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Results for “ULTRAVIOLET THERAPY”

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At least 55 records · Page 3Linked to original sources
PubMed1999

A systematic review of laser therapy for venous leg ulcers.

A systematic review of randomised controlled trials (RCTs) was conducted to establish the effectiveness of low-level laser therapy as a treatment for venous leg ulcers. Wound-care journals, conference proceedings and electronic databases (including Medline and Cinahl) were searched up to October 1997 for RCTs comparing low-level laser therapy with sham laser, no laser, or non-coherent light of other wavelengths. In addition, companies who manufacture or distribute therapeutic lasers were contacted for any unpublished or ongoing studies. Results from searches were scrutinised by one reviewer to identify possible RCTs and full reports of these were obtained. Details of eligible studies were extracted and summarised using a data extraction sheet. Data extraction was checked by a second reviewer. Meta-analysis was used to combine the results of trials where the interventions and outcome measures were sufficiently similar. A total of four eligible RCTs were identified. Two compared treatment with laser therapy to sham or placebo laser treatment. One study compared laser therapy with ultraviolet therapy. The fourth was a three-armed study which compared the effects of laser therapy alone, laser therapy plus infrared light, and non-coherent unpolarised red light. The comparisons of laser therapy with placebo, and laser therapy with ultraviolet therapy, showed no significant difference between treatments with regard to ulcer healing rates. The comparison of laser with red light showed a significant increase in complete healing at nine months for the combination of laser and infrared light compared to non-coherent unpolarised red light. We have not found any evidence of the benefit of low-level laser therapy per se on venous leg ulcer healing. It appears that a combination of HeNe laser and infrared light may promote the healing of venous ulcers, however more research is needed.

Evidence-Based Medicine↗
PubMed1993

Ultraviolet recall associated with etoposide and cyclophosphamide therapy.

Ultraviolet recall (UR) or sunburn reactivation is an infrequently reported phenomenon. It is characterized by an erythematous eruption in the distribution of previous ultraviolet-induced sunburn. The timing of the eruption correlates well with the speculation that it is induced by the administration of a chemotherapeutic agent(s). The case of a young man who developed UR after treatment with etoposide (VP16) and cyclophosphamide is reported.

Adult↗
PubMed2006

Ultraviolet recall reaction after total body irradiation, etoposide, and methotrexate therapy.

Ultraviolet (UV) reactivation reactions are rare and can occur in areas of prior sunburn or UV light therapy after the administration of chemotherapy, antibiotics, and other medications. Reactions may occur within days, as described after methotrexate therapy, or may appear months later, as described with ampicillin. Such reactions have been variably termed "UV recall," "sunburn recall," "photo recall," and "photodermatitis reactivation," making classification difficult. We report a UV reactivation reaction in a patient with acute lymphocytic leukemia treated with total body irradiation, etoposide, and methotrexate. We propose the terms "UV recall" and "UV enhancement" be used in future reports to classify UV reactivation reactions in a scheme analogous to the terminology for cutaneous reactions after radiotherapy.

Antimetabolites, Antineoplastic↗
PubMed2004

Laser and novel light source treatments for psoriasis.

BACKGROUND AND OBJECTIVES: There are many treatment modalities for psoriasis including topical therapy, ultraviolet light therapy, systemic agents, and more recently the advent of the biologic agents. STUDY DESIGN/MATERIALS AND METHODS: In addition, selective treatment using lasers and light sources that target the individual psoriatic plaques have also been employed. RESULTS/CONCLUSION: This article will highlight and review the employment of laser-assisted devices in the treatment of plaque psoriasis.

Humans↗
PubMed1991

Variation in 8-methoxypsoralen profiles during long-term psoralen plus ultraviolet A therapy and correlations between serum 8-methoxypsoralen levels and chromametric parameters.

Three serum 8-methoxypsoralen (8-MOP) kinetics tests were performed on 15 patients undergoing PUVA therapy. The first test was carried out before beginning PUVA treatment, the 2nd one at the 10th session and the 3rd test at the 20th PUVA session. Blood samples were taken every 30 min after the drug was taken and a standard meal ingestion during 3 h to determine the serum 8-MOP peak level and corresponding time. For 14 patients, UVA-induced erythema was measured with a Minolta CR 200 chromameter, 3 (before beginning PUVA treatment, just before 10th session and 48 h later) or 5 times (before beginning PUVA treatment, just before 10th session and 48 h later, just before 20th session and 48 h later). There was a wider distribution of serum 8-MOP peak levels in the 3rd test than in 2nd one and in the 2nd one than in the first one. These facts suggest a heterogeneity in 8-MOP metabolism in the 15 patients: 11 patients showed an earlier serum 8-MOP peak and an earlier appearance of the drug in blood in the 3rd and 2nd test than in the first one. For 9 of these 11 patients, serum 8-MOP peak levels were higher and higher from the first profile to the 3rd one, suggesting an inhibition of 8-MOP metabolism in time. In the remaining 4 patients, the 8-MOP peak time and the appearance of the drug in blood were delayed in the 3rd test compared with the first profile.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1982

Constant low-dose ultraviolet light therapy for psoriasis.

In a bilateral comparison study, symmetric plaques of psoriasis were used to compare the effects of a constant low dose (3 minutes, 30 seconds) of ultraviolet light therapy to the standard increasing ultraviolet light dose. The low constant dose of ultraviolet light was as efficacious in clearing psoriasis lesions as the higher increasing dose.

