PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “ADRENAL GLAND NEOPLASMS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 541 records · Page 30Linked to original sources
PubMed1984

Magnetic resonance imaging and its application in urology.

Magnetic resonance imaging (MRI) adds an additional dimension to radiologic diagnostic technique. In addition to topographic anatomic display, this new nonionizing modality is capable of providing functional information as well as data about the chemical composition of a given organ and blood flow velocity. In a short period of time in clinical experience its application in urology already includes evaluation of adrenal pathology regarding adrenal hyperplasia and adrenal tumors, diagnosis and staging of renal cell carcinoma, evaluation of retroperitoneal lymphadenopathy, and retroperitoneal fibrosis. In the pelvis, MRI promises to improve our diagnosis and staging of malignancy in the urinary bladder and prostate gland. This is only the beginning of clinical evaluation and the true potential of magnetic resonance, and further clinical indications are constantly evolving.

Adrenal Gland Neoplasms↗
PubMed1996

[Technique of MRT-guided core biopsy in the abdomen using an open low-field scanner: feasibility and initial clinical results].

PURPOSE: Due to high soft-tissue contrast and multiplanar imaging capabilities MRI is an interesting modality to perform image-guided biopsies. We checked on the feasibility of MR-guided core biopsies of abdominal masses with an open low-field scanner (0.2 Tesla; vertical field axis). METHODS: 9 patients underwent MR-guided biopsies of abdominal target lesions (6 focal liver lesions, two adrenal masses, one pelvic mass). Different MR-compatible core biopsy instruments were used (needle diameters 14G-18G). MR scans during the procedures were obtained applying T1-weighted gradient echo sequences suitable for breath-hold imaging. RESULTS: In each case, needle guidance was reliable, so that the biopsy instrument could be positioned correctly. Multiplanar imaging capabilities enabled even angled approaches to upper abdominal masses to be realized safely. The combination of magnet design and table design offered suitable access to the patient. CONCLUSION: Using an open low-field scanner, MR-guided core biopsies of abdominal masses are practicable.

Abdomen↗
PubMed1995

[An isolated fetal kidney cyst as a sign of congenital neuroblastoma. A case report and overview of the literature].

As a normal scan at 20 weeks of gestation a pregnant woman was referred at 36 weeks because of a cystic tumour in the fetal kidney. The cyst, 27 mm in diameter, was localised at the cranial pole of the right kidney. A fetal neuroblastoma was suspected. At the fourth day after birth adrenalectomy was performed and the histological finding confirmed the prenatal diagnosis. Two years later the child is healthy. In review of the literature we found that sonographic pattern and localisation of fetal neuroblastoma are different, but in all cases the detection was performed in the third trimester of gestation.

Adrenal Gland Neoplasms↗
PubMed1986

[Results of the diagnosis of adrenal masses using percutaneous CT-guided fine needle biopsy].

This paper reports the results of 42 CT-aided fine needle biopsies of adrenal masses in 40 patients (26 were smaller than 3 cm., six smaller than 1 cm.). There were 25 adenomas, seven metastases, one primary carcinoma, one case of tuberculosis, two phaeochromocytomas and four post-inflammatory lesions. Diagnostic material was obtained in 88%. There was one incorrect diagnosis and on five occasions the result was indefinite, leading to an accuracy of 73%. Exclusion or demonstration of malignancy was, however, correct in 85%. There were no complications except for one unimportant pneumothorax.

Addison Disease↗
PubMed1970

ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase.

Pure monoiodo ACTH-(125)I was prepared that was biologically active and free of unlabeled ACTH. Extracts of adrenal cortex that contained ACTH-sensitive adenyl cyclase, bound ACTH-(125)I; extracts that lacked the ACTH-sensitive cyclase did not bind ACTH-(125)I. Unlabeled ACTH inhibited the binding of ACTH-(125)I. Five ACTH derivatives which varied widely in biological activity were tested. All inhibited the binding of ACTH-(125)I in direct proportion to their biological activity. Albumin, insulin, and four unrelated iodinated hormones were inert. The addition of excess hormone or acetic acid produced rapid dissociation of bound ACTH-(125)I. This study demonstrates directly the binding of ACTH to its biologically significant site.

Adenylyl Cyclases↗
PubMed1971

Inhibition of replication in functional mouse adrenal tumor cells by adrenocorticotropic hormone mediated by adenosine 3':5'-cyclic monophosphate.

Adrenocorticotropic hormone (ACTH) inhibited replication in functional adrenal tumor cells with a concomitant stimulation of steroidogenesis and a characteristic change of morphology from a flattened to a spherical type. [(3)H]Thymidine incorporation into DNA was inhibited by about 50% 6 hours after ACTH treatment. Both cyclic AMP and dibutyryl cyclic AMP inhibited [(3)H]thymidine incorporation and caused the characteristic morphological change noted with ACTH. The extent of stimulation of steroidogenesis and the amount of inhibition of [(3)H]thymidine incorporation in response to various doses of ACTH were closely related and both were in parallel with the concentration of cyclic AMP in the cells. Cyclic GMP and cyclic IMP did not inhibit [(3)H]thymidine incorporation significantly, and did not change the morphology of the cells. AMP inhibited [(3)H]thymidine incorporation into DNA and caused the characteristic morphological change. However, AMP did not increase the cyclic AMP content of the cells. CMP, GMP, and UMP showed a significant inhibition of [(3)H]thymidine incorporation into DNA, but the extent of the inhibition was much less than that with AMP. These nucleotides did not change the morphology of the cells.

