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PubMed1978

Social functioning and self-care in hospitalized psychogeriatric patients.

Evaluations of social disability have been found useful in determining factors of diagnostic, therapeutic and prognostic significance in the management of psychogeriatric patients. A random sample of 100 psychogeriatric patients aged 65 or over admitted to three Toronto hospitals were studied prospectively. Standardized clinical and social interview schedules were used to assess patients' mental state, self-care capacity, social isolation, burden on the family and household contribution before admission. These assessments were carried out to determine their significance with respect to diagnosis and outcome. Self-care capacity, as measured by the Activities of Daily Living Performance Test or by informant report, was related to diagnosis and outcome measures in this sample. Social isolation was significantly correlated with length of hospital stay. Burden on the family was not found to be significantly associated with diagnosis or outcome although there was a tendency for patients with organic disorders to present more difficulties for their families. The severe burden imposed on relatives suggests the need for utilization of community social and medical services to provide relief for families of psychogeriatric patients. The implications for management are considered in the light of the above findings.

Activities of Daily Living↗

PubMed1979

Environmentally induced differences in susceptibility of rats to CNS stimulants and CNS depressants: evidence against a unitary explanation.

It has been suggested that socially isolated rats are more aroused then rats raised in social groups. This hypothesis was tested by examining amphetamine-induced activity and stereotypy in social and isolated rats of both sexes in both the active and inactive phases of their diurnal activity cycle. In socially raised rats it was possible to produce behavioural profiles similar to those of isolated rats by increasing the arousal level of the social rat. However, the complex interaction of housing conditions, diurnal variation and gender with drug dose suggests that one intervening variable such as arousal is too simplistic an explanation. In subsequent experiments, stereotypy was enhanced by a familiar environment, and there was a clear dissociation between the effects of CNS stimulants and CNS depressants. The increased susceptibility of isolates to CNS stimulants depends on social isolation for a short period before 45 days of age; the decreased susceptibility of isolates to CNS depressants may be produced by isolation at any age. We conclude that there is no evidence that isolated rats are hyperaroused.

Animals↗

PubMed1978

The social behavior of elderly aphasic versus nonaphasic long-term patients.

A study was made of the social consequences of communicative disorders among 51 elderly hospitalized long-term patients. Independent variables used to account for variations in social behavior were: 1) the presence or absence of aphasia, an impairment resulting in varying degrees of loss of verbal recognition, comprehension and language production; 2) sex; and 3) the level of nursing-care needs as an indicator of overall physical independence. A rating scale for measuring "Social Involvement" was constructed. It involved four analytically-derived factors - Interpersonal Behavior, Familial and Social Contacts, Group Participation, and Extent of Social Contacts. Since a comparison of the 15 aphasic and 36 nonaphasic subjects on the basis of these four factors revealed no substantial main effect, it would seem that social isolation was not attributable to aphasia per se. Rather, a number of significant interactions indicated that differences in the levels of social involvement were attributable to the combined influences of sex, presence or absence of aphasia, and varying levels of physical independence. The relationship between social involvement and social isolation has implications for the overall management and rehibilitation of long-term patients.

Aged↗

PubMed1978

The biology of social attachments: opiates alleviate separation distress.

The possibility that brain opiate systems participate in the control of social affect was assessed by determining capacity of low doses of exogenous opiates (0.125-0.50 mg/kg oxymorphone, and 0.10-0.50 mg/kg morphine sulfate) to reduce distress vocalizations of socially isolated puppies. Low doses of opiates were capable of profoundly reducing crying as well as the motor agitation they exhibit during brief periods of social isolation. Since reductions in crying could be obtained with morphine in the absence of any gross behavioral disturbances, the possibility is entertained that brain opiates may function to control the intensity of emotions arising from social separation. Possible parallels between the biological nature of narcotic addiction and the formation of social bonds are discussed.

Animals↗

PubMed1977

Social-olfactory experience and initiation of copulation in the virgin male rat.

Two experiments examined the role of olfactory sensation for initiation of normal copulatory behavior of mature male rats. Experiment 1 compared copulatory performance of peripherally anosmic social isolates with that of intact isolate controls. The results revealed significantly lower mounting, intromission, and ejaculation frequencies of the anosmic group and suggested that nonolfactory cues attain significance via an associative-learning process. Experiment 2 compared three social isolate groups of mature males with varying sexual experience prior to anosmia. Four 1-hr tests were conducted at 5-day intervals. The results indicated comparable copulatory performance of the experienced groups and absence of copulation by the majority of the nonexperienced group. With a 12-day continuous exposure to intact females, all noncopulators eventually impregnated. The results are discussed with reference to the requirement of social experience for initiation of normal sexual performance in the male rat.

Animals↗

PubMed2026

Large-Scale Neuroimaging and Genetic Analyses of the Human Thalamus in Loneliness.

