Intra-aortic balloon counterpulsation. Indications and long-term results in postoperative left ventricular power failure.
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Although the intra-aortic balloon pump (IABP) saves many lives, complication rates as high as 36% have been reported. Many of the complications require surgical attention. In 794 patients of the Massachusetts General Hospital in Boston, an IABP was inserted into either the femoral or iliac artery between Nov 1, 1968, and June 30, 1981. Eighty-seven major vascular complications occurred in 70 (8.8%) of them. Of those 70 patients, 95% denied previous symptoms of vascular disease, and 78% had had normal pulses before insertion. The two most common complications were limb ischemia (n = 36) and arterial trauma (n = 20). Other complications included sepsis (n = 14), wound problems (n = 10), and hemorrhage (n = 7). No limbs were lost. Analysis of each group of complications allowed specific conclusions to be drawn concerning prevention, early diagnosis, and the most appropriate treatment.
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Dynamic left ventricular outflow obstruction is associated with structural findings of asymmetric septal hypertrophy (less commonly concentric left ventricular hypertrophy) and systolic anterior motion of the anterior mitral valve leaflet. A patient who did not have this usual substrate for outflow obstruction presented with an acute anterior wall myocardial infarction complicated by congestive heart failure and cardiogenic shock. When an intra-aortic balloon pump was placed, the patient rapidly deteriorated and a dynamic outflow gradient was detected.
Intra-aortic balloon catheters have a central lumen able to accommodate dedicated 0.030" guidewires but not conventional 0.035" guidewires. Due to its extreme lubricity, the 0.035" hydrophilic "glidewire" fits into these catheters and is particularly useful in its stiff, angled version for femoral percutaneous insertion in patients with severe calcific iliac disease.
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Presented are the results of the use of the transfemoral approach for coronary arteriography, as a safe alternative to the brachial approach, in evaluating patients in cardiogenic shock. Five patients, each with an intraaortic balloon pump device in operation, were evaluated. No complications were encountered using the transfemoral approach.
The decline of the activated partial thromboplastin time (APTT) following discontinuation of heparin infusion was measured in six intra-aortic balloon pump (IABP) patients. The heparin infusion requirement was determined for eight other IABP patients during stable therapeutic anticoagulation. Following discontinuation of infusion, APTT declined with a relatively constant half-life (t 1/2 of 2.4 +/- 0.08 hr, suggesting elimination by first-order kinetics. In comparison, the t 1/2 following single bolus doses has been shown to be markedly dose dependent, increasing from 30 min at low doses to 2 hr at very high doses. The heparin requirement for IABP patients was found to be 16 +/- 2.5 U/kg/hr, similar to that reported for other clinical situations. The t 1/2 of the APTT following discontinuation of heparin infusion can be used to time invasive procedures that would best be done with normal hemostasis.
Flow velocity changes during multivessel angioplasty suggests that collateral flow has an important role in determining safety and ischemic threshold during these procedures. The physiology of collateral flow with and without intra-aortic balloon pumping has been demonstrated in this individual and provides insight into the mechanisms of reduced ischemia during high-risk coronary interventions.
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To determine the influence of IABP on infarct size and collateral blood flow in each of 12 openchest anaesthetised mongrel dogs two small branches of the left coronary artery were occluded consecutively. The perfusion areas of both branches were comparable in size. IABP was started immediately before ligation of the first branch for a 90-min period followed by a reperfusion period of 90 min. Subsequently the second vessel was also occluded for 90 min as a control without IABP while myocardial oxygen consumption remained constant and was then reperfused. Infarct size was expressed as a percentage of the perfusion area. A difference in infarct size with and without IABP (18 +/- 17, 18 +/- 10% respectively) could not be observed. However a significant increase of collateral blood flow due to IABP in the subendocardial layer from 8.9 +/- 4.8 to 14.9 +/- 4.6 ml/100 g/min (p less than 0.05) was prevalent. In the subepicardial layer the augmentation from 23.7 +/- 19.9 to 26.9 +/- 15.2 was not significant. Thus, in spite of a small increase of collateral blood flow in the subendocardial layer of the ischemic myocardium the infarct size was not reduced by IABP in our dog model.
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