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PubMed1991

Gay identity and risky sexual behavior related to the AIDS threat.

This paper explores the relationship between risky sexual behavior and issues of gay identity in homosexual men. We identify three main conceptual categories important to gay identity: sexual identity, gay social interaction, and identity development milestones. Each of these categories are analyzed as to their predictive effect on risky sexual behavior related to the threat of HIV, at six-month and eighteen-month intervals. The results suggest that successful integration into a gay network plays a role in reducing risky sexual behavior among homosexual men, regardless of the chronological timing of personal events marking a gay man's "coming out" history.

Acquired Immunodeficiency Syndrome↗

PubMed1999

Sexual offending and antisocial sexual behavior among patients with schizophrenia.

BACKGROUND: A number of studies have indicated excessive offending behavior among people with schizophrenia; however, sexual offending has not been widely described. METHOD: This study reports on a subgroup of 15 men with schizophrenia, diagnosed according to ICD-10 guidelines, in a secure hospital who had committed sexual offenses or shown antisocial sexual behavior. A comparison group comprised 55 male patients with schizophrenia and a history of violent behavior who were being treated in the same hospitals as the study group. RESULTS: In 12 of the 15 cases, the sexual offending/behavior postdated illness onset and occurred in the context of psychotic symptoms. Although 12 of the offenders were known to psychiatric services, contact was erratic and only 4 were taking medication. At assessment, those with sexual offenses or antisocial sexual behavior were twice as likely as the larger study sample to report unimpaired sexual interest. This may be of particular relevance in that the group also reported difficulty in forming close personal relationships. CONCLUSION: Illness-related factors appear to make an important contribution to sexual offending by this group of patients, highlighting the need for comprehensive and vigorous treatment.

Adolescent↗

PubMed1981

Cholinergic influences on estrogen-dependent sexual behavior in female rats.

The ability of cholinergic agents to influence hormone-dependent sexual behavior in female rats was examined. In the first experiment, female sexual behavior, indicated by the incidence of lordosis, was significantly increased in estrogen-treated female rats following bilateral infusion of a cholinergic receptor agonist, carbachol (.5 microgram/cannula), into the medial preoptic area of the brain. Infusion of an artificial cerebrospinal fluid vehicle failed to facilitate lordosis. The incidence of lordosis was normally highest 15 min after carbachol infusion, began to wane by 45 min, and had returned to control levels by 90 min. Further, centrally administered carbachol activated lordosis at lower levels of estrogen priming than did systemically administered progesterone. In a second experiment, female rats, brought into sexual receptivity by administration of estrogen and progesterone, received preoptic infusions of an acetylcholine synthesis inhibitor, hemicholinium-3. Significant reductions in the incidence of lordosis were observed following bilateral infusion of hemicholinium-3 (1.25 microgram/cannula). This inhibition of lordosis was prevented when carbachol (.5 microgram/cannula) was infused along with hemicholinium-3. Results confirm the importance of cholinergic influences on sexual behavior in female rats.

Acetylcholine↗

PubMed1991

Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat.

The ability of dopamine (DA) receptor antagonists to disrupt anticipatory and consummatory measures of sexual behavior displayed by male rats in bilevel chambers was investigated. In Experiment 1, systemic administration of haloperidol, pimozide, and the D1 antagonist SCH 23390 reduced the number of anticipatory level changes (LC) displayed during a 5-min period before the introduction of a sexually receptive female, increased the mount and intromission latencies (ML and IL), and decreased the number of intromissions before ejaculation (NI) and the total number of ejaculations (NE). The dosages of these drugs required to reduce the LC were lower than those required to increase the ML or IL. Clozapine and the D2 antagonist sulpiride reduced the LC and increased the IL at comparable dosages, although neither drug affected the NI or NE. High dosages of haloperidol, pimozide, and clozapine delayed or abolished level changing and the initiation of copulation. In Experiment 2, bilateral infusions of haloperidol into the nucleus accumbens reduced the LC but did not affect consummatory measures of copulation, whereas bilateral infusions into the dorsal striatum increased the NE. Midline infusions of haloperidol to the medial preoptic area (MPOA) produced nearly all the effects of systemic administration, including a reduced LC, increased ML and IL, a decreased NI, and a decreased NE. These results indicate that both anticipatory and consummatory measures of sexual behavior were disrupted by DA receptor antagonists; however, the measure of anticipatory sexual behavior was more sensitive to disruption than consummatory measures of copulation. DA in the nucleus accumbens and MPOA may be involved in the control of anticipatory sexual behavior, whereas in the MPOA it may also be involved in the initiation of copulation and copulatory rate.

