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Otitis media, hearing loss, and child development: a NICHD conference summary.

Growing evidence indicates that a significant relationship exists between the conductive hearing loss resulting from recurrent otitis media (OM) during the first 3-5 years of life and subsequent problems in acquisition of language and academic skills. To assess current knowledge of OM and its consequences for cognitive and linguistic development, to exchange viewpoints, and, if possible, to determine directions for future research, a conference was sponsored by the National Institute of Child Health and Human Development (NICHD). Among the epidemiologic studies cited, some found a very high incidence of OM in North American Indians and Eskimos, caused, according to one hypothesis, by a genetically different eustachian tube. Another researcher advised that basic language development should be carefully assessed in all cases of OM in young children. Conferees agreed that intervention programs must be developed and implemented until preventive measures are available. One model program emphasizes prevention of developmental difficulties based on the known and suspected sequelae of OM and on the known principles of language development. Conference participants recommended that all infants and young children, particularly those at risk, be examined for OM during regular medical checkups. In addition to treating the disorder, measures should be taken to deal with any significant hearing loss. If drug therapy is inadequate to clear effusion from the middle ear, surgery should be considered. Speech and language intervention should be undertaken when required.

Child↗

PAH-DNA adducts in cord blood and fetal and child development in a Chinese cohort.

Polycyclic aromatic hydrocarbons (PAHs) are an important class of toxic pollutants released by fossil fuel combustion. Other pollutants include metals and particulate matter. PAH-DNA adducts, or benzo[a]pyrene (BaP) adducts as their proxy, provide a chemical-specific measure of individual biologically effective doses that have been associated with increased risk of cancer and adverse birth outcomes. In the present study we examined the relationship between prenatal PAH exposure and fetal and child growth and development in Tongliang, China, where a seasonally operated coal-fired power plant was the major pollution source. In a cohort of 150 nonsmoking women and their newborns enrolled between 4 March 2002 and 19 June 2002, BaP-DNA adducts were measured in maternal and umbilical cord blood obtained at delivery. The number of gestational months occurring during the period of power plant operation provided a second, more general measure of exposure to plant emissions, in terms of duration. High PAH-DNA adduct levels (above the median of detectable adduct level) were associated with decreased birth head circumference (p=0.057) and reduced children's weight at 18 months, 24 months, and 30 months of age (p<0.05), after controlling for potential confounders. In addition, in separate models, longer duration of prenatal exposure was associated with reduced birth length (p=0.033) and reduced children's height at 18 (p=0.001), 24 (p<0.001), and 30 months of age (p<0.001). The findings suggest that exposure to elevated levels of PAHs, with the Tongliang power plant being a significant source, is associated with reduced fetal and child growth in this population.

Adult↗