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At least 541 records · Page 30Linked to original sources

PubMed1997

A Monte Carlo study of the quality dependence of diamond thermoluminescent dosimeters in radiotherapy beams.

Monte Carlo simulations with the EGS4 code system have been performed to determine the quality dependence of diamond TLDs in photon beams ranging from 25 kV to 25 MV x-rays and also in megavoltage electron beams. It has been shown that diamond TLDs in the form of discs of thickness 0.3 mm and diameter 5.64 mm show no significant dependence on the incident energy in clinical electron beams when irradiated close to dmax, but require an energy correction factor of 1.050 +/- 0.008 compared with diamond TLDs irradiated in 60Co gamma-rays. The correction factor increases with depth of irradiation and this effect is greater for thicker detectors. The Monte Carlo predicted sensitivity in x-ray beams is constant within 2.5% over the energy range 250 kV to 25 MV. However the sensitivity decreases by about 60% for 25 kV x-rays compared with 60Co gamma-rays.

Cobalt Radioisotopes↗

PubMed1997

The response of a MOSFET, p-type semiconductor and LiF TLD to quasi-monoenergetic x-rays.

A metal oxide semiconductor field effect transistor (MOSFET), p-type semiconductor and a TLD can all be used for x-ray dosimetry, with each system having the common disadvantage of a response which is dependent upon the incident photon energy, particularly for energies < 1 MeV. A Pantak HF-320 quasi-monoenergetic x-ray unit was used to determine the response of two Thomson and Nielson TN-502RD MOSFETs, a Scanditronix EDP-10 semiconductor (build-up cap 10 mm: tissue equivalence), an EDD-5 semiconductor (build-up cap 4.5 mm: tissue equivalence) and an Lif:Mg:Ti TLD over the energy range 12-208 keV. The sensitivity of each detector was normalized to the value produced by exposure to 6 MV x-rays. The maximum relative sensitivities of the two MOSFET detectors were 4.19 +/- 0.25 and 4.44 +/- 0.26 respectively, occurring at an incident x-ray energy of 33 keV. The maximum relative sensitivity of the Scanditronix EDP-10 of 2.24 +/- 0.13 occurred at 65 keV, and for the EDD-5, it was 7.72 +/- 0.45 at 48 keV. The TLD produced a maximum relative sensitivity of 1.31 +/- 0.09 at 33 keV. Compared with available data based on heteroenergetic x-ray sources, these measurements have identified a more representative response for each detector to low-energy x-rays.

Equipment Design↗

PubMed1997

A study of LiF GR-200 for radiotherapy mailed dosimetry.

A study of the measurement performance of LiF GR-200 for radiotherapy mailed dosimetry is presented. The study was carried out in the practical working conditions of a mailed system where a lengthy delay between dosimeter preparation and the final readout can occur. Prompt and delayed TL measurements were employed to determine, among other characteristics, the reusability and the stability during storage at room temperature. From the results obtained it can be concluded that GR-200, although producing dose results adequate for mailed dosimetry, does not improve the performance attainable with LiF TLD-100.

Calibration↗

PubMed1998

A Monte Carlo study of the quality dependence factors of common TLD materials in photon and electron beams.

