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PubMed1981

[Pentachlorophenol concentrations in tissues and body fluids of normal persons (author's transl)].

Pentachlorophenol (PCP) analyses were performed on tissues and body fluids removed at autopsy from 21 human subjects from the geographical area of Northern Bavaria. The measured concentration of PCP in the urine range between 0.26 micrograms/ml and the detection limit (about 0.001 micrograms/ml); the median was 0.0044 micrograms/ml. The blood levels varied between 0.069 micrograms/ml and the detection limit (about 0.005 micrograms/ml); the median was 0.023 micrograms/ml. These results are well comparable with the data given in literature. The concentrations in blood and plasma are about 5 times higher than in urine. For levels below 0.1 micrograms/ml, in blood and plasma nearly the same PCP-concentration were found. All the investigated tissue contained PCP within concentrations from 0.219 micrograms/g to 0.007 micrograms/g. For the tissue samples the following medians were calculated: liver 0.067 micrograms/g, kidney 0.043 micrograms/g, brain 0.047 micrograms/g, spleen 0.019 micrograms/g, body fat 0.013 micrograms/g. Fatal ended PCP-intoxications described in literature, showed PCP-levels in average 1,000 times higher than our results. The PCP-levels in bodyfluids of occupationally exposed groups were found in an order of magnitude of 1.0 micrograms/ml. For the population in Northern Bavaria there are existing no probably hints for health impairments due to PCP-exposure at the recent time.

Adolescent↗
PubMed2006

Needlestick injuries and other occupational exposures to body fluids amongst employees and medical students of a German university: incidence and follow-up.

The aim of this study was to obtain data concerning the incidence, reporting and follow-up of occupational exposure to blood or other body fluids (OEB). A questionnaire was distributed to employees and medical students (N=787) and official reports of OEB during the year 2003 (N=203) and their consequent follow-up (N=100) were evaluated. The percentages of needlestick injuries were 29.5% for students and 22.5% for employees. Incidence rates per 1000 employee days were 0.61 for needlestick injuries or sharp object injuries and 0.27 for mucocutaneous exposure to body fluids. The mean rate of underreporting was approximately 45%. Contrary to expectations, only 4.3% of nurses and 3.9% of doctors officially reported an OEB in 2003. The number of persons who did not attend for a serological test increased during the follow-up period. Considering all documented test results, 35 out of 100 affected persons were lost to follow-up due to default of appearance. As a consequence, the employer should provide safety devices and enforce didactical interventions with practical training and incident reporting. Periodical occupational health medicals, including serological testing, should be mandatory for all employees, including medical students and student nurses. To increase compliance after OEB, a short follow-up period using improved laboratory tests requires further discussion.

Follow-Up Studies↗
PubMed2000

Isolation of nerve growth factor (NGF) from human body fluids; saliva, serum and urine: comparison between cobra venom and cobra serum NGF.

Several investigators have isolated nerve growth factor (NGF) from various tissues and organs of different animals. There is no published documentation about NGF from body fluids, such as blood serum, saliva, and urine. Contrary to the unsuccessful attempts to detect or isolate NGF in serum in the past, this investigation reports the isolation of NGF from human serum, saliva, and urine. It further reports the comparison of properties between NGFs derived from cobra venom and cobra serum. NGF from serum, saliva, and urine was isolated by high pressure liquid chromatography (HPLC) and was identified as described by Lipps (1998). The identified fractions of NGF were further purified to study the biological and immunological properties. The biological activities of NGFs from human body fluids and cobra serum on PC12 cells were miniscule in comparison to the cobra venom derived NGF. The molecular weights of NGFs from human serum, saliva, and urine were identical, 36.0 kDa. However, the molecular weights of cobra serum and cobra venom NGFs were different, 55.0 kDa and 13.5 kDa, respectively. NGF level is age dependent and varies under different conditions. Using anti-human NGF, diagnostic tests can be developed for neurological disorders. This investigation also emphasizes the replacement of invasive blood collection for serum by use of saliva and urine for clinical diagnostic use in general.

Animals↗
PubMed1995

Effect of temperature on electrochemical deposition of calcium phosphate coatings in a simulated body fluid.

