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PubMedDate not supplied

[Computed tomography in the diagnosis of soft tissue neoplasms of the trunk and extremities].

Analysis of CT data on 213 patients with soft tissue and trunk tumors has shown that a majority of malignant and benign tumors have a similar picture (except lipoma). Features of the contours of a tumor and its inner structure do not permit the assessment of its nature. The only significant differential-diagnostic sign of malignant soft tissue tumors is destruction of an adjacent bone, noted in 17.6%. The majority of malignant and benign soft tissue tumors (70.9%) on CT scans look like a single node; recurrent tumors look multinodular (78.2%). Verification of soft tissue tumors, revealed by CT, should be done using morphological methods.

Adult↗
PubMedDate not supplied

[Computerized tomography in the diagnosis of soft tissue neoplasms of the extremities and trunk].

Analysis of CT data on 213 patients with soft tissue and trunk tumors has shown that a majority of malignant and benign tumors have a similar picture (except lipoma). Features of the contours of a tumor and its inner structure do not permit the assessment of its nature. The only significant differential-diagnostic sign of malignant soft tissue tumors is destruction of an adjacent bone, noted in 17.6%. The majority of malignant and benign soft tissue tumors (70.9%) on CT scans look like a single node; recurrent tumors look multinodular (78.2%). Verification of soft tissue tumors, revealed by CT, should be done using morphological methods.

Adult↗
PubMedDate not supplied

[Results of the treatment of non-rhabdomyosarcomatous soft tissue neoplasms within the scope of the CWS 81 study].

347 children with all types of soft tissue sarcoma (STS) have been entered between 1981 and April 1986 into the CWS-81 study. Excluding 229 patients with rhabdomyosarcoma, 118 patients with other STS were analysed in the histological subgroups, separately. 33 synovial sarcomas (SyS), 15 undifferentiated sarcomas (US) and 13 extrasceletal Ewing's sarcoma (EES) were treated with a multimodale trial including chemotherapy and radiotherapy after initial not-mutilating resection or biopsy only, Relapse-free survival rate by Kaplan-Meier was 66% in SyS, 48% in EES and 38% in US, respectively. Patients treated according to the guidelines of the CWS-protocol showed better prognosis than patients with major protocol violations or patients with recurrence when entered into the trial. In SyS only 2 of the 7 patients with recurrence developed metastases. The tumor response rate within 7-9 weeks chemotherapy exclusively given was 71% in patients with stage III and IV. Non-responding tumors to chemotherapy had bad prognosis, irrespective of histological subtype or further treatment. EES and US developed earlier recurrence and more often metastases than SyS or rhabdomyosarcomas. The administered VACA-chemotherapy seems not to be very effective in EES and US. In all other varieties of STS recurrence at the primary site assumed relatively greater importance. Chemotherapy and radiation were not administered in all patients. Fibrosarcoma (FS) was diagnosed in 13 patients. Six of these were entered in the trial at the time of local recurrence and 4 of these 6 relapsed again locally, one with metastasis concurrently.(ABSTRACT TRUNCATED AT 250 WORDS)

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1976

Tumors of fibrous tissue origin in childhood. A clinicopathologic study of cutaneous and soft tissue neoplasms in 66 children.

Fibroblastic lesions in children present difficulties in diagnosis and in a justifiable therapeutic approach. This series reviews the clinical and pathologic features of fibroblastic soft tissue lesions from 66 children. Although radical procedures were occasionally required to achieve local control of an aggressive lesion, conservative surgery was generally successful. Recurrences were frequent, but only one lesion, in an adolescent, metastasized. No prognostic value could be found in anatomic location or in histologic features. Even cellular lesions with frequent mitoses ordinarily did not require the aggressive therapy needed in similar lesions in adults. In this series, incomplete original excision was frequent and usually related to the infiltrating margins of the lesion.

Child↗
PubMed1996

[Our experience with surgical treatment of soft tissue neoplasms].

On the basis of the data on 650 cases of soft-tissue sarcoma, improvements to surgical treatment of these tumors have been made versus localization, local extension and histological pattern. Optimal size of area to be excized has been determined. Procedures for organ-saving surgery involving resection of nerves, vessels and underlying bones, in cases of locally-extended tumors, have been evolved. Optimal procedures for skin reconstruction have been suggested. The rationale has been given for indications to amputation. The 5-year survival in patients with soft-tissue sarcoma was 52,6%, while local recurrence incidence-23%.

Humans↗
PubMed2003

Cutaneous sclerosing perineurioma of the digits: an uncommon soft-tissue neoplasm. Report of two cases with immunohistochemical analysis.

BACKGROUND: Cutaneous sclerosing perineurioma is a recently characterized, uncommon tumor composed of perineurial cells, which exhibits immunoreactivity for epithelial membrane antigen (EMA). These lesions occur preferentially in children and young adults and usually develop as dermal or subcutaneous nodules in the hands or palms. METHODS: We report two cases of cutaneous sclerosing perineurioma in young patients without stigmata of neurofibromatosis. Histologically, these lesions were well-circumscribed masses and were characterized by a variable number of epithelioid and spindle cells with wavy nuclei end elongated cytoplasmic processes embedded in a dense collagen stroma. RESULTS: These cells showed focal whorling formation, demonstrated robust immunoreactivity for EMA and CD99, and were uniformly negative for S-100 protein, actin (HHF-35), CD34, cytokeratin AE1-3, and CD57. CONCLUSION: We comment on the differential diagnosis of fibrous cutaneous lesions based on immunohistochemistry.

Adolescent↗