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'Where' and 'what' in visual search.

A line segment target can be detected among distractors of a different orientation by a fast 'preattentive' process. One view is that this depends on detection of a 'feature gradient', which enables subjects to locate where the target is without necessarily identifying what it is. An alternative view is that a target can be identified as distinctive in a particular 'feature map' without subjects knowing where it is in that map. Experiments are reported in which briefly exposed arrays of line segments were followed by a pattern mask, and the threshold stimulus-mask interval determined for three tasks: 'what'--subjects reported whether the target was vertical or horizontal among oblique distractors; 'coarse where'--subjects reported whether the target was in the upper or lower half of the array; 'fine where'--subjects reported whether or not the target was in a set of four particular array positions. The threshold interval was significantly lower for the 'coarse where' than for the 'what' task, indicating that, even though localization in this task depends on the target's orientation difference, this localization is possible without absolute identification of target orientation. However, for the 'fine where' task, intervals as long as or longer than those for the 'what' task were required. It appears either that different localization processes work at different levels of resolution, or that a single localization process, independent of identification, can increase its resolution at the expense of processing speed. These possibilities are discussed in terms of distinct neural representations of the visual field and fixed or variable localization processes acting upon them.

Attention

Memory scanning speed in language-disordered children.

Twelve students from classrooms for children with severe language disorders and 12 age-matched controls were evaluated for short-term memory scanning speed using the Sternberg task. Sets of two, three, and four digits were presented via earphones as memory sets, followed by single-probe digits. Reaction time was measured for a verbal response of "yes" or "no" indicating whether the probe was a member of the initial set. Average per-item scanning speed for the normal children was 66 ms, which was significantly different from the 253-ms average scanning speed of the language-disordered group. Many similarities were noted in the performance of the two groups on the memory scanning task. No differences were found in estimates of encoding and response speed, in percentage of errors or in serial or numerical position effects across groups. Results indicate that children with developmental language disorders may demonstrate reduced processing speed or memory retrieval time, which could contribute to linguistic deficits.

Adolescent

How serial is serial processing in vision?

Visual search for an element defined by the conjunction of its colour and orientation has previously been shown to be a serial processing task since reaction times increase linearly with the number of distractor elements used in the display. Evidence is presented that there are parallel processing constituents to this serial search. Processing time depended on the ratio of the number of the two distractor types used, suggesting that only one type was scanned. Which type was scanned also depended on the distractor ratio, indicating that this decision was made after stimulus presentation and was based on a parallel figure-ground separation of the stimulus elements. Furthermore, in accordance with this serial scanning model, there was an increase in processing speed (elements scanned per second) with increase in number of elements to be scanned. This increased efficiency suggests that clumps of elements were processed synchronously. Under the stimulation conditions used, clumps contained six to sixteen elements and each clump was processed in 50-150 ms.

Attention

Mental slowing in elderly persons: a cognitive psychophysiological analysis.

In recent attempts to formulate an integrative model of mental slowing in elderly persons, regression analyses have been done in which reaction-time data from a large number of studies spanning a broad range of speeded decision-making tasks were combined. The results of these meta-analyses were then used to support the conclusion that there is a generalized, proportional decline in mental processing speed among elderly adults that affects all elements of mentation equally. We present a series of similar regression analyses in which both reaction time and the latency of the P300 component of the event-related brain potential are included. The results of these analyses indicate that there are elements of mental processing that may be slowed additively, not proportionately, in older persons. Furthermore, the results raise some questions about the logic underlying the interpretation of the meta-regression analysis.

Adult

ST analysis of Holter tapes.

In recent years, it has become increasingly clear that for an important subset of patients with coronary artery disease, many or all of their ischemic episodes are not accompanied by anginal pain. For these patients, it is desirable to detect these ischemic episodes as periods of ST-segment depression on Holter tapes. In the past, such detection has been difficult because the analysis methods were artifact-sensitive and failed to differentiate ischemic from nonischemic ST-segment changes. This work describes a new ST-segment analysis algorithm that has been added to the existing computer-based Holter analysis system. This system is highly artifact-resistant and has been designed to minimize the loss of processing speed while maintaining extremely high accuracy.

