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Objective detection of transiently evoked otoacoustic emissions.

Newborn hearing screening with transiently evoked otoacoustic emissions (TEOAE) is a well-established method. A screening device must be equipped with a test procedure for objective TEOAE detection. The statistical tests implemented in the commercially available screening devices are the correlation, an estimation of the signal-to-noise ratio and a binominal test. The aim of the present study is to compare the TEOAE detection performance of these tests with that of several other tests in the time and frequency domains (variance ratio F(SP) and its modification F(SP)*, Friedman test, modified q-sample uniform scores test). The comparison was based on a data sample of 420 TEOAE. The frequency range examined was 1.5-4.0 kHz. As a new feature, two frequency sub-ranges (1.5-2.5 kHz, 2.5-4.0 kHz) were tested separately. The modified variance ratio F(SP)* was the most powerful test, whereas the tests implemented in the known screening devices showed the lowest detection performance.

Acoustic Stimulation↗

Objective detection and localization of multiple sclerosis lesions on magnetic resonance brainstem images: validation with auditory evoked potentials.

To develop an objective method for detecting multiple sclerosis (MS) brainstem lesions, magnetic resonance (MR) images (multiple planar, spin-echo, acquired in three planes of section) of sixteen MS patients and fourteen normal subjects were analyzed with an algorithm that detected regions with a relatively increased intensity on both a spin-echo image and a T2 image. To be considered a lesion, such regions had to overlap in at least two orthogonal planes. Using a digitized atlas of the human brainstem, the lesion locations were mapped with respect to the brainstem anatomy. This method was evaluated by comparing the location of MS lesions with the brainstem auditory evoked potentials obtained from these subjects. Brainstem lesions were detected in five MS patients; four had lesions impinging upon the auditory system and one did not. All four had abnormal evoked potentials. The fourteen normal subjects, the one MS patient with brainstem lesions outside the auditory pathway, and the eleven other MS patients with no brainstem lesions all had normal evoked potentials. The requirement that lesions be detected in at least two planes of section greatly improved the specificity of the algorithm. The consistency between the MR and brainstem auditory evoked potentials results supports the validity of this imaging analysis algorithm for objectively localizing brainstem lesions.

Adult↗

Three-dimensional object detection under arbitrary lighting conditions.

A novel method of 3D object recognition independent of lighting conditions is presented. The recognition model is based on a vector space representation using an orthonormal basis generated by the Lambertian reflectance functions obtained with distant light sources. Changing the lighting conditions corresponds to multiplying the elementary images by a constant factor and because of that, all possible lighting views will be elements that belong to that vector space. The recognition method proposed is based on the calculation of the angle between the vector associated with a certain illuminated 3D object and that subspace. We define the angle in terms of linear correlations to get shift and illumination-invariant detection.

Algorithms↗

GABA-antagonist inverts movement and object detection in flies.

Movement detection is one of the most elementary visual computations performed by vertebrates as well as invertebrates. However, comparatively little is known about the biophysical mechanisms underlying this computation. It has been proposed on both physiological and theoretical grounds that inhibition plays a crucial role in the directional selectivity of elementary movement detectors (EMDs). For the first time, we have studied electrophysiological and behavioral changes induced in flies after application of picrotoxinin, an antagonist of GABA. The results show that inhibitory interactions play an important role in movement detection in flies. Furthermore, our behavioral results suggest that the computation of object position is based primarily on movement detection.

Action Potentials↗

Effects of axial spatial resolution and sampling on object detectability and contrast for multiplanar position emission tomography.

A multiplanar positron emission tomography (PET) system is simulated using Gaussian curves to model the axial point spread functions (PSFs) of the planes to study the effects of resolution and sampling. Poor spatial resolution or insufficient sampling may cause deleterious data losses or artifacts in the reconstructed image. For a multiplanar PET system with an axial full width at half-maximum (FWHM) of 6 mm and a 12 to 13 mm ring separation, a ripple in sensitivity of 9% is observed. A 1 mm object placed at the central direct plane results in detection of 59% of the signal in that plane. The theoretical observed contrast of a 3 mm object positioned at the center plane is 25% of the true contrast and decreases to 24% when the object is positioned between the central direct and cross planes. A PET system with an axial FWHM of 12 mm and a ring separation of 5-6 mm has a uniform sensitivity. A 1 mm object placed at the central direct plane detects 14% of the object signal in that plane. The theoretical observed contrast for a 3 mm object is 13% of true contrast when the object is positioned between the central direct and cross planes. It should be noted that all dimensions refer to the z direction through the center of the gantry in the simulated multiplanar system. The uniform sensitivity due to wider axial FWHMs decreases the amount of data loss for inter-ring gaps; however, the blurring associated with wider FWHMs decreases observed contrast.(ABSTRACT TRUNCATED AT 250 WORDS)

Health Physics↗

Dynamics of cortico-subcortical cross-modal operations involved in audio-visual object detection in humans.

