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At least 559 records · Page 31Linked to original sources
PubMed1999

Quantitative posturagraphy as an alternative noninvasive tool for alcohol/drug/chemical testing--preliminary thoughts.

This article provides preliminary ideas regarding how the quantitative posturagraphy technique can be used as an alternative noninvasive tool to currently available blood/urine test for alcohol/drug/chemical exposure. It is argued that the urine or blood level of any chemical is highly dependent on the individual's metabolism without providing any insight into individual's task performance abilities under exposure to neurotoxic chemicals. On the other hand, the quantitative posturagraphy if carried out as proposed in this article will provide quantitative data regarding individual's ability to maintain "safe" upright balance while carrying out certain tasks. The proposed evaluation method is simple, portable, quick, and noninvasive and has been found to be sensitive to detecting low level solvent induced modifications in postural stability.

Ethanol↗
PubMed1991

Effects of various dietary cation-anion balances on response to experimentally induced hypocalcemia in sheep.

We examined the effect of dietary cation-anion balance on bone Ca mobilization, measured by challenging wethers with a 5.6% EDTA infusion at a rate of 1.4 ml kg of BW-1. Dietary cation-anion balance was calculated as milliequivalents [(Na + K) - (Cl + S)]. Six crossbred wethers (average BW, 67.8 kg) were fed rations with high Ca (.74% dry basis) or normal Ca (.45%) and three different dietary cation-anion treatments, which differed in their mineral supplementation. Dietary cation-anion balances were 354, 125, and 32 meq kg of DM-1 for control and two treatments. A 6 x 4 incomplete Latin square design (six treatments, four periods) was used with five 15-d periods of 14 d of adaptation followed by 1 d of EDTA infusion. Concentrations of total and EDTA titratable plasma Ca were not affected by the level of dietary Ca or treatments. The decrease in plasma EDTA titratable Ca at conclusion of EDTA infusion (120 min) was least in wethers fed the lowest cation-anion balance within high Ca, and recovery of plasma EDTA titratable Ca during the 240-min postinfusion period was faster for sheep fed this diet than for the control. The amount of Ca mobilized and its rate of mobilization during the EDTA infusion period tended to be higher for diets with reduced cation-anion balances than for the control. Thus, reducing cation-anion balance increased the sheep's ability to mobilize Ca during hypocalcemia.

Acute Disease↗
PubMedDate not supplied

Let first-level supervisors do their job.

Performing well as a first-level supervisor is like walking the circus high wire. In both positions, the ability to maintain one's balance when shifting forces pull in opposite directions is a measure of one's success. First-level supervisors must be able to harmonize the demands of management, the demands of the collective work force (often represented by unions), and the demands of workers with the requirements for doing the tasks at hand. These needs are more often than not conflicting and even at times mutually exclusive. First-level supervisors usually have mixed emotions about their situation and often lose their sense of identity as they try to perform this precarious balancing act. Today these supervisors are part of management, but chances are they were once among the employees they are now trying to supervise. Although first-level supervisors have the responsibility for implementing the goals of upper management, their organizational authority to carry out the necessary actions is frequently unclear and often insufficient. By allowing these lowest-level managers to use the levers of influence inherent in their position, higher-level managers will be improving the performance of the whole organization.

Administrative Personnel↗
PubMed1999

Development of a draft British standard: the assessment of heat strain for workers wearing personal protective equipment.

Existing methods for estimating heat stress, enshrined in British/International Standards (the Wet Bulb Globe Temperature (WBGT) index [BS EN 27243] and the Required Sweat Rate equation [BS EN 12515; ISO 7933 modified]), assume that the clothing worn by the individual is water vapour permeable; the WBGT index also assumes that the clothing is relatively light. Because most forms of personal protective equipment (PPE) either have a higher insulative value than that assumed or are water vapour impermeable, the Standards cannot be accurately applied to workers wearing PPE. There was, therefore, a need to develop a British Standard which would allow interpretation of these existing Standards for workers wearing PPE. Relevant information was obtained through reviewing the literature and consulting experts. Two questionnaire surveys of potential users of the Standards were conducted, and physiological data collected both experimentally and in work situations were considered. The information collected was used to develop the draft British Standard. It provides information and data on: The general effect of PPE on heat balance of the body (the ability of the body to maintain its 'core' temperature within an acceptable range). The effect of specific forms of PPE on metabolic heat production rate. The thermal insulation and evaporative resistance of types of PPE. The effect of the closure of the garments to the body on heat transfer. The effect of the PPE on the proportion of the body covered. The effect of an air supply (for example, Breathing Apparatus [BA]) to the wearer. Guidance is given on conducting an analysis of the work situation, taking account of the impact of PPE. Detailed methods of interpreting both BS EN 27243 and BS EN 12515 for workers wearing PPE are given, taking account of the factors listed above. Three worked examples using BS EN 27243 and BS EN 12515 are given in the Annex of the draft Standard.