A Monte Carlo simulation of the quality dependence of different TL materials, in the form of discs 3.61 mm in diameter and 0.9 mm thick, in radiotherapy photon beams relative to 60Co gamma-rays has been performed. The beam qualities ranged from 50 kV to 25 MV x-rays. The TL materials were: CaF2, CaSO4, LiF and Li2B4O7. The effects of the dopants on energy deposition in the TL material have also been determined for the highly sensitive LiF:Mg:Cu:P (TLD-100H) and for CaF2:Mn. It was found that there was a significant difference in the quality dependence factor derived from Monte Carlo simulations between LiF and LiF:Mg:Cu:P but not between CaF2 and CaF2:Mn. The quality dependence factors for Li2B4O7 varied from 0.990 +/- 0.008 (1 sd) for 25 MV x-rays to 0.940 +/- 0.009 (1 sd) for 50 kV x-rays relative to 60Co gamma-rays; Monte Carlo simulations were also performed for Li2B4O7 in megavoltage electron beams. For CaF2, the quality dependence factor varied from 0.927 +/- 0.008 (1 sd) for 25 MV x-rays to 10.561 +/- 0.008 (1 sd) for 50 kV x-rays. The figure for CaSO4 ranged from 0.943 +/- 0.008 (1 sd) for 25 MV x-rays to 9.010 +/- 0.008 (1 sd) for 50 kV x-rays. The quality dependence factor for CaF2 increases by up to 5% with depth and by up to 15% with field size for the kilovoltage x-ray beams. For LiF-TLD, however, there was no significant dependence on the field size or depth of irradiation in the kilovoltage energy range.

Borates↗

PubMed1998

Thermoluminescent response and relative efficiency of TLD-100 exposed to low-energy x-rays.

The dose-response of LiF:Mg,Ti (TLD-100) exposed to 15 and 35 kVp (8.0 +/- 0.1 and 8.1 +/- 0.1 keV effective energy respectively) x-rays and 60Co gamma-rays has been measured in the dose interval from (1.2-5.4) x 10(3) Gy for x-rays, and from 0.14 to 850 Gy for gamma-rays. In both cases the total TL signal and glow curve peaks 3 to 9 show supralinearity. The supralinearity function f(D) is similar for both x-ray beams, except for peak 8, where a 30% difference is observed. The maxima of f(D) for the total TL signal and peaks 5 to 8 are 2.1, 1.7, 6.4, 3.3 and 7.5 respectively for 8.1 keV x-rays and 3.7, 3.1, 13.6, 9.9 and 11.0 for gamma-rays. The measured relative efficiencies for x-rays with respect to 60Co, for the total TL signal and peaks 5 and 7, were 1.04, 0.97 and 3.2 respectively.

Aluminum↗

PubMed1999

Feasibility of reading LiF thermoluminescent dosimeters by electron spin resonance.

Lithium fluoride is a commonly used solid state dosimeter. During irradiation, electrons and holes become trapped in crystal imperfections; thermoluminescence dosimetry measures their thermally induced recombination. Electron paramagnetic resonance (EPR) spectroscopy can be used to measure the resonant absorption of microwaves by the unpaired electrons trapped in LiF. In an effort to extend the use of LiF dosimeters to smaller sizes and to the harsh environments encountered in internal dosimetry, EPR was evaluated as an alternative technique to read the radiation dose delivered to TLD-100 dosimeters. TLD-100 rods were irradiated with a 60Co source to doses of 10 Gy to 100 Gy. A radiation-induced signal (with a g-value of 2.002) could be detected only at liquid nitrogen temperatures at doses above 20 Gy. The EPR spectrum of irradiated LiF contains three components, one of which correlates positively with dose. However, the low sensitivity of the technique, and difficulty in interpreting the EPR spectrum from polycrystalline dosimeters, preclude its use as a dosimetry technique.

Crystallization↗

PubMed2000

Energy correction factors of LiF powder TLDs irradiated in high-energy electron beams and applied to mailed dosimetry for quality assurance networks.

