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Determinants of sleep quality in women with systemic lupus erythematosus.

OBJECTIVE: To characterize sleep complaints in women with systemic lupus erythematosus (SLE) and to identify correlates of sleep quality. METHODS: Sleep quality in 100 women with SLE was assessed using the Pittsburgh Sleep Quality Index (PSQI). Participants completed standardized questionnaires assessing depressed mood, leisure time physical activity, functional disability, and pain severity. A clinical examination determined disease activity, cumulative damage, and whether patients fulfilled the American College of Rheumatology criteria for fibromyalgia. A series of hierarchical multiple regressions were computed. RESULTS: The mean +/- SD global PSQI score was 6.98 +/- 4.03, with moderate to severe sleep impairment reported by 56% of the sample. The first model testing the importance of demographic factors was not statistically significant. In the disease-related model, the use of prednisone and functional disability both contributed to poor sleep quality (P < 0.001). The addition of level of exercise participation to the demographic set significantly added to the model (P = 0.001). Depression significantly added to the demographic set, explaining 29% of the variance (P < 0.0001). When these variables, along with disease related variables, were simultaneously regressed on the PSQI Global Score, only depressed mood appeared as a significant independent determinant of global sleep quality (P < 0.001). However, the point estimates for the Beta coefficients were consistent with effects for lack of exercise and prednisone use. CONCLUSION: A significant proportion of women with SLE suffer from poor sleep quality. The findings suggest that depressed mood, prednisone use, and lack of exercise contribute to decreased overall sleep quality.

Disability Evaluation↗

The meaning of good sleep: a longitudinal study of polysomnography and subjective sleep quality.

The present study sought to investigate the meaning of subjectively good sleep, using a longitudinal and intraindividual design. Eight subjects slept in an isolation unit according to an irregular schedule of 6 h sleeps and 1 h naps, designed to give normal amounts of time in bed (1/3 of total), but variable sleep quality. Eight sleeps and eight naps were used for longitudinal simple and multiple regression analyses with standard polysomnographical sleep variables as predictors and subjective sleep quality as dependent variables. The results showed that subjective sleep quality (and related variables) was closely related to sleep efficiency, but not sleep stages. At least 87% efficiency was required for ratings of 'rather good' sleep. In addition, sleep quality ratings improved with closeness (of the awakening) to the circadian acrophase (17.00-21.00 hours) of the rectal temperature rhythm. The subjective ease of awakening differed from most other other variables in that it was related to low sleep efficiency. Objective and subjective homologues of sleep length and sleep latency showed high mean intraindividual correlations (r = 0.55 and 0.64, respectively). It was concluded that objective measures of sleep continuity were closely reflected in perceived sleep quality and that sleep quality essentially means sleep continuity.

Journal Article↗

Subjective sleep quality in cystic fibrosis.

OBJECTIVES: To evaluate sleep quality in patients with cystic fibrosis (CF). METHODS: The Pittsburgh Sleep Quality Index (PSQI) questionnaire was administered to 37 CF patients with moderate to severe lung disease in a clinically stable state. Sleep studies were performed concurrently. PSQI scores were correlated with results of anthropometric variables, arterial blood gas tensions, lung function variables, and polysomnographic variables. Potential differences in objective measurements between patients with high and low scores on the PSQI were assessed. RESULTS: Thirty-seven patients with CF were studied, aged 27+/-8 (mean+/-1 SD) years and forced expiratory volume in 1 s (FEV(1)) 36+/-12% predicted. The mean PSQI was 5.7+/-4.0. Fourteen of the 37 patients had a high PSQI, i.e. >5. Significant correlations between objective variables and both component scores and total PSQI were as follows: age and 'subjective sleep quality' (r=0.4, P<0.05), age and 'sleep duration' (r=0.3, P<0.05), FEV(1) % predicted and 'subjective sleep quality' (r=-0.4, P<0.05), carbon monoxide transferred per litre of lung volume (KCO) % predicted and 'daytime dysfunction' (r=-0.4, P<0.01), PaCO(2) and 'sleep latency' (r=0.4, P<0.01), arterial carbon dioxide tension (PaCO(2)) and 'habitual sleep efficiency' (r=0.3, P<0.05), PaCO(2) and total PSQI (r=0.4, P<0.05), absolute minimum sleep oxyhemoglobin saturation by pulse oximetry (SpO(2) %) and 'sleep latency' (r=-0.4, P<0.05), absolute minimum sleep SpO(2) % and 'sleep duration' (r=-0.4, P<0.05), absolute minimum sleep SpO(2) % and total PSQI (r=-0.4, P<0.05) and awake transcutaneous CO(2) and 'sleep duration' (r=0.45, P<0.05). Better sleep efficiency (P<0.05) and a greater % of rapid eye movement (REM) sleep (P<0.05) were found in those patients with a PSQI of < or =5. CONCLUSIONS: A number of CF patients reported poor sleep quality. A relationship was shown between subjective sleep quality and physiological variables describing disease severity. Better sleep efficiency and % REM sleep were seen in patients with low PSQI scores. These results suggest a useful role for the PSQI in assessing sleep quality in patients with CF.