Very recently, a number of neuroimaging studies in humans have begun to investigate the question of how the brain integrates information from different sensory modalities to form unified percepts. Already, intermodal neural processing appears to depend on the modalities of inputs or the nature (speech/non-speech) of information to be combined. Yet, the variety of paradigms, stimuli and technics used make it difficult to understand the relationships between the factors operating at the perceptual level and the underlying physiological processes. In a previous experiment, we used event-related potentials to describe the spatio-temporal organization of audio-visual interactions during a bimodal object recognition task. Here we examined the network of cross-modal interactions involved in simple detection of the same objects. The objects were defined either by unimodal auditory or visual features alone, or by the combination of the two features. As expected, subjects detected bimodal stimuli more rapidly than either unimodal stimuli. Combined analysis of potentials, scalp current densities and dipole modeling revealed several interaction patterns within the first 200 micro s post-stimulus: in occipito-parietal visual areas (45-85 micro s), in deep brain structures, possibly the superior colliculus (105-140 micro s), and in right temporo-frontal regions (170-185 micro s). These interactions differed from those found during object identification in sensory-specific areas and possibly in the superior colliculus, indicating that the neural operations governing multisensory integration depend crucially on the nature of the perceptual processes involved.

Acoustic Stimulation↗

Objective detection of auditory steady-state responses: comparison of one-sample and q-sample tests.

Auditory steady-state responses (ASSR) are expected to be useful for the objective, frequency-specific assessment of hearing thresholds in small children. To detect ASSR close to the hearing threshold, a powerful statistical test has to be applied. At present, so-called one-sample tests are used. These tests only evaluate the phase, or the phase and amplitude, of the first harmonic, that is, the fundamental frequency. It is shown that higher harmonics with significant amplitudes are also contained in the ASSR spectrum. For this reason, statistical tests that only consider the first harmonic ignore a significant portion of the available information. The use of a q-sample test, which, in addition to the fundamental frequency, also includes higher harmonics in the detection leads to a better detection performance. The evaluation of test performance uses both detection rate and detection time.

Acoustic Stimulation↗

Objective detection of evoked potentials using a bootstrap technique.

Evoked potentials are usually evaluated subjectively, by visual inspection, and considerable differences between interpretations can occur. Objective, automated methods are normally based on calculating one (or more) parameters from the data, but only some of these techniques can provide statistical significance (p-values) for the presence of a response. In this work, we propose a bootstrap technique to provide such p-values, which can be applied to a wide variety of parameters. The bootstrap method is based on randomly resampling (with replacement) the original data and gives an estimate of the probability that the response obtained is due to random variation in the data rather than a physiological response. The method is illustrated using auditory brainstem responses (ABRs) to detecting hearing thresholds. The flexibility of the approach is illustrated, showing how it can be used with different parameters, numbers of stimuli and with user-defined false-positive rates. The bootstrap method provides a new, simple and yet powerful means of detecting evoked potentials, which is very flexible and readily adapted to a wide variety of signal parameters.

Adolescent↗

Objective detection of faking on role-play tests of assertion: gender differences.

The validity of role-play tests of assertiveness can be reduced by the effects of faking. Kern demonstrated that faking could be detected using assessors' global judgements. The present analysis is based on Kern's 1994 videotapes, examining the effectiveness of more objective measures. Undergraduates who were low in assertiveness and instructed to fake high assertiveness on the Idiographic Role-play Test (n = 23) emitted more statements indicative of social-evaluative concerns than the veridically highly assertive testees (n = 27). Significant gender differences in the detectability of faking were also obtained. Whereas 24 female fakers and nonfakers were differentiated via verbalizations of likability, 26 male fakers and nonfakers were differentiated via empathic-assertive statements. The implications and limitations of this method to detect faking are discussed.

Adult↗

[The contextual effect in object detection from picture].

