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[Stomach neoplasm in patients with gastric ulcer].

The authors analysed the course of the disease in 903 patients with gastric ulcer and in 406 cases of gastric carcinoma which developed in patients suffering from peptic ulcer. Among 345 patients who did not undergo operation, in 24 (7%) carcinoma occurred in the edge of the ulcer or in the cicatrix. Initial stages (I-II) were revealed in 19 patients. Dysplasia of the mucous membrane was found in most patients 1-9 years before the occurrence of carcinoma. Patients with gastric ulcer belong to the risk group. The risk is highest in II and III degree dysplasia and atrophic gastritis. In III degree dysplasia surgical treatment must be considered.

Adult↗

[Microangiopathic hemolytic anemia. A form of presentation of stomach neoplasm].

The authors report the case of a 53-year-old female with symptomatic anemia and hemorrhagic diathesis. The patient presented thrombocytopenia, microangiopathic hemolytic anemia and leukoerythroblastic reaction in peripheral blood film. The diagnosis of metastatic gastric carcinoma was made by subsequent studies. A review is made of the literature concerning microangiopathic hemolytic anemia, namely its etiology, mechanisms of pathogenesis and association with metastatic carcinoma.

Adenocarcinoma↗

[Early diagnosis of stomach neoplasms].

The primary prevention of the carcinoma of the stomach promises little success in near future. Therefore the effort is directed to early recognition and healing (secondary prevention). The optimum method for this is the combination of X-ray-examination, gastroscopy and aimed biopsy. But also by early diagnosis and therapy in the invasive carcinoma the chances of survival are to be improved. At present only 5-6% of the patients with gastric carcinoma survive longer than 5 years. The author adopts a definite attitude to the groups with risk of carcinoma. The search for further factors of persons endangered by carcinoma (habit of nutrition, kind of constitution and preparation of food, other exogenous factors) must be continued intensively in order to get selected groups which may be controlled consequently.

Biopsy↗