Animals↗

PubMed2004

[Study on the relationship between hepatitis C virus infection and sharing injection equipment, sexual behavior among injecting drug users].

OBJECTIVE: To study hepatitis C virus (HCV) transmission through different modes of sharing injection equipment and sexual behavior among injecting drug users (IDUs) in Liangshan of Sichuan province. METHODS: A community-based survey was conducted to investigate past and current demographic data, injection equipment sharing patterns and sexual behavior of IDUs. Blood samples were also taken to test for HCV. The survey was conducted between Nov 8 and Nov 29, 2002. 379 subjects were screened through outreach recruitment and peer informing. SPSS (11.5) was used for data analysis. RESULTS: HCV prevalence was 71.0% (269/379). Needles or syringes sharing in the past three months and past syphilis infection were strongly associated with HCV transmission after univariate analysis using chi-square test. Trend analysis indicated that HCV infection rate increased along with the increase of needles or syringes sharing, sharing of rinse water and the number of peers sharing the equipments. Data from multivariate logistic regression showed that sharing of needles or syringes and history of syphilis infection were significantly associated with HCV transmission. No significant difference was found between HCV infection and sexual behavior after univariate analysis using chi-square test. CONCLUSION: Further sero-epidemiological prospective cohort studies should be conducted to clarify the relationship between different modes of sharing injection equipment, sexual behavior and HCV infection.

Adult↗

PubMed2002

Health-seeking and sexual behaviors among primary healthcare patients in Nairobi, Kenya.

BACKGROUND: Health-seeking and sexual behaviors are important elements in the control of sexually transmitted infections (STIs). GOAL: To examine patterns of health-seeking behavior and related sexual behavior relevant to improved prevention and care among patients attending primary healthcare (PHC) clinics. STUDY DESIGN: A questionnaire covering social, demographic, and healthcare-seeking and sexual behavior information was administered to 555 patients attending three primary healthcare clinics in low socioeconomic areas of Nairobi, Kenya. RESULTS: Women's knowledge about health in general and STIs in particular was poor. A major gender difference in delay of health seeking for STIs was observed (5 days for men versus 14 days for women). Significantly more men than women reported a history of STIs (68% versus 47%; P = 0.04). Men reported more extramarital affairs (17% versus 8%; P < 0.001). A high prevalence of gonorrhea (3%) and chlamydia (6%) was found in this population, with no difference between the genders. The urine dipstick was ineffective for the detection of these STIs. CONCLUSIONS: There is a need for better understanding of behavioral factors, as well as gender and social aspects of health care. Health education and health promotion in these areas should be strengthened. Improved screening tests are needed for the detection of STI.

Adolescent↗

PubMedDate not supplied

Psychoactive drugs and human sexual behavior: the role of serotonergic activity.

A wide range of both prescription and nonprescription drugs has been reported to affect human sexual functioning. While the sexual side effects resulting from drug use have often been attributed to adrenergic, anticholinergic or dopaminergic activity, the present review considers the potential role of serotonin. Based on animal studies, serotonin has been shown to either facilitate or inhibit sexual activity depending on which serotonin receptor subtype is activated. However, few studies have been done in the human that assess the effects of drugs that bind selectively to serotonin receptors. Consequently, little is known about the role of serotonin in human sexual functioning. In this review, a wide range of drugs that affect both brain serotonergic systems and human sexual behavior is examined in an effort to determine the possible role of serotonin in human sexual behavior. A review of the literature is consistent with the hypothesis that the 5-HT1A and the 5-HT2 receptor subtypes play a facilitatory role in human sexual behavior. The evidence suggests that drugs that act as agonists on these receptor sites enhance sexual functioning in the human, while those that act as antagonists inhibit sexual functioning.

Animals↗

PubMedDate not supplied

Can we get people to participate in a study of sexual behavior?

