PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “THYROID GLAND FUNCTION TESTS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 559 records · Page 31Linked to original sources
PubMed1985

[Lugol's solution and thyroid gland activity in cattle. Determination of the total thyroxine in blood plasma as a method for evaluating thyroid gland activity].

The aim of the present investigations was to examine if an intrauterine treatment with Lugol's solution in cows influences the activity of the thyroid gland. The thyrotropin-stimulation test was used to evaluate the function of the thyroid gland. An injection of 10 I. U. thyreotropin induced within 3 hours an increase of the T4 blood concentrations which reached maximal values 9 hours after the treatment and thereafter decreased again. Thyreotropin concentrations increasing from 5 to 30 I. U. led to a dose-dependent increase of the T4 blood concentrations. The T4 values obtained by 40 i. U. thyreotropin were lower than that induced with 30 I. U. of the hormone. The T4 concentrations increased stronger and remained elevated longer in cows pretreated intrauterine with Lugol's solution than in untreated control cows. The experiments demonstrated that an intrauterine infusion of Lugol's solution may result in an increased activity of the thyroid gland.

Animals↗
PubMed1991

[Occult papillary carcinoma of the thyroid presenting as a solitary pulmonary metastasis].

This is a report of a quite rare case of occult papillary carcinoma of the thyroid in which the initial clinical manifestation was a solitary lung metastasis. A 58-year-old woman was referred to the Fukuoka University Hospital because a coin lesion approximately 5 cm in diameter was detected in the right lower lobe of the lung by routine roentgenographic examination. This abnormal finding by chest X-ray had been pointed out about fifteen years before. Although she did not remember the exact size of the lung tumor, it had grown minimally since that time. Otherwise, she had been in good health all her life. No abnormalities in clinical and laboratory tests were found on admission. The tumor was clinically suspected to be of benign nature (probably sclerosing hemangioma), and pulmonary lobectomy was performed. Microscopic examination of the tumor revealed a papillary carcinoma with focal areas of follicle formation and colloid production, consistent with metastatic thyroid carcinoma. Immunoperoxidase stain for thyroglobulin was strongly positive in the tumor, and this finding confirmed the thyroid origin. Repeated physical examination of the thyroid gland, thyroid scan, and thyroid function tests were all unremarkable, however, she was closely followed up for two years. Then, a thyroid nodule with cystic change was detected on the ultrasonogram. The patient underwent a right hemithyroidectomy, disclosing papillary adenocarcinoma histologically. This case suggests that thyroid cancer should be considered as possible primary site in cases of long-standing coin lesion on chest X-rays in patients without remarkable complaints and in whom the primary site is unknown. A search of the literature has revealed only five cases with occult thyroid carcinoma associated with solitary pulmonary metastasis.

Carcinoma, Papillary↗
PubMed1984

Pituitary-thyroid hormone economy in healthy aging men: basal indices of thyroid function and thyrotropin responses to constant infusions of thyrotropin releasing hormone.

