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Critical care of the obstetric patient.

The obstetric patient poses exceptional challenges in the intensive care unit. Knowledge of the physiologic changes of pregnancy and specific pregnancy-related disorders is necessary for optimal management. Intensive care unit diagnoses may include preeclampsia, including the HELLP syndrome, pulmonary embolic disease, amniotic fluid embolism, status asthmaticus, respiratory infection, the acute respiratory distress syndrome, and sepsis. The management of mechanical ventilation is based on principles of avoiding lung injury, and hypercapnia may be tolerated even during the pregnancy. When the clinician is faced with the extraordinary instance of cardiopulmonary arrest, perimortem cesarean delivery must be considered to improve the potential for maternal and fetal survival.

Cardiopulmonary Resuscitation↗

Factors implicated in the outcome of pregnancies complicated by acute respiratory failure.

OBJECTIVE: To investigate factors predictive of the outcome of acute respiratory failure during pregnancy. STUDY DESIGN: We retrospectively reviewed the records of all pregnant women diagnosed with acute respiratory failure at a tertiary referral center from January 1, 1995, to September 30, 2000. Maternal characteristics, etiology of respiratory failure and treatment were compared between survivors and nonsurvivors. RESULTS: Twenty patients with acute respiratory failure were identified; 16 of them survived (mortality, 20%). Acute respiratory failure was diagnosed in the postpartum period in 16 (80%), and the majority of cases occurred in the first 2 postpartum days (93.8%). There was no statistically significant difference between the 2 groups in terms of patient characteristics, immediate precipitants of acute respiratory failure (including pneumonia, cardiogenic pulmonary edema, acute respiratory distress syndrome, asthma, pulmonary embolism and amniotic fluid embolism) and laboratory characteristics except for pH. However, patients who manifested disseminated intravascular coagulopathy (DIC) and sepsis as precipitating causes or complications of the immediate precipitating disease entities as well as initial loss of consciousness were predictive of poor maternal outcome. CONCLUSION: The immediate etiology of acute respiratory failure is not predictive of maternal outcome, but lower pH, initial loss of consciousness, DIC and sepsis are risk factors for maternal mortality.

Acute Disease↗

[Pathology of pulmonary embolism].

The incidence of pulmonary embolism was surveyed in 500 serial autopsy records (1984-1989) in Nagoya University Hospital. This disease occurred in 77 cases (15.4%) and acute fatal pulmonary embolism was the cause of death in 30 cases (6.0%). This incidence was higher than has previously been reported in Japan, and almost the same as the incidence reported is USA or Western Europe. Thromboembolism was the major cause of this phenomenon in our series. Thirty-four cases were thrombo-embolized. Venous thrombi in 15 cases resulted from intravenous catheter. Tumor emboli were observed in 18 cases, bone or soft part sarcomas in 6 cases, hepatocellular carcinomas in 6 and renal cell carcinomas in 3. Fungus emboli were observed in 19 cases. Aspergillus was the major cause of thrombi in 14 immunocompromised patients. Six typical cases (1. post traumatic thromboembolism, 2. fatal thromboembolism due to catheter, 3. tumor embolism, 4. fungal embolism, 5. amniotic fluid embolism and 6. bone marrow embolism) were discussed from the viewpoint of clinicopathology.

Adolescent↗

Non-haemorrhagic obstetric shock.

The causes of non-haemorrhagic obstetric shock (pulmonary thromboembolism, amniotic fluid embolism, acute uterine inversion and sepsis) are uncommon but responsible for the majority of maternal deaths in the developed world. Clinically suspected pulmonary thromboembolism should be treated initially with heparin and objective testing should be performed. If the diagnosis is confirmed, heparin is usually continued until delivery, following which anticoagulation in the puerperium is achieved with either warfarin or heparin. Amniotic fluid embolism is a rare complication of pregnancy, occurring most commonly during labour. The management of amniotic fluid embolism involves maternal oxygenation, the maintenance of cardiac output and blood pressure, and the management of any associated coagulopathy. Acute uterine inversion arises most commonly following mismanagement of the third stage of labour. The shock in uterine inversion is neurogenic in origin, although there may also be profound haemorrhage. The management of this condition includes maternal resuscitation and replacement of the uterus either manually, surgically or by hydrostatic pressure. Genital tract sepsis remains a significant cause of maternal death, the most common predisposing factor being prolonged rupture of the fetal membranes. The management of septic shock in pregnancy includes resuscitation, identification of the source of infection and alteration of the systemic inflammatory response.

