Target organ toxicity: endocrine system. May 20-21, 1980, Morgantown, West Virginia.
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Pituitary hormone secretion is changed by sleep-awake rhythm, which also regulates by the hypothalamo-pituitary axis. The endocrine rhythm is also affected by such factors as aging and environment conditions. Nocturnal secretion of growth hormone is known to be induced by slow-wave sleep. Plasma prolactin levels seem to increase during REM sleep. Serum thyroid stimulating hormone levels increase during the night. Plasma adrenocorticotropin and cortisol levels increase in the early morning and decreased in the night, which are not related to the sleep stage. The sleep-related hormone secretion is not shown in the patients with disordered hypothalamo-pituitary axis. The evaluation of sleep-related changes in pituitary hormone is important to assess the hypothalamo-pituitary function.
Horse radish peroxidase-labelled cholera toxin (choleragen) binds to the receptors of entero-endocrine cell (Ec-cells) plasmalemma. Unlike columnar epitheliocytes, the effect of choleragen on Ec-cells.
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Experiments on male rats have shown that correlative interrelationships of the liver and endocrine apparatus of the pancreas depend on the content of corticosteroids in the body. The administration of a physiological dose of hydrocortisone raises the synthesis of RNA, phospholipids and glycogen in the liver accompanied by B-insulocyte hypertrophy. Large hormone doses result in the suppression of protein synthesis in hepatocytes with further development of fatty degeneration of the liver and hypofunction of pancreatic islet B-cells. Corticosteroid deficiency causes metabolic derangement of hepatocytes, a rise of the quantity and synthetic activity of pancreatic A-cells which can be corrected by means of hydrocortisone substitution therapy.
The presence of biorhythms in the endocrine organs (pituitary gland, adrenal gland, thyroid gland, islet organ, gonades , and kidney) are reviewed. Biorhythms ( circadian and circannual rhythms) have an influence on the action of this organs. The acrophases of the hormones in the serum have different peaks and their time-correlation is different. The importance of this data for experiments and for the clinical practice is discussed.
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