In order to assess the effects of aging, as distinct from those of thyroid disease or extrathyroidal illness, on certain indices of thyroid function, we studied 74 healthy, ambulatory men recruited from the Baltimore Longitudinal Study on Aging. We determined basal serum values of T4, T3, rT3, thyroxine-binding globulin (TBG), and T3 resin uptake (T3RU) and calculated the free T4 index (FT4I = T4 X T3RU/100), free T3 index (FT3I = T3 X T3RU/100), and T4/TBG ratio for each subject. We used an ultrasensitive RIA to measure variations in basal concentrations of TSH within the normal range. We then infused TRH at a constant rate (0.4 microgram/min iv) for 240 min into 63 of the same men; serum samples, collected at 15-min intervals during the infusion, were analyzed for TSH by routine RIA. Subjects were divided into 3 groups according to age; A (n = 26, mean age = 39.4), B (n = 23, mean age = 60.0), and C (n = 25, mean age = 79.6). Analysis of variance with Duncan's multiple range test and regression analysis were used to evaluate data. There was no significant (P greater than 0.05) variation with age of basal serum values of T4, TBG, or T3RU. Comparison of groups A and C showed significant decreases of mean values of serum T3 (-11%, P less than 0.05), FT3I (-13%, P = 0.02), FT4I (-11%, P less than 0.01), and T4/TBG ratio (-12%, P less than 0.01) and an increase in serum TSH (+38%, P less than 0.05). For these variables, the mean values for group B were intermediate between, but not significantly different from, those of A and C. Regression analysis showed significant correlations of age with T3, FT3I, FT4I, T4/TBG, and TSH at P levels similar to those obtained by Duncan's test. No elderly individual exhibited a baseline elevation of TSH (greater than 7 microU/ml) or depression of T4 (less than 5 micrograms/dl), suggesting that primary hypothyroidism was not present in our old group. The basal TSH concentration did not correlate significantly with any index of thyroid function except with FT3I in group C (r = -0.43, P less than 0.05). In all age groups the TSH responses to TRH exhibited a biphasic pattern with early and late peaks.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMed1977

The treatment of Cushing's disease by trans-sphenoidal hypophysectomy.

Thirteen patients aged 24 to 65 with Cushing's disease have been treated by transphenoidal hypophysectomy. There was one incident of meningitis and one late death from myocarditis. No radiotherapy was given. In 12 patients pituitary histology showed Crooke's changes and an adenoma was present in seven. On review of the 12 survivors two to 11 years later, 11 are in complete remission. One patient still showed some clinical features of Cushing's syndrome but steroid levels were normal. In five of the seven premenopausal women normal menstruation has returned and pregnancy has occurred in three. In four patients replacement hormone therapy is no longer required and a further four take only partial treatment. We conclude that transphenoidal hypophysectomy is an effective treatment for Cushing's disease.

Adrenal Cortex Function Tests↗
PubMed1992

[The function of the hypophyseal-thyroid system in the children of Zhitomir Province living in areas polluted by the radionuclides resulting from the accident at the Chernobyl Atomic Electric Power Station].

A study of 1167 children (age: 7-15 years) inhabiting districts contaminated with radionuclide due to Chernobyl atomic station accident indicates that children with thyroid hyperplasia revealed high requirement and intensity of the peripheral metabolism of thyroid hormones that results finally in relative hormonal deficit (subclinical hypothyroidism) and thyroid hyperplasia. This is a sequel of maximum functional tension of the thyroid with impending breakdown of adaptation and this should be considered as a pathological process requiring correction, i.e. presence of subclinical hypothyroidism in children with thyroid hyperplasia requires substitution therapy with thyroid hormones.

Accidents↗
PubMed1991

[Status of the thyroid gland in patients with schizophrenia].

A study was made of pituitary-thyroid function in patients with different forms of schizophrenia. Radioimmunoassay was used. All the patients with schizophrenia showed impairment of interrelations within the pituitary-thyroid system, which manifested by accumulation in the peripheral blood of metabolically active T3 due to enhanced degradation of T4 in the peripheral tissues. The rise of TTH concentration represents one of the mechanisms of correction, aimed at the attainment of the physiological content of T4 at the expense of its additional output for its level in the blood serum is appreciably reduced.

Humans↗
PubMedDate not supplied

[Proceedings: Pituitary thyroid axis in subacute thyroiditis (author's transl)].

We studied 10 patients with subacute thyroiditis. All had an increase in free thyroxine index, PBI, T4 and PBI/T4 ratio, an absence of thyroidal radioiodine uptake and no increase in plasma TSH after TRH injection. Exogenous TSH increased the uptake in 6/9 patients. The three patients who did not respond to TSH had higher PBI/T4 ratio than others. After treatment for one month there was either a normalization of laboratory tests either a subnormal thyroid function associated with an absence of response to TRH. All tests became normal two months later.

Humans↗