Absorbed dose determination with thermoluminescent dosimeters (TLDs) generally relies on calibration in 60Co gamma-ray reference beams. The energy correction factor fCo(E) for electron beams takes into account the difference between the response of the TLD in the beam of energy E and in the 60Co gamma-ray beam. In this work, fCo(E) was evaluated for an LiF powder irradiated in electron beams of 6 to 20 MeV (Varian 2300C/D) and 10 to 50 MeV (Racetrack MM50), and its variation with electron energy, TLD size and nature of the surrounding medium was also studied for LiF powder. The results have been applied to the ESTRO-EQUAL mailed dosimetry quality assurance network. Monte Carlo calculations (EGS4, PENELOPE) and experiments have been performed for the LiF powder (rho = 1.4 g cm3) (DTL937, Philitech, France), read on a home made reader and a PCL3 automatic reader (Fimel, France). The TLDs were calibrated using Fricke dosimetry and compared with three ionization chambers (NE2571, NACP02, ROOS). The combined uncertainties in the experimental fCo(E) factors determined in this work are less than about 0.4% (1 SD), which is appreciably smaller than the uncertainties up to 1.4% (1 SD) reported for other calculated values in the literature. Concerning the Varian 2300C/D beams, the measured fCo(E) values decrease from 1.065 to 1.049 +/- 0.004 (1 SD) when the energy at depth in water increases from 2.6 to 14.1 MeV; the agreement with Monte Carlo calculations is better than 0.5%. For the Racetrack MM50 pulsed-scanned beams, the average experimental value of fCo(E) is 1.071 +/- 0.005 (1 SD) for a mean electron energy at depth Ez ranging from 4.3 to 36.3 MeV: fCo(E) is up to 2% higher for the MM50 beams than for the 2300C/D beams in the range of the tested energies. The energy correction factor for LiF powder (3 mm diameter and 15 mm length) varies with beam quality and type (pulsed or pulsed-scanning), cavity size and nature of the surrounding medium. The fCo(E) values obtained for the LiF powder (3 mm diameter and 15 mm length) irradiated in water, have been applied to the EQUAL external audit network, leading to a good agreement between stated and measured doses, with a mean value of 1.002 +/- 0.022 (1 SD), for 170 beam outputs checked (36 electron beam energies) in 13 'reference' radiotherapy centres in Europe. Such fCo(E) data improve the accuracy of the absorbed dose TLD determination in electron beams, justifying their use for quality control in radiotherapy.

Calibration↗

PubMed2004

LiF:W as a scintillator for dosimetry in diagnostic radiology.

The use of ionization chambers in diagnostic radiology is not feasible in measurement situations requiring small and robust dose sensors. The composition of LiF:W developed as a scintillator for the measurement of thermal neutrons seems profitable for an application in dosimetry of low-energy photons. Properties of a small LiF:W scintillator were determined with DV- and DH-standard radiation qualities. For a tube voltage range of 40 to 150 kV (corresponding to a HVL of 1.56 to 13.69 mm Al) a maximum variation in sensitivity of +/-13% was determined for a scintillator thickness of 3.7 mm. The scintillator signal was linear in a range from 6.6 mGy min(-1) to at least 13.7 Gy min(-1). Higher dose rates could not be obtained in the measurement setup. The temperature dependence of the luminescence response was found to decrease from +3.7% (at +2.5 degrees C) to -7.0% (at +45 degrees C) with respect to the luminescence response at 20 degrees C. LiF:W appears to be an interesting choice as a dosimetric scintillator in diagnostic radiology making immediate measurements of dose and dose rate with high spatial resolution feasible.

Equipment Design↗

PubMed2004

Variations in dose response with x-ray energy of LiF:Mg,Cu,P thermoluminescence dosimeters: implications for clinical dosimetry.

In many medical procedures where accurate radiation dose measurements are needed, the variation of detector response with x-ray energy is of concern. The response of LiF:Mg,Cu,P TLDs to a range of x-ray energies was analysed in monoenergetic (synchrotron), diagnostic and therapy radiation beams with the aim of implementing this dosimeter into clinical practice where existing dosimetry techniques are limited due to lack of sensitivity or tissue equivalence (e.g. neonatal radiography, mammography and brachytherapy). LiF:Mg,Cu,P TLDs in different forms from two manufacturers (MCP-N: TLD Poland, GR200: SDDML China) were irradiated using x-ray beams covering 10 keV to 18 MVp. Dose readings were compared with an ionization chamber. The effect of different TLD types and annealing cycles on clinical utility was investigated. The measured energy response of LiF:Mg,Cu,P TLDs was fit to a simple model devised by Kron et al (1998 Phys. Med. Biol. 43 3235-59) to describe the variation of TLD response with x-ray energy. If TLDs are handled as recommended in the present paper, the energy response of LiF:Mg,Cu,P deviates by a maximum of 15% from unity and agrees with the model to within 5% or experimental uncertainty between 15 keV and 10 MeV. LiF:Mg,Cu,P TLDs of all forms have consistent and superior energy response compared to the standard material LiF:Mg,Ti and are therefore suitable for a wide range of applications in diagnostic radiology and radiotherapy.

