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PubMed2001

Time of day effects on isometric and isokinetic torque developed during elbow flexion in humans.

The aim of this study was, firstly, to confirm or refute the existence of circadian rhythms during several velocities of concentric action of the elbow flexor muscles and, secondly, to compare the characteristics of these circadian rhythms with those obtained during isometric actions. Eight volunteer subjects participated in this study. The circadian rhythms were obtained from six test sessions (TS) carried out at different times of day over 6 days with only one TS a day. During each TS, oral temperature and the torque of the muscle action were measured. The subjects made, on an isokinetic ergometer, two maximal isokinetic concentric elbow flexions at five angular velocities (60, 120, 180, 240 and 300 degrees.s-1) and at an angle of 60 degrees. Torque-angular velocity relationships, which characterised the functioning of the muscle during concentric and isometric actions, were established for the different times of day. The values of the torque recorded at each of the angular velocities presented a clear circadian rhythm. After normalisation of the torque values, no significant differences were observed among the computed characteristics of the circadian rhythms obtained at different angular velocities. Since the circadian rhythms during isometric and concentric torque were the same, the characteristics of the circadian rhythms of the musculo-skeletal system can be studied using either type of muscle action. The results indicated that torque and temperature varied concomitantly during the day. Thus, the recording of body temperature allows one to estimate the times of occurrence of maximal and minimal values in the circadian rhythm of muscle torque.

Adult↗

PubMed2006

Molecular impact of clenbuterol and isometric strength training on rat EDL muscles.

Clenbuterol, a beta2-adrenergic-receptor agonist, is known to provoke muscle hypertrophy and a slow-to-fast phenotype change. A more glycolytic phenotype should be paralleled by changes in muscle glycolytic metabolism. Two groups (n=16 for each) of 3-month-old male Wistar rats (UCL: untrained clenbuterol, and ECL: exercised clenbuterol) received a chronic administration of clenbuterol (2 mg/kg body weight/day). Two other groups of animals (U: untrained and E: exercised), were given a 0.9% NaCl solution instead of clenbuterol. E and ECL animals followed an 8-week progressive isometric force strength-training program. Both clenbuterol administration and training resulted in an increase in extensor digitorum longus (EDL) mass despite the fact that this muscle was indirectly mobilised during isometric force strength training. Clenbuterol and training induced a consistent slow-to-fast phenotype change without drastically increasing specific activities of glycolytic enzymes. Except for GAPDH and hexokinase, modifications in glycolytic-enzyme-specific activities were not explained by transcriptional changes. Lactate dehydrogenase activity was not affected by clenbuterol but was strongly augmented by training. In EDL of ECL rats, both treatments presented an opposite effect compensating each other. GLUT1 mRNA expression was augmented in EDL of UCL and ECL animals, whereas monocarboxylate transporter 1 mRNA amounts were decreased in EDL of UCL rats. Citrate synthase activity was reduced by clenbuterol treatment but remained unchanged in EDL of E animals. Creatine kinase activity was enhanced only by clenbuterol alone. These data show that clenbuterol-induced muscle hypertrophy and slow-to-fast phenotype changes are not associated with a glycolytic-enzyme-activity increase. They also suggest that in EDL isometric force strength training can reverse clenbuterol-induced molecular adaptations.

Adrenergic beta-Agonists↗

PubMed2006

Derivation and left ventricular pressure phase plane based validation of a time dependent isometric crossbridge attachment model.

