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PubMed2006

Determination of volatile organic compounds pollution sources in malaysian drinking water using multivariate analysis.

A field investigation was conducted at all water treatment plants throughout 11 states and Federal Territory in Peninsular Malaysia. The sampling points in this study include treatment plant operation, service reservoir outlet and auxiliary outlet point at the water pipelines. Analysis was performed by solid phase micro-extraction technique with a 100 microm polydimethylsiloxane fibre using gas chromatography with mass spectrometry detection to analyse 54 volatile organic compounds (VOCs) of different chemical families in drinking water. The concentration of VOCs ranged from undetectable to 230.2 microg/l. Among all of the VOCs species, chloroform has the highest concentration and was detected in all drinking water samples. Average concentrations of total trihalomethanes (THMs) were almost similar among all states which were in the range of 28.4--33.0 microg/l. Apart from THMs, other abundant compounds detected were cis and trans-1,2-dichloroethylene, trichloroethylene, 1,2-dibromoethane, benzene, toluene, ethylbenzene, chlorobenzene, 1,4-dichlorobenzene and 1,2-dichloro - benzene. Principal component analysis (PCA) with the aid of varimax rotation, and parallel factor analysis (PARAFAC) method were used to statistically verify the correlation between VOCs and the source of pollution. The multivariate analysis pointed out that the maintenance of auxiliary pipelines in the distribution systems is vital as it can become significant point source pollution to Malaysian drinking water.

Chloroform↗
PubMed2006

The short-form Buss-Perry Aggression Questionnaire (BPAQ-SF): a validation study with federal offenders.

The 12-item short form of the Buss-Perry Aggression Questionnaire (BPAQ-SF) was originally developed by Bryant and Smith (2001) and modified and confirmed using confirmatory factor analysis with mentally ill offenders by Diamond, Wang, and Buffington-Vollum (2005). In the current study, construct validity of the BPAQ-SF was assessed with a sample of 1,181 male and 435 female general population federal offenders. Confirmatory factor analysis supported the four-factor structure. Tests confirmed factorial invariance across gender for all loadings and covariances. Reliabilities were found to be adequate and comparable to those found in the studies cited above. Concurrent validity was supported by high correlations between the subscales of the BPAQ-SF and several relevant subscales on the Personality Assessment Inventory (PAI). In addition, those offenders with prior history of violence, head injuries, childhood abuse, residential treatment, custody, or foster care as a child had higher scores on the BPAQ subscales.

Aggression↗
PubMed1983

Cost principles for nonprofit organizations--Office of Management and Budget. Notice.

This notice offers interested parties an opportunity to comment on a proposed revision to Circular A-122, "Cost Principles for Nonprofit Organizations." The proposed revision establishes special provisions for costs related to political advocacy. Similar revisions are being simultaneously proposed for civilian and defense contractors through appropriate actions by the Department of Defense, NASA and GSA, the three agencies with authority to issue procurement regulations. The purpose of these proposals is to ensure that federal tax dollars are not used, directly or indirectly, for the support of political advocacy. Over the past 25 years, the volume of federal activity conducted through grantees and contractors has dramatically grown. Sound management of federal grants and contracts has correspondingly gained in importance. The responsibility of the President through OMB to improve the management of the executive branch of government with a view to efficient and economical service, and to fulfill other statutory and constitutional responsibilities, extends to issues of grant and contract management no less than to issues of direct federal activity.

Costs and Cost Analysis↗
PubMed1982

Medicare program; Medicare hospital reimbursement reforms: limitations on reimbursable costs and the rate of hospital cost increases--HCFA. Interim final rule with comment period.

These rules implement section 1886 of the Social Security Act (established by section 101 of the Tax Equity and Fiscal Responsibility Act of 1982). These rules amend current regulations on hospital cost limits, providing for new exemptions and exceptions. These amendments make exceptions available to hospitals consistent with the new cost limits published elsewhere in this issue of the Federal Register, and specifically exempt from those cost limits rural hospitals with less than 50 beds in existence as of the enactment of the law. These rules also set forth new regulations establishing a three-year ceiling on the allowable annual rate of increase in operating costs per case for inpatient hospital services. This ceiling takes the form of a target amount of cost per case against which a hospital's incurred cost per case will be compared. Hospitals are provided incentives to keep their cost increases below the target rate. A hospital that has costs per case less than the target amount will be paid a portion of the difference between actual cost and the target amount. A hospital that has costs per case that are greater than the target amount will be paid the target amount plus 25 percent of its costs in excess of the target for the first two years of the ceiling, and none of the excess in the third year. However, payment to a hospital under these new target rate regulations will not be greater than the amount determined under the new schedule of limits on hospital inpatient operating costs published elsewhere in this issue of the Federal Register.

