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PubMed1975

Expression of congenital defects in the haemopoietic micro-environment. Erythroid and granulocyte-macrophage progenitor cells in pre-natal 'steel' (Slj/Slj) anaemic mice.

The erythropietin sensitivities of dissociated cell cultures and explanted fragments of fetal livers of congenitally anaemic Slj/Slj mice, and their normal littermates, have been compared. The erythropoietin responsiveness of Slj/Slj foetal liver cells is deficient in both types of culture. The maximum liver complement of erythroid colony forming cells (CFUe) occurs on the 16th day of development when 'normal' livers contain approximately 6 X 10(5) erythroid colony forming cells/liver. In Slj/Slj fetuses the maximum reached is only 1 X 10(5). Granulocyte-macrophage colony forming cells (CFUc) in Slj/Slj fetal livers are also reduced to approximately 60% of normal numbers. Erythroid colony forming cells are also reduced in the spleen and femoral bone marrow of Slj/Slj mice in the 2-3 days preceding birth. Granulocyte-macrophage colony forming cells are rare in the femoral marrow of pre-natal Slj/Slj mice, but their production in the Slj/Slj pre-natal spleen appears unaffected.

Anemia↗
PubMed2002

[Anophthalmia as an isolated congenital defect].

CASE REPORT: We present the case of a newborn male whose only anomaly was an anophthalmia in his left eye. Complementary explorations were carried out to discard associated systemic pathologies. DISCUSSION: Anophthalmia/microphthalmia is the most frequent congenital eye malformation in the newborn. Its prevalence in Spain for the past twenty years was 21.34/100,000 newborn. The most usual presentation is as part of syndromes, appearing only exceptionally in an isolated way. It is important for the ophthalmologist to be aware of this pathology since the early treatment, because the corresponding orbital prosthesis may help to avoid, at least in part, dysmorphogenesis and derived aesthetic problems.

Anophthalmos↗