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Results for “STAPHYLOCOCCAL TOXOID”

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At least 55 records · Page 3Linked to original sources
PubMed1976

[Effect of immunization of pregnant women with staphylococcal toxoid on the immunologic status of the child].

A study was made of the effect of immunization of women during pregnancy of the immunological status of puerperants and their neonates, and also on the course of pregnancy in women and on development of a child aged under one year. Elevation of the IgG level in the blood serum, of the IgA -- in the milk of puerperants, and of the IgM -- in the blood serum of neonates, and also a marked increase in the antistaphylolysin titre in the mother and the neonate was revealed as a result of immunization. Clinical obervations showed such immunization to be harmless for the women, the neonate and the child the first year after birth. Immunization had a favourable effect on the state health of the children the first year after birth; this was expressed in a greater, in comparison with other children, resistance against infections diseases.

Adult↗
PubMed1976

[Quantitative changes of immunoglobulins in immunization with staphylococcal toxoid].

It was determined the amount of the three classes of immunoglobulins (IgG, IgA and IgM) and the titre of the alfa-antitoxins in the serum of hyperimmunized donors of plasma against the staphylococcus aureus. An increase of the IgG and the titre of the alfa-antitoxins was established during the immunisazions course. In the light of the contemporary knowledge about the immune reactions in the staphylococcusinfection it was assumed, that the obtained plasma from donors immunized with staphylococcus aureus should provide a satisfactory effect by its clinical use.

Adolescent↗
PubMed1990

[The immunomodulating properties of a diphtheria bacterial vaccine in in vitro experiments].

In this investigation lymphocytes sensitized with Corynebacterium diphtheriae antigens obtained from carriers and convalescents were used. The new diphtheria bacterial vaccine Codivac, in contrast to other comparable preparations (diphtheria toxoid, staphylococcal toxoid, staphylococcal vaccine, levamisole), was found to produce a more direct effect by modulating the levels of T-lymphocytes, depending on their initial levels in the patient. Codivac, together with other preparations, can be used for the study of the problems of immunostimulation and immunocorrective therapy.

Adjuvants, Immunologic↗
PubMed1982

[Protective action of a combined preparation and staphylococcal anatoxin in reproducing a local staphylococcal infection in white mice].

In experimental local staphylococcal infection in white mice, previously immunized with staphylococcal toxoid and the combined preparation (staphylococcal toxoid + protective somatic staphylococcal antigen), the advantage of the latter in protecting the animals against infection with Staphylococcus aureus belonging to different phage groups has been revealed. Immunization with the combined preparation, carried out in 2 injections, has been found to stimulate antimicrobial immunity, simultaneously with antitoxic one, which indicates the expediency of the further study of the combined preparation.

Animals↗
PubMed1987

[Immunological activity of a Proteus vaccine administered to volunteers simultaneously with a pyoimmunogen and adsorbed staphylococcal anatoxin].

The comparative study of the immunological activity of Proteus vaccine prepared from soluble antigenic complexes was made after the immunization of volunteers with this vaccine used in the form of a single preparation and in combination with pyoimmunogen (Pseudomonas aeruginosa vaccine) and/or adsorbed staphylococcal toxoid. The injection of the vaccine in the form of a single preparation and in different combinations increased the ingestion of Proteus cells by neutrophils. The injection of Proteus vaccine simultaneously with pyoimmunogen and staphylococcal toxoid ensured the intensive phagocytosis of staphylococci. All combinations with Proteus vaccine, used in this investigation, stimulated the intensive formation of antibodies to Proteus vaccine strain and Re-glycolipid. Proteus vaccine introduced in combination with adsorbed staphylococcal toxoid essentially stimulated the synthesis of anti-alpha-staphylolysin.

Adolescent↗
PubMed1984

[Immunological effectiveness of the combined vaccination of donors with inactivated chromatographic influenza vaccine and adsorbed staphylococcal anatoxin].

The influence of combined immunization with inactivated chromatographic vaccine and adsorbed staphylococcal toxoid on the activity of the immune system of volunteer donors has been studied. With the T- to B-cell ratio in the peripheral blood remaining stable, the third injection of staphylococcal toxoid induces a certain suppression of the capacity of lymphocytes for blast transformation in the presence of mitogen and specific antigens. The intensity of the accumulation of anti-alpha-staphylolysin is subject to considerable individual variations and depends on its level prior to immunization. The level of influenza antihemagglutinins remains most stable when the interval between the injection of inactivated chromatographic influenza vaccine and the beginning of immunization with adsorbed staphylococcal toxoid is 3-6 months.