Participants detected a target from search stimuli which contained either eight (Experiment 1) or four (Experiment 2) living or nonliving common objects. Objects were represented either as pictures or as words. The target and other stimuli were from a same category, either living or nonliving, in the congruent condition, and were from a different category in the incongruent condition. The results of Experiment 1 showed that picture targets were detected more quickly in the incongruent than in the congruent condition while word targets were detected more quickly in the congruent than in the incongruent condition. These results indicate an interference effect of visual context in picture detection and a facilitation effect of semantic context in word detection. However, Experiment 2 using four stimuli did not show the same contextual effects as Experiment 1, probably because the task became easy.

Adult↗

Using hidden scale for salient object detection.

This paper describes a method for detecting salient regions in remote-sensed images, based on scale and contrast interaction. We consider the focus on salient structures as the first stage of an object detection/recognition algorithm, where the salient regions are those likely to contain objects of interest. Salient objects are modeled as spatially localized and contrasted structures with any kind of shape or size. Their detection exploits a probabilistic mixture model that takes two series of multiscale features as input, one that is more sensitive to contrast information, and one that is able to select scale. The model combines them to classify each pixel in salient/nonsalient class, giving a binary segmentation of the image. The few parameters are learned with an EM-type algorithm.

Algorithms↗

Unconscious inhibition and facilitation at the objective detection threshold: replicable and qualitatively different unconscious perceptual effects.

Although the veridicality of unconscious perception is increasingly accepted, core issues remain unresolved [Jack, A., & Shallice, T. (2001). Introspective physicalism as an approach to the science of consciousness. Cognition, 79, 161-196], and sharp disagreement persists regarding fundamental methodological and theoretical issues. The most critical problem is simple but tenacious-namely, how to definitively rule out weak conscious perception as an alternative explanation for putatively unconscious effects. Using a direct task and objectively undetectable stimuli, the current experiments demonstrate clearly reliable unconscious perceptual effects, which differ qualitatively from weakly conscious effects in fundamental ways. Most importantly, the current effects correlate negatively with stimulus detectability, directly rebutting the exhaustiveness, null sensitivity, and exclusiveness problems [Reingold, E., & Merikle, P. (1988). Using direct and indirect measures to study perception without awareness. Perception & Psychophysics, 44, 563-575; Reingold, E., & Merikle, P. (1990). On the inter-relatedness of theory and measurement in the study of unconscious processes. Mind and Language, 5, 9-28)], which all predict positive correlations. Moreover, the current effects are entirely bidirectional [Katz, (2001). Bidirectional experimental effects. Psychological Methods, 6, 270-281)] and radically uncontrollable, including below-chance performance despite intentions to facilitate. In contrast, weakly conscious effects on direct measures are unidirectional, facilitative, and potentially controllable. Moreover, these qualitative differences also suggest that objective and subjective threshold phenomena are fundamentally distinct, rather than the former simply being a weaker version of the latter [Merikle, P., Smilek, D., Eastwood, J. (2001). Perception without awareness: Perspectives from cognitive psychology. Cognition, 79, 115-134]. Accordingly, it is important to distinguish between rather than conflate these methods. Further, the current effects reinforce recent work [e.g. Naccache, L., Blandin, E., & Dehaene, S. (2002). Unconscious masked priming depends on temporal attention. Psychological Science, 13, 416-424] demonstrating that unconscious effects, although not selectively controllable, are nonetheless mediated by strategic and individual difference factors, rather than being immune to such influences as long thought.

Adult↗

Objective detection of averaged auditory brainstem responses.

Detection of an auditory brainstem response, ABR, usually relies on visual evaluation of two or more data acquisition runs of a fixed number of sweeps to determine if there is sufficient replication of the averaged waveforms to indicate a response. Visual interpretation can be difficult when the signal-to-noise ratio is poor because of either a small response or high levels of physiological background noise. Moreover, variations in the background noise from run to run can result in poor or spurious replications of component peaks and troughs in the waveform. A previous study (Elberling & Don, 1984) described a statistical approach for objective evaluation of the quality of an ABR recording. The method uses variance analysis in calculating the ratio of the magnitude of the ABR to the estimated averaged background noise. This study further applies this method to obtain a quantitative definition of the ABR threshold, to demonstrate its application in automatic threshold detection, and to estimate the number of sweeps required to reach detection criterion. Application of this method is valuable in reducing the variability of test interpretation and in maximizing the efficiency of recording ABRs by avoiding the averaging of excessive or insufficient numbers of sweeps. These improvements enhance the cost-benefit of ABR testing to the patient.

