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Results for “stimulus-response compatibility”

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PubMed1992

Effects of severe closed-head injury on three stages of information processing.

The present study investigated the loci of the information-processing delay that characteristically follows severe closed-head injury (CHI). Sternberg's additive-factors logic was used to determine the effects of severe CHI on the central information-processing stages of stimulus encoding, memory comparison, and decision-making/response-selection. The task variables used to define the stages operationally were stimulus quality, memory set size, and stimulus-response compatibility. Twenty subjects who had sustained a severe CHI more than 18 months earlier and 20 matched control subjects completed a stimulus encoding by response selection task in Experiment 1, and a Sternberg high-speed memory scanning task in Experiment 2. The CHI group performed the stimulus encoding and decision-making/response-selection stages of processing significantly slower than did the control group. However, no significant group differences were found on the memory comparison stage, suggesting that memory comparison processes may be relatively intact in long-term patients with severe head trauma. The results are discussed in relation to a global and a late-specificity hypothesis of central processing deficits following severe CHI. The possibility that cognitive processes demanding less attention may be more resilient to injury is also considered.

Adult↗

PubMed1981

Perceiving vowels in isolation and in consonantal context.

Recent studies have shown that vowels tend to be identified more accurately in consonantal context than in isolation. This contextual advantage is often explained perceptually, e.g., by assuming that the formant transitions associated with the consonants convey significant vowel information. In two experiments with stylized synthetic speech patterns, we were unable to replicate the contextual advantage. These negative results were probably due to certain unnatural stimulus characteristics. In another experiment we used natural speech stimuli to assess whether nonperceptual factors associated with the identification task contribute to the contextual advantage. Subjects responded to the test items either by (a) circling written CVC syllables, (b) circling written isolated vowels, or (c) vocally mimicking the items (a task that we assume imposes minimal memory load on subjects). Of these response conditions, only the first yielded an advantage for vowels in context, suggesting that the effect depends on two factors: Stimulus-response compatibility and memory load.

Humans↗

PubMed1992

Influence of anatomical factors and spatial compatibility on the stimulus-response relationship in the absence of the corpus callosum.

Simple and choice reaction times (RTs) to lateralized flashes of light were measured in two acallosal subjects, a callosotomized patient with sparing of the splenium, six IQ-matched controls and six controls with above average IQ. The aim of the study was to investigate the influence of stimulus-response factors on visuomotor integration in the absence of the corpus callosum. The results showed that simple-RTs are faster for all groups when sensory input and motor output are coordinated in the same hemisphere, regardless of the spatial relationship between stimulus (S) and response (R). The difference between ipsilateral and contralateral RTs, taken as a measure of interhemispheric transmission time (ITT), was more than three times longer in the patients lacking the corpus callosum than in the controls. In the choice-RT paradigm, the main determinant of the response speed was S-R spatial compatibility rather than the anatomical relationship between the neural structures receiving the visual input and those controlling the motor output. Spatially compatible S-R pairings were always faster than incompatible pairings. The compatibility effect was present in all subjects but it was significantly larger in the callosum-deprived patients and their IQ-matched controls with respect to the high-IQ controls. The latter finding suggests that cognitive factors may be involved in the production of the spatial compatibility effect.

Adult↗

PubMed1995

[Study of the organization of sensorimotor stages in man using delayed evoked potentials].

The main aim of this study was to test the relative organization of three of the stages of Sanders' 1990 information processing model: "features extraction", "response choice", and "motor adjustment". The variables influencing these stages: stimulus degradation, stimulus-response (SR) compatibility and preparatory period have been manipulated. Event related potentials (N100, N200, P300) and reaction time were recorded from ten healthy subjects, in a dichotic listening task. Reaction times are lengthened for degraded stimuli, in the absence of a preparatory period and for SR non compatible conditions. However, the interaction between preparatory period and stimulus degradation variables, suggests an overlapping of the corresponding stages contrary to Sanders' postulate. The non compatible condition increases the latency of N200 and P300 components. The results suggest that the response choice processing would be contemporary to the N200 component. They are discussed within the framework of models of early communication between sensory and motor systems.

Adult↗

PubMed1994

Mental processing during reactions toward and away from a stimulus: an ERP analysis of auditory congruence and S-R compatibility.

