SEARCH · PubMed Health

Results for “FLUORIDES, TOPICAL”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 559 records · Page 31Linked to original sources

PubMedDate not supplied

Fluoride varnishes in caries prevention.

The first fluoride varnishes were developed during the 1960s (Duraphat) sodium fluoride varnish) and 1970s (Fluor Protector) silane fluoride varnish) to prolong the contact time between fluoride and enamel. Fluoride varnishes adhere to enamel, and calcium fluoride formed after application acts as a long-term reservoir of fluoride. Currently Duraphat varnish is the most widely used topical fluoride for professional application in Europe, and the use of fluoride varnishes is increasing in the USA. Duraphat varnish has been effective in three decades of clinical studies, but the results of Fluor Protector varnish are inconclusive. The percent caries reductions found in the 1990s have generally been lower than those reported in earlier studies, probably because of the higher exposure to other preventive measures in the more recent studies. In studies comparing Duraphat varnish and APF gel, Duraphat varnish was equally or more effective than APF gel. Sealants were most effective in preventing occlusal caries. Four applications per year, or three weekly applications once a year, have been found to be effective. However, several studies have shown that two applications per year may provide comparable results. Application is fast and easy. Professional prophylaxis is not necessary, and the patient can leave immediately after the treatment. No acute toxicity has been reported after using any fluoride varnish.

Acidulated Phosphate Fluoride↗

PubMed1993

Effect of home-use fluoride gels on glass ionomer and composite restorations.

The effect of home-use topical fluorides on the surface integrity of two glass ionomers and a composite was studied using SEM. Class V cavities prepared in extracted teeth were restored with two commercial glass ionomers and a composite. Teeth were randomly divided into groups and each group treated for 24 h with one of the following fluoride gels: acidulated phosphate fluoride (pH5), stannous fluoride (pH4.5), sodium fluoride (pH7), and a non-proprietary sodium fluoride (pH5.8). Surface degradation of the restorations was studied using SEM, rated according to specific criteria, and statistically analyzed by the Wilcoxon test (Rank Sums). It was found that the APF and the non-proprietary gel had a significant effect on both Gl matrix and particles and on the composite particles (p < 0.01). The neutral sodium fluoride had no significant effect on the materials (p > 0.01).

Acidulated Phosphate Fluoride↗

PubMed1986

Enamel fluoride retention after DCPD and APF application and prolonged exposure to fluoride in vitro.

The effect of a topical fluoride regimen consisting of a four-minute pre-treatment with a saturated dicalcium phosphate dihydrate (DCPD) solution followed by a four-minute application of APF was compared with that of a four-minute application of APF alone with respect to the deposition of fluoride in enamel in an apatitic form in vitro. Following the topical applications, specimens were washed in either (1) an inorganic wash solution for 24 hrs or (2) an inorganic wash solution with 1 ppm F added for 28 days; specimens were then subjected to KOH extraction for 24 hrs. Fluoride-by-depth profiles revealed that the DCPD/APF treatment resulted in a significant increase in the apatitic F concentration of enamel to a depth of 20 microns, while APF application alone did not. All groups exposed to the 1 ppm F wash acquired significant amounts of apatitic F, with the differences between groups remaining relatively constant.

Acidulated Phosphate Fluoride↗

PubMed1989

Effectiveness of water fluoridation.