BACKGROUND AND OBJECTIVES: Interpreting the results of any study requires careful analysis to determine how selective participation may have influenced the findings. Participation in a study of sexual behavior may be influenced by who is doing the study, who the participants are, what it means to participate, what the study involves, and what is meant by sexual behavior. GOAL OF THIS STUDY: Identify potential sources of bias that could be detected by asking the question "Can we get people to participate in a study of sexual behavior?" STUDY DESIGN: Review of important examples of participation bias from the literature. Examination of a convenience sample of key studies of sexual behavior to see how they have addressed participation-related issues. RESULTS: There are many examples of studies where misleading results were caused by participation bias. Many key studies of sexual behavior did not address fully the potential impact of selective participation. CONCLUSION: No study is completely without participation bias. Understanding potential sources of bias is essential when designing a study or interpreting the results.

Data Collection↗

PubMed1990

Progesterone inhibition of sexual behavior is accompanied by an activation of aggression in female Syrian hamsters.

Previous studies have shown that progesterone can have biphasic activational and inhibitory roles in the regulation of sexual behavior in female Syrian hamsters. The purpose of this study was to determine whether these biphasic effects on sexual behavior are mirrored in a reciprocal regulation of aggression. Ovariectomized female Syrian hamsters were treated with estradiol followed 2 and 3 days later by either 1) two oil injections (O-O), 2) an oil and a progesterone injection (O-P), 3) a progesterone and oil injection (P-O), or 4) two progesterone injections (P-P). Females were tested for aggression and sexual behavior in conjunction with these hormone treatments. On the final test session, P-P females had significantly lower lordosis durations than did O-P females, confirming the progesterone inhibition of sexual behavior previously reported. Without hormone treatment all females showed high baseline levels of aggression. On the last behavioral test, aggression in O-O females and P-O females was comparable to their baseline levels of aggression. In contrast, aggression in P-P females was significantly higher than the baseline levels of aggression. These results suggest that like its effects on sexual behavior, progesterone can have both inhibitory and activational effects on aggression in female Syrian hamsters.

Aggression↗

PubMed1999

Cytokines inhibit sexual behavior in female rats: II. Prostaglandins mediate the suppressive effects of interleukin-1beta.

The proinflammatory cytokine interleukin-1 (IL-1) induces several behavioral alterations that are characteristic of illness, such as anorexia and reduced locomotor and social activity. We have recently demonstrated that IL-1 inhibits sexual activity, motivation and attractivity in female, but not in male rats following either central or peripheral administration. In the present study we examined the involvement of prostaglandin (PG) synthesis in mediating IL-1-induced suppression of female sexual behavior. Administration of the cyclooxygenase blockers indomethacin or ibuprofen completely prevented IL-1-induced suppression of female sexual behavior, including the reduction in proceptive behavior, the lordosis response to a male's mounts, and the preference for a sexually active partner. In a subsequent study, ex-vivo release of hypothalamic PGE2 and the secretion of corticosterone (CS) were measured in males and estrous females following IL-1 administration. At the same time and dose of IL-1 administration that significantly reduced sexual behavior in female but not male rats, IL-1 produced a significant increase in PGE2 release in female, but not in male rats. In contrast, IL-1 induced a significant elevation of serum CS levels in males but not in females. These findings suggest that PG synthesis is involved in mediating the effects of IL-1 on female sexual behavior. Furthermore, differential secretion of PGs and CS may underlie the gender difference in the effects of IL-1 on sexual behavior.

Animals↗

PubMedDate not supplied

Prepubertal genital grooming and penile erections in relation to sexual behavior of rats.

The development of genital grooming (GG) and spontaneous penile erections (SPE) was evaluated in socially housed male rats from 25 to 47 days of age, and their sexual behavior was tested from 42 to 74 days of age. GG was the first behavior that appeared (27 days of age) prior to SPE (44 days of age). The values of frequency and duration of GG and SPE showed a gradual increase as puberty was reached. The mean age in which copulatory responses were first observed were: 54.5 days of age for mounts, 55 days of age for intromission and 59 days of age for ejaculation. The proportion of GG bouts that were followed by SPE showed a gradual increase throughout the recording days. A high correlation was found between the early onset and higher frequency of GG and an early onset of sexual behavior. Similarly, higher frequency and/or longer duration of SPE were correlated with an early onset and a better performance of sexual behavior. These results are consistent with previous studies, which suggest an important role of GG on the manifestation of sexual behavior; moreover, considering the high correlation between the occurrence of SPE and sexual behavior, it is possible that, as GG, SPE play an important role in the readiness of adult male rats for reproduction.