Huxley's crossbridge attachment model predicts tension (contractile force) development in isometric (fixed length) cells using constant attachment and detachment rates. Alternative models incorporating time-varying calcium concentrations are complex (coupled linear differential equations) and use time-dependent inputs (calcium, elastance, etc.) to model multiple states. We hypothesize that by incorporating the known significant rise and fall in intracellular calcium, via either an asymmetric damped function or a symmetric Gaussian function, into a time-varying, rather than constant, attachment rate function, the Huxley model prediction for tension (i.e., chamber pressure) in isovolumic (isometric) non-ejecting beats will improve. To test the hypothesis that the time-dependent model-predicted (TDM) pressure fits the in vivo isometric (isovolumic) LV pressure phase-plane (PPP) contour better than the constant attachment rate predicted pressure, we used the TDM to fit non-ejecting, premature ventricular contraction (PVC) PPP contours in 6 subjects. Conventional model fit was poor (relative error 74.0%+/-12.5%), while the asymmetric damped TDM rate function provided slight improvement relative to the conventional time-independent model (relative error 55.4%+/-9.8%). The symmetric Gaussian rate function TDM provided the best PPP fit to all non-ejecting beats tested (relative error 19.8%+/-4.8%). We conclude that approximating the lumped attachment rate via a time-varying, rather than constant, rate function generates a physiologically viable model of crossbridge behavior. The PPP provides the optimal arena for alternate mathematical formulation assessment of LVP contour prediction by time-dependent attachment rate functions and facilitates modeling of cardiac contraction and relaxation.

Adult↗

PubMed1983

Atropine-induced cardioacceleration in patients on chronic propranolol therapy: comparison with the positive chronotropic effect of isometric exercise.

The hemodynamic effects of intravenous atropine administration were examined in 24 patients on chronic propranolol therapy. In the first 13 patients the safety of atropine administration was tested by giving the drug in small increments to a total dose of either 1.2 mg (five patients) or 1.7 mg (eight patients). The heart rate after atropine administration in these patients varied between 57 and 82 bpm and no adverse effects were noted. The other 11 patients received 1.2 mg atropine intravenously with hemodynamic measurements obtained prior to and 3 minutes after administration of the drug. Heart rate increased from 57.5 +/- 8.7 to 72.8 +/- 13.9 bpm, mean pulmonary arterial and left ventricular end-diastolic pressure declined, and cardiac index increased. Total systemic resistance decreased in most of the patients. Isometric exercise performed prior to atropine administration in the same 11 patients accelerated heart rate from 57.4 +/- 8.6 to 68.4 +/- 10.8 bpm. A close correlation, r = 0.909, was demonstrated between the postatropine heart rate and the rate during isometric exercise. It is concluded that atropine in a dose of 1.2 to 1.7 mg may be administered safely in patients on chronic propranolol therapy. Isometric exercise may be useful in unmasking vagal tone in beta-blocked patients.

Adult↗

PubMed1984

Favorable effects of hydralazine on the hemodynamic response to isometric exercise in chronic severe aortic regurgitation.

The hemodynamic effects of isometric exercise and the response to hydralazine therapy were evaluated in 11 patients with chronic, severe aortic regurgitation (AR). Isometric exercise produced a significant increase in heart rate (from 78 +/- 11 to 93 +/- 19 beats/min [mean +/- standard deviation], p less than 0.05), mean blood pressure (from 83 +/- 8 to 104 +/- 20 mm Hg, p less than 0.05), mean right atrial pressure (from 3 +/- 2 to 7 +/- 5 mm Hg, p less than 0.05) and mean pulmonary artery wedge pressure (from 12 +/- 7 to 18 +/- 10 mm Hg, p less than 0.05). Small and insignificant changes were seen in cardiac index (from 3.4 +/- 0.8 to 3.9 +/- 1.0 liters/min/m2), systemic vascular resistance (from 1,097 +/- 257 to 1,171 +/- 284 dynes s cm-5), pulmonary vascular resistance (from 120 +/- 76 to 130 +/- 89 dynes s cm-5) and stroke volume index (from 44 +/- 10 to 43 +/- 12 ml/m2). After oral hydralazine administration (100 to 300 mg), hemodynamic values during isometric exercise were: Heart rate increased further, to 105 +/- 14 beats/min (p less than 0.05), mean blood pressure was 102 +/- 16 mm Hg (difference not significant [NS]) cardiac index increased markedly, to 5.2 +/- 1.4 liters/min/m2 (p less than 0.05), stroke volume index increased to 49 +/- 12 ml/m2 (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1985

Left ventricular responses to upright isometric handgrip and deadlift in men with coronary artery disease.