Brachytherapy↗

PubMed2004

Electron paramagnetic resonance (EPR) dosimetry using lithium formate in radiotherapy: comparison with thermoluminescence (TL) dosimetry using lithium fluoride rods.

Solid-state radiation dosimetry by electron paramagnetic resonance (EPR) spectroscopy and thermoluminescence (TL) was utilized for the determination of absorbed doses in the range of 0.5-2.5 Gy. The dosimeter materials used were lithium formate and lithium fluoride (TLD-100 rods) for EPR dosimetry and TL dosimetry, respectively. 60Co gamma-rays and 4, 6, 10 and 15 MV x-rays were employed. The main objectives were to compare the variation in dosimeter reading of the respective dosimetry systems and to determine the photon energy dependence of the two dosimeter materials. The EPR dosimeter sensitivity was constant over the dose range in question, while the TL sensitivity increased by more than 5% from 0.5 to 2.5 Gy, thus displaying a supralinear dose response. The average relative standard deviation in the dosimeter reading per dose was 3.0% and 1.2% for the EPR and TL procedures, respectively. For EPR dosimeters, the relative standard deviation declined significantly from 4.3% to 1.1% over the dose range in question. The dose-to-water energy response for the megavoltage x-ray beams relative to 60Co gamma-rays was in the range of 0.990-0.979 and 0.984-0.962 for lithium formate and lithium fluoride, respectively. The results show that EPR dosimetry with lithium formate provides dose estimates with a precision comparable to that of TL dosimetry (using lithium fluoride) for doses above 2 Gy, and that lithium formate is slightly less dependent on megavoltage photon beam energy than lithium fluoride.

Electron Spin Resonance Spectroscopy↗

PubMed2002

Energy response of LiF:Mg, Ti dosemeters to ISO 4037 and typical diagnostic x-ray beams in Tanzania.

The energy response of three types of LiF:Mg, Ti dosemeter to standard x-ray calibration qualities and diagnostic x-rays has been studied. The aim of this study was to investigate whether the inherent mismatch between these qualities compromises the accuracy of the evaluated occupational doses in diagnostic x-ray facilities. A sample of 10 dosemeters of each type was exposed to air kerma of 5 mGy from each of six ISO 4037 (series 407) x-ray radiation protection calibration qualities (2.7 mm Al to 2.45 mm Cu HVL (half-value layer)) and 11 diagnostic x-ray qualities (1.45-4.9 mm Al HVL). The results show that the TLD energy response to ISO 4037 and diagnostic x-rays as normalised to 137Cs ranged from 1.1 to 1.44 and 0.57 to 1.54 respectively. This implies an energy response range from -52 to +7% for diagnostic x-rays relative to ISO 4037 x-rays, hence a maximum over-response of 52%. Despite this discrepancy, the results show that the mismatch between calibration and diagnostic x-ray beams does not significantly compromise the accuracy of individual doses in diagnostic x-ray facilities.

Fluorides↗

PubMed2004

Performance characteristics of LiF thermoluminescent dosemeters employed in the National Personnel Radiation Dose Services in Tanzania.