In its first usage, stimulus-response (S-R) compatibility defined strict S-R relationships. The later use of more complex two-dimensional stimuli led to the formulation of the Simon effect as a tendency to respond toward the side of stimulation. Ragot and Guiard (1992, European Journal of Cognitive Psychology, 4, 219-232) observed an inversion of the Simon effect in the auditory modality. The present study was undertaken to present a more thorough observation of this seemingly paradoxical inversion through the use of brain event-related potentials (ERPs). Two experimental variables were manipulated: (a) stimulus congruence, expressing the degree of correspondence between two randomly varying conflictual or nonconflictual attributes of the stimulus (spoken word droite or gauche presented to the right or left ear), and (b) S-R compatibility as such, expressing the relationship between the relevant stimulus attribute (word) and the responding hand. Results show that the nature of the spoken word acts on N100 latency and is therefore the first stimulus attribute to be processed. Data on P300 indicate that S-R compatibility is the last variable to be taken into account. The observed results are integrated into a cascade/parallel model.

Adult↗

PubMed1994

Neuronal coding of stimulus-response association rules in the motor cortex.

Two monkeys were trained to perform wrist movements to align a pointer with visual targets. In the spatially 'compatible' condition, monkeys had to point at the target position (left/right), whereas in the 'incompatible' condition, they had to point at the position opposite to the target. A large proportion of neurones recorded in the primary motor cortex showed changes in activity according to either the side of the target or the side of the movement. However, more than 40% of neurones changed their activity as a function of the stimulus-response mapping rule. Some of these neurones, being sensitive only to the stimulus-response compatibility effect, must therefore be viewed as specifically involved in the neural mechanisms that control the association process between sensory inputs and motor outputs.

Animals↗

PubMed1985

Inhibition by verapamil of neutrophil responses to formylmethionylleucylphenylalanine and phorbol myristate acetate. Mechanisms involving Ca2+ changes, cyclic AMP and protein kinase C.

Verapamil inhibits in human neutrophils the respiratory burst, the secretion and the change of transmembrane potential induced by formylmethionylleucylphenylalanine, a Ca2+-dependent stimulus, and by phorbol myristate acetate, a Ca2+-independent stimulus. Besides the blocking of Ca2+ channels, many mechanisms are responsible for the inhibition of neutrophil responses. In fact, verapamil (i) increases the intracellular cAMP concentration, potentiates the cAMP response induced by the chemotactic peptide and induces the appearance of a cAMP response also when the stimulant is phorbol myristate acetate; (ii) causes a decrease of Ca2+ association to cell membranes, so depleting the pools of exchangeable Ca2+ and depressing the 'Ca2+ response' in terms of rise in [Ca2+]i monitored with Quin 2 and of rapid mobilization from cell membranes monitored by chlorotetracycline fluorescence change; (iii) inhibits the Ca2+-activated phospholipid-dependent protein kinase C. The data, discussed in relation to the biochemical mechanisms of the stimulus-response coupling, are compatible with the hypothesis of an involvement of the activation of protein kinase C as key step in the sequence of transduction events for the induction of many neutrophil functions.

Calcium↗

PubMed1977

Serial reaction time as a function of the nature of repeated events.

Past research into the phenomenon of reduced latency to repeated events in serial reaction time tasks resulted in attempts to partition reaction time into components attributable to separate cognitive processes. These attempts focused on many-to-one condensing paradigms, which permitted direct assessment of the effect of response-only repetitions but not stimulus-only repetitions. The three experiments reported in the present study used a technique designed to overcome this limitation. It was found that repetition of only the symbolic content of the total stimulus-response event was a sufficient condition for a reduced response latency and that response-only repetitions tended to be facilitative only when stimulus-response relations were compatible. These and related findings were discussed with respect to their bearing on contemporary issues concerning the analysis of cognitive operations into separable and additive components.

Discrimination, Psychological↗

PubMed1995

Temporal localization of the response selection processing stage.

Response choice is one of the stages in the information processing model proposed by Sanders. It is influenced by stimulus-response (S-R) compatibility. Segmentation of the processing window in intervals between RT and peak latencies and between peak latencies, was used to test the assumption that the decisional processes would be concomitant with the N200 rather than the P300 component. ERPs were recorded in ten subjects during a spatial S-R compatibility auditory task. The S-R compatibility effect is observed on P300 latencies but is only a trend on the N200 component. An effect also observed on the interval between RT and N200 and especially between N200 and P300 while no effect is observed on the interval between RT and P300. These results support the idea that the selection processes ending with P300 occurrence could start as early as the N200 peak component.