Isometric exercise is usually discouraged for patients with coronary artery disease (CAD) because of the possible adverse effects of increased blood pressure on left ventricular (LV) function. Cardiovascular and LV responses to upright handgrip and deadlift were compared in 10 normal men (mean age 52 years) and 14 men (mean age 54 years) with documented CAD or myocardial infarction who were in a supervised exercise program. Handgrip and deadlift were each performed at 30% maximal effort for 3 minutes. LV technetium-99m multigated radionuclide angiograms, electrocardiogram and blood pressure were measured during the final 60 seconds. CAD patients had a significantly lower LV ejection fraction at rest (41%) than normal subjects (57%). Both groups showed equal and significant increases in heart rate, systolic and diastolic pressure during handgrip and deadlift. These responses were all significantly greater in both groups during deadlift. No significant changes in LV ejection fraction occurred in either group during handgrip or deadlift. LV wall motion abnormalities were present in 9 of 14 CAD patients at rest and increased with handgrip (11 men) and deadlift (13 men). No LV abnormalities occurred in normal subjects. These data indicate cardiovascular responses are similar in normal and exercise-trained CAD patients during upright submaximal isometric exercise using small or large muscle groups. Radionuclide measurements of global LV function remain stable in both groups, during similar conditions of increased systolic pressure afterload. However, LV wall motion abnormalities are aggravated in CAD patients during isometric exercise.

Blood Pressure↗

PubMed1991

Pronounced reduction of aortic flow velocity and acceleration during heavy isometric exercise in coronary artery disease.

Doppler-derived parameters of aortic flow were examined during heavy isometric exercise in 48 men with coronary artery disease (CAD) and in 48 gender- and age-matched healthy controls. The aim was to determine which parameters best separated the groups and to look for a possible relation between exercise-induced Doppler patterns and the extent of CAD. Isometric exercise was performed with a 2-hand bar dynamometer, and the subjects were required to perform 50% of maximal voluntary contraction for 2 minutes. Examination was performed with a pulsed Doppler transducer positioned at the suprasternal notch. Resting peak flow velocity, acceleration time, stroke volume index and cardiac index did not show significant differences between the groups. However, mean acceleration and stroke work were significantly lower in patients with CAD. In this group, exercise peak flow velocity decreased from 98 +/- 13 to 55 +/- 12 cm/s, flow velocity integral from 14 +/- 3 to 7 +/- 3 cm, mean acceleration from 11 +/- 0.9 to 4.7 +/- 1 m/s/s, and stroke volume index from 41 +/- 6 to 23 +/- 4 ml/m2 (p less than 0.001 for all). Cardiac index decreased from 2.7 +/- 0.4 to 2 +/- 0.2 liters/min/m2 (p less than 0.05). Acceleration time increased from 82 +/- 6 to 116 +/- 7 ms. In most of the indexes, the directional changes induced by isometric exercise were similar in patients with CAD and in normal control subjects. The differences compared with the rest values were significantly greater in the CAD group, and especially in patients presenting with 3-vessel disease.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1990

Effects of hypoxemia with and without acidemia on the isometric contraction time and the electromechanical delay of the fetal myocardium: an experimental study on the ovine fetus.

This study assessed the response of the preejection period during hypoxemia with and without acidemia. In five pregnant ewes, hypoxemia was created during 1 hour followed by fetal infusion of lactic acid during 2 hours. A micromanometer catheter positioned above the fetal aortic valve, an endocavitary phonocardiogram, and a fetal electrocardiogram allowed measurements of the two components of the preejection period--the isometric contraction time and the electromechanical delay. At the onset of hypoxemia, because of changes in isometric contraction time, the preejection period began to shorten. When acidemia was induced, the preejection period modified slowly in the opposite direction and lengthened, initially because of a prolongation of electromechanical delay and later because of an increase in the already shortened isometric contraction time. This process developed slowly and at the end of 2 hours of acidemia, preejection period were back to preexperimental values. It can be concluded that systolic time intervals can be normal and misleading when acidosis complicates hypoxemia.