Thermoluminescent dosemeters (TLDs) have been used to estimate the personal dose equivalent for external occupationally exposed workers in Tanzania. The reliability and precision of dose measurements and the accuracy of dose evaluation are important factors for the improvement and achievement of individual monitoring objectives. In this piece of work we describe a study of the major characteristics of TLDs (linearity of response, photon energy response, batch homogeneity and uniformity, calibration of TLDs and TLD systems in terms of operational quantities, fading, etc) in order to initiate a routine performance testing and quality assurance programme to be undertaken by central personal dosimetry services. The energy response of the dosemeters relative to that measured using 137Cs gamma rays was found to vary between 1.0 and 1.3 over the range of 33-1250 keV (60Co). The linearity of the response for the TL dose dependence in the dose range of 0.1-30 mGy for 48 keV and 137Cs (662 keV) radiation protection qualities varied from 15% to 7% respectively, for both energies. The minimum detectable dose, the batch homogeneity and uniformity, and the batch reproducibility were found to be 0.1 mGy, 16%, and 9% respectively while the fading characteristic of doped LiF after a received dose of 3 mGy was found to be 6.3% over a one-month period. These results are discussed in order to demonstrate the degree of accuracy achieved and the need for its improvement where necessary.

Fluorides↗

PubMed2004

Effect of reader and oven annealing on the glow curve structure and fading of a LiF:Mg,Cu,P TL dosimeter.

The effect of pre-irradiation annealing in an oven at 240 degrees C/10 min (oven anneal) and in a TLD reader at 6 degrees C s(-1), 10 s dwell time at a maximum temperature 240 degrees C (reader anneal), on the glow curve structure of a home made sample of LiF:Mg,Cu,P powder has been investigated. It is shown that on oven annealing the glow peak areas of peaks 2 and 3 increase and that of peak 4 decreases, while on reader annealing the area of peak 4 increases and those of peaks 2 and 3 effectively decrease. Values of fading during a post-irradiation storage of 6 months were measured to be 26% and 12% for samples undergoing oven and reader annealing respectively. To reduce the effect of fading several pre-heats at temperatures of 100, 110, 120 and 130 degrees C for 10 min were investigated and 120 degrees C/10 min was chosen as the optimal condition for pre-heat. It is also observed that when imposing pre-heat thermal treatment on this dosimeter or storing the irradiated dosimeter the height of peak 4 effectively increases while the integral of TL signals remains constant.

Copper↗

PubMed2004

Thermoluminescence dosimetric properties of a new thin beta detector (LiF:Mg, Cu, P; GR-200F) in comparison with highly sensitive Al2O3:C beta dosimeters.

There is an increasing need for efficient beta detectors to fulfil ICRU recommendations for new quantities especially in the field of medical physics and retrospective dosimetry. The thermoluminescence properties of thin LiF:Mg, Cu, P (GR-200F) tapes produced in 1998 by Sange Company, People's Republic of China, are investigated and compared with those of highly sensitive thin Al2O3:C beta detectors as regards their applicability in the detection of low energy photons and beta particles. The radiation dose response, minimum detectable dose, reproducibility of measurements and effect of residual signal at low dose are assessed for the possible low level beta dosimetry use. The radiation dose response and photon and beta detection efficiencies are tested underpractical laboratory conditions. The effects of indoor fluorescent light and residual signal after the first read-out are investigated with a view to optimising handling conditions such as post-irradiation and pre-heating treatments for routine dosimetry. The photon energy responses of the detectors are investigated using 150 keV filtered x-rays and 60Co gamma-rays.

Aluminum Oxide↗

PubMed2006

A one-year open-label trial of risperidone augmentation in lithium nonresponder youth with preschool-onset bipolar disorder.

