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PubMedDate not supplied

No shadows. Interview by Terry Philpot.

The Iris Murdoch Building in Stirling has been designed to meet the needs of people with dementia, and attracts health and social care staff to conferences and education programmes. Everything in the centre is obvious for what it is--nothing is hidden. Non-reflective paint and acoustic tiles eliminate shadows and echoes. Colour and texture are used to identify different areas in the building. The design minimises confusion and reduces reliance on memory.

Activities of Daily Living↗
PubMedDate not supplied

Balanced centralized and distributed database design in a clinical research environment.

Clinical research databases can meet both research and clinical needs, but this ideal is seldom achieved. Priorities often differ for those who collect and ultimately use the data and those who develop data systems. Traditional database designs also create logistical barriers that hamper communication. The Michigan Alzheimer's Disease Research Center has developed a secure, distributed data system with centralized data entry that provides an intuitive, individually customized interface for investigators in their clinics, laboratories and offices. Data are kept in a form that can be readily understood without reference to a code-book. Investigators can modify and query their own copies of the database without knowledge of programming languages. Balancing centralized and distributed designs for research databases enhance the accuracy and completeness of data collection and increases the use of data for research and clinical care.

Aged↗
PubMed2006

People, places...and other people? Integrating understanding of intrapersonal, social and environmental determinants of physical activity.

"People or places: what should be the target?" was the provocative title of a keynote session at the fifth Australian National Physical Activity Conference held in Melbourne in 2005. This paper will argue that in fact there need not be major conflict between these views, and that couching recent debate about physical activity promotion as a polarised choice between these presents a false dichotomy. To illustrate this, the paper will consider several problems with singular approaches to understanding and promoting physical activity, and will then describe emerging empirical evidence on the nexus between people and places. To balance an increasing emphasis in the scientific literature on physical environmental determinants of physical activity, the role of intrapersonal and social factors will also be revisited. It is concluded that growing evidence supporting the multiple domains of influence on physical activity justifies calls for multi-disciplinary and multi-sectoral partnerships and approaches to the promotion of active lifestyles.

Environment Design↗
PubMed2005

The use and impact of assistive devices and other environmental modifications on everyday activities and care in young children with cerebral palsy.

PURPOSE: The study describes use of assistive devices and other environmental modifications, and their impact on everyday activities and care in young children with cerebral palsy (CP). METHOD: Ninety-five children (55 boys, 40 girls; mean age 58 months, SD 18 months) and their parents were studied using a cross-sectional design. The Pediatric Evaluation of Disability Inventory (PEDI) was applied to assess daily activities using the three measurement scales: functional skills, caregiver assistance, and modifications of the environment. Use of modifications was described related to the five severity levels of the Gross Motor Function Classifications System (GMFCS). Impact was rated on the Caregiver Assistance scale of the PEDI and on a five-point Likert scale. RESULTS: Out of the 1075 provided environmental modifications, 980 were in regular use to support mobility, self-care and social function among 84 children. The number increased with GMFCS levels; children at levels IV and V used 80% of the modifications, with large variations between the children at same level. Adaptations of housing and transportation facilitated effective use of assistive devices. Half of the parents rated the modifications to have moderate to very large effect on the child's mobility, 25% on self-care skills, and 20% on social function. Furthermore, 65% reported that the modifications lightened the caregiving for mobility, 75% for self-care and 25% for social function. Functional independence and care demands often benefited from different types of modifications. CONCLUSION: The variations in use and benefits of environmental modifications indicate need of comprehensive assistive technology assessments, including child factors, family factors, technology factors and service system factors.

Activities of Daily Living↗
PubMed1999

[Variability and development of viral populations: assessment and implications].

RNA virus populations consist of complex distributions of closely related but not identical genomes known as viral quasi-species. The quasi-species concept describes the dynamics of these genomes subjected to a continuous process of variation, competition, and selection. Quasi-species dynamics has broad implications not only in the understanding of the molecular mechanisms underlying adaptation of RNA viruses but also in the design of strategies for control and prevention of viral disease. Viral load and genetic heterogeneity have a determinant influence on the adaptation of RNA virus to their environment. Vaccines designed to control diseases caused by highly variable viruses must contain several B and T epitopes to provide an ample and diversified immune response. Similarly, antiviral drugs should be used in combination therapy to minimize selection of resistant viruses. The theoretical model of quasi-species has opened the way for new antiviral therapies based on augmentation of the mutation rate during replication of viral RNA. Finally the quasi-species concept provides the basis for defining the selective factors that could influence the evolution of RNA virus and promote the emergence or reemergence of viral diseases.

Antibiosis↗
PubMed2003

Reorganization of water distribution system of Greater Jammu using computer software OPT DIS.