Algorithms

Backward masking, information processing, and schizophrenia.

Many researchers have used backward masking to examine information-processing speed in schizophrenic subjects. The validity of this approach rests upon two main assumptions. One is that the mask effectively limits the time a previously presented stimulus is available for processing. The other is that the components of the masking mechanism in schizophrenic subjects are comparable to those in control groups. It is argued that the masking procedures used in these studies fail to meet either assumption. Alternative interpretations of these investigations, however, suggest important hypotheses for further research in our quest to understand information-processing deficits associated with schizophrenia.

Humans

Spatial code interference on directional responses.

The interference from an irrelevant position cue was compared in a reaction-time paradigm using voice and manual responses. The subjects were required to say 'left' or 'right' or to press left or right keys in response to arrow directions, and the arrows were presented at left or right side display positions irrelevant to the task. Display position significantly increased latency when it did not match the response to the relevant direction cue for both spatial (key-press) and non-spatial (voice) responses (73 and 59 ms, respectively). When presented alone, the position cue was processed faster than the direction cue for both manual and verbal responses. Results are discussed in terms of a common abstract mediator for left-right responses between modes and the processing speed difference between the relevant and irrelevant cue. The irrelevant left-right position code may occupy some limited-capacity channel ahead of the left-right code derived from processing the relevant direction cue.

Humans

An automated technique for analysis of current transitions in multilevel single-channel recordings.

Detailed kinetic studies of ion channel gating are best carried out using the patch-clamp technique which permits the measurement of the ionic current through individual channels. Typical patch-clamp recordings show the current signal, in the form of a sequence of rectangular pulses (analogous to a random telegraph signal), riding on slow baseline drift, partially obscured by high-frequency noise and distorted by filtering. In order to analyze such recordings, we have developed a set of interactive Pascal programs based on a feature-detection algorithm capable of identifying current transitions in multiple-channel recordings in the presence of substantial levels of noise and drift. Software operation is largely automated but includes provisions for examination and correction of the output. The software was optimized and systematically evaluated using simulated data with variable amounts of noise and drift. Results indicate that satisfactory performance is obtained for signal-to-noise ratio as low as four even with uncommonly large baseline drift. Steady-state processing speeds varied from 1,000 to 4,000 samples per second depending on data complexity.

Automation

Cognitive impairment following closed head injury.

Cognitive impairments are usually the most disabling sequelae of CHI. The earliest stage of recovery from moderate to severe closed head injury is a period of PTA that typically includes memory loss for events preceding and surrounding the injury and memory loss for events occurring since the injury. Following resolution of PTA, deficits may be present in a number of cognitive domains. Memory and attention/information processing speed and efficiency are typically the cognitive domains most severely affected by head injury. Intellectual, language, and perceptual skills tend to be relatively preserved. Neurologic variables such as pupillary reactivity and worst GCS score are prognostic of cognitive impairment at 1 to 2 years postinjury. Following mild head injury, impairments of memory and information processing may be apparent within the first week of recovery. These deficits usually resolve in 1 to 3 months, although chronic complaints persist in a minority of individuals. The long-term cognitive effects of CHI are typically more severe for younger children than older children. Neuropsychologic assessment provides an objective way to measure the presence and severity of cognitive impairment.

Adult

Vision, aging, and driving: the problems of older drivers.

