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Alpha particle emission from reference glass surfaces implanted with 210Po.

Implanted long-lived radon decay products in glass surfaces have been used as a measure of past radon exposure in homes. Special track-etch devices (so-called 'retro-detectors') attached to the glass surface, have the ability to specifically measure the implanted activity of 210Po in situ. Calibrating these devices for 210Po is fairly straightforward, but the retro-detectors are also sensitive to the background activity of the glass substrate. Thus, for the successful calibration of retro-detectors, it is necessary to determine the complete alpha emission energy spectrum of the reference glass sheet utilised as a calibration pad. In order to achieve accurate knowledge of the alpha surface emission rate, we have combined several different approaches, i.e. alpha spectrometry of the pad surface with both surface-barrier and pulse-ionisation detectors, and activity determination of the glass matrix by means of radiochemical methods. The part of the alpha emission spectrum originating from the glass volume is then calculated theoretically and compared with experimental results.

Journal Article↗

Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.

A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered 211At-labeled chimeric 81C6 using a quality factor of 5 for alpha-emissions.

Animals↗

Alpha-particle irradiation of haemopoietic tissue in pre- and postnatal mice. 1: Distribution of plutonium-239 after mid-term contamination.

Pregnant mice (at 13 days gestation) and age-matched controls were injected with 30 kBq 239Pu/kg and the distribution of plutonium in maternal and foetal tissues measured. Approximately 2% of the activity injected into the mother reached each foetus in 24 h, 95% of which was contained in membranes and placenta. The concentration of plutonium in foetal liver was 3 times the average foetal body concentration; both liver and body concentrations in the foetus increased by the end of gestation. Each pup accumulated only 0.01% extra injected activity after 9 days lactation and, as the resulting concentrations in the neonatal skeleton were low, we conclude that the greatest haemopoietic risk to the offspring from mid-term contamination in utero is in the foetal liver (which received an average dose of 10-14 mGy between the time of mid-term contamination and birth). By the end of gestation about one-quarter of the original activity was transferred to foetal tissues from the maternal liver and skeleton. No significant changes in maternal distribution were detected as a result of lactation. The results of this study are discussed, along with a compilation of previously published data.

Animals↗