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Results for “genetically engineered animals”

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At least 55 records · Page 3Linked to original sources
PubMed1997

Genetically engineered mice as animal models for NIDDM.

Genetically engineered animals carrying defined alterations in their genome can represent invaluable tools for better understanding complex polygenic diseases such as non-insulin-dependent diabetes mellitus (NIDDM) at the molecular level. The structure or expression of a number of genes potentially involved in insulin action or pancreatic beta-cell function have recently been altered in the mouse using transgenic or gene-targeting approaches. The obtention of such mice is the first step towards the development of animal models carrying multiple gene defects which would be very useful in NIDDM research.

Animals↗
PubMed1996

Genetic engineering of animal RNA viruses.

The ability to genetically manipulate viruses has led to extraordinary advances in understanding virus biology and to the establishment of useful vector systems. Initially confined to DNA viruses and retroviruses, RNA viruses have more recently become attractive candidates for expression of heterologous genes and offer promising perspectives for biomedical applications.

Animals↗
PubMed2003

Recent advances in alpha1-adrenoceptor pharmacology.

alpha(1)-Adrenergic receptors (ARs) mediate some of the main actions of the natural catecholamines, adrenaline and noradrenaline. They participate in many essential physiological processes, such as sympathetic neurotransmission, modulation of hepatic metabolism, control of vascular tone, cardiac contraction, and the regulation of smooth muscle activity in the genitourinary system. Here, we review recent progress on subtype-specific subcellular localization, participation in signaling cascades, and the pivotal function of alpha(1)-ARs, as delineated through studies on genetically engineered animals. Together, these findings will provide new insights into the physiological and pathophysiological roles of the alpha(1)-ARs.

Animals↗
PubMed1997

Mutant and transgenic mice in immunotoxicology: an introduction.

An overview is given in simple terms of the techniques behind transgenic, knock-out and knock-in mice. The principles for the creation and use in toxicology of genetically engineered animals are outlined, and some examples are given from areas related to immunotoxicology. Genetically engineered animals have so far been used only to a very limited extent in immunotoxicology. Practical aspects of work with transgenic animals are discussed, and sources of information and services related to transgenic animals are listed.

Allergy and Immunology↗
PubMed2003

[Experimental ureteral obstruction and knockout animals].

Obstructive uropathies caused by congenital malformations of the urinary tract are relatively frequent in newborn. These obstructive lesions are the main cause for renal disease in infancy. Most of these uropathies are treated by surgical interventions restoring the drainage function of the urinary tract. Clinically these patients are cured but the question remains wether these patients will develop renal disease in adult life, since it has been recently shown in animal models that transient, neonatal and prenatal, ureteral obstruction induces significant renal deterioration later in life. Except for angiotensin converting enzyme inhibitors that slow down the progression of renal disease, no specific drugs reducing renal fibrosis exist. Animal models of ureteral obstruction have allowed to clearly identify the events leading to tubulointerstitial fibrosis. Furthermore, more recently, the use of ureteral obstruction in genetically engineered animals has shown pro- and anti-fibrotic properties of a large number of molecules. These studies using genetically engineered animals have suggested several new future promising therapeutic directions to treat renal fibrosis.

Animals↗
PubMed1997

Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa.

Patients with retinitis pigmentosa (RP) typically develop night blindness early in life due to loss of rod photoreceptors. The remaining cone photoreceptors are the mainstay of their vision; however, over years or decades, these cones slowly degenerate, leading to blindness. We created transgenic pigs that express a mutated rhodopsin gene (Pro347Leu). Like RP patients with the same mutation, these pigs have early and severe rod loss; initially their cones are relatively spared, but these surviving cones slowly degenerate. By age 20 months, there is only a single layer of morphologically abnormal cones and the cone electroretinogram is markedly reduced. Given the strong similarities in phenotype to that of RP patients, these transgenic pigs will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials.

Animals↗
PubMed2002

It's a knockout! Male infertility and neuropathology.

An increasing number of genetically engineered animals are produced worldwide for use in both basic and applied research. Here, I provide an update of some of the latest mouse knockouts in The Jackson Laboratory Transgenic/Targeted Mutation Database (TBASE), concentrating on those associated with male infertility and neuropathology.

Animals↗
PubMed1998

Alcohol and anesthetic mechanisms in genetically engineered mice.

Genetically engineered animals (e.g., transgenics, gene knockouts, gene knockins) are being utilized with increasing frequency to investigate the mechanisms of action of alcohol and anesthetics. By creating and analyzing animals that harbor precise, preplanned changes in candidate genes, researchers are rapidly making progress toward uncovering how these drugs exert their effects on the central nervous system to bring about their behavioral effects. Since these sedative / hypnotic agents are likely to exert their effects by altering neurotransmission, the majority of investigations to date have focused on neurotransmitter receptors and modulators of neurotransmission such as kinases.

Alcoholic Intoxication↗
PubMed1988

New approaches to animal vaccines utilizing genetic engineering.

Control of infectious diseases in livestock is an important determinant in the success of a nation's effort to efficiently meet its need for animal products. Genetic engineering offers many new options in the design of animal vaccines. Monoclonal antibodies, DNA cloning, recombination, and transfection are examples of techniques that facilitate innovative strategies in antigen identification, production, and delivery. This article reviews the use of genetic engineering in the production of vaccines directed against foot-and-mouth disease virus and other important pathogens of animals. The advantages and disadvantages of vaccines produced through the use of genetic engineering are discussed.

Animal Diseases↗