Costs and Cost Analysis↗
PubMed1994

Preventive eye care in people with diabetes is cost-saving to the federal government. Implications for health-care reform.

OBJECTIVE: Diabetic retinopathy, which leads to macular edema and retinal neovascularization, is the leading cause of blindness among working-age Americans. Previous research has demonstrated significant cost savings associated with detection of eye disease in Americans with type I diabetes. However, detection and treatment of eye disease among those with type II diabetes was previously thought not to be cost-saving. Our purpose was to estimate the current and potential federal savings resulting from the screening and treatment of retinopathy in patients with type II diabetes, based on recently available data concerning efficacy of treating both macular edema and neovascularization along with new data on federal budgetary costs of blindness. RESEARCH DESIGN AND METHODS: We used computer modeling, incorporating data from population-based epidemiological studies and multicenter clinical trials. Monte Carlo simulation was used, combined with sensitivity analysis and present value analysis of cost savings. RESULTS: Screening and treatment for eye disease in patients with type II diabetes generates annual savings of $247.9 million to the federal budget and 53,986 person-years of sight, even at current suboptimal (60%) levels of care. If all patients with type II diabetes receive recommended care, the predicted net savings (discounted at 5%) exceeds $472.1 million and 94,304 person-years of sight. Nearly all savings are associated with detection and treatment of diabetic macular edema. Enrolling each additional person with type II diabetes into currently recommended ophthalmological care results in an average net savings of $975/person, even if all costs of care are borne by the federal government. CONCLUSIONS: Our analysis indicates that prevention programs aimed at improving eye care for patients with diabetes not only reduce needless vision loss but also will provide a financial return on the investment of public funds.

Blindness↗
PubMed1988

A national comparison of public- and private-sector alcoholism treatment delivery system characteristics.

The primary purpose of this study was to investigate the question of the existence, nationally, of separate public- and private-sector alcoholism treatment delivery systems in regard to the economic status of clients served, types of care provided and treatment setting. The analysis was based on data from the 1982 National Federal Census Survey of Treatment units. Public- and private-sector profiles based on the aforementioned delivery system characteristics were constructed and compared. Each of the profiles was also compared to a hypothesized profile, based on perceptions drawn from the literature, of the characteristics of treatment delivery in the private sector, generally, or the private-for-profit sector, specifically. The results of the analysis support the conclusion that two separate systems of treatment delivery existed, nationally, during the study period. The distribution of the nation's alcoholism treatment units among the public and private ownership sectors and ownership trends were also investigated using data from national federal census surveys conducted in 1979, 1980, 1982 and 1984. The implications of the study findings for the future are discussed.

Alcoholism↗
PubMed1994

Evaluation of prognostic factors and staging in gestational trophoblastic tumor.

OBJECTIVE: To evaluate factors influencing survival and compare current classification systems in women treated for malignant gestational trophoblastic tumor. METHODS: A consecutive series of 454 women treated between 1968-1992 was reviewed retrospectively to identify potential clinical prognostic factors using univariate analysis of life tables. All patients were evaluated using clinical classification, World Health Organization, and recently modified International Federation of Gynecology and Obstetrics (FIGO) staging systems, applied retrospectively. Multivariate Cox regression analysis was used to model potential independent prognostic factors within subsets of the patient population. RESULTS: Factors identified by univariate analysis as potential prognostic influences included age, duration of disease, type of antecedent pregnancy, clinicopathologic diagnosis, site of metastases, number of metastatic sites and foci, tumor size, and prior therapy. The pre-therapy hCG level was not significantly associated with survival (P < .04). Multivariate Cox modeling consistently identified prior therapy, type of antecedent pregnancy, number of metastatic sites, and duration of disease as independent prognostic factors. Clinicopathologic diagnosis and hCG level were of borderline significance only in some models of the total patient population. All classification systems were able to identify low- and high-risk subsets of patients with approximately equal efficiency. The addition of FIGO substages enhanced discrimination between prognostic groups in patients with stage III disease. CONCLUSIONS: Existing systems for the classification of malignant gestational trophoblastic tumor are based in part on factors that are not independently prognostic, such as hCG level or tumor size. These systems discriminate between low- and high-risk patients with approximately equal efficiency. The clinical classification system is currently preferred for determining initial therapy in women with malignant gestational trophoblastic tumors.

