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PubMed1967

Sidere mutato.

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England↗
PubMed2004

Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties.

To prevent bone loss that occurs with increasing age, nutritional and pharmacological factors are needed. Traditional therapeutic agents (selective estrogen receptor modulators or SERMs, biphosphonates, calcitonin) may have serious side effects or contraindications. In an attempt to find food components potentially acting as SERMs, we submitted four plant aqueous extracts derived from Greek flora (Sideritis euboea, Sideritis clandestina, Marticaria chamomilla, and Pimpinella anisum) in a series of in vitro biological assays reflective of SERM profile. We examined their ability (a) to stimulate the differentiation and mineralization of osteoblastic cell culture by histochemical staining for alkaline phosphatase and Alizarin Red-S staining, (b) to induce, like antiestrogens, the insulin growth factor binding protein 3 (IGFBP3) in MCF-7 breast cancer cells, and (c) to proliferate cervical adenocarcinoma (HeLa) cells by use of MTT assay. Our data reveal that all the plant extracts studied at a concentration range 10-100 microg/mL stimulate osteoblastic cell differentiation and exhibit antiestrogenic effect on breast cancer cells without proliferative effects on cervical adenocarcinoma cells. The presence of estradiol inhibited the antiestrogenic effect induced by the extracts on MCF-7 cells, suggesting an estrogen receptor-related mechanism. In conclusion, the aqueous extracts derived from Sideritis euboea, Sideritis clandestina, Marticaria chamomilla, and Pimpinella anisum may form the basis to design "functional foods" for the prevention of osteoporosis.

Breast Neoplasms↗
PubMed2006

Towards improved empirical isobase models of Holocene land uplift for mainland Scotland, UK.

A new approach to modelling patterns of glacio-isostatic land uplift during the Holocene in mainland Scotland, UK, is described. The approach is based upon altitude measurements at the inner margin or locally highest point of raised estuarine surfaces dated by radiocarbon assay supported by microfossil analyses. 2,241 altitudes have been analysed by a technique new to studies of former sea-levels, Gaussian Trend Surface Analysis, and isobase models for four Holocene shorelines: the Holocene Storegga Slide tsunami shoreline, abandoned rapidly circa 7,900 sidereal years BP; the Main Postglacial shoreline, abandoned during circa 6,400-7,700 sidereal years BP; the Blairdrummond shoreline, abandoned during circa 4,500-5,800 sidereal years BP, and a speculative fourth shoreline, the Wigtown shoreline, abandoned during circa 1,520-3,700 sidereal years BP, are shown in a series of maps. The implications of the shoreline patterns for glaicio-isostasy in the area are discussed. It is maintained that the statistical technique used enables broad estimates to be made of near shore sea surface change.

Age Factors↗