BACKGROUND: Although loneliness is prevalent and significantly impacts society globally, its neural and genetic bases remain poorly understood. The thalamus, which receives sensory information from the environment, may have a more significant role in social interactions than previously recognized. Here, we integrate neuroimaging and genetic approaches to characterize structural differences within the thalamus associated with loneliness. METHODS: We obtained thalamic nuclei volumes on brain scans from 45,834 individuals (age range: 45-82 years) in the UK Biobank and grouped them into 6 anatomical groups. We investigated effects of loneliness and social isolation using self-reported data. Then, we performed a genome-wide association study (GWAS) analysis on the genetic overlap between thalamic volumes and loneliness. RESULTS: The volumes of the whole thalamus and its medial, lateral, and posterior nuclei are significantly reduced in individuals with loneliness compared with those who do not feel lonely. Loneliness with frequent social contact is associated with smaller volumes, whereas social isolation without loneliness shows no such reduction in thalamus volumes. Leveraging data from GWASs on thalamic volumes (n = 30,114) and loneliness (n = 370,342) in the UK Biobank, we identified shared loci between thalamus structure and loneliness. CONCLUSIONS: Our findings support the emerging view that the thalamus plays important roles in social interactions and in the experience of loneliness.

Genetic architecture↗

PubMed1979

Rehabilitation of socially withdrawn preschool children through mixed-age and same-age socialization.

24 socially withdrawn preschool children were located through classroom observations and assigned to 3 conditions: (a) socialization with a younger child during 10 play sessions, (b) socialization with an age mate during a similar series of sessions, and (c) no treatment. The socialization sessions, particularly those with a younger partner, were found to increase the sociability of the withdrawn children in their classrooms. Significant increases occurred mainly in the rate with which positive social reinforcement was emitted. Generally, the results support a leadership deficit theory of social isolation. Possible mechanisms responsible for the observed changes are discussed.

Age Factors↗

PubMed1977

The attitudes of psychiatrists toward etiological theories of schizophrenia.

This study is an analysis of psychiatrists' opinions on the etiology of schizophrenia. A random sample of members of the American Psychiatric Association uncovers a general hesitation on their part to subscribe to any particular etiological theory. Only four theories are viewed as causally related to schizophrenia: social isolation, cognitive breakdown, biochemical imbalance, and maternal deprivation. Attitudes toward etiological theories are significantly different among psychoanalysts, behaviorists, and eclectics. Attitudes also are related to the setting in which the psychiatrist practices.

Attitude of Health Personnel↗

PubMed1976

The role of serotonergic pathways in isolation-induced aggression in mice.

Male mice that became aggressive following four weeks of social isolation were treated with seven known serotonin receptor antagonists. All of the antiserotonergic drugs selectively antagonized the fighting behavior of the isolated mice; the antiaggressive activity was selective since, at antifighting doses, none of the drugs either significantly altered spontaneous motor activity or impaired inclined-screen performance. Antagonism of 5-HTP-induced head-twitch was used as an in vivo measure of antiserotonergic activity and a statistically significant correlation existed between potency as an antiserotonergic and potency as an antiaggressive. PCPA, a serotonin depletor, also significantly antagonized isolation-induced aggression for at least 24 hr postdrug administration. The interrelationship between cholinergic and serotonergic mechanisms in the mediation of isolation aggression was investigated. The involvement of serotonergic systems in isolation-induced aggression is discussed.

5-Hydroxytryptophan↗

PubMed1977

[Isolation, loneliness and suicidal ideas in the aged (author's transl)].

The relationship between various dimensions of social isolation, loneliness and suicidal ideas among a group of 406 respondents over 65 years of age were analyzed. The survey findings show that suicidal ideas emerge as a result of both, a loss of or a social denial to intimate and highly valued personal relationships. Generally, these suicidal ideas are connected to feelings of loneliness which are unrelated to the quantity of other social contacts. It seems to be of particular relevance whether the disengagement occurred voluntarily and whether the personal life style showed consistency of persistency resp. Based on these findings the fundamental problems of a social psychological approach to gerontology are discussed. These problems arise out of the more or less perfect correspondence between objective indicators of a social situation and its subjective correlates.

Aged↗

PubMed1977

[Social-political aspects of psychological stress].

Emotional stress is often based on defective social conditions like social isolation or the urge for maximal efficiency in production and consumption. The improvement of these social conditions and the elimination of the resulting pathogenic stress is a political task. There is a curious and unrealistic separation of responsibilities which is justified by tradition only: the social part of the therapy is abandoned to political institutions and groups whereas the psychiatrist whose therapy should be comprehensive concerns himself with individual problems only. As he neglects the noxious social circumstances and aims entirely at the social adaptation of the patient the psychiatrist denies the defectiveness of the social conditions as they are and corroborates a system which is the true cause of numerous psychiatric disturbances.