Acids↗

PubMed1987

Retrusive endurance, fatigue and recovery of human jaw muscles at various isometric force levels.

The effect of a sustained isometric retrusive contraction on maximum voluntary retrusive force levels was measured in normal jaw function. Surface electromyographic recordings of the suprahyoids, masseter and posterior temporalis were taken and force was measured with a force transducer. Subjects sustained isometric force at the 25, 50, 75 and 100 per cent level, and measurements made before, during and after these sustained isometric tasks. There was no change in the brief maximum voluntary contraction levels of the retruder muscles during or after such tasks, which suggests a lack of contractile or electrical failure in these muscles. Pain intolerance, rather than demonstrable neuromuscular fatigue, was the limiting factor for sustained submaximal or even maximal contraction effort.

Adult↗

PubMed1991

The effect of tendon viscoelastic stiffness on the dynamic performance of isometric muscle.

The effect of tendons viscoelastic stiffness on the dynamic response of the cat's tibialis anterior muscle under isometric conditions was determined. It was shown that the dynamic response model of the muscle derived under sinusoidal contraction-relaxation in the range of 20-80% of its maximal isometric tension was not statistically different before and after the disection of the whole distal tendon. It was suggested that under isometric conditions in the force range of 20-80% of the maximal, the tendon acts as a very stiff force transmission linkage without significantly modifying the muscle's performance.

Animals↗

PubMed1989

Isometric contractile function recovery following tourniquet ischemia.

The purpose of this study was to document the recovery of isometric contractile function following tourniquet ischemia. Male Wistar rats (N = 27) were subjected to unilateral hindlimb tourniquet ischemia of 0 hr (control, N = 6), 1 hr (N = 5), 2 hr (N = 5), 3 hr (N = 5) and 4 hr (N = 3). Following a 2-week recovery period, isometric force measurements were made from both gastrocnemii of each rat with the contralateral limb acting as the control side. Each muscle was analyzed for maximal twitch (Pt, N/g), maximal rate of rise of twitch tension (DP/dt, N/sec), time to peak tension (TPT, msec), half relaxation time (RT 1/2, msec), maximal tetanus (P0, N/g, at 100 Hz), and fatigue (Burke Fatigue Protocol). Pt, P0, and DP/dt were significantly different from control values (P less than 0.05) for all hours of tourniquet ischemia. A strong negative correlation (P less than 0.001) was found for twitch (R = -0.84), tetanus (R = -0.78), and maximal rate of force development (R = -0.83) with respect to increasing hours of ischemia. The recovery of isometric twitch and tetanic function following tourniquet ischemia is inversely related to the ischemic interval. This study quantified the relationship between muscle ischemia and recovery of function following a 2-week interval and stresses the functional physiological changes which occur in skeletal muscle following tourniquet ischemia.

Animals↗

PubMed1990

Recruitment, force and fatigue characteristics of quadriceps muscles of paraplegics isometrically activated by surface functional electrical stimulation.

This study deals with the recruitment characteristics of unfatigued electrically stimulated quadriceps muscles of paraplegic subjects and with the time-dependent force output of these muscles under sustained stimulation conditions. Both these aspects of the performance of paralysed stimulated muscles were studied under isometric conditions and at different muscle lengths. The forces in the knee joint resulting from stimulation of the quadriceps were also calculated. Recruitment force curves due to a ramp-like stimulation function indicated a strong dependence on muscle length and demonstrated a sigmoid-shaped curve with three distinct regions: negligible force up to threshold stimulation intensity; rapid force increase; and levelling-off of the curve after which the force remains constant even though intensity is further increased. When normalized to the maximal force, recruitment was found to be independent of muscle length, generating a typical recruitment curve for every patient, under isometric stimulation. The peak forces were obtained at the same flexion angles previously published for normal subjects, but with much lower values. Muscle fatigue in tetanic isometric conditions, defined as the decrease in force due to sustained stimulation with fixed parameters, was found to be length dependent and to have a double exponential decay. The first is the acute force loss and is the more significant for functional purposes; the second is the more moderate and asymptotic region, in which partial force recovery in the form of bursts is observed.

