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Social environment and smoking initiation.

This paper reports exploratory research to predict smoking initiation prospectively as a function of both personal (peer and family) and more macro (school and community) social environment. At the macro level, older peer smoking by school system and school board by school system were significant predictors of smoking onset. At the personal level, the effect of gender varied with time. Males began to smoke earlier than females, but females had higher onset rates in the period from the end of Grade 7 to the end of Grade 9. Significant sibling and peer influences replicate the consistent findings in the smoking initiation area. Implications for the longitudinal study of the smoking onset process are given.

Adolescent

Assessing psychosocial adjustment of children with chronic illnesses: a review of the technical properties of PARS III.

Four groups of investigators in the Research Consortium on Chronic Illness in Childhood have used the Personal Adjustment and Role Skills Scale (PARS) III to assess the psychosocial adjustment of children with chronic physical illnesses and no mental impairment. The PARS III consists of 28 items that measure psychosocial functioning in six areas: peer relations, dependency, hostility, productivity, anxiety-depression, and withdrawal. Analyses of the measure's reliability and validity, using a total combined sample of 450 school-age children (ages 5-18 years) with a variety of chronic illnesses and three comparison samples of healthy children, provide evidence that the PARS III can be used successfully to assess psychosocial adjustment of children with chronic illnesses and no cognitive impairments.

Adolescent

[Organic fitness and capacity for motor performance of handicapped adolescents in vocational training].

In our modern working world, young adults with disabilities not only face problems in securing employment, but, also, in finding adequate vocational training places. This had in the 1970s lead to the establishment of vocational training institutions. Local employment offices and employers however, again and again complain about poor organic capacity and endurance in young people trained in these centres. It consequently is very difficult for these young people to be placed in the open labour market. A study of the various principal demands on motor functioning and of pulmonary capacity was to clarify the extent to which deficits in motor and cardiopulmonary fitness exist. A total of 328 subjects (mean age 18:5 years), among them 17 wheelchair users, were examined relative to their motor and organic capacity. Significant deficits were found in nearly all component functions compared to nonhandicapped peers, with arm and trunk muscle strength the only exception to this negative performance picture. The motor deficits found were greatest in respect of dexterity and balance. Possible reasons for these motor deficits are discussed, and measures concerning disability-specific sports classes are discussed.

Persons with Disabilities

Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism.

The majority of human T cells express an antigen receptor consisting of a disulphide-linked heterodimer (Ti) of relative molecular mass 80,000-90,000 (Mr 80-90K) which is noncovalently associated with a set of at least three proteins of Mr 20-28K termed CD3 (Leu4, T3). Whereas both chains of Ti, an acidic alpha-chain of Mr 48-54K and a more basic beta-chain of Mr 40-44K, contain variable and constant region domains, the component peptides of CD3 are invariant. Several laboratories have more recently reported the expression of CD3 in association with a novel protein. On the surface of long-term T-cell lines and one thymocyte clone this novel structure consists of a 40K protein noncovalently linked to a 55 or 62K protein identified as the protein product of the Ti gamma-chain gene, a T-cell specific gene which like the Ti alpha- and Ti beta-chain genes undergoes rearrangement of variable (V) and joining (J) region gene segments. On the human T-cell leukaemic line PEER we have detected only a single 55K glycoprotein associated with CD3. We here demonstrate that an anti-Ti gamma-peptide antiserum reacts with the 55K CD3-associated protein on PEER. Most previously described human Ti gamma-chain complementary DNA clones encode the products of non-functional rearrangements. One of the Ti gamma cDNAs isolated from PEER, however, represents a functional rearrangement reported for the first time in a cell which expresses a Ti gamma-chain protein product on the cell surface. Interestingly, a 48-base-pair (bp) sequence in the constant (C) region domain of this functional Ti gamma-chain cDNA is triplicated in PEER and duplicated in other cDNAs isolated from PEER and other cell lines.

Antigens, Differentiation, T-Lymphocyte

Functional somatic complaints in adolescents: relationship to negative life events, self-concept, and family characteristics.

While recurrent somatic complaints are commonly encountered in children and adolescents, occult organic disease is rarely found in patients with these complaints. Recent studies have confirmed the clinical impression that a relationship exists between functional somatic complaints and negative life events in adolescents. Our goal was to investigate additional psychosocial characteristics that may be associated with functional complaints. One hundred fifteen adolescents coming for the first time to an adolescent medicine clinic completed standard measures of negative life events, psychophysiologic symptoms, self-esteem, peer social comparison, and family functioning before an independent evaluation by a physician. Patients with functional somatic complaints (chest pain, recurrent abdominal pain, limb pain, and hyperventilation syndrome) reported significantly more negative life events, lower self-esteem, more psychophysiologic symptoms and a lower self-evaluation than did patients coming for physical examination or routine health maintenance. Functional somatic complaints in adolescents may be associated with poor psychosocial adjustment and reaction to negative life events. In addition to ruling out organic disease, physicians dealing with these patients should evaluate other areas, including stressful life events, peer relations, and self-esteem.