Although there are well-recognized declines in visual functioning with age, their contribution to the problems of older persons on tasks in the natural environment, including driving, are largely unknown. Adults ranging in age from 22-92 years were surveyed in regard to their visual difficulties when driving and performing everyday tasks. The visual problems of drivers increased with age along five different visual dimensions: unexpected vehicles, vehicle speed, dim displays, windshield problems, and sign reading. Several of the age-related visual problems that were reported appear to be related to the types of automobile accidents more common among older drivers. The study also replicated the findings from an earlier investigation of non-driving tasks that showed visual declines with age on five dimensions: visual processing speed, light sensitivity, dynamic vision, near vision and visual search. These findings indicate promising areas of research regarding the effects of visual aging on tasks in the natural environment.

Adult

Use of a neural net computer system for analysis of flow cytometric data of phytoplankton populations.

Flow cytometry has been used over the past 5 years to begin detailed exploration of the distribution and abundance of picoplankton in the oceans. Light scattering and fluorescence measurements on individual plankton cells in seawater samples allow construction of population signatures from size and pigment characteristics. The use of "list mode" data has made these studies possible, but on-shore analysis of copious data does not permit on-site reexamination of important or unexpected observations, and overall effort is greatly handicapped by data analysis time. Here we describe the application of neural net computer technology to the analysis of flow cytometry data. Although the data used in this study are from oceanographic research, the results are general and should be directly applicable to flow cytometry data of any sort. Neural net computers are ideally suited to perform the pattern recognition required for the quantitative analysis of flow cytometry data. Rather than being programmed to perform analysis, the neural net computer is "taught" how to analyze the cell populations by presenting examples of inputs and correct results. Once the system is "trained," similar data sets can be analyzed rapidly and objectively, minimizing the need for laborious user interaction. The neural network described here offers the advantages of 1) adaptability to changing conditions and 2) potential real-time analysis. High accuracy and processing speed near that required for real-time classification have been achieved in a software simulation of the neural network on a Macintosh SE personal computer.

Computer Systems

Regularized linear method for reconstruction of three-dimensional microscopic objects from optical sections.

The inverse problem involving the determination of a three-dimensional biological structure from images obtained by means of optical-sectioning microscopy is ill posed. Although the linear least-squares solution can be obtained rapidly by inverse filtering, we show here that it is unstable because of the inversion of small eigenvalues of the microscope's point-spread-function operator. We have regularized the problem by application of the linear-precision-gauge formalism of Joyce and Root [J. Opt. Soc. Am. A 1, 149 (1984)]. In our method the solution is regularized by being constrained to lie in a subspace spanned by the eigenvectors corresponding to a selected number of large eigenvalues. The trade-off between the variance and the regularization error determines the number of eigenvalues inverted in the estimation. The resulting linear method is a one-step algorithm that yields, in a few seconds, solutions that are optimal in the mean-square sense when the correct number of eigenvalues are inverted. Results from sensitivity studies show that the proposed method is robust to noise and to underestimation of the width of the point-spread function. The method proposed here is particularly useful for applications in which processing speed is critical, such as studies of living specimens and time-lapse analyses. For these applications existing iterative methods are impractical without expensive and/or specially designed hardware.

Computer Simulation

[The use of lekozim phonophoresis for the treatment of eye burns].

Experimental investigations concerning the influence of lecozyme phonophoresis on the development of a burn process in the eye have shown that lecozyme phonophoresis has a positive action on the development of a burn process, speeds up the stoppage of inflammatory signs, epithelialization and vascularization of the cornea, stimulates the formation of its less intensive opacifications. The most favourable term to use lecozyme phonophoresis is the second day after the moment of a burn trauma. To achieve a positive effect, 5 procedures are enough, while a longer course or treatment or later terms for its usage (7, 14, 21 days after burn) impairs the development of the burn process. The usage of lecozyme phonophoresis in two stages (5 sessions within the first day and 10 sessions after epithelialization of the cornea) allows to achieve the best results--stoppage of inflammatory signs, reduction of vascularization and opacifications of the cornea.

Animals

Magnetic resonance imaging and neuropsychological findings in human immunodeficiency virus infection.