Biomechanical Phenomena↗

PubMed1994

Inhibition in the release of immunoreactive beta-endorphin from the periaqueductal grey during isometric contractions of cat hind-limb muscles: the effects of clonidine.

Glass microelectrodes, coated with antibodies specific for beta-endorphin, were inserted into the right periaqueductal grey (PAG) (at PO.5-1.0 mm, LR 2.0 mm and 6.0 mm below the dorsal surface of the colliculi) of cats anesthetized with alpha-chloralose to determine whether immunoreactive beta-endorphins (ir-END) were released in response to fatiguing isometric contractions of the hind-limb muscles. Probes were inserted into the PAG prior to, during and following muscle contraction in the absence or presence of clonidine. ir-END was released from the PAG up to 3 h after surgery was completed while cats remained at rest. In the absence of clonidine, mean arterial pressure increased by 65 +/- 12 mmHg during contractions and the release of ir-END was inhibited during the contraction periods compared to resting periods. Clonidine abolished the pressor response to muscular contraction when injected into the PAG, but did not cause the release of ir-END during fatiguing isometric contractions. These data suggest that isometric contractions of skeletal muscle do not induce the release of ir-END-like substances from the PAG and clonidine does not attenuate the muscle pressor response by causing the release of ir-END from this level in the PAG.

Animals↗

PubMed1995

Fatiguing isometric contraction of hind-limb muscles results in the release of immunoreactive neurokinins from sites in the rostral medulla in the anesthetized cat.

Antibody-coated microprobes were used to determine whether immunoreactive neurokinins (irNK) were released from sites in the brainstem during fatiguing isometric contractions of the triceps surae muscles in cats anesthetized with alpha-chloralose. Contractions were generated by stimulating the tibial nerve using a microprocessor-controlled stimulator. Microprobes were inserted into the periaqueductal grey (P 0.5-1.0 mm) or the medullary brainstem (either 3.0 or 3.5 mm rostral to the obex) prior to, during and following fatiguing contractions. No release of irNK was detected from the periaqueductal grey as a result of fatiguing isometric contractions. When probes were inserted 3.0 mm rostral to the obex, a basal release of irNK was detected from the medulla but this was inhibited during isometric contractions from sites corresponding to the lateral tegmental field. When probes were inserted into the more rostral site in the medulla (3.5 mm rostral to the obex), irNK were released in response to contractions from sites corresponding to lateral reticular nucleus, ventral regions of the nucleus tractus solitarius and the medial vestibular nucleus. No irNK were released from this site (3.5 mm rostral to obex) either during passive leg flexing, during nerve stimulation following gallamine injection and muscle paralysis or during stimulation of the central end of the cut tibial nerve. These results demonstrate that neurokinins are released from discrete sites in the medulla in response to fatiguing muscle contractions and suggest that tachykinin neurons may be a component of the pathways regulating blood pressure during ergoreceptor activation.

Anesthesia↗

PubMed1986

A strain-gauge myograph for isometric measurements of tension in isolated small blood vessels and other muscle preparations.