Adult↗

Objective detection of 40 Hz auditory evoked potentials: phase coherence vs. magnitude-squared coherence.

The relative performance of phase coherence (PC) and magnitude-squared coherence (MSC) for detection of steady-state evoked potentials was studied using 40 Hz auditory evoked potentials (AEPs) in 10 normal human subjects. In addition, simulation experiments were carried out to determine the effects of signal amplitude and phase variability on detection performance. All simulations showed MSC performance to be better than PC performance, with further improvements when MSC was supplemented with weighted averaging. However, human 40 Hz AEP data showed essentially identical detection performance for PC and MSC, with or without weighted averaging. These data support a "phase aggregation" model (at least near threshold) over the more usual model in which an AEP signal is added to a stationary noise. Human data collected under "no-stimulus" conditions agree well with theoretical distributions for both PC and MSC. For equal test time, long analysis periods (with less averaging) yielded equal performance to short analysis periods (with more averaging), for both PC and MSC.

Acoustic Stimulation↗

Avoiding spectral leakage in objective detection of auditory steady-state evoked responses in the inferior colliculus of rat using coherence.

Local field potentials (LFP) are bioelectric signals recorded from the brain that reflect neural activity in a high temporal resolution. Separating background activity from that evoked by specific somato-sensory input is a matter of great clinical relevance in neurology. The coherence function is a spectral coefficient that can be used as a detector of periodic responses in noisy environments. Auditory steady-state responses to amplitude-modulated tones generate periodic responses in neural networks that may be accessed by means of coherence between the stimulation signal and the LFP recorded from the auditory pathway. Such signal processing methodology was applied in this work to evaluate in vivo, anaesthetized Wistar rats, activation of neural networks due to single carrier sound stimulation frequencies, as well as to evaluate the effect of different modulating tones in the evoked responses. Our results show that an inappropriate choice of sound stimuli modulating frequencies can compromise coherence analysis, e.g. misleading conclusions due to mathematical artefact of signal processing. Two modulating frequency correction protocols were used: nearest integer and nearest prime number. The nearest prime number correction was successful in avoiding spectral leakage in the coherence analysis of steady-state auditory response, as predicted by Monte Carlo simulations.

Acoustic Stimulation↗

Ultra-rapid object detection with saccadic eye movements: visual processing speed revisited.

Previous ultra-rapid go/no-go categorization studies with manual responses have demonstrated the remarkable speed and efficiency with which humans process natural scenes. Using a forced-choice saccade task we show here that when two scenes are simultaneously flashed in the left and right hemifields, human participants can reliably make saccades to the side containing an animal in as little as 120 ms. Low level differences between target and distractor images were unable to account for these exceptionally fast responses. The results suggest a very fast and unexpected route linking visual processing in the ventral stream with the programming of saccadic eye movements.

Adult↗

Objective detection of brainstem auditory evoked potentials with a priori information from higher presentation levels.

This paper describes a brainstem auditory evoked potentials (BAEPs) detection method based on supervised pattern recognition. A previously used pattern recognition technique relying on cross-correlation with a template was modified in order to include a priori information allowing detection accuracy. Reference is made to the patient's audiogram and to the latency-intensity (LI) curve with respect to physiological mechanisms. Flexible and adaptive constraints are introduced in the optimization procedure by means of eight rules. Several data samples were used in this study. The determination of parameters was performed through 270 BAEPs from 20 subjects with normal and high audiometric thresholds and through additional BAEPs from 123 normal ears and 14 ears showing prominent wave VI BAEPs. The evaluation of the detection performance was performed in two steps: first, the sensitivity, specificity and accuracy were estimated using 283 BAEPs from 20 subjects showing normal and high audiometric thresholds and secondly, the sensitivity, specificity and accuracy of the detection and the accuracy of the response threshold were estimated using 213 BAEPs from 18 patients in clinic. Taking into account some a priori information, the accuracy in BAEPs detection was enhanced from 76 to 90%. The patient response thresholds were determined with a mean error of 5 dB and a standard deviation error of 8.3 dB. Results were obtained using experimental data; therefore, they are promising for routine use in clinic.

Audiometry↗