Listeriosis in mother and fetus during the first trimester of pregnancy. Case report.
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Typhoid fever in pregnancy may result in infection of the fetus, with consequent abortion. Currently, it is a rare complication of pregnancy in the industrially developed countries. This report documents a case of maternal typhoid fever with septic abortion, in which trans-placental infection of the fetus caused its demise.
A historical study evaluated maternal outcomes in pregnancy complicated by smallpox. The overall case fatality was estimated to be 34.3% (95% confidence interval [CI] 31.4-37.1), and the proportion of miscarriage or premature birth was estimated to be 39.9% (95% CI 36.5-43.2). Vaccination before pregnancy reduced the risk for death.
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Antiphospholipid syndrome (APLS) is characterized by the presence of antibodies against phospholipids in circulating blood, recurrent arterial and/or venous thrombosis, recurrent and spontaneous abortions and thrombocytopenia. This syndrome develops in the presence of autoimmune diseases, most frequently lupus erythematosus, neoplastic and infectious processes. Circulating antibodies damage endothelium of the vessels and result in active thrombogenesis and slow fibrinolysis. Morphologically, APLS presents with thrombosis, focal angiomatosis, hemorrhage, endothelium and vascular wall alterations in the absence of inflammatory cell reaction. These lesions may be associated with vasculitis in various organs.
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Neospora caninum is one of the most important causes of abortion in cows. The occurrence of N. caninum infection in beef and dairy cattle has been reported worldwide, and in most provinces in Canada. The objective of this review is to summarize our current understanding of N. caninum in dairy and beef cattle for Canadian bovine practitioners. The review covers the life cycle of the agent, its mechanisms of transmission, clinical signs, and tests for diagnosing the infection. Data on the prevalence of the infection in Canadian dairy and beef cattle are reviewed and briefly compared with estimates from other parts of the world. Most importantly for Canadian bovine practitioners, the impacts of the infection, risk factors for its occurrence, and methods of control are also discussed. By reviewing the scientific literature on N. caninum from a Canadian perspective, culling decisions based on the interpretation of diagnostic tests are more effectively made in the control of N. caninum-associated disease.
The aim of the study was the clinical and pathology description of patients who died due to post-delivery or postabortion sepsis. We performed the retrospective analysis based on the postmortem examination of patients who died after post-delivery or postabortion sepsis at the Anti-Sepsis Center during 1987-2000. For thirteen years at gynecological department of the Anti-Sepsis Center out of 524 patients hospitalized with the diagnosis of postpartum or postabortion sepsis 45 died (8.6%). During all those years lethality fluctuated between 2.2%-15.5%. The existence of extragenital diseases in pre-delivery period was afterwards the risk-factor for the development of polyorganic insufficiency with sepsis. These irreversible changes was the cause lethal outcome. The main factors were delayed hospitalization, severity of complications and septic shock.
Fetal blood sampling under ultrasound guidance allows prenatal diagnosis of hemoglobin and coagulation disorders but also infectious fetal diseases (i.e. toxoplasmosis, rubella, cytomegalovirus). In utero, therapeutic possibilities have considerably reduced the number of therapeutic abortions.
During a period of 6 months, 537 pregnant women from a rural area in Saudi Arabia were tested serologically for brucellosis. Of the 513 women who were tested routinely, 18 were found to have a positive titre (3.5%). Of 24 patients in whom the test was carried out because of symptoms suggestive of brucellosis, all were positive. Thirty of the 42 positive cases had titres exceeding 1:160. The incidence of abortion among pregnant women with Brucella titres less than 1:160 was 7.7% contrasting with 17.6% among those with titres above 1:160 (P less than 0.04). This observation calls for further study of the incidence of brucellosis in pregnant women in infected areas, and the connection between elevated Brucella titre and abortion.
Although the clinical diagnosis of appendicitis in pregnancy seems to be complicated by the physiologic changes of pregnancy, evidence from controlled studies is lacking. The aims of this study were to determine whether there are any features of appendicitis in pregnant women that would help to establish the diagnosis and whether any difference exists between the presentation of appendicitis in pregnant and nonpregnant women. Twenty-eight pregnant women with a clinical diagnosis of appendicitis were compared with an equal number of nonpregnant patients matched for age and randomly selected from a group of patients who had appendicitis. No differences were observed in the presenting symptoms, physical signs and laboratory tests. The false-positive rates were identical. The results indicated that the diagnosis of appendicitis is no more difficult in the pregnant state than in the nonpregnant state.
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