Isometric tension measurements in vitro on small vessels are important in studies of pharmacodynamic vascular effects of drugs and autacoids. The present study describes a precision myograph equipped with a newly constructed highly isometric strain-gauge transducer used in conjunction with a very sensitive, low-noise and virtually drift-free dc-amplifier. The isometric quotient of the transducer, defined as deflection in micrometer per g of force, is about 5.2. The transducer resonance frequency is 341 c/sec with a damping constant of 1.05. The highest sensitivity of the transducer in connection with the matching dc-amplifier is about 170 mV/V/g force. The practical working range of the myograph is from 2 mg to about 10 g of applied tensile force. Tubular segments of vessels with internal diameters down to 150 micron can be mounted in the myograph on two stainless-steel pins submerged in a 5 ml preparation bath. Precise mounting and setting of passive (resting) tension is assured by the use of micrometer-equipped adjustable miniature mounting tables suspended by roller bearings. The myograph may be provided with electrodes for field-effect stimulation of the vessel preparations. Other muscle preparations may also be mounted in the myograph. Application of the myograph in studies on rabbit coronary arteries is demonstrated by a length-tension diagram obtained in experiments with tubular segments (inner diameter about 500 micron) of the circumflex branch on the left coronary artery, which shows a typical course in development of active and passive tension of the smooth musculature when exposed to alternating potassium depolarization and increasing mechanical stretching. The potassium contracture of the coronary vessels and the log-concentration/response relationship at accumulating potassium concentrations were also investigated.

Animals↗

PubMed1994

Agonist and antagonist EMG activation during isometric torque development at the elbow in spastic hemiparesis.

Voluntary isometric step contractions of the elbow flexor and extensor muscles were studied in a group of patients with paresis arising as the result of unilateral cerebral lesion and in a control group of normal subjects. For each subject the maximum isometric torque in flexion and extension was obtained, along with a series of graduated torque steps up to this maximum, in order to perform a regression analysis between torque developed and the associated agonist and antagonist EMG. This relationship proved to be linear in all normal subjects and in all but the most paretic spastic patients. If the patients were grouped according to their ability to make discrete large angle flexion and extension movements at the elbow, a clear correspondence was seen between increasing movement disability and the degree of paresis. No significant differences were found in the torque/EMG relationship of spastic patients when either elbow extensors or flexors were acting as the agonist in a contraction. Similarly, no evidence of exaggerated antagonist co-activation was found. It is concluded that, in the upper arm muscles, hemiparesis following stroke cannot, under isometric conditions, be attributed to hyperactivity of antagonist muscles.

Adult↗

PubMed1991

Sustained isometric contraction of skeletal muscle results in release of immunoreactive neurokinins in the spinal cord of the anaesthetized cat.

Antibody microprobes were used to study release of immunoreactive neurokinins in the dorsal horn of the anaesthetized spinal cat following sustained isometric contraction of ipsilateral hindlimb muscles. Microprobes had immobilized antibodies to neurokinin A (NKA) on their outer surfaces and bound a proportion of released molecules when inserted in the central nervous system. Bound molecules were detected in autoradiographs as zones of reduced binding of 125I-NKA in which microprobes were incubated after withdrawal from the spinal cord. The left hindlimb was immobilized using an epoxy bandage splint and isometric contraction of muscles induced by intermittent tetanic stimulation of a ventral root. A basal presence of immunoreactive neurokinins was detected and this was increased by sustained isometric muscle contraction. It is probable that ergoreceptors contain and release neurokinins.

Anesthesia, General↗

PubMed1992

Release of immunoreactive enkephalinergic substances in the periaqueductal grey of the cat during fatiguing isometric contractions.

Antibody-coated microprobes were used to determine whether immunoreactive enkephalins were released in response to fatiguing isometric contractions of the hind-limb muscles in cats anesthetized with alpha-chloralose. Contractions were performed by stimulating the tibial nerve via a microprocessor-controlled stimulator. Microprobes were inserted into the periaqueductal grey (P 0.5-1.0 mm) prior to, during and following fatiguing contractions. During fatiguing contractions, mean arterial blood pressure increased by 76 +/- 9 mmHg above resting and recovery levels. Levels of immunoreactive enkephalins were elevated in the dorsolateral periaqueductal grey during the isometric contraction when compared to resting levels. It is possible that isometric muscle contraction causes the release of Met-enkephalin-like substances in the periaqueductal grey.

Animals↗