Adolescent

Surface expression of only gamma delta and/or alpha beta T cell receptor heterodimers by cells with four (alpha, beta, gamma, delta) functional receptor chains.

Surface expression of TCR dimers by cells synthesizing three or four distinct types of receptor chains was analyzed. Cells containing intact gamma, alpha, and beta chains had only gamma delta dimers on the cell surface. In human PEER cells, addition of a functional alpha chain led to the loss of gamma delta dimer expression and expression of only alpha beta dimers. This result was not due to transcriptional down-regulation of the gamma or delta loci. In murine cells expressing all four chains, both gamma delta and alpha beta dimers could be demonstrated on a single cell. No other chain combinations (alpha gamma, alpha delta, beta gamma, or beta delta) were detected. Thus, there is stringent control of assembly and/or transport of TCR heterodimers, such that functional receptors consist only of alpha beta and gamma delta pairs, and no additional repertoire diversity is generated by cross pairing.

Antigens, Differentiation, T-Lymphocyte

Antitrust's recent attack on the peer review practitioner: is the Health Care Quality Improvement Act a viable remedy?

Peer review, an increasingly important function in the hospital setting, is unique in that physicians are granted the task of evaluating and supervising the actions of their counterparts. Regardless of the consequences resulting from the peer-review system now operating within the hospitals, it will continue to be a mainstay until a more workable alternative is proved successful.

Hospital Administration

The importance of peer group ("crowd") affiliation in adolescence.

Many researchers have speculated about the role peer groups play in adolescent development, but few have examined teenagers' own perspective on the importance of group affiliations. The two studies reported here, involving 1,300 7th to 12th graders in three Midwestern U.S. communities, assessed teenagers' valuation of belonging to a "crowd" as well as the reasons they cited to support or oppose crowd affiliation. The importance of crowd affiliation declined across age. Younger adolescents generally favored membership, emphasizing the crowd's ability to provide emotional or instrumental support, foster friendships and facilitate social interaction. Older respondents expressed dissatisfaction with the conformity demands of crowds and felt their established friendship networks obviated the need for peer group ties. The importance of crowd affiliation was not related to the strength of respondents' sense of identity but did vary significantly with their willingness to conform to peers and the centrality of their position in peer groups or the type of crowd to which they belonged. Findings emphasized that adolescent peer groups can serve multiple functions, whose salience shifts with age.

Adolescent

Psychosocial functioning in prepubertal major depressive disorders. II. Interpersonal relationships after sustained recovery from affective episode.

Psychosocial relationships with parents, peers, and siblings, as well as school functioning, were measured at two points in time by parental interview in 21 prepubertal children: during an episode of major depression and after they had sustained an affective recovery from the index episode for at least four months. School functioning was completely normalized, but deficits in the child's intrafamilial and extra-familial relationships had improved only partially. The pattern of improvement was merely quantitative. Moderate deficits during the depressive episode reached, after affective recovery, the level of the normal control group. In contrast, severe deficits only improved to a moderate level of severity. It is suggested that treating the affective disorder is not sufficient in many children with major depression and that efficacy studies of psychotherapeutic interventions in affectively recovered children are needed.

Achievement

Early stress and adult emotional reactivity in rhesus monkeys.

This chapter examines the relationship between early social experiences and behavioural and emotional reactivity in adolescence and adulthood that has been established through extensive research with rhesus monkeys. Classic studies carried out in the 1960s first demonstrated that rearing under conditions of social isolation resulted in severe behavioural abnormalities that carried over into adulthood. In the 1970s techniques for reversing such isolation-induced deficits were developed. More recent studies have examined the long-term consequences of more subtle variation in early rearing environments. Monkeys reared from birth without mothers but with extensive peer contact develop relatively normal social behavioural repertoires and function well in familiar and stable social settings. However, peer-reared monkeys display extreme behavioural and physiological reactions to environmental challenges, such as brief social separation, later in life. In contrast, monkeys reared by unusually nurturant foster mothers appear to develop effective strategies for coping with subsequent environmental challenges. Some general principles that have emerged from these studies with rhesus monkeys will be outlined and their implications regarding possible relationships between early social experiences and responses to challenge later in life in humans will be discussed.

Age Factors

The clinical interview.

Subjects were given in-depth interviews aimed at assessing their level of functioning within their families, with peers, at school, and in leisure activities. Subjects were interviewed when the mean age of the study population was 11 and again at mean age 16. At the time of the first interview, index subjects were impaired relative to controls in interpersonal relations, work and play activities, self-esteem, and mood. There were no apparent differences due to rearing environment or sex, and no interactions with genetic background. At the time of the second interview, index-control differences were even more widespread, with index children showing impairment in virtually all examined areas of psychosocial function. Again, there were no group differences or interactions involving environment or sex. While index and control subjects remained highly discriminable from preadolescent to adolescent periods, there was less evidence of symptom stability in individual subjects over the 5-year period.

