pigs and was significantly decreased after LPS injection. In addition, the repeated isolation stressor was shown to increase hippocampal levels of interleukin-1beta (IL-1beta). The present results indicate that repeated social isolation of neonatal pigs may cause long-term effects on proinflammatory regulation at the periphery and in the brain following immune challenge with particular importance of TNF-alpha in mediating these interactions.

Adaptation, Physiological↗

The influence of social structure on social isolation in amphetamine-treated Java monkeys (Macaca fascicularis).

Amphetamine-induced social isolation in monkeys has often been considered a valid animal model for certain negative symptoms of schizophrenia. However, there appear to be many ambiguities in relation to the exact nature of the isolation. Therefore, the effect of orally administered amphetamine (AMP) on the occurrence of social isolation in Java monkeys was studied. In part I the rank dependency of the effects of AMP (0.5mg/kg) was investigated in four alpha-males and three beta-males. AMP increased 'proximity' and 'passive groom', and decreased 'active allogroom' in alpha-males. In contrast, AMP decreased all three behavioural elements to a certain extent in beta-males. It is concluded that AMP induces social isolation in beta-males, but not in alpha-males. In part II of this study the AMP-induced behaviour of the treated monkey and the simultaneously occurring changes in the non-treated monkeys were investigated in a detailed study of a single social group. AMP significantly reduced the frequency of 'exploration', 'locomotion', 'self-groom', 'swing', 'active groom', 'inspect', 'approach' and originally-present stereotypies. Thus AMP apparently reduces the ability to initiate behaviour which is characteristic for the adult animal. AMP did not affect the frequency of 'present' and 'play' and enhanced that of 'aggression' and 'fear' in the beta-male; it also elicited various juvenile-like behaviours in both alpha- and beta-males, suggesting that AMP induces a behavioural regression. Furthermore, the behaviour of the non-treated monkeys of the group was decisive for the occurrence of social isolation of the treated monkey. Thus, the effects of AMP on the social behaviour of Java monkeys depend on the individual sensitivity, the social position which the subject occupies in its group, and the behaviour of the partners of the treated subject.

Journal Article↗

The social distribution of primary social isolation among the aged: a subcultural approach.

This is a report of research on subcultural variation in primary social isolation in a representative sample of older persons in an urban area. The research classifies the respondents by subcultural status and examines the rates of primary social isolation. Most persons (85%) can be classified in sixteen of forty hypothetical subcultures, but only seven subcultures contain enough respondents to be numerically important. Two subcultures are identified with above average rates of primary social isolation and three with below average rates of primary social isolation. Sociologically, it makes sense to look at primary social isolation as a group phenomenon.

Aged↗

Chronic (-)-deprenyl administration attenuates dendritic developmental impairment induced by early social isolation in the rat.

It has been demonstrated that postweaning social isolation alters dendritic development in the medial prefrontal cortex (mPFC) of the rat. In addition, (-)-deprenyl, a monoamine oxidase B (MAO-B) inhibitor, promotes dendritic growth in prefrontocortical pyramidal cells. This study examined whether prefrontocortical dendritic developmental impairment induced by postweaning social isolation is attenuated by chronic (-)-deprenyl administration. Weanling Sprague-Dawley male rats were randomly reared in social and isolated environments between postnatal days 21 and 51 (P21-P51). At P52, half of the animals were behaviorally evaluated in the open-field test and sacrificed for histological analysis. The remaining isolated rats were subdivided into saline- and daily (-)-deprenyl-treated animals for 30 additional days (P52-P82). Socially-reared rats remained undisturbed except for daily saline administration. At P82, all animals were behaviorally evaluated and sacrificed for histological analysis. Dendritic quantification of the Golgi-Cox-Sholl-stained neurons indicated that chronic (-)-deprenyl administration partially compensated the dendritic growth impairment induced by social isolation. In addition, both isolated-saline- and (-)-deprenyl-treated rats showed a sustained locomotor hyperactivity in the open-field test.

Animals↗