Calcium phosphate coatings were deposited on titanium plate by an electrochemical method in simulated body fluid at 5-62 degrees C. X-ray diffractometry and FTIR studies demonstrated that the deposits at 5, 22 and 37 degrees C were amorphous and those at 52 and 62 degrees C contained Mg(OH)2, CaCO3 and carbonate apatite of low crystallinity. The calcium, magnesium and phosphorus contents of deposit increased in direct proportion to the square root of loading time of cathodic potential. Induction periods, which might be thought to be the time required to decrease the pH of the electrolyte around the cathode by the formation of H2 gas and to start deposition of calcium phosphate, were observed on all the regression lines. It is concluded that in the electrochemical synthesis of calcium phosphate in this temperature range the diffusion process is a rate-determining step.

Body Fluids↗
PubMed1975

Observations of the role of body fluid volumes and plasma renin activity in the management of hypertension.

Reduction of the (expanded) body fluid volumes found in some patients with renal hypertension may be essential in the management of these cases. Illustrative examples are given of this "volume dependent" form of hypertension. In such patients, plasma renin activity (PRA) is low. Other forms of hypertension may be regarded as caused by "inappropriate renin secretion". Most often, however, both factors are operative. This concept is supported by experimental evidence obtained in animals. The combined effect of salt depletion (which increases PRA) and beta-adrenergic blockade with propranolol (during which treatment PRA is lowered) was systematically studied in 3 groups of hypertensive patients (including one group with chronic renal insufficiency). The results indicate that this combined therapy lowers the blood pressure in various types of hypertension, the effect being sometimes more than additive. There was, however, no correlation between the PRA levels and the blood pressure decrease after salt depletion or after propranolol. Consequently, on the basis of the PRA values, no group of patients could be identified for which this treatment would be specifically indicated.

Adult↗
PubMed2006

In-vitro study of the spontaneous calcification of PHEMA-based hydrogels in simulated body fluid.

In-vitro calcification of poly(2-hydroxyethyl methacrylate) (PHEMA)-based hydrogels in simulated body fluid (SBF) under a steady/batch system without agitation or stirring the solutions has been investigated. It was noted that the formation of calcium phosphate (CaP) deposits primarily proceeded through spontaneous precipitation. The CaP deposits were found both on the surface and inside the hydrogels. It appears that the effect of chemical structure or reducing the relative number of oxygen atoms in the copolymers on the degree of calcification was only important at the early stage of calcification. The morphology of the CaP deposits was observed to be spherical aggregates with a thickness of the CaP layer less than 0.5 microm. Additionally, the CaP deposits were found to be poorly crystalline or to have nano-size crystals, or to exist mostly as an amorphous phase. Characterization of the CaP phases in the deposits revealed that the deposits were comprised mainly of whitlockite [Ca(9)MgH(PO(4))7] type apatite and DCPD (CaHPO4.2H2O) as the precursors of hydroxyapatite [Ca(10)(PO(4))6(OH)2]. The presence of carbonate in the deposits was also detected during the calcification of PHEMA based hydrogels in SBF solution.

Biocompatible Materials↗
PubMed1990

Simulation and evaluation of nicotine intake during passive smoking: cotinine measurements in body fluids of nonsmokers given intravenous infusions of nicotine.

The technique of monitoring cotinine concentrations in body fluids as a means of measuring nicotine intake during passive smoking has been evaluated in two studies, both of which used intravenous infusion to stimulate nicotine intake. In the first study, nicotine and cotinine were given separately, for 1 hour in four different intravenous doses (3.2, 15.4, 30.9, and 61.7 nmol/min) to each nonsmoker. In the second study, nicotine and cotinine were infused for 4 hours; each subject received five different doses of nicotine (1.5, 3.1, 6.2, 10.8, and 15.4 nmol/min) and one of cotinine (10.8 nmol/min). The concentration of cotinine was constant in both plasma and saliva from 1 to 4 hours after the nicotine infusion; the plateau levels of cotinine were found to be linearly and directly related to the nicotine intake. The ratio of salivary to plasma cotinine was 1:1.27. A linear relationship was also found between nicotine and cotinine infusion rates and the AUC values for cotinine. The fraction metabolized to cotinine was found to be about 0.5. The results from these studies show that: (1) there is a linear relationship between the plateau concentration of cotinine and the amount of nicotine infused over a period of 1 up to 4 hours; (2) salivary cotinine provides the same information on nicotine intake as does plasma cotinine; and (3) single measurements of either plasma or salivary cotinine concentrations at 1 to 4 hours after the exposure could be used to predict the nicotine intake during 1 to 4 hours of environmental tobacco smoke exposure.

