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Oral manifestations in glycogen storage disease type 1b.

Glycogen storage disease type 1b is a rare metabolic disorder which affects the transport system of glucose-6-phosphatase metabolism. As a result, hepatomegaly, failure to thrive, renal dysfunction and recurrent infections occur in affected patients. In this paper, the oral complications in three children with glycogen storage disease type 1b are discussed. Oral ulcers were a common finding, probably due to severe neutropenia and impaired neutrophil migration which characterises the onset of this rare disorder.

Child, Preschool↗

[Oral manifestations of acute leukemia].

It is well known that non-specific mucosal alterations can occur during diseases of the leukopoetic system. In most cases they are an early sign and therefore provide the opportunity for timely diagnosis of the disease. In this clinical study type and frequency of oral lesions, gingival and periodontal indices, and hematologic status were examined at the time of diagnosis of the different types of acute leukemia. The results showed a significant difference in the frequency of oral lesions between acute myelogenous and acute lymphoblastic forms, irrespective of age and sex of the patient. There was no correlation between type and frequency of lesions and hematologic status.

Adult↗

Neurofibromatosis: oral and radiographic manifestations.

Oral manifestations of neurofibromatosis have been reported in only 4% to 7% of affected persons. All oral tissues, hard and soft, have been reported to be affected with tumors, but the tongue has been the most common site. We report on the oral and radiographic findings in twenty-two patients with neurofibromatosis. The prevalence of oral and radiographic findings in our sample was 72%, which is much higher than previously reported. The five most common findings are oral neurofibromas, enlarged fungiform papillae, intrabony lesions, wide inferior alveolar canals, and enlarged mandibular foramina.

Adolescent↗

[Oral manifestations in gastroesophageal reflux disease].

The gastroesophageal reflux (passage of gastric contents into the oesophagus and the mouth) is the main sign/symptom of a very frequent gastroesophageal reflux disease. Thus, acid regurgitation originates from stomach and it is responsible of the onset of typical symptoms and mucosal injury. Also in oral cavity the noxious acid agent is able to injury oral cavity (soft and hard tissues). These effects are described from international literature, even if a greater interest has shown to date only for hard tissue injury.

Gastroesophageal Reflux↗

Oral manifestations of diabetes.

Periodontal disease, a microvascular complication of diabetes mellitus, is a group of infections and lesions affecting the tissues that form the attachment apparatus of a tooth or teeth. An individual with uncontrolled diabetes will have an increased risk of infection and abnormal healing time that will compromise the health of the oral cavity. A collaborative team approach between the home care clinician and dental professionals results in accurate patient assessment and education that results in better overall health outcomes.

Diabetes Mellitus↗

Oral manifestations in myelodysplastic syndrome. Review of the literature and report of a case.

Gingival hyperplasia in a patient with myelodysplastic syndrome is described. Gingival infiltration was the first sign of acceleration of a stable disease process and was followed by development of a more aggressive phase of chronic myelomonocytic leukemia that was not responsive to therapy. Oral and dental assessment of patients with the myelodysplastic syndromes should be a part of routine management.

Aged↗

Meth mouth: a review of methamphetamine abuse and its oral manifestations.

Illicit methamphetamine use is reported widely by news media and discussed increasingly among scholars, clinicians, and members of civic and law enforcement organizations and legislative bodies. This article examines the phenomenon of methamphetamine abuse, including its extent, its effects on both users and society, and its implications for dentistry. Meth mouth refers to a pattern of oral signs and symptoms of methamphetamine abuse, thought to include rampant caries and tooth fracture, leading to multiple tooth loss and edentulism.

Central Nervous System Stimulants↗

Oral manifestations of cyclic neutropenia in a Japanese child: case report with a 5-year follow-up.

Cyclic neutropenia is an uncommon hematologic disorder characterized by a marked decrease in the number of neutrophils in the peripheral blood occurring at regular intervals. The neutropenic phase is characteristically associated with clinical symptoms such as recurrent fever, malaise, headaches, anorexia, pharyngitis, ulcers of the oral mucous membrane, and gingival inflammation. This case report describes a Japanese girl who has this disease and suffers from periodontitis and oral ulceration. Her case has been followed up for the past 5 years from age 7 to 12. The importance of regular oral hygiene, careful removal of subgingival plaque and calculus, and periodic and thorough professional mechanical tooth cleaning was emphasized to arrest the progress of periodontal breakdown. Local antibiotic application with minocycline ointment in periodontal pockets was beneficial as an ancillary treatment, especially during neutropenic periods.