Adsorption↗
PubMed1992

[The capacity of purified staphylococcal anatoxin to correct antigen-specific and antigen-nonspecific immunological defects].

Purified staphylococcal toxoid is capable of partially preventing the development of antigen-specific (induced by the supraoptimal dose of sheep red blood cells) and antigen-nonspecific (induced by Tahyna virus) defects of humoral immune response, as well as abolishing these defects. The presence and manifestation of the correction of virus-induced immunodeficiency is determined by the dose of the toxoid and the interval between the injections of purified staphylococcal toxoid and the infective agent.

Animals↗
PubMedDate not supplied

[The characteristics of the autoimmune reactions in donors immunized with influenza vaccine and staphylococcal anatoxin].

Regularities in the formation of autoantibodies to human IgA, IgM, IgG and their fragments, such as F(ab')2, Fab, Fc, in donors immunized with influenza vaccine (44 subjects) and staphylococcal toxoid (15 subjects) were studied with regard to the dynamics of specific immune response. After immunization with staphylococcal toxoid autoimmune reactions were registered only in the precipitation tests during 3-5 weeks of observation. In donors immunized with influenza vaccine the induction of isotypically heterogeneous autoimmune reactions was established. These reactions were represented mainly by IgA and IgG autoantibodies to immunoglobulins of different classes and their fragments. The duration of autoimmune reactions registered in this group of donors was specially noteworthy. The levels of autoantibodies to most of the antigens under study remained significantly elevated for 6 months. After immunization with influenza vaccine the presence of direct correlation between the level of specific immune response and the level of autoantibody formation was established.

Adult↗
PubMedDate not supplied

[An experimental validation of immunotherapy with purified staphylococcal anatoxin].

Inbred mice have proved to be a promising model for the evaluation of antigen-specific and antigen-nonspecific immunomodulating activity of purified staphylococcal toxoid in humans. This toxoid induces the formation of pronounced humoral response to homologous and heterologous infections in humans and mice. In animal experiments purified staphylococcal toxoid has shown its capacity for the correction of secondary immune deficiency of different origin; when introduced into humans having secondary immunodeficiency associated with bacterial infections of different etiology, the preparation reproduces this effect.

Acute Disease↗
PubMed1997

Identification of antigenic sites on staphylococcal enterotoxin B and toxoid.

The staphylococcal enterotoxins (SEs) are capable of causing both food poisoning and a toxic shock-like illness in man. In addition, SEs are known to act as superantigens, stimulating T-cells according to their T-cell receptor Vbeta type. Relatively little is known of their antigenic determinants and how these may relate to the structure and function of the toxins. As a step in the study of these relationships, the entire molecule of SEB was synthesized in duplicate as a series of octapeptides overlapping by seven residues. This series thus represented all the potential linear epitopes of eight residues or less. The reactivity of the octapeptide series with antisera raised to purified SEB and to formaldehyde-inactivated SEB has been used to locate several antigenic sites on native SEB and to identify antigenic differences in the toxoid. Three antigenic peptides identified from the antigenic profile were synthesized and characterized. These represented amino acids 21-32, 93-107 and 202-217 of SEB. None of these peptides affected SEB-induced T-cell proliferation. However, the occurrence or absence of cross-reactivity of these peptides with antibodies to native SEB corresponds to the degree of exposure and/or the rigidity of these regions within SEB.

Amino Acid Sequence↗
PubMed1990

[The characteristics of the protective and antigenic activities of purified staphylococcal anatoxin in trials with mice of different genotypes].

The protective potency of purified staphylococcal toxoid by the survival rate of immunized mice challenged with the culture of Staphylococcus aureus strain L-1726 and the antigenic properties of the toxoid, determined by the level of antitoxin in the blood of mice and by the intensity of cell-mediated immunity in the spleen-cell migration inhibition test, were studied. The experiments were made on CBA and C57BL/6 mice. Purified staphylococcal toxoid was shown to possess antigenic and protective properties in a wide range of doses between 0.15 and 15 binding units per mouse. The protective effect of the toxoid in CBA mice was manifested in the presence of circulating antibodies and cell-mediated reaction or only in the presence of the toxoid. In C57BL/6 mice the protective effect of the toxoid was less pronounced and appeared in combination with the induction of cell-mediated immunity in the presence of an extremely low antibody level (0.062 I.U.).

Animals↗