Acoustic Stimulation↗

PubMed1988

Latencies of event related potentials as a tool for studying motor processing organization.

The aim of this experiment was to better define the relative organization of motor processing using both behavioral measures and ERPs. Using the additive factors method, three motor variables; (1) stimulus-response (S-R) compatibility, (2) movement extent, and (3) time uncertainty, were all manipulated in a visuo-bimanual, four-choice, pointing task. As expected, all three variables significantly lengthened RT without interaction. All three motor variables also affected ERP latencies. Both P300 and N200 latencies were lengthened by greater movement extent. Moreover, N200 and P300 latencies were differentially affected by S-R compatibility and time uncertainty. Finally, both RT-minus-N200 and RT-minus-P300 were significantly lengthened by S-R incompatibility and greater time uncertainty whereas movement extent had no effect. In sum, ERP results did not support the assumptions of the classical serial model but rather of a contingent-parallel model. Furthermore, the ERP data can be used to infer the relative order of the different stages in this model.

Adult↗

PubMed1979

Effects of S-R mapping and response modality on performance in a Stroop Task.

Forty subjects performed a choice reaction time task in which the stimulus was the word Red or Green printed in either red or green ink. Subjects responded verbally in one block of trials and by key pressing in another block. For one group, ink color was the relevant cue, and for another group, the word was the relevant cue. Half of the subjects in each group were instructed to make the response that corresponded to the relevant cue (compatible S-R [stimulus-response] mapping); the other half were instructed to make the response that did not correspond (incompatible S-R mapping). In general, subjects who performed under compatible S-R mapping instructions reacted faster when the irrelevant cue corresponded to the response than when it did not. In contrast, subjects show performed under incompatible S-R mapping instructions reacted faster when there was a lack of correspondence between the irrelevant cue and the response than when there was correspondence. Results were consistent with a notion of logical recoding; that is, that instructing subjects to recode the relevant cue into the alternate color may have caused them to recode the irrelevant cue in the same logical manner. Results might also be interpreted to suggest that the Stroop effect is related to congruence between the relevant and the irrelevant cues rather than to correspondence between the irrelevant cue and the response.

Color Perception↗

PubMed1987

The effects of videogame playing on the response selection processing of elderly adults.

Within an information processing framework, age-related declines in speeded responding are attributed to one or more stages of processing. It was the purpose of this experiment to demonstrate the potential reversibility of this decline in at least one processing stage, response selection. Two groups of elderly participants (57 to 83 years) were pretested on a two-choice reaction time (RT) task under two levels of spatial stimulus-response (S-R) compatibility, a task demand shown to affect response selection. Following the pretest, one group participated in 7 weeks of videogame play, whereas a second group did not. All participants were posttested on the same two-choice RT task. The results of the analysis of covariance revealed that those elderly individuals who played videogames were faster than the control participants under both levels of S-R compatibility. The effect of videogame play, however, was greater for low compatibility. These results are taken as support for a potential to improve response selection through videogame play.

Aged↗

PubMed1990

Androgyne becomes bisexual in sexological theory: Plato to Freud and neuroscience.

Plato conceptualized primordial humans as androgynes, the children of the moon. The primordial hermaphroditism of the mammalian embryo became known 2 1/2 millennia later in the mid-19th century. By 1864 Ulrichs had transposed the new knowledge from embryology to sexology to explain those to whom he gave the name Urnings (after Uranus who gave womanless birth to Venus from sea spume) as having "a woman's mind trapped in a man's body" (anima muliebris corpore virili inclusa). Urning became displaced by sexual inversion, and eventually by homosexual, a term coined together with heterosexual by Kertbeny as recently as 1869. The embryological principle of primordial hermaphroditism became linked to evolutionary Darwinism by way of Haeckel's principle of recapitulation, epitomized as "ontogeny recapitulates phylogeny." The recapitulation principle became linked, in turn, to the principle of intrapsychic primordial bisexuality, which became a cornerstone of Freud's psychoanalytic theory. Genetics influences the outcome of bipotentiality not directly but by way of hormonal programming of the brain, prenatally or neonatally, rather than pubertally and in maturity. Bipotentiality within the brain has been investigated chiefly in the hypothalamus where male/female dimorphism has been recognized, but its determinants and stages of differentiation, both prenatal and postnatal, remain to be fully ascertained. Neuroanatomical research on the outcome of male/female bipotentiality as gay, straight, or in between is politically and morally opposed by those who postulate a bipotential preference or voluntary choice. In stimulus-response associationism, to which behavior-modification theory belongs, bisexuality is equipotential, and either alternative may be evoked, ostensibly, dependent on the stimulus situation. In ethological theory, the effectiveness of stimulus-response bonding is confined chronologically to a critical period of development and is restricted phylogenetically by an innate recognition mechanism and an innate releasing mechanism. These limits are compatible, however, with some degree of both individual and ethnic variation.