Body Temperature Regulation↗
PubMed1999

The effect of allergen immunotherapy on in vitro IL-4 and IFN-gamma production by peripheral mononuclear cells in house dust-sensitive Chinese patients with bronchial asthma.

The IFN-gamma produced by Th1 cells and IL-4 produced by Th2 cells are two most important cytokines in the regulation of IgE production. House dust immunotherapy has been tried in the treatment of house dust-sensitive Chinese asthmatic patients with good results. We examined the influence of such treatment on in vitro IL-4 and IFN-gamma production by peripheral blood mononuclear cells in house dust-sensitive asthmatic patients. Allergen immunotherapy in house-dust sensitive asthmatic patients can significantly decrease IL-4 production from peripheral mononuclear cells (p<0.05). The production levels of IL-4 in patients without treatment had higher levels than those in patients with hyposensitization (p<0.01). Such therapy also have some effect on promotion of IFN-gamma production in asthmatic patients. In conclusion, immunotherapy with house dust may have the potential ability to shift the Th1/Th2 balance of immune response to allergens and to create a favorable cytokine microenvironment to suppress the allergic reaction in the asthmatic airway.

Adolescent↗
PubMed1987

Population registers and population statistics.

The authors examine the use of population registers in the production of demographic statistics. "To do this, we first describe these registers; we then examine their further development as an independent source of population statistics--including current population estimates, vital and migration statistics--and as an alternative to population censuses. In conclusion, we consider a number of essential features of registers, including the original collection of data, the system's lifetime, privacy protection, and the government's ability to bring about a balance among conflicting interests regarding the collection and use of the data." The discussion is illustrated using examples from the Netherlands and Denmark.

Censuses↗
PubMed2003

The Stroke Rehabilitation Assessment of Movement (STREAM): a comparison with other measures used to evaluate effects of stroke and rehabilitation.

BACKGROUND AND PURPOSE: The Stroke Rehabilitation Assessment of Movement (STREAM) is a relatively new measure of voluntary movement and basic mobility. The main objectives of this study were: (1) to examine the relationship of the STREAM to other measures of impairment and disability and (2) to compare its usefulness for evaluating effects of stroke and rehabilitation and for assessing change over time with that of other measures of impairment and disability. SUBJECTS AND METHODS: The performance of 63 patients with acute stroke on the STREAM and other measures of impairment and disability was evaluated during the first week after stroke and 4 weeks and 3 months later. RESULTS: Scores on the STREAM were associated with scores on the Box and Block test, Balance Scale, Barthel Index, gait speed, and the Timed "Up Go" Test (with Pearson correlation coefficients ranging from .57 to .80) and were associated with categories of the Barthel Index and Balance Scale. The STREAM's ability to predict discharge destination from the acute care hospital, as well as to predict gait speed and Barthel Index scores at 3 months poststroke, was comparable to that of other commonly used measures. Standardized response mean estimates provided supporting evidence for the ability of the STREAM to reflect change over time. DISCUSSION AND CONCLUSION: The results obtained with the STREAM, as compared with other measures of impairment and disability in people with stroke, suggest that it may be useful in clinical practice and research.

Adult↗
PubMed2004

[The significance of free radicals and antioxidants due to the load induced by sport activity].

Sport performance is followed by a high production of free radicals. The main reasons are reperfusion after the previous imbalance between the increased need of the organism and the ability of blood supply by oxygen, increased production of ATP, decomposition of the cells particularly white blood cells, oxidation of the purin basis from DNA, stress, output of epinephrine release of free iron, increased temperature in the muscle and its inflammation, and the reception of free radicals from external environment. Peroxidation of lipids, proteins, DNA and other compounds follows the previous biochemical steps. Antioxidants are consumed by free radicals, antioxidative enzymes are released into blood plasma, intracellular calcium is increased, the production of nitric oxide rises, the levels of hydrogen peroxide and hypochlorous acid increase. These penetrate through the membranes and oxidatively damage the tissues. Training improves the ability of the organism to balance the increased load of free radicals. The damage can be lowered by the application of a mixture of antioxidants, the most important are vitamin C, A, E, glutathione, selenium, carnosine, eventually bioflavonoids and ginkgo biloba. The lack of antioxidants can significantly diminish the sport performance and therefore the supplementation with antioxidants is for top sportsmen but also for aged people advisable.

Antioxidants↗
PubMed1999

Modelling territorial behaviour of animals in variable environments.

