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PubMed2003

[The guidelines for the diagnosis and monitoring of endocrine diseases(except of diabetes mellitus)].

The 6th draft for the guidelines for the diagnosis of thyroid disease has been published from the working group of Japan Endocrine Society in 2002. However, there are still controversial about guidelines for diagnosis of Graves disease. Serum-based tests for measuring the concentration of the TRAb and TSAb are available. We should use these tests rather than measuring of radioisotope uptake recommended in the 6th draft.

Autoantibodies↗
PubMedDate not supplied

Persistent psychological distress in patients treated for endocrine disease.

BACKGROUND: The purpose of the study was to assess the frequency and characteristics of psychological distress, even after adequate treatment, in the heterogeneous population of an endocrine outpatient clinic. METHODS: 146 endocrine patients (31 males/115 females; age 39.4 +/- 12.5 years), who were cured or in remission, were studied in a university endocrine outpatient clinic. Semistructured clinical interviews to assess psychiatric (Structured Clinical Interview for DSM-IV) and psychological (Diagnostic Criteria for Psychosomatic Research, DCPR) diagnoses were employed and were supplemented by self-rated instruments (the Psychosocial Index and the Medical Outcome Study short form General Health Survey) which could provide the patients' perception of their own quality of life. RESULTS: There were 118 patients (81%) who presented with at least 1 psychiatric (DSM-IV) or psychological (DCPR) diagnosis. The most frequent diagnostic findings were generalized anxiety disorder (29%), major depression (26%), irritable mood (46%), demoralization (34%) and persistent somatization (21%). By self-rated instruments, patients with at least 1 DSM-IV or DCPR diagnosis reported significantly more stressful life circumstances, psychological distress and an impaired quality of life compared to those who had none. CONCLUSIONS: A high prevalence of psychological distress may be encountered in the long-term follow-up of endocrine patients. A biopsychosocial consideration of the person and his/her quality of life appears to be mandatory for improving therapeutic effectiveness in endocrine disorders.

Adolescent↗
PubMed1976

[Thyrotropic function of the hypophysis in endocrine diseases].

The content of thyrotropic hormone of the hypophysis (by radioimmunological method) and the level of thyrotropic hormones in the blood plasma were studied in 178 patients with various endocrine pathology (thyrotoxicosis, hypothyroidism, diabetes mellitus, Itsenko-Cushing disease, Addison's disease, adiposity). Healthy persons (33) served as control. Thyrotropic function of the hypophysis proved to be decreased in thyrotoxicosis, diabetes mellitus, adiposity, Itsenko-Cushing disease. Comparison of the plasma level of thyrotropin and thyroid hormones led to a supposition on a different mechanism of the detected changes. A marked intensification on the thyrotropic function of the hypophysis was observed in primary hypothyroidism. A tendency to increase of thyrotropin discharge was noted in the patients suffering from thyrotoxicosis given antithyroid treatment and in Addison's disease.

Adolescent↗