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Results for “SARCOMA, EXPERIMENTAL”

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At least 559 records · Page 31Linked to original sources
PubMed1979

A methodological approach to the prediction of anticancer drug effect in humans.

Tumor cells from animals and humans were treated with drugs under tissue culture conditions. Tumor cells from the sensitive L1210 model were studied first. A dose-response curve was derived between drug exposure and subsequent cytotoxicity in L1210. The concentration of drug and duration of exposure were factors critical to the subsequent development of in vitro cytotoxicity. The in vitro dosage which effected 50% leukemic cell death in L1210 cells correlated with reported in vivo drug levels. Other tumor models and human neoplastic cells were studied at this dosage level. A good correlation was noted in these studies between the in vivo responsiveness and the in vitro chemotherapy results in both animals and humans. It was suggested by these results that it may be possible to predict cancericidal drug activity for individual neoplasms by assaying the tumor cells in vitro for drug sensitivity.

Animals↗
PubMedDate not supplied

Sarcoma viruses containing the mos oncogene induce lesions resembling Kaposi's sarcoma.

Kaposi's sarcoma is most accurately described as a multifocal angioproliferative lesion primarily involving the skin, although some studies indicated concomitant and/or exclusive visceral involvement. The mechanism(s) involved in Kaposi's sarcoma development, especially AIDS multiorgan distributed form, is not completely understood. Recent reports have identified a murine retrovirus, MoMuSV-349 that induces multiorgan disseminated angiosarcomatous tumors which resemble Kaposi's sarcoma when virus is inoculated intraperitoneally in newborn BALB/c mice. Performed time point experiment on mice infected with MoMuSV-349 indicated a two stages development of Kaposi's sarcoma-like tumors; sarcomatous and angiosarcomatous. Preliminary studies have demonstrated the pathogenesis of the disease process and the role of angiogenic growth factors released by the spindled cells in the stage development of mouse tumors. It is hypothesized that growth factors such as fibroblast growth factors released by the spindled cells stimulate the proliferation of endothelial cells and neovascularization which is an essential component of Kaposi's sarcoma-like tumors. Understanding the mechanism(s) of endothelial cells proliferation and neovascularization as a response to viral insult and microenvironmental changes will raise the possibilities of developing new therapeutic approaches to block this process.

Acquired Immunodeficiency Syndrome↗
PubMed1976

[Antitumoral immunity induced by the administration of homologous and isologous tumoral cells treated by moderate heating].

Treatment of tumour cells with heat ranging between 46 and 52 degrees C attenuates strongly their virulence and renders the tumour cells immunogenic to the host. By repeated administration of heat treated tumour cells suspended in Freund's complete adjuvant, the animals acquire a state of immunity which makes them tolerant to tumour inocula 100% lethal in the controls. The immunity so conferred is cell-mediated and can be adoptively transferred to isogenic recipients with donor peritoneal exudate and, to a lesser degree, splenic cells.

Animals↗
PubMed1975

Origin and partial characterization of Fc receptor-bearing cells found within experimental carcinomas and sarcomas.

A variety of murine connective and epithelial tissue tumors, including the SAD/2 and FS9 fibrosarcomas, the TA3/Ha and CAD/2 mammary carcinomas and a primary methylcholanthrene-induced sarcoma, were found to contain a high proportion of cells with receptors for the Fc portion of immunoglobulin G ("Fc receptors"). Experiments were undertaken to assess whether these cells were neoplastic, or whether they represented the infiltration into the tumor of non-malignant host cells such as macrophages or lymphocytes. It was found that long-term established in vitro cell lines of the TA3/Ha SAD/2 and CAD/2 tumors were entirely negative for the Fc receptor, whereas injection of these cells led to the formation of tumors containing a high proportion of Fc receptor-bearing cells. Many of these cells were actively phagocytic as assessed by ingestion of iron filings or antibody-coated erythrocytes. Injection of Fc receptor-negative cultured tumor cells into F1 hybrids, in which host cells could be distinguished from the tumor cells by anti-H2 sera, revealed that many or all of the Fc receptor-bearing cells in the resultant tumor were of host origin. In contrast to its effect on normal spleen cells, anti-theta serum treatment also partially inhibited Fc rosettes, suggesting a T-lymphocyte origin for some of the Fc receptor-bearing cells. Since almost all cells with potential anti-tumor activity bear Fc receptors, it is suggested that an index of host cell infiltration of carcinomas and sarcomas can quickly and easily be ascertained by enumeration of Fc receptor-bearing cells.

Animals↗
PubMed1992

Cytogenetic and experimental models.

The sarcomas, particularly those of soft tissue origin, often contain characteristic immunohistochemical and cytogenetic features that are of diagnostic relevance. Over the past year, novel findings have been reported that are likely to improve present sarcoma diagnostic capabilities. Findings of particular interest have been reported for Ewing's sarcoma, peripheral primitive neuroectodermal tumor, rhabdomyosarcoma, and clear cell sarcoma.

12E7 Antigen↗