Water supply in old Jammu city is not evenly distributed due to undulating terrain and increase in population density. A study was undertaken to suggest measures for improvement to the distribution system. The paper presents results of analysis carried out using computer package OPT DIS developed at NEERI for optimal design of distribution sytem including system augmentation and reorganization measures needed for the design year 2021. The analysis of zone 1 of the distribution network indicates that seven pipes need alteation to cater to the demand for the year 2006 and fifteen pipes need replacement for the year 2021. New pipelines (13 nos.) are to be provided in parallel to the existing pipes in Upper Reach and 28 pipes in Lower Reach to ensure the service standards of 225 lpcd with minimum residual head of 17 m. Efficient algorithm for augmentations of water supply systems comprising combination of dead-end and loop network are having much wider application in developing countries. The software OPT DIS developed at NEERI was found to be extremely powerful and user friendly for addressing such systems with varying demand pattern, peaking factor, pipe condition, water supply modes and design horizones.

Algorithms↗
PubMed2006

The ergonomic conundrum for technology integration.

In the operatory of today, the opportunities are great. Space is at a premium and integration is a must. By consolidating the operator's primary supplies, which formerly were spread around the room, performance improves and space is gained for the successful introduction of high technology. Room cost decreases, permitting more networked rooms in less space at a lower cost. The productive potential of today's practice is greater than ever before; however, to gain the most from these opportunities, a change must occur in our perception of the treatment environment. When designing an office for the coming decades, it is vitally important to create a space for the future, not the past. Dentists must be willing to look objectively at their clinical environment and be willing to gain a clear sense of future needs. Your new treatment room can become a tool for future growth and prosperity or a museum about dentistry's past. Opportunity knocks.

Dental Equipment↗
PubMedDate not supplied

The importance of I.P. Pavlov for the development of neuroscience.

By his experimental and theoretical work on the physiology and pathophysiology of the higher nervous activity I.P. Pavlov significantly influenced the development of Neuroscience. During the 1950 Pavlovian Conference in Moscow, Stalin and the Communist Party tried to dogmatize his and his pupils' fundamental theories. But the Pavlovian ideas were developed by his pupils in open discussions with representatives of other schools in a very creative way, opening the doors for a systemic approach to understanding the integrative functional systems of brain and behavior. Pavlov emphasized the high plasticity of the central nervous system, investigated the complex functional systems within the brain and between the organism and its environment, and designed models for pathological deviations of the higher nervous activity. During his last years, he freed himself from the strong deterministic view and characterized the organism and its environment as a self-organizing system.

History, 19th Century↗
PubMedDate not supplied

New frontiers in design synthesis.

The Intelligent Synthesis Environment (ISE), which is one of the major strategic technologies under development at NASA centers and the University of Virginia, is described. One of the major objectives of ISE is to significantly enhance the rapid creation of innovative affordable products and missions. ISE uses a synergistic combination of leading-edge technologies, including high performance computing, high capacity communications and networking, human-centered computing, knowledge-based engineering, computational intelligence, virtual product development, and product information management. The environment will link scientists, design teams, manufacturers, suppliers, and consultants who participate in the mission synthesis as well as in the creation and operation of the aerospace system. It will radically advance the process by which complex science missions are synthesized, and high-tech engineering Systems are designed, manufactured and operated. The five major components critical to ISE are human-centered computing, infrastructure for distributed collaboration, rapid synthesis and simulation tools, life cycle integration and validation, and cultural change in both the engineering and science creative process. The five components and their subelements are described. Related U.S. government programs are outlined and the future impact of ISE on engineering research and education is discussed.

Astronauts↗
PubMed1977

Architecture: effect of territory, boundary, and orientation on family functioning.

Most students of family process and family therapy practitioners have failed to pay sufficient attention to the importance of the physical home environment. The thesis of this paper is that the physical home environment may facilitate or constrain inter- and intrafamily interaction, role relationships, values, and indentities. The paper presents a comprehensive review of the status of current knowledge concerning family interaction and the home environment. We propose a conceptual framework to facilitate discussion of the nature of man-environment relationships and focus attention on those aspects of the physical environment that have been noted as profoundly influencing family life. These are illustrated by three brief vignettes drawn from case studies of families in their home environment.

Architecture↗
PubMed1993

Architecture and functional design of advanced neurosurgical operating environments.

Although modern operative neurosurgery is a complex technical undertaking requiring an amalgam of technologies and instrumentations, few reported efforts have dealt with the definition and development of suitable and optimal dedicated operating environments. This report presents the first detailed description of a dedicated, self-contained neurosurgical operating suite incorporating major surgical instrumentation and visualization technologies to provide an "idealized" environment for stereotactic, microscopic, and microstereotactic procedures. Advanced computer technology for visualization to augment, simulate, document, and facilitate all aspects of neurosurgery is described. The architectural and functional design of the operating suite is itself an integral surgical instrument as well as a laboratory for development of new dimensions of neurosurgery.

Computer Systems↗