Chorionic Gonadotropin↗
PubMed1987

[Human listeriosis infections in West Germany, 1969-1985].

296 strains of Listeria monocytogenes have been submitted for confirmation and further studies to the Listeria Reference Laboratory at the Institute of Hygiene in Würzburg, Federal Republic of Germany. They have been isolated between 1969 and 1985 from human cases in the Federal Republic and West Berlin. The results of an analysis of the respective cases are presented here on the basis of questionnaires. A steady increase of Listeria isolations has been noted during the past few years. The largest number of strains originated from the district Nordrhein-Westfalen which has the largest population of all German federal districts. The highest incidence calculated from the number of strains and total population was found for the district of Saarland. There was no predominance detectable of listeriosis among the rural population. 60% of the strains came from patients living in urban areas. In 6 out of 21 cases of neonatal listeriosis at least one of the parents was engaged in professional medical services. The most frequently observed clinical entities were meningitis (41.14%) and septicaemia (36.00%). Among the newborns septicaemia was predominant with 40.90%. Listeriosis during pregnancy and among newborns was connected with 53.57% of all strains isolated. The questionnaire revealed for the underlying conditions in 35% and in 24% of cases malignancies and organ transplantations, respectively. There was no increased rate of predominance found among the elderly. However, 50% of all strains isolated originated from newborns. The sex distribution was almost equal; 52.56% from males of the total number of isolates and 51.22% from males among the newborns. 67% of these which had a meningitis after the first weeks of life were male. There was no seasonal incidence detectable. Serovar 4b was found in 66.22% of all isolates tested. 295 strains produced acid from rhamnose and alpha-methyl-d-mannose, but not from d-xylose and were thus typical for L. monocytogenes. One strain needs further studies.

Adolescent↗
PubMedDate not supplied

A primer on economic evaluations related to expansion of newborn screening for genetic and metabolic disorders.

Newborns in every state are screened for genetic/metabolic disorders, but there is no uniform national screening program. Recently, a federal panel concluded that the number of disorders screened should be increased from 9 to Twenty-nine. In order for state leaders, and for the clinicians who inform them, to make sound decisions about expanding newborn screening programs, they need to be aware of the costs and outcomes of the entire screening program. This paper examines newborn screening from several perspectives: status of state programs, screening technology, and financing. In addition, various types of economic evaluations are defined, and a number of economic studies are explored.

Cost-Benefit Analysis↗
PubMed1996

Arguing along the slippery slope of human embryo research.

One frequent argument in the debate over federal funding of human embryo research is the slippery slope argument. Slope arguments can be of several types: either logical, empirical, or full (a combination of logical and empirical slope arguments, with an additional psychological premise). A full slope argument against human embryo research suggests that funding embryo research could undermine current protections for human subjects research, erode respect for persons with disabilities, and encourage eugenics practices. While the Panel commissioned by the National Institutes of Health to issue funding guidelines regarding human embryo research acknowledges some slippery slope concerns, the Panel's final report fails to address such concerns in any depth. Given this failure seriously to address these valid concerns, federal funding of embryo research should not proceed at this time.

Advisory Committees↗
PubMed2003

Analysis of pyridines in mainstream cigarette smoke.

A new technique has been developed for the quantitative analysis of pyridines in mainstream cigarette smoke using a GC-MS technique. For analysis, 10 cigarettes are smoked using conditions based on US Federal Trade Commission recommendations. The smoke is collected in a water trap and analyzed using a GC-MS technique. A standard or a fast GC separation can be applied for the analysis. The standard separation was followed by MS detection using selected ion monitoring (SIM) acquisition on a quadrupole instrument. The fast GC was followed by MS detection with total ion acquisition on a time-of-flight instrument. The levels of pyridine depend on the type of cigarette: for a full flavor cigarette pyridine is as high as 18.0 microg/cigarette (cig.). and for an ultra light cigarette is about 3.0 microg/cig. Substituted pyridines vary between 5.0 microg/cig. to 0.1 microg/cig. for a full flavor cigarette, and between 0.2 microg/cig. and a few ng/cig. for an ultra light cigarette. The reproducibility of the technique is very good, with less than 7-8% RSD in both separation procedures for most of the analyzed compounds.