Adolescent

[Functional and ontogenetic aspects of the interactions of the child with his peers during the first 3 years].

From 5 or 6 months of age until the end of their 3rd year of life, the children, all having the same peers, were studied. This study shows that: 1. A child has diverse and relatively complex competence in communicating with its peers, well before the age of one. 2. From 6 to 36 months of age, there is a progressive change of importance in the different kinds of behavior for the child, relating to developmental factors and ways of interacting between the child and its family. 3. A child's interactions with its peers doesn't necessarily come about through objects. 4. Most of the child's interactions seem to come from basic or pivotal behaviors, which seem to work as behavioral organizers.

Child Development

Epidemiologic oversight of the medical care provided to Medicare beneficiaries.

The Health Care Financing Administration is charged by law with the assurance of the quality of the medical care rendered to Medicare beneficiaries, a function carried out through the Peer Review Organizations. To guide and support this activity, a programme of epidemiologic surveillance of the health of such persons has been devised and is being implemented. Its focus is on the objective measures of health-mortality, morbidity, disability and expenditures for health care. Its principal components are analyses of trends in those measures over time and of their variations among geographic areas, as problem-finding techniques, and evaluations of the comparative effectiveness of strategies of management of patients, as problem-solving tools. Examples of the feasibility and utility of this strategy include an evaluation of the longitudinal impact of administrative changes undertaken in 1983-1984, the assessment of variations in patient mortality rates among hospitals, the characterization of the management of patients with ischemic heart disease, and a demonstration of a methodology for the observational evaluation of revascularization in various types of patients hospitalized for acute myocardial infarction. The objectives of the programme are the improvement of review of medical practices as carried out by the Peer Review Organizations, assistance to clinicians in the management of patients, and guidance to planners in the allocation of resources.

Aged

Object relations and ego development: comparison and correlates in middle childhood.

The significance of ego development and object relations for adaptation and adjustment in middle childhood was examined in a study of 92 nine- to twelve-year-old children. Subjects completed the Sentence Completion Test (SCT) and the Blatt Object Relations Scale (BORS) in individual sessions. BORS ratings were factor analyzed and a predominant factor of parental nurturance emerged. This factor was positively related to children's self-reported perceptions of parental involvement and autonomy support but was unrelated to the SCT. SCT findings revealed an expected pattern for middle childhood with the preponderance of children falling into impulsive, self-protective, and conformist stages of ego development. Both the SCT and BORS were examined in relation to aspects of children's cognitive and social functioning, assessed via teacher ratings, peer sociometrics, self-evaluations, and academic achievement records. Results showed that the SCT was primarily related to cognitive complexity variables, while the object relations measure was associated with both peer and self-evaluations. These nonoverlapping relations with varied child outcomes are discussed both in terms of methodological limitations and theoretical significance.

Achievement

Evaluation and management of psychosomatic symptoms in adolescence.

Adolescent patients commonly experience symptoms such as headache, chest pain, abdominal pain, or dizziness that are psychophysiologic responses to stress, anxiety, and depression. Because most symptomatic adolescents initially visit medical providers, and not mental health professionals, the clinician is faced with the challenge of providing a comprehensive evaluation that is not merely focused on the symptom. In addition to a careful medical assessment, this evaluation must include a review of psychosocial functioning in the family, school, peer group, and community. Appropriate management may include supportive counseling, instruction in relaxation techniques, anti-depressant medication, and referral for psychotherapy.

Adolescent

Infantile autism and developmental receptive dysphasia: a comparative follow-up into middle childhood.

An interim follow-up study of a group of "higher functioning" boys with infantile autism and control group of boys with severe (receptive) developmental language disorder (or dysphasia) is reported. The boys were compared both initially and at follow-up for overall functioning in the areas of language, peer relationships, stereotyped behaviors, and disruptive public behaviors, as well as for the presence of a number of specific symptoms. In some respects, the behaviors that differentiated the groups initially did so also at follow-up, although there were important differences. Very few of the autistic boys had good language skills at follow-up, whereas nearly half of the dysphasic group were communicating well, a difference that is striking in view of the initial general similarity between the groups in terms of poor language functioning. However, some of the dysphasic children had developed greater difficulties in peer relationships. The implications for concepts of the nature of the deficit in severe receptive developmental language disorders are considered.

Autistic Disorder

Social interaction and interpersonal distance in normal and behaviorally disturbed boys.

Frequency of social interaction and interpersonal distance of 24 normal and 24 behaviorally disturbed white, preadolescent boys were examined. Each child's behavior was analyzed from videotapes that were recorded during four 60-min sessions, during which time the child played with the same unfamiliar peer, matched for age and emotional functioning. The results indicated that the frequency of global social interactions was a powerful discriminator between normal and disturbed boys at the older but not at the younger age levels. Proximity to peers and adults also was a powerful discriminator at both age levels. These results were discussed in relationship to the development of social skills in preadolescent children, the need to establish criteria for social competence, and the evaluation of social skills training programs from a development perspective.

Age Factors