Journal Article↗

Transcutaneous vagus nerve stimulation influences sleep quality and insomnia: A systematic review and meta-analysis.

Impairments in sleep quality, timing, or duration disrupt normal sleep patterns. This systematic review and meta-analysis investigated the effects of transcutaneous vagus nerve stimulation (tVNS) protocols on sleep outcomes. Thirteen randomized controlled trials with parallel or crossover designs that applied tVNS intervention and assessed sleep quality (Pittsburgh Sleep Quality Index) and insomnia severity (Athens Insomnia Scale and Insomnia Severity Index) were included. Effect sizes were calculated by comparing changes between the active tVNS and control groups. Moderator analyses examined whether stimulation of different targeted regions influences sleep outcomes. Meta-regression analyses examined potential relationships between the effects of tVNS protocols on sleep quality and demographic characteristics and multiple tVNS parameters, respectively. The random-effects meta-analysis indicated that tVNS protocols influenced better sleep quality and lower insomnia severity. Moderator variable analysis revealed that tVNS targeting the concha region induced better sleep quality. Meta-regression analysis revealed that better sleep quality was associated with lower ages of participants. These findings suggest that tVNS protocols, particularly those targeting the concha, were associated with favorable changes in sleep quality and insomnia severity, with age potentially moderating the treatment response.

Humans↗

The effect of surgical weight reduction on sleep quality in obesity-related sleep apnea syndrome.

Obesity-related sleep apnea syndrome (SAS) was diagnosed in 13 patients evaluated for gastric bypass surgery. A diagnostic sleep study was performed whenever a specially designed questionnaire revealed characteristic signs of sleep disturbances. Pretreatment polyhypnographic recordings of patients with SAS demonstrated considerable reduction of deep and rapid eye movement (REM) sleep stages with a correspondent prolongation of wake within sleep or non-REM sleep stages I and II. After surgical weight reduction repeated polyhypnographic recordings revealed considerable improvement or even a complete recovery of breathing in sleep and a normalization of sleep structure. Non-REM deep sleep stages (III and IV) augmented from 5.51% +/- 2.53% (mean + SEM) to 22.69% +/- 3.56% (p less than 0.002), and the REM stage increased from 9.91% +/- 1.78% to 18.15% +/- 2.13% (p less than 0.005). Surgical weight reduction in obesity-related SAS is a valuable therapeutic measure for this respiratory derangement, as well as for sleep quality.

Female↗

Effects of temazepam on sleep quality and subsequent mental efficiency under normal sleeping conditions and following delayed sleep onset.

A group of 24 healthy, normal sleepers participated in 2 experiments. The 1st experiment was designed to investigate the effects of 2 nocte doses of temazepam on subjective sleep quality and performance next morning. In contrast to placebo or no-capsule conditions both temazepam 10 and 20 mg improved a number of assessments of sleep quality, although no residual effects on performance were detected. The 2nd experiment was designed to study the effects of temazepam 20 mg on daytime sleeping and subsequent performance following a simulated night shift. Compared to placebo, temazepam had favourable effects on the subjective duration and quality of daytime sleep, but had no overall beneficial or detrimental residual effects on performance.

Adolescent↗

[Changes of sleep quality and mood disorders under the influence of phototherapy in patients with seasonal affective disorders SAD].

