Sustained isometric contraction of skeletal muscle depleted of phosphocreatine.
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This paper provides an overview of techniques suitable for the estimation, interpretation and understanding of time variations that affect the surface electromyographic (EMG) signal during sustained voluntary or electrically elicited contractions. These variations concern amplitude variables, spectral variables and muscle fiber conduction velocity, are interdependent and are referred to as the 'fatigue plot'. The fatigue plot provides information suitable for the classification of muscle behavior. In addition, the information obtainable by means of linear electrode arrays is discussed, and applications of mathematical models for the interpretation of array signals are presented. The model approach provides additional ways for the classification of muscle behavior.
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The effects of halothane on isometirc contractions of isolated pregnant uterine muscle strips were evaluated in tissue obtained from 13 midpregnant rats. Peak developed tension was depressed in a dose-related manner at halothane concentrations above 0.8 vol per cent, but was not affected at lower halothane concentrations. Time to peak tension was reduced 10-20 per cent, and relaxation time, 10 per cent, by halothane concentrations ranging up to 2.2 per cent. Total resting tension consisted of a passive component and a calcium-dependent component. In concentrations above 0.8 per cent, halothane rapidly removed 100 per cent of the calcium-dependent resting tension. At lower concentrations, halothane reduced it 50 per cent. The passive component of resting tension was unaffected by halothane. These actions of halothane can prevent postpartum hemostasis. They occur even with very low anesthetic concentrations and can be detected soon after introduction of anesthetic into the muscle bath. This indicates that the hemostatic hazards associated with the use of halothane for delivery may not be prevented by limiting the concentration of halothane or the duration of anesthetic exposure.
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