Bisexuality↗

PubMed1988

Transmembrane calcium movements mediated by ionomycin and phosphatidate in liposomes with Fura 2 entrapped.

A novel liposomal method permits studies of Ca movements across the bilayers of multilamellar vesicles (MLV) which had entrapped the Ca-dependent, fluorescent indicator dye Fura 2. Ionomycin-mediated Ca translocation across MLV of phosphatidylcholine (PC)/dicetyl phosphate (DCP), 9:1, obeyed simple first-order kinetics since log-log plots of initial rates versus ionomycin or Ca concentration yielded slopes of approximately 1. Since Ca is translocated in a Ca-dependent fashion in the course of stimulus-response coupling of cells which form diacylglycerol (DAG) and phosphatidate (PA) from polyphosphoinositides, we compared effects of PA with those of DAG. PA and DAG were preincorporated in PC/DCP vesicles, in which trace amounts of ionomycin provided transmembrane potential (due to Ca2+/H+ exchange). Significant increases in Ca movements were observed in the presence of egg lecithin PA, dioleoyl-PA, and dipalmitoyl-PA when compared with DCP- or DAG-containing MLV. DAGs such as 1-oleoyl-2-acetoylglycerol or 1,2-dioleoylglycerol in liposomes decreased rates of Ca translocation. Ca influx into PA-containing MLV was dependent on the mole percent of the PA in bilayers; the complex kinetics of Ca influx were compatible with the formation of nonbilayer states. Incorporation of cholesterol into the liposomes inhibited initial rates of Ca uptake by MLV presumably by condensing the bilayers. Ca influx increased with increasing pH of the external medium from 6.9 to 7.9 in liposomes with an internal pH of 7.4.(ABSTRACT TRUNCATED AT 250 WORDS)

Benzofurans↗

PubMed1990

Evaluation of compatibility effects in the precuing of arm and direction parameters.

The present study evaluated the role of compatibility effects in the precuing of arm and direction parameters. In the first two experiments different stimulus and response arrangements were examined. For all three experiments the spatial precue and imperative stimuli were compatibly assigned to responses (i.e., a direct correspondence existed between the stimulus and response locations). Experiments 1 and 2 indirectly tested the effect of decision processes required by the stimulus-response set. Experiment 1 replicated previous research that has found longer reaction times for the direction uncertain parameter as compared to arm uncertain. Experiment 2 examined the precuing of arm and direction parameters with stimuli that maintained right-left arrangements for both parameters. Unlike Experiment 1, reaction times did not differ for precuing the two movement parameters. Experiment 3 directly examined the effect of differential decision requirements from up-down spatial stimuli and right-left spatial stimuli for a single parameter. In support of results from the first two experiments, results indicated longer reaction times for decisions from up-down stimuli as compared to right-left stimuli. Because reaction times for precued movement parameters are a function of the stimulus and response arrangements used, differences in reaction times are most likely due to compatibility effects arising from differences in the spatial arrangements of the precued stimulus and response set.

Arm↗

PubMed1995

The Simon effect and attention deficits in Gilles de la Tourette's syndrome and Huntington's disease.