UNLABELLED: Major depression, seasonal pattern (seasonal affective disorder SAD) characterize the winter recurrence depressive episodes with remission of symptoms in spring and summer. Patients with winter depression report hypersomnia, fatigue, loss of energy, carbohydrate craving, appetite and weight gain. AIM: The aim of this study was to assess the effect of phototherapy on the quality of sleep parameters and subjective estimation of mood disorders in patients with seasonal affective disorders. METHOD: The investigated group consisted of 17 patients with SAD (15 female, 2 male) aged 18-64 (mean 38+/-12) years. Phototherapy (bright light therapy) was applied for 14 days, everyday morning--30 minutes, between 6.00 to 10.00--exposition to light of about 10,000 lux intensity. Polysomnogram (sleep EEG) was recorded before and after treatment. RESULTS: After phototherapy patients reported a significant mood improvement (57%) measured by the Seasonal Pattern Assessment Questionnaire. Sleep investigation showed: increased sleep efficiency, decreased sleep latency, decreased slow wave sleep latency and increased of sleep spindles in the first hour of sleep. CONCLUSIONS: Research confirms that phototherapy is an effective method of treatment of choice for patients with SAD. The result indicates that phototherapy markedly improved mood and sleep quality.

Adult↗

Morning or evening activity improves neuropsychological performance and subjective sleep quality in older adults.

STUDY OBJECTIVES: Sleep disturbances and decline in neuropsychological performance are common in older adults. Reduced social and physical activity is likely a contributing factor for these age-related changes in sleep and cognition. We previously demonstrated that a program of structured social and physical activity, with 2 daily activity sessions, 1 in the morning and 1 in the evening for a relatively short period of 2 weeks, improved sleep and neuropsychological performance in community-dwelling older adults. The goals of this pilot study were to determine whether a single daily morning or evening activity session for 2 weeks would also improve sleep and neuropsychological function and whether these effects were dependent on the timing of the activity sessions. DESIGN: We compared the effect of morning or evening structured activity sessions in a repeated-measures crossover design. Subjective mood, neuropsychological performance tasks, and subjective and objective measures of sleep were assessed at baseline and after the intervention. SETTING: All procedures took place in the participant's residence. PARTICIPANTS: Twelve older men and women (74.6 +/- 5.5 years of age). INTERVENTIONS: Subjects participated in 14 days of structured activity sessions in the morning (9:00-10:30 am) or evening (7:00-8:30 pm). Sessions consisted of stretching, low-impact aerobics, and game playing. MEASUREMENTS AND RESULTS: Exposure to either morning or evening activity significantly improved performance on a neuropsychological test battery. Morning activity sessions increased throughput on 4 of 8 performance tasks, while evening activity sessions improved throughput on 7 of the 8 performance tasks. Subjective sleep-quality ratings, measured by the Pittsburg Sleep Quality Index, improved following activity sessions in either the morning or the evening. Objective measures of sleep did not improve when measured by actigraphy or polysomnography. CONCLUSIONS: These results suggest that short-term exposure to either morning or evening social and physical activity improves objective measures of neuropsychological performance and subjective sleep quality in the elderly. Increasing exposure to social and physical activity may be a useful intervention to improve sleep quality and daytime function in older adults.

Affect↗

Self-reported sleep quality and fatigue correlates with actigraphy in midlife women with fibromyalgia.

BACKGROUND: Limited data are available on the relationship between self-reported sleep quality, fatigue, and behavioral sleep patterns in women with fibromyalgia (FM). OBJECTIVES: To compare self-reported sleep quality, fatigue, and behavioral sleep indicators obtained by actigraphy between women with FM and sedentary women without pain, and to examine relationships among these variables. METHODS: Twenty-three women with FM (M = 47.3, +/- 6.7 years) and 22 control women (M = 43.5, +/- 8.2 years) wore an actigraph on the nondominant wrist for 3 consecutive days at home. Each day women reported bedtimes, rise times, and ratings of sleep quality and fatigue in a diary. Self-reported sleep quality, fatigue, and indicators of sleep quality obtained from actigraphy (e.g., total sleep time, sleep efficiency, sleep latency, wake after sleep onset, and fragmentation index) were averaged. The Mann Whitney U test was used to assess group differences. Pearson Product Moment Correlation was used to evaluate relationships between sleep quality and fatigue, and among sleep quality, fatigue, and actigraphy sleep indicators. RESULTS: Women with FM reported poorer sleep quality and more fatigue compared to controls (both p <.001). Actigraphy sleep indicators were not different between groups. In women with FM but not in controls, self-reported sleep quality was directly related to actigraphy indicators of total sleep time (r =.635, p <.01) and inversely related to sleep fragmentation (r = -.46, p <.05). Fatigue in women with FM was directly related to actigraphy indicators of wake after sleep onset (r =.57, p <.01), and inversely related to sleep efficiency (r = -.545, p <.01). DISCUSSION: Self-reported sleep quality and fatigue are associated with behavioral indicators of sleep quality at home in women with FM. Actigraphy is a useful objective measure of improved sleep outcomes in intervention studies.