Adult↗
PubMed1998

[Change in the content of chemical elements in epitheliocytes of the prickle cell layer of granulating skin wounds exposed to ultraviolet rays and ultraviolet laser therapy].

Spinous layer of human epidermis was studied in control group (2 human subjects) and in 16 patients with thermic lesions prior to and following ultraviolet laser therapy (UVLT) of ultraviolet irradiation (UVI). Skin biopsy was performed in each patient on undamaged regions (individual control). Chemical elements (Ca, K, Cl, Mg, Na and Al) content prior to and following treatment was compared. Patients with equal stage (IIIB) and localisation of lesion were selected. Bioptates were obtained for diagnostic purposes. UVLT was established to prompt normalization of the content of chemical elements named in epitheliocytes of human epidermis in IIIB lesions whereas UVI does not cause this effect at the same conditions. It is proposed that this difference is dependent on the origin of appropriate irradiations.

Adult↗
PubMed1984

Comparison of suberythemogenic and maximally aggressive ultraviolet B therapy for psoriasis.

We prospectively compared the maximally aggressive erythemogenic ultraviolet B (UVB) schedule (Le Vine et al, 1979) and a suberythemogenic UVB schedule (Frost et al, 1979) in the treatment of psoriasis. Patients were treated with either the maximally aggressive erythemogenic UVB (MAEUVB) schedule or the suberythemogenic UVB (SEUVB) schedule. Each patient received daily topical treatment with 2% crude coal tar ointment on half of the body and the ointment vehicle on the other half of the body. All patients were hospitalized and treated 7 days a week. The treatment results were determined daily be grading preselected reference lesions for erythema, scaling, and thickness. With both UV schedules, no difference in response could be detected between the ointment vehicle side and the tar ointment side. In a comparison of the two UV schedules, patients treated with MAEUVB had no statistically significant difference in the resolution of their psoriasis, and the length of remission was similar. The average energy needed for the SEUVB-treated patients was 984 mjoules/cm2, whereas the average for the MAEUVB-treated patients was 984 mjoules/cm2. Our findings suggest that neither crude coal tar nor MAEUVB is needed for the optimal UVB treatment of psoriasis in the hospital.

Adult↗
PubMed2003

Medium- versus high-dose ultraviolet A1 therapy for urticaria pigmentosa: a pilot study.

BACKGROUND: There is currently no definitive cure for urticaria pigmentosa (UP). Psoralen plus ultraviolet A therapy is efficacious in alleviating symptoms and reducing cutaneous lesions. OBJECTIVE: The purpose of this study was to assess the effect of ultraviolet A1 (UVA1) in adult patients with UP and to compare the effectiveness of high-dose (130 J/cm(2)/day for 10 days) and medium-dose (60 J/cm(2)/day for 15 days) UVA1 radiation. METHODS: Ten and 12 adult patients with UP were treated with high-dose or medium-dose UVA1, respectively. The number of skin lesions and dermal mast cells, the presence of Darier's sign, the intensity of pruritus, and quality of life measures were evaluated before, at the end of treatment, and 2 and 6 months later. RESULTS: Baseline characteristics were similar among the 2 groups of patients. In the majority of patients, the number of lesions was not significantly reduced. However, the number of mast cells in lesional skin decreased markedly in most patients by the end of treatment, and it remained low for the whole study period. Pruritus and quality of life improved considerably by the end of treatment, and the improvement was maintained during the 6-month follow up. No significant differences were observed between patients receiving high- or medium-dose UVA1. CONCLUSIONS: UVA1 phototherapy ameliorates both objective and subjective symptoms of adult patients with UP and induces long-term remission in most cases. Medium-dose UVA1 appears at least as effective as high-dose UVA1.

Adolescent↗
PubMed1994

Determination of 8-methoxypsoralen kinetics: a relevant factor in the treatment of psoriasis by psoralen plus ultraviolet A therapy.

We compared the efficacy of psoralen plus ultraviolet A (UVA) therapy in 2 groups of psoriatic patients: a group of patients treated by a protocol adapted to the results of 8-methoxypsoralen (8-MOP) plasma kinetics (kinetics group) versus a control group of patients treated according to Pathak's standard protocol (UVA exposure 2 h after oral administration of a dose of 8-MOP equal to 0.6 mg/kg) (control group). The 8-MOP plasma kinetics were determined before the beginning of treatment. The parameter for comparison is the rapidity of clearing, taking into account the number of UVA exposures and UVA joules received. The analysis of the results observed show a 26.6% decrease in the number of UVA exposures and a 38.4% decrease in the dose of UVA received. These results are confirmed by the individual analysis of the rapidity with which the clearance of psoriatic lesions was obtained in patients who were treated with the standard PUVA protocol during the first attack and with the adapted protocol during the second attack.

Adolescent↗
PubMed1990

[Active methods of correction of endotoxemia in generalized suppurative infection].

The characteristics of the natural history of acute sepsis and the nature of the intoxication syndrome are analysed an on ample material (120 patients), and microbiological and immunological diagnostic findings are shown. Endotoxicosis in sepsis is attended by marked disorders of the immune status in the form of varying degrees of immunodeficiency. The authors generalize their experience with the management of endotoxicosis in sepsis. The article first shows the results of the combined use of various methods of endotoxicosis correction (homosorption, hemodiafiltration, plasmapheresis, endolymphatic therapy, ultraviolet irradiation of autoblood, hyperbaric oxygenation, application sorption) in the treatment of 120 patients with sepsis of various etiology. Active methods of detoxification via the blood and lymphatic system were first applied in the management of endotoxicosis in patients with sepsis.

Adolescent↗