PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “BRAIN DISEASE”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 559 records · Page 31Linked to original sources
PubMed1988

The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain.

The monoclonal antibody, Alz 50, is known to label many dystrophic neurites and neurofibrillary tangles in Alzheimer's disease (AD) brain. Using immunoprecipitation and immunoblotting, we have compared Alz 50 to monoclonal antibodies directed at two known components of neurofibrillary tangles, tau and ubiquitin, in order to characterize further the antigens recognized by Alz 50 in AD brain. Alz 50 labeled purified tau proteins in a highly similar fashion to two well-characterized tau monoclonal antibodies. Alz 50 precipitated proteins at the molecular weight of 50-70 kDa from AD but not normal brain; these proteins were reactive with the tau antibodies. In addition, Alz 50 precipitated proteins migrating principally around 160-180 kDa from AD but not normal brain; the relationship of the latter proteins to tau remains unclear. None of these proteins reacted with a ubiquitin antibody. We hypothesize that the proteins recognized by Alz 50 at much higher levers in AD than normal brain include modified and aggregated forms of tau.

Alzheimer Disease↗
PubMed1985

[Variants of personal reactions to disease and features of the social-occupational adaptation of patients with neurosis-like forms of organic brain disease (from the findings of a multi-year follow-up study)].

The author analyzes the findings of a long-term follow-up of 70 patients with neurosis-like forms of organic diseases of the brain (arachnoiditis, encephalitides, diencephalitides). The time-course was evaluated by the clinical improvement and by the improvement in the patient's social functioning. Three groups of patients were identified with regard to a definite type of the personal response to the disease and to specific features of social and occupational adaptation. It was demonstrated that the distribution of patients into groups and thus their clinical and socio-occupational prognosis was largely determined by the psychogenic-neurotic component of the illness rather than by the severity of the organic lesion.

Adaptation, Psychological↗