Activities of Daily Living↗

Factors influencing quality of life in multiple sclerosis patients: disability, depressive mood, fatigue and sleep quality.

OBJECTIVES: In a series of 504 patients with multiple sclerosis (MS), quality of life (QOL) and its main clinical and demographic determinants were assessed in comparison with healthy individuals. MATERIALS AND METHODS: A postal questionnaire with self-completed measures of disability (Expanded Disability Status Scale, EDSS), QOL (Quality of Life Index, QLI), depressive mood (Self-rating Depression Scale, SDS), fatigue severity (Fatigue Severity Scale, FSS) and sleep quality (Pittsburgh Sleep Quality Index, PSQI) was sent to this sample of MS patients. RESULTS: Most patients were severely disabled; almost half were mildly to severely depressed, suffering from reduced sleep quality and/or fatigue. The multiple sclerosis patients had significantly lower QLI scores than healthy controls. EDSS and SDS scores were found to be predictors of global QLI score. Regarding the different QLI domains, mean SDS scores remained predictive for all QLI items, while mean EDSS, PSQI and FSS scores were only predictive for physical domains. CONCLUSION: Our study clearly demonstrates that depressive mood is the main factor influencing QOL. The disability status, fatigue and reduced sleep quality have an impact mainly on physical domains of life quality.

Adult↗

Effect of temazepam on oxygen saturation and sleep quality at high altitude: randomised placebo controlled crossover trial.

OBJECTIVE: To determine the effects of temazepam on the quality of sleep and on oxygen saturation during sleep in subjects at high altitude. DESIGN: Randomised, blinded, crossover, placebo controlled trial. SETTING: Base camp at Mount Everest (altitude 5300 m). SUBJECTS: 11 members of British Mount Everest Medical Expedition recently arrived at base camp. INTERVENTION: Participants were randomly allocated to receive either temazepam 10 mg or placebo on their first night at base camp and the other treatment on the second night. MAIN OUTCOME MEASURES: Quality of sleep (assessed subjectively), mean arterial oxygen saturation value, and changes in saturation values (as measure of periodic breathing) while participants taking temazepam or placebo. RESULTS: All participants noted subjective improvements in sleep. Mean saturation value remained unchanged when temazepam was compared with placebo (74.65% v 75.70%, P = 0.5437). There were fewer changes in oxygen saturation when participants took temazepam and when measured as decreases > 4% below the mean value of saturation each hour (P = 0.0036, paired Student's t test (two tailed)). CONCLUSIONS: Participants taking temazepam at 5300 m showed no significant drop in mean oxygen saturation values during sleep. Both the number and severity of changes in saturation during sleep decreased and the quality of sleep improved. This may be a result of a reduction in the number of awakenings and might lead to greater respiratory stability and fewer episodes of periodic breathing. This has the effect of improving the quality of sleep and reducing the number of periods of desaturation during sleep.

Adult↗

Sleep Quality of Former Night-shift Workers.

This study explored the relationship between past night-shift work and present quality of sleep, first by a survey and second with standard laboratory recordings. Nurses (n = 479) working on a day or evening schedule answered a questionnaire about past night-shift work and present quality of sleep. An insomnia index, derived from the questionnaire, was elevated for nurses who had worked more than five nights per month for four to ten years. The index was low for the 13 nurses who had worked more than ten years on night shifts. The sleep of 15 day nurses was recorded in the laboratory. Results showed that a high insomnia index was associated with a high number of awakenings, and that former night-shift workers had a significant reduction in slow-wave sleep, whether or not they had subjective sleep complaints. These results suggest that working at night may have persistent deleterious effects on sleep quality when the experience is long and includes a substantial number of night shifts.