Child↗

Opitz (BBB/G) syndrome: oral manifestations.

We studied a new case of the G (Opitz BBB/G) syndrome in a 12-year-old boy. Several relatives had partial manifestations of the disorder. A comprehensive dental evaluation of the propositus was conducted; included is, to our knowledge, the first published cephalometric analysis of a G syndrome patient. We reviewed 139 cases of the G syndrome; 48 of them had at least one oral abnormality. These included clefting, micrognathia, ankyloglossia, and high-arched palate. Male G syndrome patients are more likely to have oral anomalies than affected females.

Abnormalities, Multiple↗

Olmsted syndrome--a rare syndrome with oral manifestations.

Olmsted syndrome is a rare, congenital condition characterized by severe palmo-planter keratosis, periorificial keratosis, and hypotrichosis. Though orofacial keratosis is one of the consistent findings of Olmsted syndrome, it has never been reported in the dental literature. We report a case of Olmsted syndrome in an eight-year-old boy who presented with massive and crippling palmoplanter keratosis and bilateral oral lesions in the form of keratotic plaques at the corners of the mouth, as well as on the dorsum of the tongue.

Child↗

[Detection of human papillomavirus (HVP)-DNA in oral manifestation of lichen planus].

Human papilloma viruses (HPV) can be detected in different epithelia with the help of the polymerase chain reaction (PCR). The role of HPV in the development of anogenital cancers has been intensively studied, and current evidence shows that most cervical cancers are associated with so-called high risk HPV types (e.g. HPV 16 and 18). HPV-infections can also be demonstrated in oral premalignant lesions and squamous cell carcinomas. Depending on the sensitivity of the detection method, 40-67% of leukoplakias, 2.5-76% of squamous cell carcinomas and 0-87% of cases of lichen planus were described to be infected with HPV 16 or 18. Whether lichen planus can be considered as a premalignant lesion is still controversial. By the use of PCR and hybridization we found infections with the high risk HPV types 16, 18 and 31 in 42% (3/7) of the patients with lichen planus. Further investigations with a higher numbers of cases in combination with the analysis of the viral gene expression as well as the clinical and histological control of the corresponding regions are necessary. The aim of these studies is to find out the prognostic value of the HPV infection for this facultative premalignant disease.

DNA Probes, HPV↗

Oral manifestations of papular-purpuric 'gloves and socks' syndrome due to parvovirus B19 infection: the first case presented in Greece and review of the literature.

Papular-purpuric 'gloves and socks' syndrome (PPGSS) is a novel, rare, self-limited dermatosis initially described in 1990. It is characterized by painful, pruritic edema and erythema, rapidly evolving to papular-purpuric lesions on the distal extremities, in a gloves-and-socks distribution, accompanied by fever and oral lesions such as petechiae, vesiculopustules and small erosions. Parvovirus B19 has been implicated in most cases as the etiological factor. Herein we present the first case of PPGSS in a 42-year-old Greek man with von Willebrand disease. On admission the patient was febrile, and presented acral edema and erythema rapidly followed by purpuric lesions on the same sites, and palatal petechiae. Complete remission of the exanthem occurred 7 days after hospitalization. Clinical and laboratory evaluation including serologic tests and PCR, confirmed the presence of parvovirus B19. Review of the existing literature on this novel syndrome and its association with parvovirus B19 is also presented.

Adult↗

[Oral manifestations during herpes virus infection. Case report].

The infections due to herpes viruses are widely spread, people being every day at high risk of contamination starting early age. The characteristic of the herpes virus infection consists of a symptom less evolution following the prime infection. As for any other herpetic infection, episodes infection exacerbation is due to some determining factors. Clinical symptom in herpes virus infection varies according to the virus type, age of the patient and site. Oral signs and symptoms are numerous, extremely intense and often, difficult to diagnose. Progressing in so many ways and being diagnosed and treated by so many medical specialties it is difficult to evaluate the actual number of cases. Consequently it is mandatory to train dentists in order to be able to accurately diagnose and treat the herpetic infection and to prevent nosocomial cross infections in dental office.

Acyclovir↗

Oral manifestations of Wegener's granulomatosis. Review of the literature and report of a case.

Wegener's granulomatosis (WG) is a rare granulomatous vasculitis which used to run a fatal course. At present, it is possible to control or sometimes even cure the disease with immunosuppressives. Successful treatment depends largely on early diagnosis. Based on a review of the literature, the diagnostic relevance of hyperplastic gingivitis (HG) is discussed. HG should be considered an early sign of WG in contrast to oral ulcers.

Aged↗