The efficacy of communal water fluoridation in reducing dental caries has been reviewed based on surveys conducted in the last decade of caries prevalence in fluoridated and nonfluoridated communities in the United States as well as in Australia, Britain, Canada, Ireland, and New Zealand. The efficacy is greatest for the deciduous dentition, with a range of 30-60 percent less caries in fluoridated communities. In the mixed dentition (ages 8 to 12), the efficacy is more variable, about 20-40 percent less caries. In adolescents (ages 14-17), it is about 15-35 percent less caries. Current data on caries prevalence in adults and seniors are extremely limited and include several populations living in communities with higher than optimal fluoride levels. For these adults and seniors, a range of 15-35 percent less caries would also apply. Viewed in toto, the current data for children, adolescents, adults and seniors show a consistently and substantially lower caries prevalence in fluoridated communities. For an accurate measurement of the efficacy of water fluoridation in reducing dental caries, it is essential that only persons with a record of continuous or long-term residency in fluoridated versus nonfluoridated areas be included in such assessments. Because of the high geographic mobility in our society and the widespread use of fluoride dentifrices, supplements, and other topical fluoride agents, such comparisons are becoming more difficult to conduct. Accordingly, the effectiveness (rather than the efficacy) of water fluoridation has decreased as the benefits of other forms of fluoride have spread to communities lacking optimal water fluoridation.

DMF Index↗

PubMed1999

Efficacy and safety of fluoride varnishes.

Clinical studies show that fluoride varnishes, such as Duraphat, are effective in increasing the fluoride content in the enamel and preventing caries. Varnish application is fast and easy. A professional prophylaxis before varnish application is not necessary, which decreases the application time. Patients receive significant preventive benefits with only semiannual varnish applications. Finally, and most importantly, studies show that fluoride varnishes are safe. Effectiveness, application ease, and safety give fluoride varnishes an advantage over other types of topical fluoride treatments, such as gels and rinses.

Acidulated Phosphate Fluoride↗

PubMed1982

Inhibiting effect on demineralization of permanent root surfaces after different topical application of fluorides and a solution containing Fe- and Al-ions.

Fifteen roots were used in this study to compare different topical fluoride compounds on the inhibiting effect of artificial root surface carious lesions. A 2% NaF-solution, Duraphat and a test solution-containing Fe+3, Al+3 with and without fluoride were tested. The results indicated that only the test solution independent of fluoride was able to increase acid resistance. No differences could be observed between the controls and the surfaces treated with the other fluoride agents. The test solution thus seem to be applicable against root surface caries.

Administration, Topical↗

PubMedDate not supplied

Fluoride uptake by proximal surfaces from professionally applied fluorides: an in vitro study.

This study was performed to examine the uptake of fluoride by mesial enamel surfaces of extracted teeth from different types of topical fluoride. Forty-eight extracted human molars and twelve premolars were randomly divided into four groups and mounted in twelve wax blocks with five teeth in proximal contact in each block. Each group was treated for four minutes with either 1.23 percent acidulated phosphofluoride conventional gel, thixotropic gel, or foam in lined trays, or 2 percent neutral sodium fluoride solution applied with a cotton tip applicator. Acid-etch biopsies were performed three times to indicate the amount of fluoride uptake at three different depths. The results demonstrated that there was a statistically significant increase in fluoride uptake in the surface layer with both gels and foam (1150, 1058 and 1120 ppm F), whereas there was an insignificant increase with the fluoride solution (27 ppm F). In the deepest layer, the thixotropic fluoride produced the greatest fluoride uptake (919 ppm F) in comparison with the uptake from conventional gel (383 ppm F), foam (297 ppm F), or solution (118 ppm F).

Acid Etching, Dental↗

PubMed1996

Caries incidence in relation to salivary mutans streptococci and fluoride varnish applications in preschool children from low- and optimal-fluoride areas.