Adrenal Gland Neoplasms↗
PubMed1988

Macronodular adrenal hyperplasia in Cushing disease.

Computed tomographic (CT) scans of the adrenal glands were obtained in nine patients with Cushing disease as a result of an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma and macronodular hyperplasia of the adrenal glands. The findings were compared retrospectively with those in six patients with Cushing syndrome as a result of an autonomous adrenal adenoma and 16 with Cushing syndrome as a result of ectopic ACTH production. Seven of nine patients with macronodular adrenal hyperplasia had hyperplastic adrenal glands in addition to single or multiple focal adrenal nodules. The six patients with hypercortisolism caused by an autonomous adrenal adenoma showed atrophic (four patients) or normal (two patients) ipsilateral and contralateral adrenal glands. Fourteen of 16 patients with the ectopic ACTH syndrome had hyperplasia of the adrenal glands without nodularity, and only two had focal nodules.

ACTH Syndrome, Ectopic↗
PubMed2004

Experience with surgical excision in childhood pheochromocytoma.

Pheochromocytoma is one of the potentially fatal causes of childhood hypertension. The study aims to analyze the results of our experiences in pheochromocytomas and the long-term results of its surgical treatment in children. The records of 15 children (11 boys, 4 girls) treated for pheochromocytoma in our unit during the period of 1984 and 2002 were reviewed retrospectively. The average age at surgery was 11.7 yr (range 6 yr 9 months-15 yr 7 months). Localized disease is defined as the cases without the invasion of surrounding tissue, regional disease as the invasion of surrounding tissue and metastatic disease as distant metastases. The mean follow-up after pheochromocytoma excision was 95 months (range 5 to 221 months). Tumors were located in the adrenal gland in 11 (bilaterally in 4) and extra-adrenally in 4. Localized disease occurred in 14 patients and regional disease in one. Only one patient was associated with von Hippel Lindau syndrome. Adrenalectomy or total excision of extra adrenal tumor was performed. Four patients (26.7%) recurred after the first operation (at 2 yr 9 months to 14 yr) and regional disease recurred in one patient three times. Early diagnosis, surgical excision, and long-term follow up are most important for the appropriate treatment of childhood pheochromocytoma.

Adolescent↗
PubMed1975

[Pseudo-tumoral suprarénal-renal dysgenesis (author's transl)].

Intimate fusion of the renal and suprarenal parenchyma, associated with cystic lesions in the zone of tissue juxtaposition, constitutes a form of suprarenal-renal dysgenesis for which the name "dystopia" has been suggested. The distinction must be made from suprarenal-renal adhesions in which a connective tissue barrier between the two parenchymas persists. In this present case, the malformation gave rise to a pseudo-tumoral syndrome of rapid appearance in association with a haemorrhage. Removal of the kidney cannot be avoided in view of the absence of any plane of cleavage with the suprarenal when the suprarenal tumour is removed.

Adrenal Gland Neoplasms↗
PubMed1985

[Adrenal metastases of bronchial cancer: value of x-ray computed tomography].

Up until now, adrenal metastases from bronchial cancer have always been an autopsy diagnosis with a frequency as high as 45%. These metastases can now be diagnosed by means of computed tomography of the adrenal glands and most of the recent studies report an incidence of 10 to 15% of adrenal metastases independently of the histological type of bronchial cancer. The authors stress the need to perform this examination in the context of pre-treatment staging and for the follow-up of bronchial cancer. The outcome of these adrenal metastases is still poorly understood, but prospective studies could provide more information concerning their prognostic significance. In cases of operable bronchial carcinoma with an isolated adrenal metastasis, it is important to be able to detect this lesion which may be able to be excised prior to the thoracic surgery.

Adrenal Gland Neoplasms↗
PubMed1994

Pathology of neuroblastic tumors.

Histogenesis, basic histologic features, nomenclature, and criteria for diagnosis and prognostic classifications based on morphological features of neuroblastic tumors (NTs) are described. NTs that arise from neuroectodermal cells of the adrenal medulla and sympathetic ganglia recapitulate the development of sympathetic ganglion. The following three basic types of NTs are recognized: neuroblastoma (NBs) and ganglioneuroblastomas (GNBs) and ganglioneuromas (GNs). NBs can be undifferentiated, poorly differentiated or differentiating; GNBs have the following three subtypes. (1) nodular, (2) intermixed, and (3) borderline. The conventional and recommended terminology and Shimada terminology of NTs are described (Tables 1 and 2). There are three basic pathologic components of NTs, neuroblastomatous, ganglioneuromatous, and intermediate components (Figs 3, 5, and 7). There are two major prognostic classifications based on morphological features of NTs, Shimada classification and histologic grading (Tables 3 and 4).

Adrenal Gland Neoplasms↗
PubMed1996

Contrast-enhanced MR imaging of the kidneys and adrenal glands.

Technical developments including motion artifact compensation and the use of paramagnetic contrast agents have substantially improved the performance of MR imaging of the kidneys and adrenal glands. MR imaging allows one to assess morphologic alterations of the kidneys as well as perfusion and functional derangements. MR imaging is the best noninvasive method for distinction of benign from malignant adrenal masses.

Adrenal Gland Diseases↗