Animals↗

PubMed1978

Androgenic influences on feminine sexual behavior in male and female rats: defeminization blocked by prenatal antiandrogen treatment.

The prenatal influence of androgen on the development of female sexual behavior in rats was investigated. The nonsteroidal antiandrogen, flutamide (4'-nitro-3'-trifluoromethylisobutyrylanilide; SCH), was administered to pregnant female rats from days 10--22 of gestation in dosages of either 1 mg/mother-day or 5 mg/mother-day. Males and females were gonadectomized in adulthood and tested for the display of lordosis in response to estradiol benzoate (EB) alone or EB with progesterone (P). Males exposed prenatally to either the 1- or 5-mg dosage of flutamide exhibited significantly higher lordosis quotients than controls when given EB alone. The addition of P was without effect in all male groups with regard to estrogen-induced lordosis. Females exposed prenatally to flutamide had significantly higher lordosis quotients than controls when given either 0.175 or 0.25 micrograms EB daily for 3 days. Addition of P to EB treatment significantly facilitated lordosis display in control and flutamide-treated females. The increase of feminine sexual behavior in both males and females of feminine sexual behavior in both males and females resulting from prenatal antiandrogen treatment suggests that androgen, prenatally, inhibits development of female sexual behavior. This androgenic inhibition of sexual receptivity (defeminization) seems to be related to the animal's sensitivity to estrogen in adulthood.

Anilides↗

PubMedDate not supplied

Effect of two brain serotonin depletors on the sexual behavior of male rats.

We tested the effects of p-chlorophenylalanine (pCPA) and p-bromomethylamphetamine (V 111) on the homosexual and heterosexual behavior of male rats. We found that the two compounds affect differently the sexual behavior of sexually active, sluggish and inactive males. pCPA and chronic V 111 treatment stimulate the sexual activity in sexually sluggish males. In sexually inactive males only pCPA proved to be effective. The situation is similar in inducing homosexual behavior. In sexually active males pCPA does not increase the number of ejaculations. Acute V 111 treatment inhibits the copulatory behavior in sexually active males but a tolerance develops to this inhibitory effect. We concluded that V 111 acts on the serotonergic system in other way than pCPA does.

Animals↗

PubMedDate not supplied

Age at first coitus. A marker for risky sexual behavior in women.

This study examines whether riskier sexual behavior or duration of sexual experience explains why women who become sexually active earlier in life have a higher prevalence of sexually transmitted disease (STD). Responses to a self-administered questionnaire on risk behavior from 4,342 single women attending Planned Parenthood clinics in Pennsylvania were analyzed. Logistic regression was used to control for years of sexual activity, race, and amount of education. Women who became sexually active between the ages of 10 and 14 years were almost 4 times more likely to report having 5 or more sexual partners in the past year (OR = 3.8; 95% CI = 2.6-5.6); 3 times more likely to report having sex with bisexual, intravenous drug-using, or human immunodeficiency virus (HIV)-infected men (OR = 3.5; 95% CI = 2.4-5.0); and twice as likely to report a history of STD within the last 5 years (OR = 2.3; 95% CI = 1.8-3.0) compared with women who became sexually active when they were 17 years of age or older. The analysis suggests that age at first intercourse is a useful marker for risky sexual behavior and history of STD.

Adolescent↗

PubMed1988

Hormonal correlates of sexual behavior in the female musk shrew: the role of estradiol.

Plasma levels of several steroid hormones in the female musk shrew, (Suncus murinus), are reported along with experiments on the causational role steroids play in female sexual behavior. Gonadally intact females sampled directly after a brief (about 7 minutes on average) sexual interaction with a male had equivalent plasma levels of estradiol (E2) but significantly higher plasma progesterone (P4) levels than resting females. In Experiment 2, females that engaged in nonsexual activities with conspecifics other than gonadally intact males had plasma levels of E2 and P4 equivalent to those of females that engaged in sexual behavior with males. Taken together, the results of these two experiments suggest that the relatively higher levels of plasma P4 noted in active musk shrews is not a response specific to sexual interactions with males. In Experiment 3, ovariectomized musk shrews were treated with E2 implants. These tonically administered physiological doses of E2 were not able to activate sexual behavior. However, two steroid-sensitive reproductive target tissues, the cervix and flank pad, were responsive to E2 treatment. Supplemental injections of P4 given to E2 treated ovariectomized females were also ineffective in restoring sexual behavior. These results suggest that physiological doses of E2 do not have direct effects on the expression of female sexual behavior in this mammalian species.