Caries incidence during a 2-year period was studied in 4- to 5-year-old children from three areas with contrasting levels of natural fluoride (F) in the drinking water and different regimens of topical fluoride varnish applications; group A (n = 448) was from an area with a low level of F (0.1 ppm) and semi-annual applications of fluoride varnish; group B (n = 374) was from a low F area (0.1 ppm) and no fluoride varnish treatments; group C (n = 206) was from an area with optimal F (1.2 ppm) and fluoride varnish treatments. All children were clinically assessed at baseline and after 2 years according to WHO criteria. The number of salivary mutans streptococci was estimated and scored at baseline and after 2 years with the Strip mutans method. The varnish containing 0.1% F was applied every 6 months on all accessible tooth surfaces after cleaning with a pumice paste. Basic preventive care was given to all children and restorative treatment on individual indications. Higher levels (p < 0.05) of salivary mutans streptococci were found in the low-fluoride areas compared to the optimal fluoride area at baseline and after 2 years. The caries incidence (mean dft +/- SD) in the different groups was A: 0.65 +/- 1.40; B: 1.09 +/- 1.85; C: 0.53 +/- 1.09. The difference between group B and groups A and C was statistically significant (p < 0.05). A positive relationship (p < 0.05-0.001) between salivary mutans streptococci scores at baseline and caries incidence was found in all three groups. This study confirms the close association between salivary mutans streptococci and caries incidence in preschool children and suggests a caries-reducing effect of topical applications of the fluoride silane varnish.

Analysis of Variance↗

PubMed1997

Unacceptably high levels of fluoride in commercial preparations of silver fluoride.

Instead of expected fluoride ion concentrations of around 60,000 ppm, commercial preparations of 40 per cent aqueous silver fluoride were found to contain 120,000-127,000 ppm. Information received from the Western Australian Chemistry Centre which provided independent confirmation of the higher than expected [F] indicates that the currently available commercial preparations contain silver difluoride rather than silver fluoride. In view of the potential of fluoride-containing products such as dentifrices (1000-1500 ppm F) and topical fluoride gels and solutions (6000-12,000 ppm F) to cause adverse effects if excessive quantities are ingested, any product that contains 120,000 ppm [F] should be regarded as carrying a high risk of toxicity when used on young children.

Australia↗

PubMed1985

Diagnosis and treatment of acute fluoride toxicity.

The literature has shown overwhelmingly that fluoride used for dental prophylaxis presents minimal risks if used appropriately. However, there is an increasing potential for ingestion of toxic doses of fluoride because of the increasing use of pleasant-tasting fluoride products. The ADA has recommended that no more than 120 mg fluoride (264 mg NaF) be dispensed at any one time. As with any medication, fluoride preparations should be prescribed in child-resistant containers, and patients or parents (or both) should be instructed as to the proper daily treatment regimens and the potential for toxic overdoses. Possibly the greatest risk of fluoride intoxication relates to the concentrated fluoride preparations used for professionally applied fluoride treatment (Table 3). Therefore, patients receiving professional topical fluoride treatments should have well-fitting trays with the minimal amount of fluoride necessary to contact the teeth. These patients should be provided with a saliva ejection system, and they should never be left unobserved during the topical application. Health professionals should be aware of the potential toxic effects of fluoride in addition to the well-known caries preventive effects. It is necessary to know how to calculate the amount of fluoride ingested and the emergency treatment recommended to prevent toxic effects in suspected overdose cases.

Child↗

PubMed1998

Fluoride use in periodontal therapy: a review of the literature.

Although the relationship between fluoride and dental caries has been widely studied and definitively determined, the relationship between fluoride and periodontal health and disease is not clear. Conflicting studies in the literature either suggest routine fluoride usage as an adjunct to conventional periodontal therapy or argue against topical fluoride use on periodontally involved teeth. This review summarizes the literature that addresses the utility of fluoride in patients with periodontal disease and aims to advance a rational criterion for the use of fluorides in the management of periodontal diseases.

Administration, Oral↗

PubMed1998

Fluoride release and re-uptake in direct tooth colored restorative materials.