Gas Chromatography-Mass Spectrometry↗
PubMed1999

Why is the death rate from lung cancer falling in the Russian Federation?

Age standardised death rates (European standard population) from lung cancer in the Russian Federation, have been rising since at least 1965, levelled out in the late 1980s and have subsequently decreased. The reasons for this decline are not apparent. This study seeks to identify the reasons for the decline in mortality from lung cancer in the Russian Federation in the 1990s. Changes in age-specific mortality from lung cancer in the Russian Federation between 1990 are described and age-cohort analysis, based on age-specific death rates for lung cancer is undertaken for the period 1965 to 1995. As other work has shown that any recent deterioration in coding of cause of death has been confined largely to the elderly, this suggests that the trend is not a coding artefact. Age-period-cohort analysis demonstrates the existence of a marked birth cohort effect, with two major peaks corresponding to those born around 1926 and 1938. These groups would have reached their early teens during the second world war and the period immediately after the death of Stalin, respectively. The present downward trend in death rates from lung cancer in the Russian Federation is partly due to a cohort effect and it is expected that this will soon reverse, with a second peak occurring in about 2003.

Adolescent↗
PubMed1992

[Cohort fertility of men and women in the Federal Republic of Germany. A measurement with data from empirical social research].

The availability of mates and the consequences for cohort fertility by sex in Germany is analyzed using pooled data from various fertility surveys conducted since 1900. "All German male cohorts born before 1930 have a greater number of children than their female counterparts. German men up to cohorts around 1930 experienced favourable conditions of the marriage market due to the consequences of the two World Wars.... The general decline of births beginning around 1970 will, however, turn around this relative position. Leaving the preferred age-difference between spouses unchanged smaller female cohorts will now be able to select partners from greater (and older) cohorts of potential male partners. These changing relative positions are already visible in the differences between male and female cohort fertility." (SUMMARY IN ENG)

Cohort Studies↗
PubMed1987

[Analgesic consumption in the Federal Republic of Germany. The extent and the risk groups].

An analysis of still unpublished sales statistics shows that during 1976-1983 the annual sales of all analgesic package units remained relatively stable (about 115 million units per year), while the consumption of large packings mostly preferred by analgesic abusers increased from 8.13 to 11.28 million (units of 100 tablets). The annual per capita consumption of analgesic substances (1983) was 18.2 g. Among these, drugs containing salicylate and phenazone headed the list, whereas phenacetin consumption is increasingly on the downgrade (0.87 g per capita). 95% of all analgesics are used outside of the clinics. Furthermore, 80% of them are purchased on the prescription-free market. High consumption of analgesics can be assumed in 5% of the normal population. Analgesic abuse is more prevalent in women, especially in some industrial areas.

Analgesics↗
PubMedDate not supplied

[The HIV epidemic in the German Federal Republic--infection epidemiology interpretation of numbers of AIDS cases].

Statistical analysis of AIDS case data shows that the flattening out of growth rates of AIDS in the FRG are solely due to the development of case rates in some groups of homosexual men in HIV epicentres and the absence of new infections in haemophiliacs and in patients receiving blood transfusions. Development in the epicentres is interpreted as early saturation. In the other groups that now constitute one-half of the cases reported in 1989 the increase has been steady. Existing gaps in epidemiological infection control are discussed.

Acquired Immunodeficiency Syndrome↗
PubMed1980

The federal confidentiality protections for alcohol and drug abuse patient records: a model for mental health and other medical records?

The federal regulations governing confidentiality of alcohol and drug abuse patient records are examined with respect to their applicability to mental health and other medical records. The analysis focuses on the purpose, scope, restrictions, and penalties of the federal statutes, and compares them to the pertinent legislative recommendations of the Privacy Protection Study Commission.

Alcoholism↗
PubMed1989

Time trends in cancer mortality in the Federal Republic of Germany: progress against cancer?

In accordance with a previous analysis of US cancer mortality, this report also indicates that cancer mortality in the FRG over the last 3 decades (1952-1985) has not shown any decline commencing in a given period and prevailing in all age groups. If present, such effects could have been interpreted as a manifestation of improvements associated with cancer treatment. The absence of such an effect, derived by using data up to 1985 and age-specific mortality rates, supports the view expressed in the US analysis that improvements in cancer treatment are unlikely to have an impact on overall cancer mortality statistics and that efforts toward prevention may be more rewarding.

Age Factors↗