Adolescent↗

Pulmonary microvascular cytology. A new diagnostic application of the pulmonary artery catheter.

When pulmonary disorders involve primarily the microvasculature, definitive diagnosis is difficult and, in some cases, is not possible until autopsy. In patients with amniotic fluid embolism, fat embolism, and lymphangitic carcinomatosis, terminal pulmonary arterioles and capillaries contain abundant diagnostic material. We hypothesized that withdrawal of blood from a pulmonary artery catheter, particularly in the wedge position, should recover diagnostic cells and debris in patients with these disorders. We describe the technique of pulmonary microvascular cytology and show examples of the recovery of fetal squames in amniotic fluid embolism, fat globules in fat embolism, and malignant cells in lymphangitic carcinomatosis. Megakaryocytes, normal inhabitants of the pulmonary capillary bed, are readily seen in wedged blood and confirm the microvascular origin of a blood sample.

Adolescent↗

[Pregnancy induced hypertension complicated acute disseminated intravascular coagulation: clinical analysis of 26 cases].

OBJECTIVE: To determine the relationship between pregnancy induced hypertension (PIH) and acute disseminated intravascular coagulation (DIC). METHODS: 26 cases with PIH complicated acute DIC were analyzed retrospectively in five hospitals of Xi'an from 1980 to 1997. RESULTS: (1) In 26 patients with PIH complicated acute DIC, 7 cases died (26.92%), while 17 neonates died (58.62%) in 29 neonates (3 cases were twin pregnancy). Cesarean section and hysterectomy were performed on 7 cases respectively, including 4 cases underwent both of them. (2) The causative factors of PIH complicated acute DIC included placental abruption (7 cases), amniotic fluid embolism (4 cases), eclamptic seizure (4 cases), surgical injury (7 cases) and bleeding (4 cases). 7 cases induced by placental abruption were all cured, 4 cases induced by amniotic fluid embolism all died. CONCLUSION: There are close relationship between PIH and DIC, PIH complicated acute DIC is the major cause of maternal and perinatal mortality, special attention should be paid on preventing DIC for PIH.

Abruptio Placentae↗

[Maternal mortality: avoidable obstetrical complications].

Since 1996, maternal mortality is registered as part of a permanent confidential inquiry in France. The National Committee has studied all cases recorded to assess the cause of death and the avoidable obstetrical complications involved. Recommendations are proposed. In 1996 and 1997, there were 196 maternal deaths in France; 165 could be analyzed. The cause was obstetrical in 123 cases (74%), non-obstetrical in 26 (16%), and unidentified in 16 (10%). Ninety-seven direct deaths occurred (78% of the obstetrical mortality cases); 31 cases of hemorrhage including 19 post partum, 20 cases of pregnancy-induced hypertension, 10 cases of eclampsia and 7 of pre-eclampsia, 16 cases of amniotic fluid embolism, 11 cases of thromboembolism and 10 cases of sepsis. The National Committee considered that 54% of these deaths were avoidable: 87% for hemorrhage, 80% for sepsis, and 65% for hypertensive diseases. The deaths due to amniotic fluid embolism were not considered avoidable. This mortality stemmed from substandard care, delayed treatment, missed diagnosis, and professional errors. Clinical recommendations are proposed for post partum hemorrhage, pre-eclampsia and eclampsia, prevention of maternal infection, and thromboembolism prophylaxy.

Eclampsia↗