We present an individual-based model describing the distribution and resource gain of territorial individuals in situations where the rank order of territory quality changes over time. The model integrates both competitive (territory-holding ability) asymmetries and a memory function. A balance of effects resulted in a peak in movement rates, but not resource gain, for individuals of intermediate ability. Furthermore, when the system was reduced to a linear array of territories (as commonly used in empirical studies) the model generated quite different predictions because of the severe limitation in movement that the linear array imposes. We suggest that the model can be used to generate testable predictions for territorial species such as salmonids, and that future empirical work should take into account the consequences of reductions in movement imposed by a linear array of territories. Copyright 1999 The Association for the Study of Animal Behaviour.

Journal Article↗
PubMed2002

Matrix metalloproteinases and the ontogeny of scarless repair: the other side of the wound healing balance.

Early gestation mammalian fetuses possess the remarkable ability to heal cutaneous wounds in a scarless fashion. Over the past 20 years, scientists have been working to decipher the mechanisms underlying this phenomenon. Much of the research to date has focused on fetal correlates of adult wound healing that promote fibrosis and granulation tissue formation. It is important to remember, however, that wound repair consists of a balance between tissue synthesis, deposition, and degradation. Relatively little attention has been paid to this latter component of the fetal wound healing process. In this study, we examined the ontogeny of ten matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in nonwounded fetal rat skin and fibroblasts as a function of gestational age. We used a semiquantitative polymerase chain reaction protocol to analyze these important enzymes at time points that represent both the scarless and scar-forming periods of rat gestation. The enzymes evaluated were collagenase-1 (MMP-1), stromelysin-1 (MMP-3), gelatinase A (MMP-2), gelatinase B (MMP-9), membrane-type matrix metalloproteinases (MT-MMPs) 1, 2, and 3, and TIMPs 1, 2, and 3. Results demonstrated marked increases in gene expression for MMP-1, MMP-3 and MMP-9 that correlated with the onset of scar formation in nonwounded fetal skin. Similar results were noted in terms of MMP-9 gene expression in fetal fibroblasts. These results suggest that differences in the expression of these matrix metalloproteinases may have a role in the scarless wound healing phenotype observed early in fetal rat gestation. Furthermore, our data suggest that the differential expression of gelatinase B (MMP-9) may be mediated by the fetal fibroblasts themselves.

Animals↗
PubMed2005

Methods for dynamic balance training during standing and stepping.

The regaining of walking ability is one of the main goals of rehabilitation following stroke. An important aspect of bipedal locomotion is efficient balancing of the trunk. In this article a novel methodology for dynamic balance training during standing and stepping is presented in a commercially available mechanical balance training device. A case study that lasted for two-weeks with two half-hour training sessions per day, involving a single subject with chronic hemiparesis, investigated the effects of the proposed dynamic balance training. Instrumented kinesiological evaluation of the subject's gait indicated important improvement in the subject's postural control during walking. Finally, the possibility of combining therapeutic functional electrical stimulation of selected lower extremity muscles with the methodology for dynamic balance training presented here is discussed.

Hemiplegia↗
PubMed2006

Effects of a group-based exercise program on functional abilities in frail older women after hospital discharge.

BACKGROUND AND AIMS: An acute illness may place older frail people at increased risk of losing independence in functional abilities. Physical exercise may reduce the risk by improving muscle strength and balance. However, the effects of physical training on functional abilities have not been studied among frail, very old people recovering from an acute illness. The aim of this study was to determine the effects of a group-based exercise program on their ability to carry out self-care (ADL) and instrumental activities (IADL) relevant to daily life after discharge from hospital. METHODS: This randomized controlled trial examined 68 community-dwelling women aged 75 years or older (mean age 83.0, SD 3.9) who were hospitalized due to an acute illness, and were mobility-impaired at admission. Participants were recruited from the geriatric ward of a primary-care health-center hospital, and were randomized into group-based strength training (n=34) and control (n=34) groups. The 10-week group-based intervention included strength training and functional exercises. The control group received instructions for a home exercise training program, including functional exercises but no further encouragement to exercise. The level of independence in ADL and IADL was evaluated, using a 13-item scale with stepwise grading from fully independent to fully dependent. Measurements took place immediately before and after the intervention, and three and nine months later. RESULTS: The intervention did not have any significant main effect (p = 0.407), nor was there any significant interaction between follow-up time and intervention (p = 0.854). CONCLUSIONS: The multicomponent outpatient strength training program did not improve autonomy in expert-evaluated ADL/IADL functions.

Activities of Daily Living↗
PubMed2000

Sex differences in mathematical reasoning ability at age 13: their status 20 years later.