Humans↗

PubMed1977

Nocturnal sleep in isolation-reared monkeys: evidence for enviromental independence.

Thirteen all-night recordings were obtained from 3 infant pigtailed (Macaca nemestrina) monkeys raised on a cloth surrogate mother and under conditions of social isolation. Totally implantable biotelemetry systems were used to record the sleep physiology from the unrestrained animals. Sleep stages and night-to-night variability were virtually identical to values previously found in 8 mother-reared group-living infants. Sustained alterations in the early rearing enviroment, even though considerably modifying the organism's development, did not appear to result in differences in sleep organization.

Animals↗

PubMedDate not supplied

[Relationship between the sequelae of zoosocial isolation and individual characteristics of the animal].

The changes were studied of various psychophysiological characteristics of mice behaviour, arising after prolonged solitary isolation in cages. The qualitative specificity of such changes is non-uniform and depends on the animals' individual characteristics (spontaneously aggressive or nonaggressive after isolation). Two types of the consequences of isolation are singled out: 1) General changes (non-specific) arising in all groups of mice; 2) Special changes (specific), typical of a certain group of animals only. In the group of aggressive mice there is a difference between aggression enhanced by isolation, and that which developed in the course of isolation. The most substantial qualitative changes in behaviour takes place in the latter case. It has been suggested that only individual approach makes it possible to determine exactly the qualitative aspects of social isolation consequences.

Aggression↗

PubMed1979

Psychological response of children to isolation in a protected environment.

A behavioral observation study of 14 children with cancer treated in a laminar airflow protected environment (PE) unit was done over a period of 2 years. A total of 3629 observations were completed, and results related to perception, sleep, intellectual functioning, physical discomfort, mood, management problems, activity patterns, social-communicative behavior, and sedation are reported. In general, despite evidence from the literature that sensory deprivation and social isolation can cause severe disturbance of the sensory apparatus, no debilitating or long-term psychological effects related to prolonged PE treatment were noted. The differences between PE and deprivation-isolation contexts are discussed, and the need for psychosocial support of these patients is emphasized.

Adolescent↗

PubMed1978

The Peer Preference Test as a measure of reward value: item analysis, cross-validation, concurrent validation, and replication.

Thirty-six preschoolers were administered and retested on a 15-item Peer Preference Test designed to measure the reward value of peers for each child. Test-retest reliability was .88, and after item analyses, 12 items were maintained in the test. The revised test was then administered to 29 other preschoolers. Test-retest reliability was .77, and item analyses indicated that each item made a significant contribution to the overall test. Concurrent validation of the test was demonstrated using both a picture sociometric and a behavioral measure. In addition, the Evers-Pasquale and Sherman (1975) study was replicated, using 10 preschool social isolates.

Behavior Therapy↗

PubMed1977

Acquisition and extinction of an operant response in differentially reared rats.

Rats reared in either socially isolated or control environments were trained to bar press for food on a variable interval schedule of reinforcement, beginning at 125 days of age for 37 consecutive days. Following this phase the subjects were tested for response persistence during an extinction test. Next, the subjects were compared on measures of spontaneous recovery and the rate of response reacquisition when the reinforcement contingencies were once again reinstated. Though no differences were discerned between the groups on measures of acquisition, maintenance, and reacquisition, isolated rats emitted many more responses than the controls during extinction testing.

Animals↗

PubMed1975

A 21-year psycho-social follow-up of 524 unselected cases of down's syndrome and their families.

The death rate was followed, and a life table has been constructed. Three crucial events were examined: 1. the period of diagnosis, 2. the problem of institutionalization versus homecare, 3. the ageing and death of the parents and its consequences for the person with D.S. Several other medical problems, psychological implications and social consequences for the person with D.S., for his parents and siblings are highlighted. The worst problem for parents with the child at home was social isolation; for the parents with the child at an institution it was the very existence of the child. To both groups the most encouraging fact was that their child was happy, friendly and in good spirits. Finally, emphasis is laid upon the medical and paramedical problems which must be discussed and solved to make a harmonious and social life for the person with D.S., for his normal siblings, and for the parents.

Adolescent↗

PubMed1979

Social experience affects the development of dendritic spines and branches on tectal interneurons in the jewel fish.

African jewel fish reared with eyeless cave fish, but without visual-tactile contact with conspecifics, exhibit hyperresponsive behavior after release in community aquaria. Because the optic tectum might be affected by these restraints on visual experience, unreleased members of the same social isolate group were compared histologically with controls reared in community aquaria. Using the rapid Golgi method, we counted dendritic spines and branches on pyriform interneurons between 402 and 529 days of age. As compared with isolates, control group interneurons exhibited significantly more spines and primary branches on apical dendrites in deep tectal layers. Our focus is the relation between experiential differences in rearing conditions and synaptic changes in the deep tectal layers.

Animals↗