Journal Article↗

[Effect of vitamin B12 on sleep quality and performance of shift workers].

In modern industry shift systems are important for optimal economic utilization of high-grade working plants. The implementation of shift systems, however, goes along with far-reaching social and health responsibilities of these organizations. This study plores, to what extent the intake of vitamin B12 before the beginning of a day shift has a stabilizing influence on the quality of sleep and the subjective estimate of the performance of the volunteers. The study was performed on 10 healthy, male staff members of a Tyrolean industrial plant with a mean age of 35 years, who work in a 12/12-h shift system as doormen. In a single blind placebo-verum-order all volunteers received first of all placebo for 2 weeks, then vitamin B12 (Methylcobal, 3 mg) for 3 weeks, at the morning before the day shift. By means of modified sleep-onset- and wake-up- records we studied the morning and evening state, the estimates of sleep time / -quality as well as the subjective judgement of the performance. The statements about periods of rest and activity were compared with the objective data of the wrist actimetry. Vitamin B12--concentrations in the serum were prepared for baseline and verum trials for each individual. In the whole group there were no significant differences in sleep-onset and wake-up ratings, nor in the subjective judgement of performance between placebo and verum. There were no significant particularities with respect to the weekdays or the time of day of activity. There was a tendency for the total sleep time in the verum trial to be shorter. The mean estimate of sleep quality under verum in significantly higher than under placebo in all volunteers.

Adult↗

[Family dynamics: sleep quality of women caregivers of family members with Alzheimer disease].

This replication study/Riccio 1996) sets out to explore the Quality of sleep of 34 women primary caregivers of Alzheimer's Disease patients at home. A descriptive, correlational and longitudinal design has been used. Key aspects considered were the quality of nocturnal sleep, the daytime sleepiness, the hours of caring, the educational level, the employment, the time for personal needs and the levels of depression and anxiety. After an initial interview, the caregivers were asked to fill in several instruments to measure the variables taken into consideration. The caregivers presented poor quality in their sleep. Quality of nocturnal sleep was negatively affected by more hours of caring (p < 0.02), high depression and anxiety levels (p < 0.05 and 0.007 respectively). The education level, the employment outside home and the amount of time spent for themselves, positively affected the quality of sleep (p < 0.01, 0.04, 0.05 respectively). This research pointed out that hours of caring, directly and indirectly, cause sleep problem to Alzheimer's Disease caregivers enhancing nursing care implications.

Adult↗

Critical incident exposure and sleep quality in police officers.

OBJECTIVE: Police officers face many stressors that may negatively impact sleep quality. This study compares subjective sleep quality in police officers with that in control subjects not involved in police or emergency services. We examined the effects of critical incident exposure (trauma exposure) and routine (nontraumatic) work environment stressors on sleep quality after controlling for the effects of work shift schedule. METHODS: Subjective sleep disturbances were measured by the Pittsburgh Sleep Quality Index in police officers (variable-shift workers, N = 551; stable day-shift workers, N = 182) and peer-nominated comparison subjects (variable-shift workers, N = 98; stable day-shift workers, N = 232). The main predictor variables were 1) duty-related critical incident exposure to on-line policing and 2) work environment stress related to routine administrative and organizational aspects of police work. RESULTS: Police officers on both variable and stable day shifts reported significantly worse sleep quality and less average sleep time than the two corresponding control groups. Within police officers, cumulative critical incident exposure was associated with nightmares but only weakly associated with poor global sleep quality. In contrast, the stress from officers' general work environment was strongly associated with poor global sleep quality. Sleep disturbances were strongly associated with posttraumatic stress symptoms and general psychopathology. CONCLUSIONS: A large percentage of police officers report disturbances in subjective sleep quality. Although the life-threatening aspects of police work are related to nightmares, the routine stressors of police service seem to most affect global sleep quality in these subjects. These findings may have implications for health and occupational performance.

Adult↗

Adults with ADHD and sleep complaints: a pilot study identifying sleep-disordered breathing using polysomnography and sleep quality assessment.