OBJECTIVES: Glass ionomers may be "recharged" through topical fluoride (F-) treatments; however, this reported "recharging," may be attributed to surface changes after F- treatment. This study examined differences in F- release and re-uptake among dual-cured and chemically-cured glass ionomers, and a photo-cured F- releasing composite. A secondary goal was to determine if tensile strength or surface roughness changed due to F- release, or F- re-uptake and re-release. METHODS: In Phase 1, initial surface roughness and diametral tensile strength were measured. F- release was measured for 30 days. Strength and roughness were then remeasured. In Phase 2, surface roughness was measured, then materials were treated with a 5000 ppm neutral F- gel, the same gel without F-, or phosphoric acid. F- release was measured for 30 days, then final surface roughness and strength were determined. RESULTS: Significant differences were found in amount and rate of F- release, and F- re-uptake and re-release among study materials and enamel controls (p < 0.001). The amount and rate of F- re-release after NaF treatment differed significantly from F- release after acid treatment in glass ionomers, although both groups showed increased F- release after surface treatment (p < 0.001). There were no significant changes in tensile strength or surface roughness after F- release or F- re-uptake and re-release as determined by ANOVA. SIGNIFICANCE: The results of this in vitro study indicate that applications of neutral 5000 ppm F- gel to aged glass ionomer restorations results in a significant fluoride uptake and subsequent release. The data suggest that the application of neutral fluoride gel to glass ionomer restorations in situ may result in increases in oral fluoride concentrations, without affecting the restoration's surface roughness or tensile strength.

Analysis of Variance↗

PubMed1989

[Prevalence of caries and fluorides].

In the whole of Switzerland, caries prevalence was high until 1960. Dental health education programs which included topical fluorides were introduced in the 1960's. Substantial declines of dental caries prevalence have been documented since 1968. In the canton of Zurich e.g. fourteen year-old children had an average of 23.8 cavities (most of them filled) in 1963 which was reduced to only 3.8 in 1987. Similar reductions, primarily due to multiple uses of fluorides, have also been obtained in younger age-groups and in other parts of Switzerland. On an epidemiological basis fluoridated salt reduced dental caries prevalence better than fluoride tablets. This is because tablets are only preferable for a minority of well-motivated families and required good compliance by the children. Modern research reveals that it is not the amount of ingested fluoride (acting systemically) but the frequency and duration of the contact of the fluoride with the erupted teeth which is most important. During pregnancy fluoride tablets benefit the mother's teeth and ensures a satisfactory fluoride level in the fetal skeleton. This is considered desirable as mothers' milk consistently contains only approximately 0.02 ppm fluoride. No caries-protective effect of the fetal fluoride, however, has been substantiated by pertinent research. Only a negligible cariostatic effect results by supplying fluoride to the infant. Caries prevention by fluoride begins to be important during the eruption of the primary teeth, at the latest at the eruption of the primary molars.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1998

Fluoride varnish: a useful new tool for public health dentistry.

Since first shown to be effective by Bibby in 1942, professionally applied topical fluorides have been used successfully as a caries-preventive intervention. In the United States, the acidulated phosphate fluoride (APF) gels have been the most widely used agent for over two decades. While effective, APF has several practical disadvantages, including unpleasant taste and the risk of fluoride overingestion. The use of APF on infants and very young children is not practical or safe. Recently, fluoride varnish has become available in the United States. It has been used widely in Europe and Scandinavia for 25 years. Its effectiveness and safety are documented in over 50 clinical trials. Fluoride varnish is easy to apply, is well accepted by children, and eliminates the risk of overingestion of fluoride. Fluoride varnish is approved by the FDA as a "device" and must be used "off label" for the prevention of caries. Because of the large body of published data documenting its effectiveness and safety, there is no legal risk in using fluoride varnish off label. In fact, the American Dental Association has granted its seal of approval to Duraphat, one of the varnish products. Varnish offers considerable advantages in the dental public health setting. Of particular note, it is practical and safe to apply to the teeth of infants and very young children.

Acidulated Phosphate Fluoride↗

PubMed1979

Effectiveness of combined preventive methods on erupting teeth in children in a fluoridated community.

