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Dry mouth and nose in the older patient. What every PCP should know.

Dry mouth and dry nose are common complaints among the older population. Dry mouth can be attributed to medical conditions and other underlying causes, whereas dry nose is usually associated with age-related changes in nasal physiology and structure. In both cases, medications can contribute to dryness, so a proper evaluation includes a careful drug review. Management of dry mouth includes hydration and use of mouthwash, sugarless gum, candy, and saliva substitutes. Dry nose can be managed with nasal sprays that moisten the nasal cavity.

Aged↗

[On a biochemical model of neurogenic sialosis: studies in rats (author's transl)].

By studying the influence on rat-parotid glands of the antihypertensive drug, guanoxane (Envacar), we attempted to establish a biochemical model of a neurogenic sialosis. Protein content and alpha-amylase activity were determined in gland extracts and in polyacrylamide gel slabs after electrophoretic separation of equal amounts of parotid-gland protein. The values for both parameters showed a marked increase during the first week of treatment as compared with the controls, but decreased subsequently. After electrophoretic separation into 4 isoamylases, the activity per unit protein decreased with time in one group of isoenzymes and increased in another. We interpret these findings as a gradual shift in the isoamylase distribution pattern of the rats' parotid glands with increasing duration of a neurogenic sialosis of the peripheralvegetative type.

Amylases↗

[Ptyalorrhea].

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Humans↗

Sialectasis.

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Humans↗