OBJECTIVE: ADHD and sleep-disordered breathing are both prevalent in adulthood. Because both conditions may be responsible for similar symptoms of cognitive impairment, the authors investigate whether their presentation may overlap in adults diagnosed with ADHD. METHOD: Data are collected from six adults with sleep complaints who were diagnosed with ADHD using rigorous clinical criteria. All participants undergo overnight polysomnography and complete questionnaires about sleep quality, circadian sleep pattern, and daytime fatigue. RESULTS: On standardized measures, all participants report poor sleep quality, two report daytime fatigue, and none report distinct deviation from normal sleep and wake cycle pattern. Polysomnography reveals evidence of sleep-disordered breathing and sleep fragmentation in all participants. CONCLUSION: Objective evidence of breathing-related sleep disorders can be found in some adults with carefully diagnosed ADHD who report sleep complaints. This report highlights the importance of identifying treatable sleep disorder comorbidity in adults with ADHD.

Adult↗

Objective and subjective sleep quality in premenopausal, perimenopausal, and postmenopausal women in the Wisconsin Sleep Cohort Study.

STUDY OBJECTIVE: Assess objectively measured sleep quality in premenopausal, perimenopausal, and postmenopausal women. DESIGN: Observational epidemiology study. SETTING: Community-based. PARTICIPANTS: Probability sample of 589 premenopausal, perimenopausal, and postmenopausal women recruited from state employee records. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: Menopausal status was determined by menstrual history, surgical history, and use of hormone replacement therapy. Sleep quality was objectively measured by full in-laboratory polysomnography and by self-reported sleep problems. Linear and logistic regression were used to estimate associations adjusted for potential confounding factors. OBJECTIVE: Sleep quality was not worse in perimenopausal or postmenopausal women, compared with premenopausal women. To the contrary, postmenopausal woman had more deep sleep (16% vs 13% stages 3/4, P < 0.001) and significantly longer total sleep time (388 minutes vs 374 minutes, P = 0.05). Menopausal status was moderately related to self-reported dissatisfaction with sleep but was not consistently associated with symptoms of insomnia or sleepiness. CONCLUSIONS: Menopause is not associated with diminished sleep quality measured by polysomnography. Although perimenopausal and postmenopausal women, relative to premenopausal women, were less satisfied with their sleep, menopause was not a strong predictor of specific sleep-disorder symptoms. Symptoms and signs of sleep abnormalities in midlife women should not be attributed primarily to menopause before ruling out underlying sleep disorders.

Adult↗

Climacteric symptoms and sleep quality.

OBJECTIVE: To evaluate the effect of climacteric vasomotor symptoms on sleep quality measured by self-report and polysomnography in postmenopausal women. METHODS: Seventy-one healthy postmenopausal women were recruited, of whom 63 completed the study. Each subject recorded climacteric symptoms and subjective sleep quality for 14 days. Sleep quality was evaluated objectively by all-night polysomnography using the static charge-sensitive bed. RESULTS: During polysomnography, a high frequency of climacteric vasomotor symptoms was not associated with changes in sleep latency, percentage of sleep stages, number of arousals, sleep efficiency, or total sleep time. However, a high frequency of climacteric vasomotor symptoms (range 0-8.9, r = .60, P < .001), somatic symptoms (range 0-5.0, r = .25-.44, P < .05), and mental symptoms (range 0-5.0, r = .41-.51, P < .001) was related to impaired subjective sleep quality. In stepwise regression analysis, 32% of the impairment in subjective sleep quality was explained by vasomotor symptoms (P < .001), 14% by palpitations (P < .001), and 4% by mood instability (P = .029). High body mass index predicted impaired objective sleep quality, such as prolonged latencies to stage-2 sleep (r = .27, P = .031) and slow-wave sleep (r = .51, P = .003) and decreased oxygen saturations (r = -.54, P < .001). Older women had decreased sleep efficiency (r = -.27, P = .030) and lower oxygen saturations (r = -.36, P = .004). Serum estradiol level had only a minor effect on objective sleep quality. CONCLUSION: Impaired subjective sleep quality associated with climacteric vasomotor symptoms did not manifest as abnormalities in polysomnographic sleep recordings. Body mass index and age appeared to have the strongest effect on objective sleep quality.

Aged↗