Androgens↗

PubMed1985

AIDS and sexual behavior reported by gay men in San Francisco.

In November 1983, we surveyed 655 gay men in San Francisco regarding their sexual practices during the previous month and the same month one year ago. The sample was selected to include men in situations that would lead to high risk of sexual activities related to AIDS (acquired immune deficiency syndrome) transmission (i.e., men frequenting bathhouses and gay bars) as well as men in low-risk situations (those going to neither place and men in primary relationships). The Bath group showed little change in frequency of bathhouse use and in number of sexual partners from that location. The other groups showed substantial reductions in frequency of sexual contacts from bars, baths, T-rooms, or parks. Men in monogamous relationships showed little change in sexual behavior within their relationship. Men in non-monogamous relationships and men not in relationships reported substantial reductions in high-risk sexual activity, but not a corresponding increase in low-risk sexual behavior. Knowledge of health guidelines was quite high, but this knowledge had no relation to sexual behavior. Using sex to release tension, use of sex to express gay identity, and knowledge of persons with AIDS in the advanced stages of disease were related to frequency and type of sexual behavior.

Acquired Immunodeficiency Syndrome↗

PubMed1992

High-risk sexual behaviors of intravenous drug users in- and out-of-treatment: implications for the spread of HIV infection.

This paper examines the sexual behaviors of 255 intravenous drug users (IVDUs) to assess the potential for the sexual transmission of HIV and to examine differences in sexual behaviors between in- and out-of-treatment IVDUs. In-treatment subjects (N = 152) were a random sample of clients at a large, publicly funded methadone maintenance program. Out-of-treatment subjects (N = 103) were recruited through a chain referral technique, using the in-treatment subjects. Forty-five percent of the study subjects reported multiple partners and 32% reported exchanging sex for money or drugs in the preceding 6 months. Fifty-three percent reported no use of condoms. After controlling for demographic differences between the in- and out-of-treatment groups, out-of-treatment IVDUs reported significantly more partners than in-treatment IVDUs (4.6 vs 2.3, significant t < 0.01), and more often had exchanged sex for money or drugs (44 vs 26%, relative odds 1.8, p < .05). In- and out-of-treatment subjects did not differ with respect to condom use. We conclude that IVDUs both in- and out-of-treatment continue to be at risk of contracting and spreading HIV infection through sexual behaviors, and that being in drug treatment is associated with a lower incidence of high risk sexual behaviors.

Acquired Immunodeficiency Syndrome↗

PubMed1994

Sexual behavior of American adolescents: results from a U.S. national survey.

PURPOSE: This paper reports on data from a 1990 U.S. national survey of the sexual behavior of male and female adolescents aged 12-17. METHODS: A household survey using a multi-stage area probability sample of the United States was undertaken in 1990. Adolescents were interviewed about sexual history, contraceptive use, and motivations, attitudes, and expectations with regard to sexual behavior and risk. RESULTS: The majority of 17-year-olds and about half of 16-year-olds, both male and female, had initiated sexual activity, with males initiating at younger ages than females. Sexual activity was episodic; only half of sexually experienced adolescents reported having sex in the month prior to the interview. Many sexually active respondents expressed less desire to have sex than confidence that they would have sex. Over half of respondents reported using a condom at most recent intercourse, with boys being more likely than girls to report condom use. Condom use at last intercourse was unrelated to perceptions of risk and concern about AIDS. CONCLUSIONS: Given the importance of some of the undesirable consequences of sexual activity in adolescents, such as AIDS and unwanted pregnancy, accurate and up-to-date information on sexual behavior of this age group is crucially important. The results of this study underscore the need for in-depth, population-based research on adolescent sexual behavior.

Acquired Immunodeficiency Syndrome↗