Neurobehavioral functioning and magnetic resonance imaging (MRI) were investigated in 25 patients with various Centers for Disease Control (CDC) stages of human immunodeficiency virus (HIV) infection and in a control group of seven normal subjects. Unequivocal slowing of information processing speed and cerebral atrophy were related to the stage of HIV infection, with patients in CDC group IV exhibiting the most abnormal findings. Slowing of response speed was directly related to the severity of cerebral atrophy.

Adult

Neuropsychological assessment in MS: clinical, neurophysiological and neuroradiological relationships.

We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent magnetic resonance imaging examination. MS performed worse than controls on all WAIS-P subtests and had learning, short- and long-term verbal memory impairment. Cognitive deficits were not related to abnormal emotional states, but were found to be associated with attentional process and information-processing speed impairment. Cognitive impairment did not correlate with severity of physical disability. The most severe memory deficits were found in patients with extensive periventricular damage.

Adult

Categorization of disoriented faces in the cerebral hemispheres of normal and commissurotomized subjects.

We examined the capacity of the cerebral hemispheres to process faces that deviate from canonical perspective. In Experiment 1, normal Ss performed a gender categorization of faces presented at varying angular orientations in the left visual field (LVF) or right visual field (RVF). Orientation affected processing speed, more so in the RVF than in the LVF. The function relating reaction times to disorientation of the faces was approximately monotonic and reflected the increased difficulty in extracting relevant configurational information as the faces were rotated from canonical perspective. In Experiment 2, 3 commissurotomized Ss performed the same task. They responded above chance in the 2 visual fields, and the pattern of their results was similar to that obtained with the normal Ss, but the effect of disorientation was considerably more pronounced. It is suggested that the right hemisphere contribution becomes more critical the further the visual pattern departs from conventional view. Issues regarding the specification of processes correcting for disorientation and comparison of normal and commissurotomized Ss are discussed.

Adult

Automatic film processing: analysis of 9 years of observations.

A survey method known as the sensitometric technique for the evaluation of processing (STEP) has been used to monitor processing speed of over 2,000 automatic film processors in hospitals, private offices, and mammography facilities since 1981. Analysis of data obtained through this program revealed underprocessing at 33% (76 of 231) of observed hospitals in 1987, 7% (13 of 179) of mammography facilities in 1988, and 42% (101 of 241) of private practices in 1989. Underprocessing at mammography facilities decreased from 18% (25 of 139) in 1985, which was contrary to the trend in hospitals. The consequence of underprocessing is higher radiation exposure and a degradation in film contrast. Evaluation of automatic film processors is a necessary part of any comprehensive evaluation of a diagnostic radiography facility. The STEP procedure was designed only as a field survey test; to ensure optimal conditions for obtainment of diagnostic quality radiographs, facilities should perform quality assurance evaluations of their processing equipment and verify that processing recommendations of manufacturers are being followed.

Technology, Radiologic

Auditive and cognitive factors in speech perception by elderly listeners.

A key issue in research on speech perception in the elderly is whether the difficulties in understanding speech are caused by auditive and/or cognitive factors. Resolving this issue is not only scientific interest but has many practical, i.e. diagnostic and rehabilitative, implications as well. We developed a test battery comprising auditive (sensitivity, frequency selectivity and temporal resolution), cognitive (memory performance, processing speed and intellectual abilities), and speech perception tests (at the phoneme, spondee and sentence level). This test battery was administered to 72 elderly subjects (aged 60 to 93 years). The results show that the deterioration of speech perception in the elderly consists of two statistically independent components (a) a large component mainly representing the progressive high-frequency hearing loss with age which accounts for approximately two-thirds of the systematic variance of the tests of speech perception, and (b) a smaller component (accounting for one-third of the systematic variance of the speech perception tests) mainly representing a general performance decrement due to reduced mental efficiency, which is indicated by a general slowing of performance and a reduced memory capacity. Although both components are correlated with age, it was found that the balance between auditive and cognitive contributions to speech perception performance did not change with age.

Aged