Reported is the 20-year follow-up of 1,975 mathematically gifted adolescents (top 1%) whose assessments at age 12 to 14 revealed robust gender differences in mathematical reasoning ability. Both sexes became exceptional achievers and perceived themselves as such; they reported uniformly high levels of degree attainment and satisfaction with both their career direction and their overall success. The earlier sex differences in mathematical reasoning ability did predict differential educational and occupational outcomes. The observed differences also appeared to be a function of sex differences in preferences for (a) inorganic versus organic disciplines and (b) a career-focused versus more-balanced life. Because profile differences in abilities and preferences are longitudinally stable, males probably will remain more represented in some disciplines, whereas females are likely to remain more represented in others. These data have policy implications for higher education and the world of work.

Adolescent↗
PubMed1987

Effect of eye movements on dynamic equilibrium.

The purpose of this study was to determine whether visual improvement of balance varies depending on the movement of the eye. Three movements were compared: static visual fixations, saccadic eye movements, and smooth pursuit eye movements. The subjects in this study were 35 healthy female volunteers. Balance was defined as the subjects' ability to maintain their equilibrium while keeping the unstable platform on which they stood within 5 degrees of the horizontal plane. The testing protocol consisted of five recorded practice trials, during which the subjects tried to maintain their balance without any visual instructions, and nine experimental trials, during which they tried to maintain their balance while visually following a videotaped target light projected onto a screen. The target light was sequenced randomly to remain stationary, move in a continuous horizontal path, or alternately jump between right and left. Data were analyzed using a one-way multivariate analysis of variance for repeated measures. A significant effect of vision on balance was found. The t tests for correlated samples revealed that time in balance during visual fixations and saccades was significantly longer than during tracking eye movements. We, therefore, concluded that tracking eye movements have a negative effect on balance. This information can be useful in treating patients with balance problems. For example, instructing patients to fixate visually on an object may aid their stability. Visual tracking of a moving limb, however, may impair a patient's stability.

Adolescent↗
PubMed1998

Cognitive, perceptual, and motor abilities in skilled basketball performance.

The differences among athletes of differing skill should assist successful identification and selection of the best athletes in a specific sport. For the purpose of this study, a laboratory study was conducted with a group of 13 men on the elite male national team of basketball players, 22 to 23 years of age, and a control group of 15 men of equal age (physical education class) to assess differences in their scores on cognitive skills (memory-retention, memory-grouping analytic ability), perceptual skills (speed of perception, prediction, selective attention, response selection), and motor skills (dynamic balance, whole body coordination, wrist-finger dexterity, rhythmic ability). Analysis showed that elite male basketball players scored higher on hand coordination and lower on dynamic balance given their anthropometric measurements. Elite players were better on memory-retention, selective attention, and on prediction measures than the control group. The above skills are important in basketball performance. Researchers may examine whether other factors contribute more in the development of perceptual and cognitive skills.

Adult↗
PubMed1995

Blood pressure and fluid-electrolyte balance in ANF-transgenic mice on high- and low-salt diets.

Transgenic mice overexpressing an atrial natriuretic factor (ANF) fusion gene (TTR-ANF) and their nontransgenic siblings were placed on a high- (8%) or low (< 0.008%)-salt diet for 14 days to determine whether the lifelong elevation of ANF in the transgenic animals compromised their ability to maintain fluid-electrolyte balance. Steady-state dietary intake and urinary output of sodium and chloride were not statistically different between TTR-ANF and control groups on either diet. By contrast, water intake and urine volume were markedly elevated in the TTR-ANF group on either diet. Arterial blood pressure, measured in anesthetized mice at the end of the dietary regimen, was significantly and similarly reduced in the TTR-ANF compared with control groups on either diet, although high salt intake was associated with increased pressure in both groups. Renal excretion of fluid and electrolytes was studied in the anesthetized mice before and after acute blood volume expansion. Although the absolute increase in fluid and electrolyte excretion was much greater on the high- than on the low-salt diet in both groups, TTR-ANF mice had an exaggerated response relative to controls on either diet. On the basis of these results, we conclude the following. 1) When they are stimulated, renal salt-conserving mechanisms are sufficiently powerful to overcome the expected natriuretic effects of chronic elevation of plasma ANF; however, the natriuretic potential of ANF can be expressed in the short term when the counterregulatory mechanisms are inactivated. 2) ANF exerts a chronic hypotensive effect that is independent of changes in renal salt excretion.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1978

Oral contraceptive use alters the balance of platelet prostaglandin and thromboxane synthesis.

The ability of platelet microsomes to generate platelet aggregating activity on addition of arachidonic acid was evaluated in women taking oral contraceptives and in controls taking no medication but matched for age, sex, and family history. Oral contraceptive users generated significantly more platelet aggregating activity per 100 ug of platelet microsomal protein than controls. Variation in generation of platelet aggregating activity during the menstrual cycle was also observed with highest activity during the third week. These studies show an altered balance of platelet prostaglandin and thromboxane synthesis in oral contraceptive users which may contribute to their increased incidence of thromboembolic phenomena.

Adult↗