Several preventive methods were used in combination to reduce dental caries in children residing in a fluoridated area. The method included dental health education, prophylaxis, pit and fissure sealants, topical fluoride and restorative care. Prophylaxis, sealant and fluoride procedures were repeated every 6 months. Sealant was applied to all fully erupted caries free posterior teeth in the mouth. This report compares results obtained for teeth that erupted after the study began with those teeth that were already present at the time treatment procedures were applied. Percent reductions in caries increment for newly erupted teeth at the end of 3 years for treated 6th graders was 77.5% in DMFT and 79.2% DMFS as compared to 71% and 58.3% for previously erupted teeth. Results for children in 1st grade did not how such beneficial results. Permanent first molars in younger children appear to be highly susceptible to caries. Sealant retention for newly erupted teeth follows the same pattern as for teeth previously erupted.

Adolescent↗

PubMed1981

Rational use of fluorides in caries prevention. A concept based on possible cariostatic mechanisms.

The aim of this review has been to suggest that future fluoride preventive programs should be based on what is at present known about the possible cariostatic mechanisms of fluoride. The relative role of enamel fluoride in caries prevention has become increasingly questioned during the last two decades. No significant relationship has been demonstrated between caries experience of the individual and fluoride content of the enamel. Furthermore, the fluoride content in surface enamel between teeth developed in low and "optimal" fluoride areas is too small to explain any significant effect on dissolution rate of the enamel. As the major explanation for the cariostatic effect of fluoride must therefore be sought in its local effect on the oral environment, the possible effects on plaque colonization, composition and metabolic activities are discussed. The effect of even low concentrations of fluoride in the liquid phase on enamel dissolution is described, and it is concluded that the major cariostatic effect of water fluoridation, fluoride tooth paste and mouth rinses can probably be ascribed to regular increases in fluoride ion activity in the oral fluids. The effect of high concentrations of topical fluoride solutions is thought to be a result of a slow dissolution of calcium fluoride deposited in initial caries lesions, whereby an increased fluoride ion concentration is maintained locally for longer periods of time. Finally, the clinical consequences of these considerations are described.

Adolescent↗

PubMed1980

Antimicrobial effect of fluorides on Bacteroides melaninogenicus subspecies and Bacteroides asaccharolyticus.

This study was undertaken to determine whether the suspected periodontopathogens Bacteroides melaninogenicus ss melaninogenicus and intermedius and Bacteroides asaccharolyticus are killed by clinically used topical fluorides. The viability of each organism was examined after exposure to three fluoride compounds, stannous (SnF2), acidulated phosphate (APF), and neutral sodium (NaF), for 1 and 8 h. Stannous fluoride was found to be effective at lowest fluoride concentrations with APF next in effectiveness. NaF required the highest concentrations of fluoride to kill test organisms. Longer exposure times were found to be more effective at lower concentrations. Data obtained in this study with gram-negative organisms support and extend previous information regarding the antibacterial effect of fluorides against gram-positive periodontopathogens.

Acidulated Phosphate Fluoride↗

PubMed1990

Clinical evidence of the role of pre-eruptive fluoride in caries prevention.

Recent clinical and laboratory evidence has suggested that systemic fluoride plays a more minor role in caries inhibition than was previously believed. This paper reviews clinical data on water fluoridation, the topical administration of fluorides, and fluoride supplements in the light of more recent understanding of the disease dental caries. Due to reduced functional usage, erupting teeth tend to accumulate plaque which has cariogenic potential. For this reason, the period from tooth emergence to the establishment of interproximal contact and full occlusion is the most critical for caries initiation. Analyses of clinical data indicate that maximum protection against caries is obtained when teeth erupt into an environment with low concentrations of ionic fluoride. The similarity in caries reductions obtained in water fluoridation studies and long-term studies with topically administered fluoride regimens, including fluoride-containing dentifrices, indicates that the pre-eruptive effect of fluoride is of borderline significance relative to the more significant post-eruptive effect. Water fluoridation and topical fluoride programs are thus important measures for the control of caries at the community level. For the individual, topical application of fluoride is seen as an integral part of caries treatment aimed at arresting progressive caries. Fluoride application is thus considered a supportive therapy, in conjunction with cariogenic plaque control. Daily use of fluoridated dentifrices from tooth eruption is more efficacious than daily use of fluoride supplements from birth.

Dental Caries↗