Adult↗
PubMed1996

ANP as a neuroendocrine modulator of body fluid homeostasis.

The role played by the central nervous system (CNS) in the control of body fluid homeostasis has been demonstrated by several authors. The AV3V plays a key role in central control of sodium excretion since its cholinergic, adrenergic, angiotensinergic and osmotic stimulation enhances and its destruction blocks sodium excretion in rats and goats. Cholinergic stimulation of the AV3V induced an increase in plasma ANP as well as a marked elevation in content of the peptide in medial basal hypothalamus, neuro and adenohypophysis. On the other hand, a decline in plasma ANP after AV3V lesions was accompanied by dramatic declines in content of ANP in these same structures. Our previous work has also indicated the essential role of the AV3V region and its ANPergic neurons in the control of ANP release in response to volume expansion (BVE) and indicated that alpha-adrenergic and muscarinic receptors are critical in mediating these responses. Lesions of the AV3V region, or of the median eminence or posterior lobe of pituitary gland blocked the increase in plasma ANP concentration in response to BVE. That this effect is related to blockage of the activity of the brain ANPergic neurons is supported by findings in sheep and in rats that the injection of the antiserum directed against ANP into the AV3V region at least partially blocked the BVE-induced release of ANP. We and others have also previously shown that denervation of baroreceptors inhibits ANP release induced by BVE. Activation of the ANP neurons also cause release of ANP from the anterior and neural lobe of pituitary gland. ANP neurons may activate oxytocinergic neurons in the supraoptic and paraventricular, which projects to neural lobe. Oxytocin would circulate to the atria and may directly activate release of ANP from the atrial myocytes, since i.v. or i.p. injection of oxytocin increases sodium excretion as well as elevates plasma ANP. Oxytocin is present in the neural lobe in large quantity, which could reach the atria myocytes in high concentration and release ANP that circulate to the kidneys and evokes natriuresis to return circulating blood volume to normal.

Animals↗
PubMed1995

Exposure to blood and body fluid: factors associated with non-compliance in follow up HIV testing among health care workers.

Due to lack of previous research, this study examined the factors associated with non-compliance in follow up human immunodeficiency virus (HIV) testing among health care workers after blood and/or body fluid exposure. A descriptive correlation design was used with 178 health care workers who did not return for recommended follow up HIV testing post-blood and/or body fluid exposure at three urban hospitals. The 36 question Likert scale was designed to measure the five concepts of the Health Belief Model: susceptibility, seriousness, benefit, barriers, and health motivation. The internal consistency reliability measured .48. Forty five subjects (25%) returned the questionnaire. The most significant factor determined to affect return rate for follow up testing was related to benefits and susceptibility (F = 4.57, df = 2.42, R = .42, P = .02). Return rate was most significantly correlated with the idea of decreasing the chance of dying from acquired immunodeficiency syndrome (AIDS) (r = .31, P = .04). Similar results of recommended future studies may indicate changes in post-exposure education or institutional policies and procedures.

Adult↗
PubMedDate not supplied

Epidemiology and prevention of blood and body fluid exposures among emergency department staff.

Emergency Department (ED) staff are vulnerable to occupational exposure to infectious blood and body fluids (BBF). Universal precautions are often ignored in the ED setting. Identification of body locations at high risk of BBF exposure may allow development of site specific protective garments that minimize risk and inconvenience. All permanent staff (92) in a 58,000 visit public university hospital ED with potential for BBF exposure were surveyed. Respondents estimated the number of BBF contacts sustained during the past year, describing their most recent contact in detail. Seventy-eight of 91 (85%) responded, reporting average rates of 54.1 intact skin, 1.5 nonintact skin, and .87 mucous membrane BBF contacts per full-time employee per year. Of the most recent incidents, 94% involved blood, 22% involved vomit or urine, and 11% involved saliva. Eighty-eight percent of BBF contacts were to unprotected skin or mucous membranes, either when no barrier was worn or at the gap between gloves and sleeves. Most (66%) were distal to the elbow; 13% involved the face. Use of long gloves or another continuous protective barrier from the fingers to the elbow, in addition to increased use of face masks or shields, would markedly reduce the rate of ED BBF contacts with a minimum of inconvenience.

Blood-Borne Pathogens↗