Tourette's syndrome and Huntington's disease have long been clinically associated with attentional deficits. In this study, we aimed to determine the nature and quantify the extent of such deficits. A technique was devised to ascertain the efficiency with which Tourette's syndrome and Huntington's disease patients could shift and direct attention away from naturally expected stimulus-response (S-R) linkages. This was done by varying the relationships formed between stimulus and response location. Attentional efficiency was indicated by relative speed of responding to relevant (congruent) and irrelevant (incongruent) stimuli, in a paradigm developed from the Simon effect. There were five conditions progressively increasing in complexity. The stimuli consisted of left and right pointing arrows and, in some cases, various conditionality manipulations were also employed, such that in the presence of a certain symbol (i.e. 'x') the nature of the response had to be reversed, whereas in the presence of an alternative symbol (i.e. '='), the response was compatible with the direction of the arrow. As predicted, Tourette's syndrome and Huntington's disease patients, regardless of medication or depression status and unlike controls, were particularly disadvantaged in responding to various conflicting S-R configurations. Tourette's syndrome and Huntington's disease patients may experience difficulties in making attentional shifts, or in inhibiting inappropriate responses; they may also be more susceptible (than controls) to the conflict that can arise when the spatial code formed for the stimulus is irrelevant for selecting the appropriate response. We conclude that our findings support the notion that cognitive deficits in Tourette's syndrome and Huntington's disease may stem from abnormalities of the major pathways interconnecting the basal ganglia and the frontal lobes.

Adult↗

PubMed1990

The effects of lower body negative pressure on baroreceptor responses in humans.

In healthy human subjects the immediate responses of pulse interval and the steady-state responses of arterial blood pressure and cardiac output to changes in carotid sinus transmural pressure were determined before and during the application of a subatmospheric pressure to the lower part of the body. Increases in carotid sinus transmural pressure, effected by applications of subatmospheric pressure to the neck (neck suction) resulted in prolongation of pulse interval and decrease in blood pressure; opposite responses were obtained to application of a positive pressure (neck pressure). Application of lower body negative pressure resulted in a decrease in pulse interval (heart rate increase) but little change in blood pressure. During lower body negative pressure, the responses of pulse interval to neck pressure were reduced but those to neck suction were unaffected; the responses of blood pressure to neck suction were enhanced but those to neck pressure were unaffected. From experiments in which cardiac output was also determined, it was seen that lower body negative pressure reduced cardiac output, increased calculated total body vascular resistance and augmented the resistance response to neck suction although not to neck pressure. These results are compatible with the view that application of lower body negative pressure does not change the sensitivity of the baroreceptor reflex and that the changes in the responses are due to non-linearities of the stimulus-response curves.

Adult↗

PubMed1978

Coding of information about tactile stimuli by neurones of the cuneate nucleus.

1. The responses of cuneate neurones to controlled tactile stimulation of the foot pads were examined in unanaesthetized, decerebrate cats. The neurones were divided into three functional classes; one sensitive to steady tactile stimuli, and two dynamically sensitive classes which could be readily differentiated by their responsiveness to cutaneous vibration. Each class appeared to receive an exclusive input from only one of the three known groups of tactile receptors associated with the foot pads, namely the Pacinian corpuscles, the Merkel endings and the intradermal, encapsulated endings known as Krause or Meissner corpuscles. 2. Cuneate neurones responsive to steady indentation of the skin displayed approximately linear or sigmoidal stimulus-response relations over indentation ranges up to approximately 1.5--2 mm. Response variability at a fixed stimulus intensity was relatively low and showed little systematic change over the full range of the stimulus-response curves. 3. One class of dynamically sensitive cuneate neurones responded to cutaneous vibration over a range of approximately 5-80 Hz with maximal responsiveness around 30 Hz. The other class, the Pacinian neurones, responded over a range of approximately 80- greater than 600 Hz with maximal responsiveness at 200-400 Hz. The thresholds and combined band width of vibratory sensitivity of these populations were comparable with known subjective thresholds and range of cutaneous vibratory sensibility. 4. Responses of cuneate neurones were phase-locked to the vibratory stimulus suggesting that information about vibration frequency could be coded by the patterns of impulse activity. Quantitative measures indicated that maximal phase-locking occurred in responses to vibration frequencies of 10-50 Hz with a progressive decline at higher frequencies. Above 400 Hz, impulse activity occurred almost randomly throughout the vibratory stimulus cycle and therefore carried little further signal of vibratory frequency. The decline, with increasing frequency, in the ability of cuneate neurones to signal information about vibratory frequency parallels the known subjective capacities for frequency discrimination. 5. A switch-over occurred at approximately 80 Hz in the population of cuneate neurones able to provide the more reliable signal of vibratory frequency; above 80 Hz, the Pacinian neurones; below 80 Hz, the neurones receiving intradermal, rapidly adapting receptor input from the pads. 6. The observed properties of cuneate neurones are compatible with a role in signalling information which could contribute to subjective tactile abilities.

Action Potentials↗