OBJECTIVE: The aim of this study was to assess the safety and efficacy of risperidone augmentation of lithium in preschool-onset bipolar disorder (BD) among youth who insufficiently respond to lithium monotherapy. METHOD: Thirty-eight subjects between the ages of 4 and 17 years (mean age = 11.37 +/- 3.8 years) with onset of BD in preschool years (manic or mixed episode) entered this 12-month trial. All subjects received lithium monotherapy. Patients who failed to adequately respond to lithium monotherapy after 8 weeks and those who relapsed after an initial response were given risperidone augmentation for up to 11 months. The Young Mania Rating Scale (YMRS) was the primary outcome measure. Response was defined as a > or =50% decrease from baseline. Additional data were collected on diagnostic comorbidity, family history, number of hospitalizations, perinatal risk factors, history of physical or sexual abuse, Child Depression Rating Scale-Revised (CDRS-R), Clinical Global Impression (CGI) scale for BD (CGI-BP), Children's Global Assessment Scale (C-GAS), and adverse medication effects. RESULTS: Of the 38 subjects treated with lithium monotherapy, 17 responded, whereas 21 required augmentation with risperidone. Response rate in the youths treated with lithium + risperidone was 85.7% (n = 18/21). Significant predictors of inadequate response to lithium monotherapy requiring augmentation were: (1) attention-deficit/hyperactivity disorder (ADHD), (2) severity at baseline, (3) history of sexual or physical abuse, and (4) preschool age. Combination treatment of lithium and risperidone was found to be safe and well tolerated. CONCLUSIONS: A substantial proportion of youth with a history of preschool-onset BD treated with lithium were either nonresponders or partial responders. Subsequent augmentation of lithium with risperidone in these cases was well tolerated and efficacious. Potential predictors of lithium nonresponse identified in this study may guide the choice of medications earlier in the treatment process.

Adolescent↗

PubMed1994

An in vitro study of the effects of different crystal growth solutions on the topography of the enamel surface.

This study evaluated the effect on the topography of the enamel surface of applying various solutions based on polyacrylic acid. This base solution consisted of 50 per cent aqueous polyacrylic acid (molecular weight 5000) and concentrated sulphuric acid (98 per cent). Previously, similar solutions have been found to initiate a crystal growth on the enamel surface and have been proposed as being suitable for the attachment of orthodontic brackets via a composite resin interface. The base solution was modified by the addition of various ionic salts: the sulphates of lithium, magnesium and potassium, respectively. Human premolar teeth were then treated to a standard format and the effect on the enamel surface was examined by the use of a scanning electron microscope at x 500 and x 1500 magnification. The resultant micrographs of the specimens were presented to three independent observers who assessed the length, quality, and degree of coverage of the crystals. The solution containing potassium sulphate gave the longest crystals, whilst the greatest degree of coverage was obtained with the magnesium sulphate solution. Each solution was found to produce a consistent and recognizable morphology.

Acid Etching, Dental↗

PubMed1995

Solid-phase synthesis of a nucleopeptide from the linking site of adenovirus-2 nucleoprotein, -Ser(p5'CATCAT)-Gly-Asp-. Convergent versus stepwise strategy.

The synthesis of a nucleopeptide with the sequence -Ser(p5'CATCAT)-Gly-Asp- has been undertaken by either convergent or stepwise solid-phase strategies, both of which use base-labile permanent protecting groups. The coupling of phosphitylated protected peptides onto oligonucleotide-resins did not afford the desired nucleopeptide, which was nevertheless obtained after oligonucleotide elongation at the hydroxyl group of the resin-bound peptide and deprotection under mild basic conditions. A preliminary study on the stability of different nucleopeptides to bases is also reported.

Adenoviruses, Human↗

PubMed2003

Study on the reaction mechanism of C-6 lithiation of pyrimidine nucleosides by using lithium hexamethyldisilazide as a base.

The reaction mechanism of C-6 lithiation of uridine mediated by lithium hexamethyldisilazide (LiHMDS) has been investigated. LiHMDS alone dose not lithiate at C-6 of uridine. However, in the presence of an appropriate silylating agent, e.g. trimethylsilyl chloride, the reaction of 1 with LiHMDS allowed to lithiate at C-6 and gave the corresponding C-6 silylated product 2. The experimental results shown below revealed that O-4 (N-3) of uracil moiety may be temporarily masked by silylation, which triggers the C-6 lithiation by lowering the pKa of H-6. The reaction could efficiently be applied to the synthesis of 6,5'-C-cyclouridine, a nucleoside analogue fixed in a specific glycosyl torsion angle by a carbon-carbon bridge.

Lithium Compounds↗